Dr Maria Hughes - Researcher Profile

Biography

Position

Research Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

BIOCHEMISTRY AND MOLECULAR BIOLOGY

Institution: Monash University

Year awarded: 2003

Publications

Journal Articles

Velkov, T., Hughes, M.L.R., Horne, H.J., Simpson, J.S., Porter, C.J., Scanlon, M., 2009, Characterization of lipophilic drug binding to rat intestinal fatty acid binding protein, Molecular And Cellular Biochemistry [P], vol 326, issue 1-2, Springer New York LLC, USA, pp. 87-95.

Diwakarla, S., Nagley, P., Hughes, M.L.R., Chen, B., Beart, P.M., 2009, Differential insult-dependent recruitment of the intrinsic mitochondrial pathway during neuronal programmed cell death, Cellular And Molecular Life Sciences [P], vol 66, issue 1, Birkhaeuser Verlag AG, Switzerland, pp. 156-172.

Diwakarla, S., Mercer, L.D., Kardashsyan, L., Chu, P.W.Y., Shin, Y., Lau, C.L., Hughes, M.L.R., Nagley, P., Beart, P.M., 2009, GABAergic striatal neurons exhibit caspase-independent, mitochondrially mediated programmed cell death, Journal Of Neurochemistry [P], vol 109, issue Suppl 1, Wiley-Blackwell Publishing Ltd, UK, USA, pp. 198-206.

Beart, P.M., Lim, M.L.R., Chen, B., Diwakarla, S., Mercer, L., Cheung, N.S., Nagley, P., 2007, Hierarchical recruitment by AMPA but not staurosporine of pro-apoptotic mitochondrial signaling in cultured cortical neurons: evidence for caspase-dependent/independent cross-talk, Journal of Neurochemistry, vol 103, issue 6, Blackwell Publishing, Oxford England UK, pp. 2408-2427.

Lim, M.L.R., Mercer, L., Nagley, P., Beart, P.M., 2007, Rotenone and MPP+ preferentially redistribute apoptosis-inducing factor in apoptotic dopamine neurons, Neuroreport, vol 18, issue 4, Lipponcott Williams & Wilkins, Philadelphia PA USA, pp. 307-312.

Lim, M.L.R., Chen, B., Beart, P.M., Nagley, P., 2006, Relative timing of redistribution of cytochrome c and Smac/DIABLO from mitochondria during apoptosis assessed by double immunocytochemistry on mammalian cells, Experimental Cell Research, vol 312, issue 7, Elsevier Inc., San Diego USA, pp. 1174-1184.

Lim, M.L.R., Lum, M., Hansen, T.M., Roucou, X., Nagley, P., 2002, On release of Cytochome c from mitochondria during cell death signaling, Journal of Biomedical Science, vol 9, issue 6, Karger, Basel Switzerland, pp. 488-506.

Nagley, P., Zhang, C., Lim, M.L.R., Merhi, M., Needham, B.E., Khalil, Z., 2001, Mitochondrial DNA deletions parallel age-linked decline in rat sensory nerve function, Neurobiology of Aging, vol 22, issue 4, Elsevier Science Inc, New York NY USA, pp. 635-643.

Lim, M.L.R., Minamikawa, T., Nagley, P., 2001, The protonphore CCCP induces mitochondrial permeability transition without cytochrome c release in human osteosarcoma cells, FEBS Letters, vol 503, issue 1, Elsevier Science BV, Amsterdam Netherlands, pp. 69-74.

Lee, H., Lim, M.L., Lu, C., Liu, V.W., Fahn, H., Zhang, C., Nagley, P., Wei, Y., 1999, Concurrent increase of oxidative DNA damage and lipid peroxidation together with mitochondrial DNA mutation in human lung tissues during aging: smoking enhances oxidative stress to the aged tissues, Archives of Biochemistry and Biophysics, vol . 362 issue 2, Academic Press, San Diego CA USA, pp. 309-316.

Activities

Affiliations with institutes

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences