Mr David Steer - Researcher Profile

Biography

David works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2002

SCIENCE (HONS)

Institution: Monash University

Year awarded: 1996

Publications

Journal Articles

Yan, X., Porter, C.J., Hardy, S.P., Steer, D.L., Smith, A.I., Quinsey, N.S., Hughes, V.A., Cheung, K.J., Keyburn, A., Kaldhusdal, M., Moore, R., Bannam, T.L., Whisstock, J., Rood, J.I., 2013, Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens, mBio [E], vol 4, issue 1, American Society for Microbiology, USA, pp. 1-9.

Gatsos, X., Steer, D.L., Junaid, T.A., Smith, A.I., Adler, B., Albert, M.J., 2012, Application of protein purification methods for the enrichment of a cytotoxin from Campylobacter jejuni, BMC Microbiology [P], vol 12, issue Art No.:303, BioMed Central Ltd, UK, pp. 1-10.

Han, X.Y., Kennan, R.M., Steer, D.L., Smith, A.I., Whisstock, J.C., Rood, J.I., 2012, The AprV5 subtilase is required for the optimal processing of all three extracellular serine proteases from Dichelobacter nodosus, PLoS ONE [P], vol 7, issue 10 (Art. No.: e47932), Public Library of Science, USA, pp. 1-8.

Law, R.H., Caradoc-Davies, T.T., Cowieson, N.P., Horvath, A.J., Quek, A.J., Amarante Da Encarnacao, J., Steer, D.L., Cowan, A.D., Zhang, Q., Lu, B.G., Pike, R.N., Smith, A.I., Coughlin, P.B., Whisstock, J.C., 2012, The x-ray crystal structure of full-length human plasminogen, Cell Reports [E], vol 1, issue 3, Cell Press, USA, pp. 185-190.

Menon, K., Steer, D.L., Short, M., Petratos, S., Smyth, I.M., Bernard, C.C., 2011, A novel unbiased proteomic approach to detect the reactivity of cerebrospinal fluid in neurological diseases, Molecular & Cellular Proteomics [P], vol 10, issue 6 (Art. No: M110.000042), American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 1-14.

Noor, N.M., Steer, D.L., Wheaton, B.J., Ek, C.J., Truettner, J.S., Dietrich, W.D., Dziegielewska, K.M., Richardson, S.J., Smith, A.I., VandeBerg, J.L., Saunders, N.R., 2011, Age-dependent changes in the proteome following complete spinal cord transection in a postnatal South American opossum (Monodelphis domestica), PLoS ONE [P], vol 6, issue 11, Public Library of Science, USA, pp. e27465-1-e27465-16.

Lai, Z., Hanchapola, I., Steer, D., Smith, A., 2011, Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: Determinants and constraints, Biochemistry [P], vol 50, issue 23, American Chemical Society, USA, pp. 5182-5194.

Wong, W., Wijeyewickrema, L.C., Kennan, R.M., Reeve, S.B., Steer, D.L., Reboul, C., Smith, A.I., Pike, R.N., Rood, J.I., Whisstock, J.C., Porter, C.J., 2011, S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction, Journal Of Biological Chemistry [P], vol 286, issue 49, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 42180-42187.

Rainczuk, A., Meehan, K., Steer, D.L., Stanton, P.G., Robertson, D.M., Stephens, A.N., 2010, An optimized procedure for the capture, fractionation and proteomic analysis of proteins using hydrogel nanoparticles, Proteomics [P], vol 10, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 332-336.

Penfold, S.A., Coughlan, M.T., Patel, S.K., Srivastava, P.M., Sourris, K.C., Steer, D., Webster, D., Thomas, M.C., MacIsaac, R.J., Jerums, G., Burrell, L.M., Cooper, M.E., Forbes, J.M., 2010, Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy, Kidney International [P], vol 78, issue 3, Nature Publishing Group, UK, USA, pp. 287-295.

Lai, Z.W., Steer, D.L., Smith, A.I., 2009, Membrane proteomics: The development of diagnostics based on protein shedding, Current Opinion in Molecular Therapeutics [P], vol 11, issue 6, Current Drugs Ltd., UK, pp. 623-631.

David, A., Steer, D.L., Bregant, S., Devel, L., Makaritis, A., Beau, F., Yiotakis, A., Dive, V., 2007, Cross-linking yield variation of a potent matrix metalloproteinase photoaffinity probe and consequences for functional proteomics, Angewandte Chemie-International Edition, vol 46, issue 18, Wiley-V C H Verlag GMBH, Weinheim Germany, pp. 3275-3277.

Albert, M.J., Haridas, S., Steer, D.L., Dhaunsi, G.S., Smith, A.I., Adler, B., 2007, Identification of a Campylobacter jejuni protein that cross-reacts with cholera toxin, Infection and Immunity, vol 75, issue 6, American Society of Microbiology, Washington DC USA, pp. 3070-3073.

Steer, D., Lew, R., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2002, Amino Acids: Versatile Peptidomimetics, Current Medicinal Chemistry, vol 9, issue 8, Bentham Science Publishing Ltd, Netherlands BR, pp. 811-822.

Steer, D., Lew, R., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2002, Inhibitors of metalloendopeptidase EC 3.4.24.15 and EC 3.4.24.16 stabilized against proteolysis by the incorporation of -amino acids, Biochemistry, vol 41, issue 35, American Chemical Society, Washington USA, pp. 10819-10826.

Steer, D.L., Lew, R.A., Perlmutter, P., Smith, A.I., Aguilar, M.I., 2002, The use of -amino acids in the design of protease and peptidase inhibitors, Letters in Peptide Science, vol 8, Kluwer Academic Publ., Dordrecht The Netherlands, pp. 241-246.

Steer, D., Lew, R., Perlmutter, P.P., Smith, A.I., Aguilar, M., 2000, Design and Synthesis of Inhibitors Incorporating beta-Amino Acids of Metalloendopeptidase EC 3.4.24.15, Journal of Peptide Science, vol 6, John Wiley & Sons, Chichester W Sussex UK, pp. 470-477.

Steer, D., Thompson, P.E., Blondelle, S.E., Houghton, R.A., Aguilar, M., 1998, Comparison of the binding of a-helical and beta-sheet peptides to ahydrophobic surface, Journal of Peptide Research, vol 51 no 6, Munksgaard, Copenhagen Denmark, pp. 401-412.

Thompson, P.E., Steer, D., Aguilar, M., Hearn, M.T., 1998, Tropane-based amino acids for peptide structure-function studies: inhibitors of platelet aggregation, Bioorganic and Medicinal Chemistry Letters, vol 8 no 19, Elsevier Science Ltd, Oxford UK, pp. 2699-2704.

Conference Proceedings

Steer, D., Aguilar, M., Hearn, M.T., Thompson, P.E., 1998, Synthesis and evaluation of Fmoc protected tropane based amino acids and their Incorporation into peptides as fibrinogen peptidomimetics, Proceedings, 23rd Lorne Annual Conference on Protein Structure and Function, Lorne VIC, 8-12 February 1998, Lorne Protein Workshop Inc, Melbourne Vic Australia, p. B40.

Steer, D., Aguilar, M., Smith, A.I., Perlmutter, P.P., 1998, Synthesis of beta-amino acids and their incorporation into an Inhibitor of Metalloendopeptidease 24.15, 3rd Australian Peptide Conference "From Discovery to Therapeutics", Laguna Quays The Whitsundays QLD Oct 4-9, 1998, Pink Panther Printing, Melbourne Vic Australia, p. 48.

Steer, D., Thompson, P.E., Aguilar, M., 1997, Comparison of the binding behaviour of amphipathic a-helical and b-sheet peptides at hydrophobic surfaces, Proceedings, 22nd Annual Lorne Conference on Protein Structure and Function, Lorne, Australia, Feb.10-14, 1997, Lorne Protein Workshop Inc., Lorne Australia, p. B68.

Steer, D., Aguilar, M., Hearn, M.T., Thompson, P.E., 1997, Synthesis of FMOC protected tropane based amino acids and their incorporation into fibrinogen related peptides, Proceedings of the Australian Society for Biochemistry and Molecular Biology, Melbourne, Sept. 29-Oct. 2, 1997, Australian Soc. for Biochemistry & Molecular Biol., Kent Town SA, p. B1-87.

Thompson, P.E., Steer, D., Higgins, K., Aguilar, M., Hearn, M.T., 1997, Synthesis, conformational analysis and application of tropane-based FMOC-amino acid derivatives: novel antagonists of fibrinogen receptor, GPIIb/IIIa, 1st International Peptide Symposium, Kyoto, Japan, Nov. 30-Dec. 5, 1997, Kluwer Academic Publishers B.V., Amsterdam Netherlands, p. 105.