Dr Ian Young - Researcher Profile

Biography

Ian works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Lecturer.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Murdoch University

Year awarded: 2005

DOCTOR OF PHILOSOPHY

Institution: Murdoch University

Year awarded: 1979

Publications

Book Chapters

Young, I., Renfree, M., Mesiano, S., Shaw, G., Jenkin, G., Smith, R., 2011, The comparative physiology of parturition in mammals: hormones and parturition in mammals, in Hormones and Reproduction of Vertebrates - Volume 5: Mammals, eds David O. Norris and Kristin H. Lopez, Academic Press, United States, pp. 95-116.

Young, I.R., 2001, The comparative physiology of parturition in mammals, in The Endocrinology of Partuition. Basic Science and Clinical Application, eds Roger Smith, Karger, Basel Switzerland, pp. 10-30.

Hooper, S.B., Young, I.R., 1998, Endocrine maturation of the fetus, in Endocrinology of Pregnancy, Humana Press, Totowa New Jersey USA, pp. 353-385.

Journal Articles

Smith, J.T., Young, I.R., Veldhuis, J.D., Clarke, I.J., 2012, Gonadotropin-inhibitory hormone (GnIH) secretion into the ovine hypophyseal portal system, Endocrinology [P], vol 153, issue 7, The Endocrine Society, USA, pp. 3368-3375.

Dellios, N.L., Lappas, M., Young, I.R., Palliser, H.K., Hirst, J.J., Oliva, K., Ayhan, M., Rice, G.E., 2010, Increased expression of alpha-enolase in cervico-vaginal fluid during labour, European Journal of Obstetrics, Gynecology and Reproductive Biology [P], vol 153, issue 1, Elsevier Ireland Ltd, Ireland, pp. 16-22.

Goldschlager, T., Rosenfeld, J.V., Young, I.R., Jenkin, G., 2009, Anterior cervical discectomy and fusion in the ovine model, Journal of Visualized Experiments [E], vol E, Journal of Visualized Experiments, US, pp. 1-10.

Jenkin, G., Challis, J., Robinson, J., Young, I., 2009, Geoffrey Donald Thorburn 1930-1996, Historical Records of Australian Science [P], vol 20, issue 1, CSIRO Publishing, Australia, pp. 109-130.

Szarek, E., Farrand, K., McMillen, C., Young, I.R., Houghton, D.C., Schwartz, J., 2008, Hypothalamic input is required for development of normal numbers of thyrotrophs and gonadotrophs, but not other anterior pituitary cells in late gestation sheep, Journal of Physiology, vol 586, Blackwell Publishing, Oxford, UK, pp. 1185-1194.

Young, I.R., Rice, G.E., Palliser, H.K., Ayhan, M., Dellios, N.L., Hirst, J.J., 2007, Identification of bactenecin-1 in cervicovaginal fluid by two-dimensional electrophoresis in an ovine model of preterm labour, Proteomics, vol 7, issue 2, Wiley-V C H Verlang GMBH, Weinheim Germany, pp. 281-288.

Bott, E.M., Young, I.R., Jenkin, G., McLaren, W.J., 2006, Detection of morphological changes of the ovine cervix in response to sex steroids using a fluorescence confocal endomicroscope, American Journal of Obstetrics and Gynecology, vol 194, issue 1, Mosby, Inc., St Louis USA, pp. 105-112.

Palliser, H.K., Hirst, J.J., Rice, G.E., Ooi, G.T., Dellios, N., Escalona, R.m., Young, I.R., 2006, Labor-associated regulation of prostaglandin E and F synthesis and action in the ovine amnion and cervix, Journal of The Society for Gynecologic Investigation, vol 13, issue 1, Elsevier Science Inc, New York USA, pp. 19-24.

Hirst, J.J., Parkington, H.C., Young, I.R., Palliser, H.K., Peri, K.G., Olson, D.M., 2005, Delay of preterm birth in sheep by THG113.31, a prostaglandin F2alpha receptor antagonist, American Journal of Obstetrics and Gynecology, vol 193, issue 1, Mosby, Inc., USA, pp. 256-266.

Palliser, H.K., Hirst, J.J., Ooi, G.T., Rice, G.E., Dellios, N.L., Escalona, R.M., Parkington, H.C., Young, I.R., 2005, Prostaglandin E and F receptor expression and myometrial Sensitivity at labor onset in the sheep, Biology of Reproduction, vol 72, issue 4, Society Study of Reproduction, USA, pp. 937-943.

Nguyen, P., Young, I.R., Walker, D.W., Hirst, J.J., 2004, Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep, Journal of Endocrinology, vol 182, issue 1, Society for Endocrinology, Bristol UK, pp. 81-88.

Jenkin, G., Young, I.R., 2004, Mechanisms responsible for parturition; the use of experimental models, Animal Reproduction Science, vol 82-83, Elsevier, Amsterdam The Netherland, pp. 567-581.

Young, I.R., Chan, E.C., Smith, R., Chrousos, G.P., Veldhuis, P.J.D., Canny, B., 2002, Effect of Antalarmin, a Novel Corticotropin-Releasing Hormone Antagonist, on the Dynamic Function of the Preterm Ovine Fetal Hypothalamo-Pituitary-Adrenal Axis, Neuroendocrinology, vol 76, issue 1, Karger, Switzerland, pp. 47-54.

Nardo, L., Soong, Y., Wu, D., Young, I., Walker, D.W., Szeto, H.H., 2002, Site and mechanism of action of dynorphin A-(1-13) and N-methyl-D-aspartate on ACTH release in fetal sheep, American Journal of Physiology-Endocrinology and Metabolism, vol 282, issue 6, American Physiological Society, USA, pp. E1301-E1307.

Hughan, S.C., Loose, J.M., Caddy, D.J., Canny, B., Tilbrook, A., Young, I., 2001, Combined xylazine and ketamine as an analgesic regimen in sheep, Australian Veterinary Journal, vol 79, issue 3, Australian Veterinary Association, Brunswick Vic Australia, pp. 207-211.

Jenkin, G., Ward, J.W.A., Loose, J.M., Schneider-Kolsky, M.E., Young, I., Canny, B., O'Connor, A., de Kretser, D.M., Wallace, E.M., 2001, Physiological and regulatory roles of activin A in late pregnancy, Molecular and Cellular Endocrinology, vol 180, Elsevier Science Ireland Ltd, Ireland, pp. 131-138.

Simmonds, P.J., Phillips, I.D., Poore, K.R., Young, I., Coghill, I.D., Canny, B., 2001, The role of the pituitary gland and ACTH in the regulation of mRNAs encoding proteins essential for adrenal steroidogenesis in the late-gestation ovine fetus, Journal of Endocrinology, vol 168, issue 3, Society for Endocrinology, Stokebristol England, pp. 475-485.

McLaren, W.J., Young, I.R., Rice, G.E., 2000, Immunohistochemical localization of prostaglandin G/H synthase 1 and 2 in sheep placenta after glucocorticoid-induced and spontaneous labour, Journal of Reproduction and Fertility, vol 120, Jour. Reproduct. Fertility Limited, Cambridge England, pp. 33-39.

Nardo, L., Young, I.R., Hooper, S.B., 2000, Influence of growth hormone on the lung growth response to tracheal obstruction in fetal sheep, American Journal of Physiology: Lung cell and molecular physiology, vol 278, American Physiology Society, Bethesda MD USA, pp. L453-L459.

McLaren, W.J., Young, I.R., Rice, G.E., 2000, Localisation and temporal changes in prostaglaudin G/H synthase -1 and -2 content in ovine intrauterine tissues in relation to glucocorticoid-induced and spontaneous labour, Journal of Endocrinology, vol 165, Society of Endocrinology, Bristol UK, pp. 399-410.

Iannello, R., Gould, J., Young, J., Giudice, A., Medcalf, R.L., Kola, I., 2000, Methylation-dependent silencing of the testis-specific Pdha-2 basal promoter occus through selective targeting of an activating transcription factor/cAMP-responsive element-binding site, The Journal of Biological Chemistry, vol 275 issue 26, Amer Soc for Biochemistry & Molecular Biology, Bethesda USA, pp. 19603-19608.

Poore, K.R., Canny, B., Young, I.R., 1999, Adrenal responsiveness and the timing of parturition in hypothalamo-pituitary disconnected fetuses with and without constant ACTH infusion, Journal of Neuroendocrinology, vol 11, Blackwell Science, Oxford UK, pp. 343-349.

Leung, S.T., Wathes, D.C., Young, I.R., Jenkin, G., 1999, Effect of labour induction on the expression of oxytocin receptor, cytochrome P450 aromatase and estradiol receptor in the reproductive tract of the late-pregnant ewe, Biology of Reproduction, vol 60, Society for the Study of Reproduction, Madison WI USA, pp. 814-820.

Poore, K.R., Young, I.R., Hirst, J.J., 1999, Efficiency of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep, American Journal of Obstetrics and Gynecology, vol 180, Mosby Year Book, St Louis MO USA, pp. 1244-1253.

Ford, M., Thorburn, G.D., Caddy, D.J., Young, I.R., 1999, Pulsatile output of prostaglandin F<2Biology of Reproduction, vol 61, Society for the Study of Reproduction, Madison WI USA, pp. 411-415.

Poore, K.R., Young, I.R., Canny, B., Thorburn, G.D., 1998, Angiotensin II in fusion in vivo does not modulate cortisol secretion in the late-gestation ovine fetus, American Journal of Physiology (Regulatory Integrative and Comparative Physiology), vol 257 (44 no 2), American Physiological Society, Bethesda MD USA, pp. 357R-362R.

Ford, M., Young, I.R., Caddy, D.J., Thorburn, G.D., 1998, Fetal and maternal endocrine changes approaching parturiton in the goat: lack of evidence for prostaglandin E2 and F2 as signals for luteolysis1, Biology of Reproduction, vol 58, Society for the Study of Reproduction, Madison Wisconsin USA, pp. 1065-1070.

Canny, B., Young, I.R., Veldhuis, P.J., 1998, Hypothalamo-pituitary disconnection of the late gestation ovine fetus results in profound changes in cortisol secretion that are not reflected in commensurate changes in adrenocorticotropin secretion, Endocrinology, vol 139 (7), The Endocrine Society, Bethesda MD USA, pp. 3210-3219.

Young, J., Gould, J., Kola, I., Iannello, R., 1998, Review: Pdha-2, Past and Present, Journal of Experimental Zoology, vol john r mccarrey & john l vandeberg, Wiley-Liss Inc., USA, pp. 231-238.

Poore, K.R., Young, I.R., Canny, B., Thorburn, G.D., 1998, Studies on the role of ACTH in the regulation of adrenal responsiveness and the timing of parturition in the ovine fetus, Journal of Endocrinology, vol 158 (2), The Society for Endocrinology, Bristol UK, pp. 161-171.

Houghton, D.C., Young, I.R., McMillen, I.C., 1997, Photoperiodic history and hypothalamic control of prolactin secretion before birth, Endocrinology, vol 138, The Endocrine Society, Bethesda MD USA, pp. 1506-1511.

Iannello, R., Young, J., Sumarsono, S.H., Tymms, M.J., Dahl, H.M., Gould, J., Hedger, M., Kola, I., 1997, Regulation of Pdha-2 Expression is mediated byproximal promoter sequences and CpG Methylation, Molecular and Cellular Biology, vol 17, American Society for Microbiology, Washington DC USA, pp. 612-617.

Miller, S., Wongprasartsuk, S., Young, I.R., Wlodek, M.E., McFarlane, J.R., de Kretser, D.M., Jenkin, G., 1997, Source of Inhibin in Ovine Fetal Plasma and Amniotic Fluid, Biology of Reproduction, vol 57, Society for the Study of Reproduction, Wisconsis USA, pp. 347-353.

Miller, S., Wongprasartsuk, S., Young, I.R., Wlodek, M.E., McFarlane, J.R., de Kretser, D.M., Jenkin, G., 1997, Source of inhibin in ovine fetal plasma and amniotic fluid during late gestation: Half-life of fetal inhibin, Biology of Reproduction, vol 57, Society for the Study of Reproduction, Madison Wisconsin USA, pp. 347-353.

Conference Proceedings

Simmonds, P., Phillips, I.D., Canny, B., Poore, K.R., Coghill, I.C., Young, I.R., 1999, ACTH regulates adrenal steroidogenic enzyme mRNA in the late gestation ovine foetus, The Endocrine Society of Australia Proceedings 1999, Melbourne VIC 26-29 September 1999, Endocrine Society of Australia, Adelaide SA Australia, p. 104.

Stone, S.C., Canny, B., Caddy, D.J., Tilbrook, A.J., Young, I.R., 1999, Endocrine responses of pregnant ewes to anaesthesia, surgery and analgesic drugs, The Endocrine Society of Australia Proceedings 1999, Melbourne VIC 26-29 September 1999, Endocrine Society of Australia, Adelaide SA Australia, p. 77.

Jenkin, G., Young, I.R., Wallace, E.M., de Kretser, D.M., Coghill, I.C., Canny, B., 1999, Hypoxia is a specific stimulus to fetal activin A and follistatin release in late gestation, The Endocrine Society of Australia Proceedings, Melbourne VIC 26-29 September 1999, Endocrine Society of Australia, Adelaide SA Australia, p. 134.

Simmonds, P., Phillips, I.D., Coghill, I.C., Poore, K.R., Canny, B., Young, I.R., 1999, Regulation of ACTH receptors, steroidogenesis factor 1 and P450 side chain cleavage enzyme gene expression in the adrenal gland of the sheep fetus, The Endocrine Society Program and Abstracts, San Diego California USA 12-15 June 1999, The Endocrine Society Press, Bethesda MD USA, p. 535.

Coghill, I.C., Young, I.R., Canny, B., 1999, The induction of heightened adrenal responsiveness to ACTH in the late-gestation ovine foetus is associated with increased cortisol negative feedback, The Endocrine Society of Australia Proceedings 1999, Melbourne VIC 26-29 September 1999, Endocrine Society of Australia, Adelaide SA Australia, p. 104.

Canny, B., Loose, J.M., Young, I.R., 1999, The pituitary neurointermediate lobe (NIL) modulates the HPA axis in late-gestation sheep fetus, The Endocrine Society Program and Abstracts, San Diego California USA 12-15 June 1999, The Endocrine Society Press, Bethesda MD USA, p. 535.

Hirst, J.J., Poore, K.R., Grigsby, P.L., Young, I.R., Jenkin, G., 1999, Use of selective inhibitors of prostaglandin synthase type-2 for delaying preterm delivery, Perinatal Society of Australia and New Zealand 3rd Annual Congress, Melbourne VIC 21-24 March 1999, The Perinatal Society of Australia and New Zealand, Parramatta NSW, p. 4.

Poore, K.R., Canny, B., Young, I.R., 1998, Chronic low-dose ACTH infusion restores cortisol secretion and permits parturition in hypothalamo-pituitary disconnected fetuses, The Endocrine Society of Australia Proceedings, Perth WA 23 -26 August 1998, The Endocrine Society of Australia, Melbourne Vic Australia, p. 58.

Hertzog, P.J., Young, J., Holland, K.A., Hardy, M., Bertoncello, I., Owczarek, C.M., Kola, I., 1998, Different functions of the two type I interferon receptor components revealed by IFNAR1 and IFNAR 2 knockout mice, 2nd Joint Meeting of the International Cytokine Society and the International Society for Interferon and Cytokine Research, Jerusalem, Israel, October 25 - 30, 1998, ICS & ISICR, USA, p. 38.

Hertzog, P.J., Owczarek, C.M., Hardy, M., Gulluyan, L., Young, J., Kola, I., 1998, Genetic analysis of the interferon system, Functional Genomics: New Horizons in Genetics & Disease, Melbourne, Australia. March 15-17, 1998, SmithKline Beecham Pharmaceuticals, Vic Australia.

Poore, K.R., Young, I.R., Hirst, J.J., 1998, Nimesulide a selective prostaglandin synthase type-2 inhibitor blocks basal prostaglandin production and glucocorticoid-induced premature labour in sheep, Proceedings of the 2nd Annual Congress of Perinatal Society of Australia and New Zealand, Alice Springs NT 29 March - 1 April 1998, Perinatal Society of Australia and New Zealand, Paramatta NSW, p. 82.

Hertzog, P.J., Owczarek, C.M., Holland, K.A., Hardy, M., Fenner, J., Bertoncello, I., Young, J., Kola, I., 1998, The function of type I interferons based on mice deficient in both receptor components, 28th Conference of the A'asian Society for Immunology, Melbourne, Victoria, The Australian Society for Immunology, Vic Australia.

Canny, B., Veldhius, J.D., Young, I.R., 1997, Changes in the nature of ACTH secretion do not explain changes in cortisol secretion in the hypothalamo-pituitary disconnected (HPD) ovine fetus, Endocrine Society of Australia Proceedings, 28/9/97-2/10/97, Endocrine Society of Australia, Australia, p. 115.

Ford, M., Young, I.R., Thorburn, G.D., 1997, Luteolysis and parturition in the pregnant goat, Proceedings of the Australian Society for Reproductive Biology, Canberra,29Sept-1Oct, 1997, ASRB, Australia, p. 109.

Leung, S.T., Borwick, S.C., Thornton, S., Young, I.R., Jenkin, G., Wathes, D.C., 1997, Oestradiol receptors do not show a major up-regulation during labour in either sheep or women, Journal of Reproduction and Fertility, York UK, July 1997, Journal of Reproduction and Fertility, Cambridge UK, p. 45.

Other

Young, J., 1997, The elucidation of mechanisms involved in the transcriptional regulation of the murine Pdha2 gene.

Postgraduate Research Supervisions

Completed Supervision

Student:

Coghill, E.

Program of Study:

A FUNCTIONAL ANALYSIS OF ERYTHROID KRUPPLE-LIKE FACTOR (EKLF). (PHD) 2002.

Supervisors:

Young, I (Main), Perkins, A (Associate).

Student:

Koh, P.

Program of Study:

THE TRANSCRIPTIONAL REGULATION OF GAMMA GLOBIN. (PHD) 2004.

Supervisors:

Perkins, A (Main), Young, I (Associate).

Student:

Nguyen, P.

Program of Study:

DEVELOPMENTAL AND PATHOPHYSIOLOGICAL REGULATION AND NEUROSTEROID SYNTHESIS IN THE FETAL AND NEONATAL SHEEP BRAIN. (PHD) 2005.

Supervisors:

Hirst, J (Main), Walker, D (Associate), Young, I (Associate).

Student:

Palliser, H.

Program of Study:

The regulation of prostaglandin synthases and receptors during spontaneous, induced and inhibited ovine labour. (PHD) 2005.

Supervisors:

Young, I (Joint-Co).

Student:

Simmonds, P.

Program of Study:

THE ROLE OF PROSTAGLANDIN E2 IN THE REGULATION OF THE OVINE FETAL ADRENAL CORTEX. (PHD) 2002.

Supervisors:

Canny, B (Main), Young, I (Associate).