Dr Daniel Malone - Researcher Profile

Biography

Position

Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION TEACHING

Institution: Monash University

Year awarded: 2005

PHARMACOLOGY

Institution: Monash University

Year awarded: 2000

Publications

Journal Articles

Lim, A.L., Taylor, D., Malone, D.T., 2012, A two-hit model: behavioural investigation of the effect of combined neonatal MK-801 administration and isolation rearing in the rat, Journal of Psychopharmacology [P], vol 26, issue 9, Sage Publications Ltd, UK, pp. 1252-1264.

Gururajan, A., Taylor, D., Malone, D.T., 2012, Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats, Journal of Psychopharmacology [P], vol 26, issue 10, Sage Publications Ltd., UK, pp. 1317-1332.

Lim, A.L., Taylor, D., Malone, D.T., 2012, Consequences of early life MK-801 administration: Long-term behavioural effects and relevance to schizophrenia research, Behavioural Brain Research [P], vol 227, issue 1, Elsevier BV, Netherlands, pp. 276-286.

Gururajan, A., Taylor, D., Malone, D., 2011, Effect of cannabidiol in a MK-801-rodent model of aspects of schizophrenia, Behavioural Brain Research [P], vol 222, issue 2, ELSEVIER SCIENCE BV, NETHERLANDS, pp. 299-308.

Yaakob, N., Malone, D., Exintaris, B., Irving, H., 2011, Heterogeneity amongst 5-HT3 receptor subunits: is this significant?, Current Molecular Medicine [P], vol 11, issue 1, Bentham Science Publishers Ltd., Netherlands, pp. 57-88.

Lim, A., Taylor, D., Malone, D., 2011, Isolation rearing in rats: effect on expression of synaptic, myelin and GABA-related immunoreactivity and its utility for drug screening via Ne subchronic parenteral route, Brain Research [P], vol 1381, ELSEVIER SCIENCE BV, NETHERLANDS, pp. 52-65.

Shin, J., Malone, D., Crosby, I., Capuano, B., 2011, Schizophrenia: a systematic review of the disease state, current therapeutics and their molecular mechanisms of action, Current Medicinal Chemistry [P], vol 18, issue 9, BENTHAM SCIENCE PUBL LTD, U ARAB EMIRATES, pp. 1380-1404.

Szabo, M., Agostino, M., Malone, D., Yuriev, E., Capuano, B., 2011, The design, synthesis and biological evaluation of novel URB602 analogues as potential monoacylglycerol lipase inhibitors, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 22, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 6782-6787.

Malone, D.T., Hill, M.N., Rubino, T., 2010, Adolescent cannabis use and psychosis: epidemiology and neurodevelopmental models, British Journal of Pharmacology [P], vol 160, John Wiley & Sons Ltd, UK, pp. 511-522.

Tokanovic, S., White, C., Malone, D.T., Exintaris, B., Ventura, S., 2010, Characterisation of the prostanoid receptor mediating inhibition of smooth muscle contractility in the rat prostate gland, Naunyn-Schmiedeberg's Archives of Pharmacology [P], vol 381, Springer, Germany, pp. 321-328.

Gururajan, A., Taylor, D., Malone, D.T., 2010, Current pharmacological models of social withdrawal in rats: relevance to schizophrenia, Behavioural Pharmacology [P], vol 21, Lippincott Williams & Wilkins, UK, USA, pp. 690-709.

Gururajan, A., Taylor, D., Malone, D.T., 2010, Effect of testing conditions on the propsychotic action of MK-801 on prepulse inhibition, social behaviour and locomotor activity, Physiology and Behavior [P], vol 99, issue 1, Elsevier Inc., USA, pp. 131-138.

Robinson, S.A., Loiacono, R., Christopoulos, A., Sexton, P., Malone, D.T., 2010, The effect of social isolation on rat brain expression of genes associated with endocannabinoid signaling, Brain Research [P], vol 1343, Elsevier BV, The Netherlands, pp. 153-167.

Gururajan, A., Malone, D.T., Taylor, D., 2009, Advances in cannabidiol research as an antipsychotic, Current Topics in Pharmacology [P], vol 13, issue 2, Research Trends (P) Ltd., India, pp. 17-23.

Malone, D.T., Jongejan, D., Taylor, D., 2009, Cannabidiol reverses the reduction in social interaction produced by low dose delta9-tetrahydrocannabinol in rats, Pharmacology, Biochemistry & Behavior [P], vol 93, issue 2, Elsevier Inc., USA, pp. 91-96.

Malone, D.T., Kearn, C.S., Chongue, L., Mackie, K., Taylor, D., 2008, Effect of social isolation on CB1 and D2 receptor and fatty acid amide hydrolase expression in rats, Neuroscience, vol 152, Elsevier Ltd, UK, pp. 265-272.

Tokanovic, S., Malone, D.T., Ventura, S., 2007, Stimulation of epithelial CB1 receptors inhibits contractions of the rat prostate gland, British Journal of Pharmacology, vol 150, issue 2, Nature Publishing Group, UK, pp. 227-234.

Long, L.E., Malone, D.T., Taylor, D.A., 2006, Cannabidiol reverses MK-801-induced disruption of prepulse inhibition in mice, Neuropsychopharmacology, vol 31, issue 4, Nature Publishing Group, UK, pp. 795-803.

Malone, D.T., Taylor, D.A., 2006, The effect of delta9-tetrahydrocannabinol on sensorimotor gating in socially isolated rats, Behavioural Brain Research, vol 166, issue 1, Elsevier BV, Netherlands, pp. 101-109.

Malone, D.T., Long, L.E., Taylor, D.A., 2004, The effect of SR 141716 and apomorphine on sensorimotor gating in Swiss mice, Pharmacology Biochemistry and Behavior, vol 77, issue 4, Elsevier, USA, pp. 839-845.

Malone, D.T., Taylor, D.A., 2001, Involvement of somatodendritic 5-HT1A Receptors in 9-tetrahydrocannabinol-induced hypothermia in the rat, Pharmacology, Biochemistry and Behaviour, vol 69, Elsevier Science, USA, pp. 595-601.

Malone, D., Taylor, D.A., 1999, Modulation by fluoxetine of striatal dopamine release following D9 tetrahydroannabinol: a microdialysis study in conscious rats, British Journal of Pharmacology, vol 128 issue 1, Stockton Press, UK, pp. 21-26.

Malone, D., Taylor, D.A., 1998, Modulation of D9 tetrahydrocannabinol - induced hypothermia by fluoxetine in the rat, British Journal of Pharmacology, vol 124, Stockton Press, UK, pp. 1419-1424.

Conference Proceedings

Taylor, D., Nielsen, S., Malone, D.T., Long, L.E., 2006, Cannabidiol reverses MK-801-induced social withdrawal in rats, Acta Pharmacologica Sinica, 2-7 July 2006, Blackwell Publishing, Beijing China, p. 78.

Long, L.E., Malone, D.T., Taylor, D., 2006, Cannabidiol reverses MK-801-induced social withdrawal in rats, 16th Annual Symposium on the Cannabinoids (ICRS), 24-28 June 2006, Semmelweis, p. 31.

Tokanovic, S., Malone, D.T., Ventura, S., 2006, Cannabinoids inhibit rat prostate smooth muscle contractility via epithelial CB1 receptors, Acta Pharmacologica Sinica, 2-7 July 2006, Blackwell Publishing, Beijing China, p. 373.

Malone, D.T., Kearn, C.S., Chongue, L., Irving, H.R., Mackie, K., Taylor, D., 2006, Effect of social isolation on CB1, D2 and FAAH expression in Sprague-Dawley rats, 16th annual symposium on the cannabinoids (ICRS), 24-28 June 2006, p. 135.

Tokanovic, S., Malone, D.T., Ventura, S., 2006, Stimulation of epithelial CB1 receptors inhibits contractions of the rat prostate gland, Proceedings of the Australian Health & Medical Research Congress 2006, 26 Nov 06 - 1 Dec 06, Australian Health & Medical Research Congress, Melbourne Vic Australia, p. 157.

Tokanovic, S., Malone, D.T., Ventura, S., 2006, The effect of cannabinoids on smooth muscle contractility of the rat prostate, 16th annual ICRS symposium on the cannabinoids, 24-28 June 2006, Semmelweis, p. 179.

Malone, D.T., Stewart, N.W., Taylor, D., 2006, The effect of chronic pubertal cannabinoid treatment on locomotor activity, exploratory behaviour and sensorimotor gating in adult rats, Proceedings of the Australian Neuroscience Society, 31 January - 3 February 2006, p. 106.

Long, L.E., Malone, D.T., Taylor, D., 2006, The effect of subchronic WIN 55,212-2 on prepulse inhibition and on the expression of CB1 receptor and FAAH in the rat brain, Proceedings of the Australian Neuroscience Society, 31 January - 3 February 2006, p. 30.

Malone, D., Taylor, D.A., 1998, Investigation of the role of 5 HT in D9THC - induced hypothermia in the rat, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 21.

Malone, D., Taylor, D.A., 1998, Modulation by endogenous serotonin of striatal dopamine release following D9tetrahydrocannabinol, Fourth IUPHAR Satellite Meeting on Serotonin, Rotterdam Holland, 23-25 July 1998, Serotonin Club, Rotterdam Holland, p. 117.

Malone, D., Taylor, D.A., 1998, Triglyceride emulsion containing -D9 tetrahydrocannabinol effect on body temperature and dopamine release in the corpus striatum, Naunyn-Schmiedeberg's Archives of Pharmacology, Munchen Germany, 26-31 July 1998, Springer-Verlag, Germany, p. R65.

Malone, D.T., Taylor, D.A., 1997, Serotonergic modulation of D9THC - induced hypothermia in the rat, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Canberra Australia, 30 November-3-December, ASCEPT, Australia, p. 82.

Other

Long, L.E., Malone, D.T., Taylor, D.A., 2005, The Pharmacological Actions of Cannabidiol, Drugs of the Future, vol 30, issue 7, Prous Science, Barcelona, Spain, pp. 747-753.

Malone, D.T., 2000, Investigation of the role of serotonin in several effects of D9-THC in the rat.

Teaching Commitment

• Year level co-ordinator, Bachelor of Pharmacy third year
• Lecturer: Bachelor of Pharmacy and Bachelor of Pharmaceutical Sciences: pharmacology, biochemistry and physiology.
• Areas of teaching expertise include the pharmacology of antipsychotics, antidepressants, the biochemistry of lipids, sensory physiology and neurophysiology

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of CRIP1a as a potential therapeutic target for the treatment of epilepsy.

Supervisors:

Exintaris, B (Joint), Malone, D (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of D2-muscarinic ligands as potential treatment for Schizophrenia.

Supervisors:

Canals, M (Joint), Malone, D (Joint-co), Christopoulos, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Validation of the Cannabinoid Receptor Interacting Protein (CRIP1a) as a novel therapeutic target.

Supervisors:

Malone, D (Main), White, P (Associate).

Completed Supervision

Student:

Gururajan, A.

Program of Study:

Behavioural pharmacology of cannabidiol in a MK-801 rodent model of aspects of schizophrenia. (PHD) 2011.

Supervisors:

Malone, D (Main).

Student:

Joshi, D.

Program of Study:

Investigation of long-term behavioural, neurochemical and molecular changes in morphine preferring rats. (PHD) 2010.

Supervisors:

Malone, D (Joint), Taylor, D (Joint-Co).

Student:

Lim, A.

Program of Study:

Investigations into aspects of schizophrenia based on the isolation rearing paradigm in the rat. (PHD) 2012.

Supervisors:

Malone, D (Main).

Student:

Long, L.

Program of Study:

Neuropharmacological studies of the effect of cannabinoids on some behavioural and molecular correlates of psychosis. (PHD) 2006.

Supervisors:

Malone, D (Joint), Taylor, D (Joint-Co).