Dr Michelle McIntosh - Researcher Profile

Biography

Position

Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION

Institution: Monash University

Year awarded: 2009

DOCTORATE OF PHILOSOPHY

Institution: Monash University

Year awarded: 2000

BACHELOR OF PHARMACY

Institution: Monash University

Year awarded: 1997

Publications

Book Chapters

Rajewski, R.A., McIntosh, M.P., 2007, Targeting - Theoretical and Computational Models, in Prodrugs: Challenges and Rewards, eds Stella, V.J.; Borchardt, R.T.; Hageman, M.J.; Oliyai, R.; Maag, H.; Tilley, J., Springer, USA, pp. 429-445.

Journal Articles

McIntosh, M.P., Rajewski, R.A., 2012, Comparative canine pharmacokinetics-pharmacodynamics of fospropofol disodium injection, propofol emulsion, and cyclodextrin-enabled propofol solution following bolus parenteral administration, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, Wiley-Blackwell, Malden, Massachusetts USA, pp. 3547-3552.

McIntosh, M.P., Iwasawa, K., Rajewski, R.A., Fujisawa, T., Goto, H., 2012, Hemodynamic profile in rabbits of fospropofol disodium injection relative to propofol emulsion following rapid bolus injection, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, Wiley-Blackwell, Malden, Massachusetts USA, pp. 3518-3525.

Anby, M.U., Williams, H.D., McIntosh, M.P., Benameur, H., Edwards, G.A., Pouton, C.W., Porter, C.J., 2012, Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems, Molecular Pharmaceutics [P], vol 9, issue 9, American Chemical Society, USA, pp. 2063-2079.

Mannila, A.H., Morizzi, J., Nguyen, T.T., Charman, S.A., McIntosh, M.P., Shackleford, D., 2012, Probing a potential in vivo drug-excipient interaction: Temporal effects of a modified beta-cyclodextrin on the intravenous pharmacokinetics of a model high-affinity drug ligand, Journal of Pharmaceutical Sciences [P], vol 101, issue 9, Wiley-Blackwell, Malden, Massachusetts USA, pp. 3381-3389.

Sou, T., Orlando, L., McIntosh, M., Kaminskas, L., Morton, D., 2011, Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach, International Journal of Pharmaceutics [P], vol 421, issue 2, Elsevier/North-Holland Biomedical Press., Netherlands, pp. 220-229.

Sou, T., Meeusen, E., De Veer, M., Morton, D., Kaminskas, L., McIntosh, M., 2011, New developments in dry powder pulmonary vaccine delivery, Trends in Biotechnology [P], vol 29, issue 4, Elsevier Ltd., Trends Journals, United Kingdom, pp. 191-198.

Behara, S., Kippax, P., McIntosh, M., Morton, D., Larson, I., Stewart, P., 2011, Structural influence of cohesive mixtures of salbutamol sulphate and lactose on aerosolisation and de-agglomeration behaviour under dynamic conditions, European Journal of Pharmaceutical Sciences [P], vol 42, issue 3, Elsevier, The Netherlands, pp. 210-219.

McIntosh, M.P., Leong, N., Katneni, K., Morizzi, J., Shackleford, D.M., Prankerd, R.J., 2010, Impact of chlorpromazine self-association on its apparent binding constants with cyclodextrins: Effect of SBE7-beta-CD on the disposition of chlorpromazine in the rat, Journal of Pharmaceutical Sciences [P], vol 99, issue 7, John Wiley & Sons, Inc., USA, pp. 2999-3008.

Urban, M., Li, C., Yu, C., Lu, Y., Krise, J., McIntosh, M.P., Rajewski, R.A., Blagg, B., Dobrowsky, R.T., 2010, Inhibiting heat-shock protein 90 reverses sensory hypoalgesia in biabetic mice, A S N Neuro [E], vol 2, issue 4, ASN NEURO Immediate Publication, USA, pp. 189-199.

Koltun, M., Morizzi, J., Katneni, K., Charman, S.A., Shackleford, D., McIntosh, M.P., 2010, Preclinical comparison of intravenous melphalan pharmacokinetics administered in formulations containing either (SBE)7m-beta-cyclodextrin or a co-solvent system, Biopharmaceutics and Drug Disposition [E], vol 31, issue 8-9, John Wiley & Sons, Ltd, online, pp. 450-454.

Trevaskis, N., McEvoy, C.L., McIntosh, M.P., Edwards, G.A., Shanker, R., Charman, W.N., Porter, C.J., 2010, The role of the intestinal lymphatics in the absorption of two highly lipophilic cholesterol ester transfer protein inhibitors (CP524,515 and CP532,623), Pharmaceutical Research [E], vol 27, Springer Science, USA, pp. 878-893.

Yeo, L., Friend, J., McIntosh, M., Meeusen, E., Morton, D., 2010, Ultrasonic nebulization platforms for pulmonary drug delivery, Expert Opinion on Drug Delivery [P], vol 7, issue 6, Informa Healthcare, London, UK, pp. 663-679.

Qi, A., Friend, J., Yeo, L.Y., Morton, D.A.V., McIntosh, M.P., Spiccia, L., 2009, Miniature inhalation therapy platform using surface acoustic wave microfluidic atomization, Lab On A Chip [P], vol 9, The Royal Society of Chemistry, London, pp. 2184-2193.

McIntosh, M.P., Narita, H., Kameyama, Y., Rajewski, R.A., Goto, H., 2007, Evaluation of mean arterial blood pressure, heart rate, and sympathetic nerve activity in rabbits after administration of two formulations of etomidate, Veterinary Anaesthesia and Analgesia, vol 34, issue 3, Blackwell Publishing, USA, pp. 149-156.

McIntosh, M.P., Carlson, B.J., Schorno, K.S., Rajewski, R.A., 2007, Single quadrupole mass spectrometry for pre-clinical pharmacokinetic analysis: Quantitation of carvedilol in dog plasma, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences [P], vol 852, Elsevier, The Netherlands, pp. 665-668.

Georg, G., McIntosh, M.P., Rajewski, R.A., Telikepalli, H., 2006, Ongoing In Vivo Studies with Cytoskeletal Drugs in Tau Transgenic Mice, Current Alzheimer Research, vol 3, issue 3, Bentham Science Publishers Ltd, UAE, pp. 215-219.

Yasuji, T., Haslam, J., Kajiyama, A., McIntosh, M.P., Rajewski, R.A., 2006, Preliminary evaluation of polymer-based drug composite microparticle production by coacervate desolvation with supercritical carbon dioxide, Journal of Pharmaceutical Sciences, vol 95, issue 3, John Wiley & Sons, Inc., USA, pp. 581-588.

Lucas, A.N., Tanol, M., McIntosh, M.P., Rajewski, R.A., 2006, Preparation and purification of desethylamiodarone hydrochloride, Synthetic Communications: an international journal for rapid communication of synthetic organic chemistry, vol 36, issue April, Taylor & Francis Inc., USA, pp. 3371-3376.

McIntosh, M.P., Batey, A.J., Coker, S.J., Porter, C.J.H., Charman, W.N., 2004, Evaluation of the impact of altered lipoprotein binding conditions on halofantrine induced QTc interval prolongation in an anaesthetised rabbit model, Journal of Pharmacy and Pharmacology, vol 56, issue 11, Pharmaceutical Press, Wallingford UK, pp. 69-77.

McIntosh, M.P., Schwarting, N., Rajewski, R.A., 2004, In vitro and in vivo evaluation of a sulfobutyl ether beta-cyclodextrin enabled etomidate formulation, Journal of Pharmaceutical Sciences, vol 93, issue 10, John Wiley & Sons, Inc., USA, pp. 2585-2594.

McIntosh, M.P., Charman, W.N., Campbell, M., Porter, C.J.H., 2004, Influence of physicochemical properties on the patterns of association of a series of aliphatic esters of halofantrine with plasma lipoproteins, Journal of Controlled Release, vol 95, issue 2, Elsevier, The Netherlands, pp. 275-289.

McIntosh, M.P., Batey, A.J., Porter, C.J.H., Charman, W.N., Coker, S.J., 2003, Desbutylhalofantrine: evaluation of QT prolongation and other cardiovascular effects after intravenous administration in vivo, Journal of Cardiovascular Pharmacology, vol 41, issue 3, Lippincott Williams & Wilkins, USA, pp. 406-413.

McIntosh, M.P., Rajewski, R.A., 2001, A simple and efficient high-performance liquid chromatographic assay for etomidate in plasma, Journal of Pharmaceutical and Biomedical Analysis, vol 24, issue 4, Elsevier BV, Netherlands, pp. 689-694.

McIntosh, M.P., Porter, C.J.H., Wasan, K.M., Ramaswamy, M., Charman, W.N., 1999, Differences in the lipoprotein binding profile of halofantrine in fed and fasted human and beagle plasma are dictated by the respective masses of core apolar lipoprotein lipid, Journal of Pharmaceutical Sciences, vol 88, issue 3, John Wiley & Sons, Inc., USA, pp. 378-384.

McIntosh, M.P., Porter, C.J.H., Wasan, K.M., Ramaswamy, M., Charman, W.N., 1999, Differences in the lipoprotein binding profile of halofantrine in fed and fasted human or beagle plasma are dictated by the respective masses of core apolar lipoprotein lipid, Journal of Pharmaceutical Sciences, vol 88 issue 3, ACS & Am Pharm Assoc, Washington USA, pp. 378-384.

Wasan, K.M., Ramaswamy, M., McIntosh, M.P., Porter, C.J.H., Charman, W.N., 1999, Differences in the lipoprotein distribution of halfantrine are regulated by lippoprotein apolar lipid and protein concentration and lipid transfer protein I activity: In vitro studies in normolipidemic and dyslipidemic human plasmas, Journal of Pharmaceutical Sciences, vol 88, issue 2, John Wiley & Sons, Inc., USA, pp. 185-190.

Wasan, K.M., Ramaswamy, M., McIntosh, M.P., Porter, C.J.H., Charman, W.N., 1999, Differences in the lipoprotein distribution of halofantrine are regulated by lipoprotein apolar lipid and protein concentration and lipid transfer protein I activity: In vitro studies in normolipidemic and dyslipidemic human plasmas, Journal of Pharmaceutical Sciences, vol 88 issue 2, ACS & Am Pharm Assoc, Washington USA, pp. 185-190.

Conference Proceedings

Sou, T., Nassta, G., Kaminskas, L., McIntosh, M., Prankerd, R., Orlando, L., Morton, D., 2011, Particle engineering of a mannitol-based powder formulation for delivery of biomolecules to the lung, Drug Delivery to the Lungs 22, 07-09/12/2011, The Aerosol Society, England, pp. 52-55.

Morton, D., McIntosh, M., Olerile, L., Prankerd, R., 2011, Probing the role of self-assembly in spray dried powder formulations, Respiratory Drug Delivery 2011, 03-06/05/2011, RDD Online and Aptar Pharma, USA, pp. 363-366.

Morton, D.A.V., McIntosh, M.P., Sou, T., 2008, Investigating effects of surface modifications on a mannitol dry powder inhaler plume by laser diffraction, RDD 2008, 11-15 May 2008, Davis Healthcare International Publishing, USA, pp. 649-653.

McIntosh, M.P., Agarwal, S., Morton, D.A.V., 2008, Investigation of powder changes on delivery characteristics from a penn century dry powder insuflator, DDL 19, 10-12/2008, The Aerosol Society, UK, pp. 53-56.

McIntosh, M.P., Batey, A.J., Porter, C.J.H., Edwards, G.A., Coker, S.J., Charman, W.N., 1999, Effect of lipoprotein association on halofantrine-induced prolongation of the QTc interval in an experimental hyperlipidemic rabbit model, AAPS PharmSci Supplement, New Orleans USA 14-18 November 1999, American Association of Pharmaceutical Sciences, USA, p. S-476.

Thomas, B.J., McIntosh, M.P., Kannar, D., Charman, S.A., Charman, W.N., 1999, In vitro distribution of coenzyme Q10 in plasma lipoproteins, AAPS PharmSci Supplement, New Orleans USA 14-18 November 1999, American Association of Pharmaceutical Sciences, USA, p. S-124.

McIntosh, M.P., Porter, C.J.H., Charman, W.N., 1998, The development of an acute post-prandial hyperlipidemia rabbit model, AAPS PharmSci? Supplement, San Francisco USA, 15-19 November 1998, American Association of Pharmaceutical Scientists, Virginia USA, pp. S91-S92.

McIntosh, M.P., Batey, A.J., Porter, C.J.H., Coker, S.J., Charman, W.N., 1998, The increased association of halopantrine with lipoproteins in hyperlipidemic plasma reduces its effect on QTc intervals, relative to fasted plasma, in New Zealand white rabbits, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 93.

Wasan, K.M., Ramaswamy, M., McIntosh, M.P., Porter, C.J.H., Charman, W.N., 1997, Deffernces in liptrotein concentration and lipid transfer protein 1 activity modify the in vitro plasma distribution of halofantrine in dyslipidemic plasma, Pharmaceutical Research, Boston USA, 2-6 November, Plenum Press, New York NY USA, p. S277.

McIntosh, M.P., Porter, C.J.H., Charman, W.N., 1997, The controlling influence of halofantrine distribution within human plasma lipoproteins as apolar lipid content, Australasian Pharmaceutical Science Association 1997 Conference, Sydney Australia, 26-28 November, APSA 1997 Organising Committee, Sydney NSW Australia, p. 54.

McIntosh, M.P., Porter, C.J.H., Wasan, K.M., Ramaswamy, M., Charman, W.N., 1997, The degree of association of halofantrine with pre- and post-prandial plasma lipoproteins is determined by their apolar lipid content, Pharmaceutical Research, Boston USA, 2-6 November, Plenum Press, New York NY USA, p. S277.

Teaching Commitment

• Unit coordinator for PAC4261 Drug Delivery and Development 
• PSC3081 (Biopharmaceutics) lecturer in pharmacokinetics, drug absorption, drug delivery, drug dissolution
• PAC2232 (Drug Delivery) lecturer in pharmacokinetics, drug absorption, bioequivalence

Activities

Affiliations with institutes

Drug Delivery, Disposition and Dynamics
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Airway delivery of oxytocin: A novel treatment for postpartum haemorrhage.

Supervisors:

Bischof, R (Joint), Mcintosh, M (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Development of a dry powder containing oxytocin suitable for inhalation for the treatment of postpartum haemorrhage.

Supervisors:

Mcintosh, M (Main), Morton, D (Associate), Orlando, L (Associate), Prankerd, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Dry Powder Formulation for Pulmonary Delivery of Peptides.

Supervisors:

Mcintosh, M (Main), Prankerd, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Improving chemotherapeutic efficancy against lymphatic metastases via the selective lymphatic delivery of chemotherapeutic nanomedicines.

Supervisors:

Porter, C (Main), Kaminskas, L (Associate), Mcintosh, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Subcutaneous pharmacokinetics of therapeutic antibodies: uptake pathways and approaches to improving absorption.

Supervisors:

Kaminskas, L (Joint), Mcintosh, M (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The development of influenza dry powder antigen formulation for pulmonary vaccine delivery..

Supervisors:

Mcintosh, M (Main), Morton, D (Associate), Kaminskas, L (Associate).

Completed Supervision

Student:

Olerile, L.

Program of Study:

Initial development and evaluation of a dry powder inhaler delivery system for the delivery of oxytocin in the treatment of postpartum haemorrhage. (Masters) 2011.

Supervisors:

Mcintosh, M (Main).