Prof Helena Parkington - Researcher Profile

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Address

Department of Physiology
Faculty of Medicine, Nursing & Health Sciences, Clayton

Contact Details

Tel: +61 3 990 52505

Fax: +61 3 990 52547

Email: Helena.Parkington@monash.edu


Biography

Helena works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

PHILOSOPHY
Institution: Monash University
Year awarded: 1981

Publications

Book Chapters

Coleman, H.A., Tare, M., Parkington, H.C., 2003, Endothelium-dependent depolarization and its implications for endothelium-derived hyperpolarizing factor, in EDHF 2002, eds P M Vanhoutte, Taylor & Francis, London UK, pp. 199-204.

Tare, M., Sandow, S.L., Coleman, H.A., Wigg, S.J., Parkington, H.C., Hill, C.E., 2003, Myoendothelial gap junctions - the critical link for endothelium-derived hyperpolarizing factor, in EDHF 2002, eds P M Vanhoutte, Taylor & Francis, London UK, pp. 223-233.

Parkington, H.C., Coleman, H.A., Tare, M., 2003, Role of EDHF in vascular tone in vivo, in EDHF 2002, eds P M Vanhoutte, Taylor & Francis, London UK, pp. 101-107.

Coleman, H.A., Tare, M., Parkington, H.C., 2001, Components of the potassium currents underlying the actions of endothelium-derived hyperpolarizing factor in arterioles, in EDHF 2000, eds Paul M. Vanhoutte, Taylor & Francis, London England, pp. 259-269.

Parkington, H.C., Coleman, H.A., 2001, Excitability in uterine smooth muscle, in The Endocrinology of Partuition. Basic Science and Clinical Application, eds Roger Smith, Karger, Basel Switzerland, pp. 179-200.

Wigg, S.J., Tare, M., O'Brien, R.C., Parkington, H.C., 2001, Influence of diabetes on endothelium-dependent responses in mesenteric and femoral arteries of rats, in EDHF 2000, eds Paul M Vanhoutte, Taylor & Francis, London England, pp. 352-359.

Journal Articles

Costa, M., Sourris, K., Lim, S.M., Yu, Q.C., Hirst, C.E., Parkington, H.C., Jameson, V.J., Dear, A.E., Liu, H.B., Micallef, S.J., Koutsis, K., Elefanty, A.G., Stanley, E., 2013, Derivation of endothelial cells from human embryonic stem cells in fully defined medium enables identification of lysophosphatidic acid and platelet activating factor as regulators of eNOS localization, Stem Cell Research [P], vol 10, issue 1, Elsevier BV, The Netherlands, pp. 103-117.

Chaisakul, J., Parkington, H.C., Isbister, G.K., Konstantakopoulos, N., Hodgson, W.C., 2013, Differential Myotoxic and Cytotoxic Activities of Pre-synaptic Neurotoxins from Papuan Taipan (Oxyuranus scutellatus) and Irian Jayan Death Adder (Acanthophis rugosus) Venoms, Basic and Clinical Pharmacology and Toxicology [P], vol E-pub, Wiley-Blackwell Publishing Ltd, UK, pp. 1-10.

Rao, J.R., Keating, D.J., Chen, C., Parkington, H.C., 2012, Adiponectin increases insulin content and cell proliferation in MIN6 cells via PPARgamma-dependent and PPARgamma-independent mechanisms, Diabetes Obesity & Metabolism [P], vol 14, issue 11, Wiley-Blackwell Publishing Ltd, UK, pp. 983-989.

Kenna, K.R., Sozo, F., De Matteo, R.M., Hanita, T., Gray, S.P., Tare, M., Moritz, K.M., Bertram, J.F., Black, M.J., Brien, J.F., Parkington, H.C., Walker, D.W., Harding, R., 2012, Alcohol exposure during late gestation: multiple developmental outcomes in sheep, Journal of Developmental Origins of Health and Disease [P], vol 3, issue 4, Cambridge University Press, UK, pp. 224-236.

Payne, N.J., Sun, G., Herszfeld, D., Tat-Goh, P.A., Verma, P.J., Parkington, H.C., Coleman, H.A., Tonta, M.A., Siatskas, C., Bernard, C.C.A., 2012, Comparative study on the therapeutic potential of neurally differentiated stem cells in a mouse model of multiple sclerosis, PLoS ONE [P], vol 7, issue 4 (Art. No.: e35093), Public Library of Science, USA, pp. 1-14.

Coleman, H., Parkington, H., 2012, ET block and the neointima: Not the B, that is the answer, Cardiovascular Research [P], vol 95, issue 1, Oxford University Press, UK, pp. 1-2.

Fleiss, B., Parkington, H.C., Coleman, H.A., Dickinson, H., Yawno, T., Zakhem, M., Hirst, J.J., Walker, D.W., 2012, Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse, Brain Research [P], vol 1433, Elsevier BV, The Netherlands, pp. 9-19.

Tare, M., Miller, S.L., Wallace, E.M., Sutherland, A.E., Yawno, T., Coleman, H.A., Jenkin, G., Parkington, H.C., 2012, Glucocorticoid treatment does not alter early cardiac adaptations to growth restriction in preterm sheep fetuses, Bjog-An International Journal Of Obstetrics And Gynaecology [P], vol 119, issue 8, Wiley-Blackwell Publishing Ltd, UK, pp. 906-914.

Chaisakul, J., Isbister, G.K., Konstantakopoulos, N., Tare, M., Parkington, H.C., Hodgson, W.C., 2012, In vivo and in vitro cardiovascular effects of Papuan taipan (Oxyuranus scutellatus) venom: Exploring "sudden collapse", Toxicology Letters [P], vol 213, issue 2, Elsevier Ireland Ltd, Ireland, pp. 243-248.

Gallo, L.A., Denton, K.M., Moritz, K.M., Tare, M., Parkington, H.C., Davies, M.M., Tran, M., Jefferies, A.J., Wlodek, M.E., 2012, Long-term alteration in maternal blood pressure and renal function after pregnancy in normal and growth-restricted rats, Hypertension [P], vol 60, issue 1, Lippincott Williams & Wilkins, USA, pp. 206-213.

Song, B., Sun, G., Herszfeld, D., Sylvain, A., Campanale, N.V., Hirst, C.E., Caine, S., Parkington, H.C., Tonta, M.A., Coleman, H.A., Short, M.A., Ricardo, S.D., Reubinoff, B., Bernard, C.C.A., 2012, Neural differentiation of patient specific iPS cells as a novel approach to study the pathophysiology of multiple sclerosis, Stem Cell Research [P], vol 8, issue 2, Elsevier BV, The Netherlands, pp. 259-273.

Martin, K., Corlett, A., Dubach, D., Mustafa, T., Coleman, H.A., Parkington, H.C., Merson, T.D., Bourne, J.A., Porta, S., Arbones, M.L., Finkelstein, D.I., Pritchard, M.A., 2012, Over-expression of RCAN1 causes Down syndrome-like hippocampal deficits that alter learning and memory, Human Molecular Genetics [P], vol 21, issue 13, Oxford University Press, UK, pp. 3025-3041.

Iqbal, J., Tonta, M.A., Mitsui, R., Li, Q., Kett, M.M., Li, J., Parkington, H.C., Hashitani, H., Lang, R.J., 2012, Potassium and ANO1/ TMEM16A chloride channel profiles distinguish atypical and typical smooth muscle cells from interstitial cells in the mouse renal pelvis, British Journal of Pharmacology [P], vol 165, issue 7, John Wiley & Sons Ltd, UK, pp. 2389-2408.

Smardencas, A., Parkington, H., 2012, Seeding of endothelial cells on the luminal surface of a sheet model of cold-stored (at 4°C) sheep carotid arteries, Cell Transplantation [P], vol 21, issue 1, Cognizant Communication Corporation, USA, pp. 285-297.

Tare, M., Parkington, H.C., Bubb, K.J., Wlodek, M.E., 2012, Uteroplacental insufficiency and lactational environment separately influence arterial stiffness and vascular function in adult male rats, Hypertension [P], vol 60, issue 2, Lippincott Williams & Wilkins, USA, pp. 378-386.

Mazzuca, M.Q., Tare, M., Parkington, H.C., Dragomir, N.M., Parry, L.J., Wlodek, M.E., 2012, Uteroplacental insufficiency programmes vascular dysfunction in non-pregnant rats: compensatory adaptations in pregnancy, Journal Of Physiology-London [P], vol 590, issue 14, Wiley-Blackwell Publishing Ltd, UK, pp. 3375-3388.

Kamkaew, N., Scholfield, C., Ingkaninan, K., Maneesai, P., Parkington, H., Tare, M., Chootip, K., 2011, Bacopa monnieri and its constituents is hypotensive in anaesthetized rats and vasodilator in various artery types, Journal of Ethnopharmacology [P], vol 137, issue 1, Elsevier Ireland Ltd, Ireland, pp. 790-795.

Fleiss, B., Coleman, H., Zakhem, M.E., Ireland, Z., Walker, D., Parkington, H., 2011, Effects of birth asphyxia on neonatal hippocampal structure and function in the spiny mouse, International Journal of Developmental Neuroscience [P], vol 29, issue 7, Pergamon, UK, pp. 757-766.

Gravina, F., Jobling, P., Kerr, K., de Oliveira, R., Parkington, H., Van Helden, D., 2011, Oxytocin depolarizes mitochondria in isolated myometrial cells, Experimental Physiology [P], vol 96, issue 9, Wiley-Blackwell, USA, pp. 949-956.

Tare, M., Mazzuca, M.Q., Parkington, H.C., Dragomir, N.M., Wlodek, M.E., 2011, Surviving life in the womb and the implications for vascular health in adulthood, Physiology News [E], vol 83, The Lavenham Press, UK, pp. 29-31.

Gasperini, R.J., Hou, X., Parkington, H.C., Coleman, H.A., Klaver, D.W., Vincent, A.J., Foa, L.C., Small, D.H., 2011, TRPM8 and Nav1.8 sodium channels are required for transthyretin-induced calcium influx in growth cones of small-diameter TrkA-positive sensory neurons, Molecular Neurodegeneration [P], vol 6, issue 1 (Art. No: 19), BioMed Central Ltd, UK, pp. 1-12.

Tare, M., Emmett, S., Coleman, H., Skordilis, C., Eyles, D., Morley, R., Parkington, H., 2011, Vitamin D insufficiency is associated with impaired vascular endothelial and smooth muscle function and hypertension in young rats, Journal Of Physiology-London [P], vol 589, issue 19, Wiley-Blackwell Publishing Ltd, UK, pp. 4777-4786.

Liaskos, M., Turnbull, L., Carneiro, L., Firth, S.D., Coleman, H.A., Parkington, H.C., Le Bourhis, L., Karrar, A., Viala, J., Mak J., Hutton, M.L., Davies, J.K., Crack, P.J., Hertzog, P.J., Philpott, D., Girardin, S.E., Whitchurch, C.B., Ferrero, R.L., 2010, Bacterial membrane vesicles deliver peptidoglycan to NOD1 in epithelial cells, Cellular Microbiology [P], vol 12, Wiley-Blackwell Publishing Ltd, UK, pp. 372-385.

Morley, R., Dwyer, T., Hynes, K.L., Cochrane, J.A., Ponsonby, A.L., Parkington, H.C., Carlin, J.B., 2010, Maternal alcohol intake and offspring pulse wave velocity, Neonatology [P], vol 97, S. Karger AG, Switzerland, pp. 204-211.

Gezmish, O., Tare, M., Parkington, H.C., Morley, R., Porrello, E.R., Bubb, K.J., Black, M.J., 2010, Maternal vitamin d deficiency leads to cardiac hypertrophy in rat offspring, Reproductive Sciences [P], vol 17, Sage Publications, Inc., USA, pp. 168-176.

Parkington, H.C., Coleman, H.A., Wintour (Coghlan), E.M., Tare, M., 2010, Prenatal alcohol exposure: Implications for cardiovascular function in the fetus and beyond, Clinical And Experimental Pharmacology And Physio..., vol 37, Wiley-Blackwell Publishing Asia, Australia, pp. 1-8.

Gravina, F.S., Parkington, H.C., Kerr, K.P., de Oliveira, R.B., Jobling, P., Coleman, H.A., Sandow, S.L., Davies, M.M., Imtiaz, M.S., Van Helden, D.F., 2010, Role of mitochondria in contraction and pacemaking in the mouse uterus, British Journal of Pharmacology [P], vol 161, issue 6, John Wiley & Sons Ltd, UK, pp. 1375-1390.

Lang, R.J., Hashitani, H., Tonta, M.A., Bourke, J.L., Parkington, H.C., Suzuki, H., 2010, Spontaneous electrical and Ca2+ signals in the mouse renal pelvis that drive pyeloureteric peristalsis, Clinical And Experimental Pharmacology And Physiology [P], vol 37, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 509-515.

Mazzuca, M.Q., Wlodek, M.E., Dragomir, N.M., Parkington, H.C., Tare, M., 2010, Uteroplacental insufficiency programs regional vascular dysfunction and alters arterial stiffness in female offspring, Journal Of Physiology-London [P], vol 588, issue Pt 11, Wiley-Blackwell Publishing Ltd, UK, pp. 1997-2010.

Steyn, F.J., Boehme, F., Vargas, E., Wang, K., Parkington, H.C., Rao, J.R., Chen, C., 2009, Adiponectin regulate growth hormone secretion via adiponectin receptor mediated Ca2+ signalling in rat somatotrophs in vitro, Journal of Neuroendocrinology [P], vol 21, issue 8, Wiley-Blackwell Publishing Ltd, UK, USA, pp. 698-704.

Iqbal, J., Latchoumanin, O.A.L., Puspita Sari, I., Lang, R.J., Coleman, H.A., Parkington, H.C., Clarke, I.J., 2009, Estradiol-17beta inhibits gonadotropin-releasing hormone-induced Ca 2+ in gonadotropes to regulate negative feedback on luteinizing hormone release, Endocrinology [P], vol 150, issue 9, The Endocrine Society, USA, pp. 4213-4220.

Parkington, H.C., Tare, M., Coleman, H.A., 2008, EDITORIAL: The EDHF Story: The Plot Thickens, Circulation Research, vol 102, issue 10, Lippincott Williams & Wilkins, USA, pp. 1148-1150.

Edgley, A.J., Tare, M., Evans, R.G., Skordilis, C., Parkington, H.C., 2008, In vivo regulation of endothelium-dependent vasodilation in the rat renal circulation and the effect of streptozotocin-induced diabetes, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 295, issue 3, American Physiological Society, United States, pp. R829-R839.

Yang, S., Wang, K., Parkington, H.C., Chen, C., 2008, Involvement of tetrodotoxin-resistant Na+ current and protein kinase C in the action of growth hormone (GH)-releasing hormone on primary cultured somatotropes from GH-green fluorescent protein transgenic mice, Endocrinology, vol 149, issue 9, The Endocrine Society, USA, pp. 4726-4735.

Clarke, I.J., Puspita Sari, I., Qi, Y., Smith, J.T., Parkington, H.C., Ubuka, T., Iqbal, J., Li, Q., Tilbrook, A.J., Morgan, K., Pawson, A.J., Tsutsui, K., Millar, R., Bentley, G.E., 2008, Potent action of RFamide-related peptide-3 on pituitary gonadotropes indicative of a hypophysiotropic role in the negative regulation of gonadotropin secretion, Endocrinology, vol 149, issue 11, The Endocrine Society, United States, pp. 5811-5821.

Maka, N., Makrakis, J., Parkington, H.C., Tare, M., Morley, R., Black, M.J., 2008, Vitamin D deficiency during pregnancy and lactation stimulates nephrogenesis in rat offspring, Pediatric Nephrology, vol 23, Springer, New York NY USA, pp. 55-61.

Fitzgerald, S.M., Bashari, H., Cox, J., Parkington, H.C., Evans, R.G., 2007, Contributions of endothelium-derived relaxing factors to control of hindlimb blood flow in the mouse in vivo, American Jounal of Physiology - Heart & Circulatory Physiology, vol 293, issue 2, Americal Physiological Society, Bethesda MD USA, pp. H1072-H1082.

Fitzgerald, S.M., Kemp, B.K., Parkington, H.C., Head, G.A., Evans, R.G., 2007, Endothelial dysfunction and arterial pressure regulation during early diabetes in mice: roles for nitric oxide and endothelium-derived hyperpolarizing factor, American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol 293, issue 2, American Physiological Society, Bethesda MD USA, pp. R707-R713.

Coleman, H.A., Parkington, H.C., 2007, Endothelin enhances activity of mechanosensitive channels: A mechanism for ET augmentation of the myogenic response, Cardiovascular Research, vol 76, issue 2, Elsevier Science BV, Amsterdam, The Netherlands, pp. 197-198.

Bubb, K., Cock, M.L., Black, M.J., Dodic, M., Boon, W.M., Parkington, H.C., Harding, R., Tare, M., 2007, Intrauterine growth restriction delays cardiomyocyte maturation and alters coronary artery function in the fetal sheep, The Journal of Physiology-London, vol 578, issue 3, Blackwell Publishing Ltd, Oxord England, pp. 871-881.

Smith, R., Van Helden, D.F., Hirst, J.J., Zakar, T., Read, M., Chan, E., Palliser, H.K., Grammatopoulos, D., Nicholson, R., Parkington, H.C., 2007, Pathological interactions with the timing of birth and uterine activation, Australian & New Zealand Journal of Obsterics and Gynaecology, vol 47, issue 6, Blackwell Publishing, Oxford, England, UK, pp. 430-437.

Lang, R.J., Hashitani, H., Tonta, M.A., Suzuki, H., Parkington, H.C., 2007, Role of Ca2+ entry and Ca2+ stores in atypical smooth muscle cell autorhythmicity in the mouse renal pelvis, British Journal of Pharmacology, vol 152, issue 8, Nature Publishing Group, UK, pp. 1248-1259.

Yang, S., Parkington, H.C., Epelbaum, J., Chen, C., 2007, Somatostatin decreases voltage-gated Ca2+ currents in GH3 cells through activation of somatostatin receptor 2, Americal Journal of Physiology-Endocrinology & Metabolism, vol 292, issue 6, American Physiological Society, Bethesda MD USA, pp. E1863-E1870.

Lang, R.J., Hashitani, H., Tonta, M.A., Parkington, H.C., Suzuki, H., 2007, Spontaneous electrical and ca2+ signals in typical and atypical smooth muscle cells and interstitial cell of cajal-like cells of mouse renal pelvis, The Journal of Physiology-London, vol 583, issue Pt 3, Blackwell Publishing, Oxford England UK, pp. 1049-1068.

Hou, X., Parkington, H.C., Coleman, H.A., Mechler, A.I., Martin, L.L., Aguilar, M.I., Small, D.H., 2007, Transthyretin oligomers induce calcium influx via voltage-gated calcium channels, Journal of Neurochemistry, vol 100, issue 2, Blackwell Publishing Ltd, UK, pp. 446-457.

Sokoya, E.M., Burns, A.R., Setiawan, C.T., Coleman, H.A., Parkington, H.C., Tare, M., 2006, Evidence for the involvement of myoendothelial gap junctions in EDHF-mediated relaxation in the rat middle cerebral artery, American Journal of Physiology, Heart and Circulatory Physiology, vol 291, issue 1, American Physiological Society, Bethesda USA, pp. H385-H393.

Lang, R.J., Tonta, M.A., Zoltkowski, B.Z., Meeker, W.F., Wendt, I.R., Parkington, H.C., 2006, Pyeloureteric peristalsis: role of atypical smooth muscle cells and interstitial cells of Cajal-like cells as pacemakers, The Journal of Physiology, vol 576, issue 3, Blackwell Publishing, Oxon UK, pp. 695-705.

Hirst, J.J., Parkington, H.C., Young, I.R., Palliser, H.K., Peri, K.G., Olson, D.M., 2005, Delay of preterm birth in sheep by THG113.31, a prostaglandin F2alpha receptor antagonist, American Journal of Obstetrics and Gynecology, vol 193, issue 1, Mosby, Inc., USA, pp. 256-266.

Palliser, H.K., Hirst, J.J., Ooi, G.T., Rice, G.E., Dellios, N.L., Escalona, R.M., Parkington, H.C., Young, I.R., 2005, Prostaglandin E and F receptor expression and myometrial Sensitivity at labor onset in the sheep, Biology of Reproduction, vol 72, issue 4, Society Study of Reproduction, USA, pp. 937-943.

Fitzgerald, S.M., Kemp-Harper, B.K., Tare, M., Parkington, H.C., 2005, Role of endothelium-derived hyperpolarizing factor in endothelial dysfunction during diabetes, Clinical and Experimental Pharmacology and Physiology, vol 32, issue 5-6, Blackwell Publishing Asia, Carlton Vic Australia, pp. 482-487.

Yang, S., Parkington, H.C., Blake, A.D., Keating, D.J., Chen, C., 2005, Somatostatin increases voltage-gated K+ currents in GH3 cells through activation of multiple somatostatin receptors, Endocrinology, vol 146, issue 11, The Endocrine Society, USA, pp. 4975-4984.

Wigg, S.J., Tare, M., Forbes, J.M., Cooper, M.E., Thomas, M.C., Coleman, H.A., Parkington, H.C., O'Brien, R.C., 2004, Early vitamin e supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats, Diabetologia, vol 47, issue 6, Springer-Verlag, New York USA, pp. 1038-1046.

Coleman, H.A., Tare, M., Parkington, H.C., 2004, Endothelial potassium channels, endothelium-dependent hyperpolarization and the regulation of vascular tone in health and disease, Clinical and Experimental Pharmacology and Physiology, vol 31, issue 9, Blackwell Publishing Asia, Carlton Vic Australia, pp. 641-649.

Parkington, H.C., Coleman, H.A., Tare, M., 2004, Prostacyclin and endothelium-dependent hyperpolarization, Pharmacological Research, vol 49, issue 6, Academic Press, UK, pp. 509-514.

Parkington, H.C., Dodd, J., Luff, S.E., Worthy, K.H., Coleman, H.A., Tare, M., Anderson, W.P., Edgley, A.J., 2004, Selective Increase in Renal Arcuate Innervation Density and Neurogenic Constriction in Chronic Angiotensin II-Infused Rats, Hypertension, vol 43, issue 3, Lippincott Williams & Wilkins, Philadelphia USA, pp. 643-648.

Tare, M., Coleman, H.A., Parkington, H.C., 2003, Regulation of vascular smooth muscle relaxation by the endothelium in health and in diabetes (with a focus on endothelium-derived hyperpolarizing factor), Neurophysiology, vol 35, issue 3/4, Kluwer Academic/Plenum Publishers, USA, pp. 256-261.

Tare, M., Coleman, H.A., Parkington, H.C., 2002, Glycyrrhetinic derivatives inhibit hyperpolarization in endothelial cells of guinea-pig and rat arteries, American Journal of Physiology- Heart and Circulatory Physiology, vol 282, issue 1, American Physiological Society, Bethesda MD USA, pp. H335-H341.

Tobin, V.A., McCance, I., Coleman, H.A., Parkington, H.C., 2002, How important is stimulation of for melatonin production in rat pineal glands?, Journal of Pineal Research, vol 32, issue 4, Blackwell Munksgaard, Copenhagen Denmark, pp. 219-224.

Sandow, S.L., Tare, M., Coleman, H.A., Hill, C.E., Parkington, H.C., 2002, Involvement of myoendothelial gap junctions in the actions of endothelium-derived hyperpolarizing factor, Circulation Research, vol 90, issue 10, Lippincott Williams and Wilkins, Philadelphia USA, pp. 1108-1113.

Parkington, H.C., Chow, J.m., Evans, R.G., Coleman, H.A., Tare, M., 2002, Role of endothelium-derived hyperpolarizing factor in vascular tone in rat mesenteric and hindlimb circulations invivo, Journal of Physiology, vol 542, issue 3, Cambridge University Press, Cambridge UK, pp. 929-937.

Wigg, S.J., Tare, M., Tonta, M.A., O'Brien, R.C., Meredith, I., Parkington, H.C., 2001, Comparison of effects of diabetes mellitus on an EDHF-dependent and an EDHF-independent artery, American Journal of Physiology - Heart and Circulatory Physiology, vol 281, American Physiological Society, Bethesda MD USA, pp. H232-H240.

Coleman, H.A., Tare, M., Parkington, H.C., 2001, EDHF is not K+ but may be due to spread of current from the endothelium in guinea pig arterioles, American Journal of Physiology - Heart and Circulatory Physiology, vol 49, issue 6, American Physiological Society, Bethesda USA, pp. H2478-H2483.

Coleman, H.A., Tare, M., Parkington, H.C., 2001, K+ currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels, Journal of Physiology, vol 531, issue 2, Cambridge University Press, Cambridge UK, pp. 359-373.

Coleman, H.A., Hart, J.D., Tonta, M.A., Parkington, H.C., 2000, Changes in the mechanisms involved in uterine contractions during pregnancy in guinea-pigs, Journal of Physiology, vol 523 issue 3, Cambridge University Press, Cambridge UK, pp. 785-798.

Tare, M., Parkington, H.C., Coleman, H.A., 2000, EDHF, NO and a prostanoid: hyperpolarization-dependent and -independent relaxation in guinea-pig arteries, British Journal of Pharmacology, vol 130 issue 3, Macmillan Publishers, Hampshire UK, pp. 605-618.

Raymond, G.L., Tonta, M.A., Parkington, H.C., Wendt, I.R., 1998, Force membrane potential and cytoplasmic Ca2+ responses to cyclic nucleotides in rat anococcygeus muscle, European Journal of Pharmacology, vol 362, Elsevier Science BV, Amsterdam Netherlands, pp. 183-192.

Holman, M.E., Tonta, M.A., Coleman, H.A., Parkington, H.C., 1998, Muscarinic receptor activation in guinea-pig chromaffin cells causes decreased membrane conductance and depolarization, Journal of the Autonomic Nervous System, vol 68, Elsevier Science BV, Amsterdam Netherlands, pp. 140-144.

Tare, M., Parkington, H.C., Tonta, M.A., Coleman, H.A., 1998, Pregnancy-induced decrease in evoked excitatory junction potentials in guinea pig uterine artery, Journal of Vascular Research, vol 35, S Karger AG, Basel Switzerland, pp. 63-71.

Conference Proceedings

Coleman, H.A., Tare, M., Parkington, H.C., 2002, Myoendothelial electrical coupling in arteries and arterioles and its implications for endothelium-derived hyperpolarizing factor, Clinical and Experimental Pharmacology and Physiology, 22/11/2000 - 24/11/2000, Blackwell Publishing Asia, Carlton Vic Australia, pp. 630-637.

Parkington, H.C., Tonta, M.A., Brennecke, S.P., Coleman, H.A., 1998, Effect of prostaglandins on human uterine smooth muscle during normal and prolonged labor, Placenta, Tokyo Japan 1-3 October 1998, WB Saunders Co Ltd, London UK, p. 30A.

Parkington, H.C., Tonta, M.A., Brennecke, S.P., Holman, M.E., Coleman, H.A., 1998, Prostaglandins hyperpolarize and suppress spontaneous contractions in human uterine smooth muscle, Journal of Physiology, London UK 8-9 January 1998, Cambridge University Press, Cambridge UK, pp. 68P-69P.

Coleman, H.A., Parkington, H.C., 1997, Endothelium-dependent activation and inhibitation of K+ currents in response to acetylcholine in submucosal arterioles of guinea-pigs, Journal of Vascular Research, Maastricht The Netherland, 6-9 July, S Karger AG, Basel Switzerland, p. 12.

Coleman, H.A., Parkington, H.C., 1997, Endothelium-dependent after-depolarization evoked by acetylcholine in submucosal arterioles of the guinea-pig, Proceedings of the International Union of Physiological Societies, St. Petersburg, Russia, International Union of Physiological Societies, St. Petersburg Russia.

Coleman, H.A., Parkington, H.C., 1997, Mechanism of action of endothelium-derived hyperpolarizing factor (EDHF) in submucosal arterioles of the guinea-pig, Progress in Microcirculation Research, St. Vincents's Hospital, Melbourne, The A & NZ Microcirculation Society, Kensington NSW Australia, p. 50.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(POSTGRADUATE QUALIFYING OR PRELIMINARY).
Supervisors:
Coleman, H (Joint), Parkington, H (Joint-co).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Design and use of conductive biopolymers in neural stem cell network formation.
Supervisors:
Forsythe, J (Joint), Parkington, H (Joint-co), Lang, R (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Failure to progress in human labour.
Supervisors:
Parkington, H (Main), Watt, M (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Pharmacological and biological examination of Australo-Papuan elapid snake venoms.
Supervisors:
Hodgson, W (Main), Parkington, H (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
The effects of the Australian box-jellyfish (Chironex fleckeri) venom in rats..
Supervisors:
Parkington, H (Main), Coleman, H (Associate).

Completed Supervision

Student:
Bubb, K.
Program of Study:
The effect of vitamin D deficiency in early life on the cardiovascular system in adulthood. (PHD) 2009.
Supervisors:
Parkington, H (Joint-Co), Tare, M (Joint).
Student:
Ganegala, H.
Program of Study:
. 2011.
Supervisors:
Hollis, J (Main), Parkington, H (Joint).
Student:
Kenna, K.
Program of Study:
Maternal ethanol consumption in late gestation: effects on vascular physiology in the offspring. (PHD) 2010.
Supervisors:
Parkington, H (Main), Walker, D (Associate).
Student:
Louey, S.
Program of Study:
THE EFFECTS OF INTRAUTERINE GROWTH RESTRICTION ON POSTNATAL GROWTH, ARTERIAL PRESSURE AND THE VASCULATURE. (PHD) 2003.
Supervisors:
Harding, R (Main), Parkington, H (Joint).
Student:
Rao, J.
Program of Study:
Effect of fat-derived hormone adiponectin on pancreatic beta cell function in type 2 diabetes. (PHD) 2010.
Supervisors:
Parkington, H (Main).
Student:
Wigg, S.
Program of Study:
THE EFFECTS OF DIABETES ON ENDOTHELIAL FUNCTION AND MECHANICAL WALL PROPERTIES IN MESENTERIC AND FEMORAL ARTERIES OF STREPTOZOTOCIN -TREATED RATS. (PHD) 2002.
Supervisors:
O''Brien, R (Joint-Co), Parkington, H (Joint).
Student:
Yang, S.
Program of Study:
. 2004.
Supervisors:
Chen, C (Main), Parkington, H (Associate).
Student:
Yang, S.
Program of Study:
Ion channels in the regulation of growth hormone secretion by regulatory hormones. (PHD) 2008.
Supervisors:
Chen, C (Main), Parkington, H (Associate).