Dr Jennifer Dyson - Researcher Profile

Biography

Jennifer works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2005

SCIENCE (HONS)

Institution: Monash University

Year awarded: 1998

Publications

Book Chapters

Dyson, J.M., Fedele, C.G., Davies, E.M., Becanovic, J., Mitchell, C.A., 2012, Phosphoinositide phosphatases: just as important as the kinases, in Phosphoinositides I: Enzymes of Synthesis and Degradation, eds T Balla,M Wymann & JD York, Springer Science+Business Media, USA, pp. 215-279.

Ooms, L.M., Dyson, J.M., Kong, A.M., Mitchell, C.A., 2009, Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays, in Lipid Signaling Protocols, eds B Larijani, R Woscholski, C A rosser, Humana Press, USA, pp. 223-239.

Journal Articles

Conduit, S.E., Dyson, J.M., Mitchell, C.A., 2012, Inositol polyphosphate 5-phosphatases; new players in the regulation of cilia and ciliopathies, FEBS Letters [P], vol 586, issue 18, Elsevier BV, Netherlands, pp. 2846-2857.

Johnson, J.F., Hall, T.E., Dyson, J.M., Sonntag, C., Ayers, K.L., Berger, S., Gautier, P., Mitchell, C.A., Hollway, G.E., Currie, P.D., 2012, Scube activity is necessary for Hedgehog signal transduction in vivo, Developmental Biology [P], vol 368, issue 2, Academic Press, USA, pp. 193-202.

Astle, M., Ooms, L., Cole, A., Binge, L., Dyson, J., Layton, M., Petratos, S., Sutherland, C., Mitchell, C., 2011, Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP) collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation, Journal Of Biological Chemistry [P], vol 286, issue 26, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 23407-23418.

Rahman, P., Huysmans, R., Wiradjaja, F., Gurung, R., Ooms, L., Sheffield, D., Dyson, J., Layton, M., Sriratana, A., Takada, H., Tiganis, T., Mitchell, C., 2011, Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton, Journal Of Biological Chemistry [P], vol 286, issue 34, American Society of Biochemistry and Molecular Biology Inc., USA, pp. 29758-29770.

Naughtin, M.J., Sheffield, D.A., Rahman, P., Hughes, W.E., Gurung, R., Stow, J., Nandurkar, H., Dyson, J.M., Mitchell, C.A., 2010, The myotubularin phosphatase MTMR4 regulates sorting from early endosomes, Journal Of Cell Science [P], vol 123, issue Pt 18, The Company of Biologists Ltd, UK, pp. 3071-3083.

Buzza, M.S., Dyson, J.M., Choi, H., Gardiner, E.E., Andrews, R.K., Kaiserman, D., Mitchell, C.A., Berndt, M.C., Dong, J., Bird, P.I., 2008, Antihemostatic activity of human granzyme B mediated by cleavage of von Willebrand factor, Journal of Biological Chemsitry, vol 283, issue 33, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 22498-22504.

Mcgrath, M.J., Cottle, D.L., Nguyen, M., Dyson, J.M., Coghill, I.D., Robinson, P.A., Holdsworth, M., Hardeman, E.C., Mitchell, C.A., Brown, S., Cowling, B.S., 2006, Four and a half LIM protein 1 binds myosin-binding protein C and regulates myosin filament formation and sarcomere assembly, The Journal of Biological Chemistry, vol 281, issue 11, The American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 7666-7683.

Dyson, J.M., Kong, A.M., Wiradjaja, F., Astle, M.V., Gurung, R., Mitchell, C.A., 2005, The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2, International Journal of Biochemistry & Cell Biology, vol 37, issue 11, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 2260-2265.

Coghill, I.D., Brown, S., Cottle, D.L., Mcgrath, M.J., Robinson, P.A., Nandurkar, H.H., Dyson, J.M., Mitchell, C.A., 2003, FHL3 is an actin-binding protein that regulates -actinin-mediated actin bundling: FHL3 localizes to actin stress fibers and enhances cell spreading and stress fiber disassembly, Journal of Biological Chemistry, vol 278, issue 26, American Society for Biochemistry and Molecular BIology Inc., Bethesda USA, pp. 24139-24152.

Dyson, J.M., Munday, A.D., Kong, A.M., Huysmans, R.D., Matzaris, M., Layton, M.J., Nandurkar, H.H., Berndt, M.C., Mitchell, C.A., 2003, SHIP-2 forms a tetrameric complex with filamin, actin, and GPIb-IX-V: localization of SHIP-2 to the activated platelet actin cytoskeleton, Blood, vol 102, issue 3, American Society of Hematology, Washington USA, pp. 940-948.

Mitchell, C.A., Gurung, R., Kong, A.M., Dyson, J.M., Tan, A., Ooms, L.M., 2002, Inositol polyphosphate 5-phospatases: Lipid phosphatases with flair, IUBMB Life, vol 25, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 25-36.

Dyson, J.M., O'Malley, C.J., Becanovic, J., Munday, A.D., Berndt, M.C., Coghill, I.D., Nandurkar, H., Ooms, L.M., Mitchell, C.A., 2001, The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin, Journal of Cell Biology, vol 155, issue 6, Rockefeller University Press, New York NY USA, pp. 1065-1079.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Characterising the role INPP5E plays in human disease Joubert syndrome and Medulloblastoma.

Supervisors:

Mitchell, C (Main), Dyson, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Characterization of the regulatory role the 72kDa 5-phosphatase in cell proliferation, apoptosis and migration.

Supervisors:

Mitchell, C (Main), Dyson, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigating the role of myotubularin related protein 4 (MTMR4) in breast cancer.

Supervisors:

Mitchell, C (Main), Dyson, J (Associate).