Dr Dakang Xu - Researcher Profile

Biography

Dakang works in the Centre for Cancer Research, Monash Institute of Medical Research as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Kobe Uni Japan

Year awarded: 2005

Publications

Book Chapters

Shen, L., Thompson, M., Xu, D., 2011, Regulatory T cells and tumor immunity in the tumor microenvironment, in Regulatory T Cells, eds Ren S. Hayashi, Nova Science Publishers Inc, New York, United States, pp. 153-168.

Xu, D., Li, H., Liu, J., 2007, Inhibition of telomerase by targeting MAP kinase signaling, in Telomerase Inhibition Strategies and Protocols, eds Lucy G Andrews and Trygve O Tollefsbol, Humana Press, USA, pp. 147-165.

Xu, D., Wilson, T.J., Hertzog, P.J., 2006, Ultraviolet-induced apoptosis in embryonic stem cells in vitro, in Embryonic Stem Cell Protocols. Volume 1: Isolation and Characterization, eds Kursad Turksen (Series Editor John M. Walker), Humana Press, Totowa NJ USA, pp. 327-338.

Journal Articles

Gantier, M.P.M., Stunden, H.J., McCoy, C., Behlke, M.A., Wang, D., Liaskos, M., Sarvestani, S., Yang, Y.H., Xu, D., Corr, S.C., Morand, E.F., Williams, B.R.G., 2012, A miR-19 regulon that controls NF-{kappa}B signaling, Nucleic Acids Research [P], vol 40, issue 16, Oxford University Press, United Kingdom, pp. 8048-8058.

Suliman, B., Xu, D., Williams, B., 2012, HDACi: molecular mechanisms and therapeutic implications in the innate immune system, Immunology And Cell Biology [P], vol 90, issue 1, Nature Publishing Group, United Kingdom, pp. 23-32.

Zheng, Y., Wang, Z., Deng, L., Yuan, X., Ma, Y., Zhang, G., Gantier, M.P.M., Liu, J., Shen, L., Xu, D., 2012, Osteopontin promotes inflammation in patients with acute coronary syndrome through its activity on IL-17 producing cells, European Journal Of Immunology [P], vol 42, issue 10, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 2803-2814.

Irving, A., Wang, D., Vasilevski, O., Latchoumanin, O., Kozer, N., Clayton, A., Szczepny, A., Morimoto, H., Xu, D., Williams, B., Sadler, A., 2012, Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense, Immunity [P], vol 36, issue 5, Cell Press, United States, pp. 795-806.

Suliman, B.A., Xu, D., Williams, B.R.G., 2012, The promyelocytic leukemia zinc finger protein: two decades of molecular oncology, Frontiers in Oncology [E], vol 2, issue 74, Frontiers Research Foundation, Switzerland, pp. 1-12.

Gantier, M., McCoy, C., Rusinova, I., Saulep, D., Wang, D., Xu, D., Irving, A., Behlke, M., Hertzog, P., Mackay-Fisson, F., Williams, B., 2011, Analysis of microRNA turnover in mammalian cells following Dicer1 ablation, Nucleic Acids Research [P], vol 39, issue 13, Oxford University Press, United Kingdom, pp. 5692-5703.

Yuan, X., Chen, L., Li, M., Dong, P., Xue, J., Wang, J., Zhang, T., Wang, X., Zhang, F., Ge, H., Shen, L., Xu, D., 2010, Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner, Clinical Immunology [P], vol 134, issue 3, Academic Press Inc. Elsevier Science, USA, pp. 277-288.

Gantier, M.P.M., Irving, A.T., Liaskos, M., Xu, D., Evans, V., Cameron, P.U., Bourne, J.A., Ferrero, R.L., John, M., Behlke, M.A., Williams, B.R.G., 2010, Genetic modulation of TLR8 response following bacterial phagocytosis, Human Mutation [P], vol 31, issue 9, John Wiley & Sons, Inc., USA, pp. 1069-1079.

Thompson, M.R., Xu, D., Williams, B.R.G., 2009, ATF3 transcription factor and its emerging roles in immunity and cancer, Journal of Molecular Medicine [P], vol 87, issue 11, Springer, Germany, pp. 1053-1060.

Shen, L., Wang, J., Shen, D., Yuan, X., Dong, P., Li, M., Xue, J., Zhang, F., Ge, H., Xu, D., 2009, CD4+CD25+CD127low/- regulatory T cells express Foxp3 and suppress effector T cell proliferation and contribute to gastric cancers progression, Clinical Immunology [P], vol 131, issue 1, Academic Press, USA, pp. 109-118.

Xu, D., Holko, M., Sadler, A.J., Scott, B.M., Higashiyama, S., Berkofsky-Fessler, W., McConnell, M.J., Pandolfi, P.P., Licht, J.D., Williams, B.R.G., 2009, Promyelocytic leukemia zinc finger protein regulates interferon-mediated innate immunity, Immunity [P], vol 30, issue 6, Cell Press, USA, pp. 802-816.

Xu, D., Dwyer, J.M., Li, H., Duan, W., Liu, J., 2008, Ets2 maintains hTERT gene expression and breast cancer cell proliferation by interacting with c-Myc, Journal of Biological Chemistry, vol 283, issue 35, American Society for Biochemistry and Molecular Biology.Inc, United Kingdom, pp. 23567-23580.

Gantier, M.P.M., Tong, S., Behlke, M.A., Xu, D., Phipps, S., Foster, P.S., Williams, B.R.G., 2008, TLR7 is involved in sequence-specific sensing of single-stranded RNAs in human macrophages, Journal of Immunology, vol 180, issue 4, American Association of Immunologists, USA, pp. 2117-2124.

Shi, W., Zhou, W., Xu, D., 2007, Identifying cis-regulatory elements by statistical analysis and phylogenetic footprinting and analyzing their coexistence and related gene ontology, Physiological Genomics, vol 31, issue 3, American Physiological Society, USA, pp. 374-384.

Dwyer, J.M., Li, H., Xu, D., Liu, J., 2007, Transcriptional regulation of telomerase activity: Roles of the the ets transcription factor family, Annals of the New York Academy of Sciences, vol 1114, New York Academy of Sciences, USA, pp. 36-47.

Li, H., Xu, D., Toh, B., Liu, J., 2006, TGF-beta and cancer: Is Smad3 a repressor of hTERT gene?, Cell Research, vol 16, issue 2, Nature Publishing Group, UK, pp. 169-173.

Li, H., Xu, D., Li, J., Berndt, M.C., Liu, J., 2006, Transforming growth factor beta suppresses human telomerase reverse transcriptase (hTERT) by Smad3 interactions with c-Myc and the hTERT gene, Journal of Biological Chemistry, vol 281, issue 35, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 25588-25600.

Zhou, J., Chehab, R., Tkalcevic, J., Naylor, M.J., Harris, J., Wilson, T.J., Tsao, S.E., Tellis, I., Zavarsek, S., Xu, D., Lapinskas, E.J., Visvader, J., Lindeman, G.J., Thomas, R.S., Ormandy, C.J., Hertzog, P.J., Kola, I., Pritchard, M.A., 2005, Elf5 is essential for early embryogenesis and mammary gland development during pregnancy and lactation, The EMBO Journal, vol 24, issue 3, Nature Publishing Group, New York USA, pp. 635-644.

O'leary, D., Pritchard, M.A., Xu, D., Kola, I., Hertzog, P.J., Ristevski, S., 2004, Tissue-specific overexpression of the HSA21 gene GABP Implications for DS, Biochimica et biophysica Acta, vol 1739, Elsevier Science BV, Netherland, pp. 81-87.

Sanij, E., Scott, B.M., Wilson, T.J., Xu, D., Hertzog, P.J., Wolvetang, E.J., 2003, Characterization of monoclonal antibodies specific to the transcription factor ETS-2 protein, Immunology Letters, vol 86, issue 1, Elsevier, The Netherlands, pp. 63-70.

Yong, Y., Zhang, Y., Zhang, W., Shen, L., Hertzog, P.J., Wilson, T.J., Xu, D., 2003, Ets1 as a marker of malignant potential in gastric carcinoma, World Journnal of Gastroenterology, vol 9, issue 10, WJG Press, Beijing Peoples Republic of China, pp. 2154-2159.

Chan, D., Wilson, T.J., Xu, D., Cowdery, H.E., Sanij, E., Hertzog, P.J., Kola, I., 2003, Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1, British Journal of Cancer, vol 88, Nature Publishing Group, London UK, pp. 137-145.

Wilson, T.J., Cowdery, H.E., Xu, D., Kola, I., Hertzog, P., 2002, A Human CD2 minigene directs CRE-mediated recombination in T cells in vivo, Genesis, vol 33, issue 4, Wiley-Liss, New York NY USA, pp. 181-184.

Xu, D., Wilson, T.J., Chan, D., De Luca, E., Zhou, J., Hertzog, P., Kola, I., 2002, Ets1 is required for p53 transcriptional activity in UV-induced apoptosis in embryonic stem cells, European Molecular Biology Organization Journal, vol 21, issue 15, Oxford University Press, UK, pp. 4081-4093.

Grants

Title:

Regulation of innate immunity and tumour progression by activating transcription factor 3.

Investigators:

Williams, B, Xu, D

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

The role of PLZF in regulating the antiviral activity of interferons.

Investigators:

Williams, B, Xu, D

Funding:

(2010 - 2013). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Exploring the cellular and molecular basis of the development of castrate resistant prostate cancer.

Supervisors:

Williams, B (Main), Xu, D (Associate).