Dr Pablo Enriori - Researcher Profile

Biography

Pablo works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Pablo is an international recognized endocrinologist with a strong clinical and basic research background in the field of Endocrinology and Metabolism. He was awarded a Master degree and a PhD in Argentina and he continues his postdoctoral training at the Oregon Health & Science University (OHSU, USA). He was promoted to the position of Assistant Professor at OHSU in 2007. In 2008 he relocated to Monash University.

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Keywords

melanocortins, high-fat diet, leptin resistance, metabolic diseases

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Buenos Aires

Year awarded: 2002

MASTER IN CLINICAL ENDOCRINOLOGY

Institution: University of Buenos Aires

Year awarded: 1996

BIOCHEMISTRY

Institution: University of Buenos Aires

Year awarded: 1988

Publications

Journal Articles

Chen, W., Wilson, J.L., Khaksari, M., Cowley, M.A., Enriori, P.J., 2012, Abdominal fat analyzed by DEXA scan reflects visceral body fat and improves the phenotype description and the assessment of metabolic risk in mice, American Journal of Physiology - Endocrinology and Metabolism [E], vol 303, issue 5, American Physiological Society, USA, pp. E635-E643.

Loh, K., Fukushima, A., Zhang, X.M., Galic, S., Briggs, D.I., Enriori, P., Simonds, S., Wiede, F., Reichenbach, A., Hauser, C., Sims, N.A., Bence, K.K., Zhang, S., Zhang, Z., Kahn, B., Neel, B., Andrews, Z.B., Cowley, M.A., Tiganis, T., 2011, Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance, Cell Metabolism [P], vol 14, issue 5, Cell Press, USA, pp. 684-699.

Enriori, P., Sinnayah, P., Simonds, S., Garcia Rudaz, M., Cowley, M., 2011, Leptin action in the dorsomedial hypothalamus increases sympathetic tone to brown adipose tissue in spite of systemic leptin resistance, Journal Of Neuroscience [P], vol 31, issue 34, Society of Neuroscience, USA, pp. 12189-12197.

Reinehr, T., Roth, C.L., Enriori, P., Masur, K., 2010, Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: Relationships to peptide YY, pancreatic peptide, and insulin sensitivity, Journal of Pediatric Endocrinology and Metabolism [P], vol 23, issue 1-2, Freund Pubishing House, Ltd, Israel, pp. 101-108.

Roth, C.L., Enriori, P., Gebhardt, U., Hinney, A., Muller, H.L., Hebebrand, J., Reinehr, T., Cowley, M.A., 2010, Changes of peripheral alpha-melanocyte-stimulating hormone in childhood obesity, Metabolism: Clinical and Experimental [P], vol 59, issue 2, WB Saunders & Co., USA, pp. 186-194.

Briggs, D.I., Enriori, P.J., Lemus, M.B., Cowley, M.A., Andrews, Z.B., 2010, Diet-induced obesity causes ghrelin resistance in arcuate NPY/AgRP neurons, Endocrinology [P], vol 151, issue 10, The Endocrine Society, USA, pp. 4745-4755.

Glavas, M.M., Kirigiti, M.A., Xiao, Q.X., Enriori, P.J., Fisher, S.K., Evans, A.E., Grayson, B.E., Cowley, M.A., Smith, M.S., Grove, K.L., 2010, Early overnutrition results in early-onset arcuate leptin resistance and increased sensitivity to high-fat diet, Endocrinology [P], vol 151, issue 4, The Endocrine Society, USA, pp. 1598-1610.

Horvath, T.L., Sarman, B., Garcia-Caceres, C., Enriori, P., Sotonyi, P., Shanabrough, M., Borok, E., Argente, J., Chowen, J.A., Perez-Tilve, D., Pfluger, P.T., Bronneke, H.S., Levin, B.E., Diano, S., Cowley, M.A., Tschop, M.H., 2010, Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity, Proceedings Of The National Academy Of Sciences O..., vol 107, issue 33, National Academy of Sciences, USA, pp. 14875-14880.

Sinnayah, P., Jobst, E., Rathner, J.A., Caldera-Siu, A.D., Tonelli-Lemos, L., Eusterbrock, A.J., Enriori, P., Pothos, E.N., Grove, K., Cowley, M.A., 2008, Feeding induced by cannabinoids is mediated independently of the melanocortin system, PL o S One (online), vol 3, issue 5, Public Library of Science, United States, pp. 1-12.

Scarlett, J.M., Zhu, X., Enriori, P., Bowe, D., Batra, A., Levasseur, P.R., Grant, W.F., Meguid, M.M., Cowley, M.A., Marks, D., 2008, Regulation of agouti-related protein messenger ribonucleic acid transcription and peptide secretion by acute and chronic inflammation, Endocrinology, vol 149, issue 10, The Endocrine Society, USA, pp. 4837-4845.

Enriori, P., Evans, A., Sinnayah, P., Jobst, E., Tonelli-Lemos, L., Billes, S., Glavas, M., Grayson, B., Perello, M., Nillni, E., Grove, K., Cowley, M.A., 2007, Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons, Cell Metabolism, vol 5, issue 3, Cell Press, USA, pp. 181-194.

Parton, L., Ye, C., Coppari, R., Enriori, P., Choi, B., Zhang, C., Xu, C., Vianna, C., Balthasar, N., Lee, C., Elmquist, J., Cowley, M.A., Lowell, B., 2007, Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity, Nature, vol 449, issue 7159, Nature Publishing Group, UK, pp. 228-232.

Konner, A., Janoschek, R., Plum, L., Jordan, S., Rother, E., Ma, X., Xu, C., Enriori, P., Hampel, B., Barsh, G., Kahn, C., Cowley, M.A., Ashcroft, F., Bruning, J., 2007, Insulin action in agrp-expressing neurons is required for suppression of hepatic glucose production, Cell Metabolism, vol 5, issue 6, Cell Press, USA, pp. 438-449.

Scarlett, J., Jobst, E., Enriori, P., Bowe, D., Batra, A., Grant, W., Cowley, M.A., Marks, D., 2007, Regulation of central melanocortin signaling by interleukin-1beta, Endocrinology, vol 148, issue 9, The Endocrine Society, USA, pp. 4217-4225.

Enriori, P., Vazquez, S., Chiauzzi, V., Perez, C., Fischer, C., Gori, J., Etkin, A., Charreau, E., Calandra, R., Luthy, I., 2006, Breast cyst fluids increase the proliferation of breast cell lines in correlation with their hormone and growth factor concentration, Journal of Clinical Endocrinology and Metabolism, vol 64, issue 1, The Endocrine Society, USA, pp. 20-28.

Jobst, E., Enriori, P., Sinnayah, P., Cowley, M.A., 2006, Hypothalamic regulatory pathways and potential obesity treatment targets, Endocrine, vol 29, issue 1, Humana Press Inc, USA, pp. 33-48.

Reinehr, T., Enriori, P., Harz, K., Cowley, M.A., Roth, C., 2006, Pancreatic polypeptide in obese children before and after weight loss, International Journal of Obesity, vol 30, issue 10, Nature Publishing Group, UK, pp. 1476-1481.

Guo, Y., Ma, L., Enriori, P., Koska, J., Franks, P., Brookshire, T., Cowley, M.A., Salbe, A.D., DelParigi, A., Tataranni, P.A., 2006, Physiological evidence for the involvement of peptide YY in the regulation of energy homeostasis in humans, Obesity, vol 14, issue 9, Nature Publishing Group, USA, pp. 1562-1570.

Enriori, P., Evans, A., Sinnayah, P., Cowley, M.A., 2006, The role of leptin in leptin resistance and obesity, Obesity, vol 88, issue Suppl. 5, Nature Publishing Group, USA, pp. 249-256.

Roth, C., Enriori, P., Harz, K., Woelfle, J., Cowley, M.A., Reinehr, T., 2005, Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss, Journal of Clinical Endocrinology and Metabolism, vol 90, issue 12, The Endocrine Society, USA, pp. 6386-6391.

Koegler, F., Enriori, P., Billes, S., Takahashi, D., Martin, M., Clark, R., Evans, A., Grove, K., Cameron, J., Cowley, M.A., 2005, Peptide YY(3-36) inhibits morning, but not evening, food intake and decreases body weight in rhesus macaques, Diabetes, vol 54, issue 11, American Diabetes Association, USA, pp. 3198-3204.

Jobst, E., Enriori, P., Cowley, M.A., 2004, The electrophysiology of feeding circuits, Trends in Endocrinology and Metabolism, vol 15, issue 10, Elsevier Ltd, UK, pp. 488-499.

Enriori, P., Fischer, C., Gori, J., Etkin, A., Calandra, R., Luthy, I., 2003, Augmented serum levels of the IGF-I/IGF-binding protein-3 ratio in pre-menopausal patients with type I breast cysts, European Journal of Endocrinology, vol 148, issue 2, BioScientifica Ltd, UK, pp. 177-184.

Cowley, M.A., Cone, R., Enriori, P., Louiselle, I., Williams, S., Evans, A., 2003, Electrophysiological actions of peripheral hormones on melanocortin neurons, Annals of the New York Academy of Sciences, vol 994, Wiley-Blackwell Publishing Inc, USA, pp. 175-186.

Enriori, P., Enriori, C., 2002, The pathogenesis of osteoporosis in older women and men: a review, The Journal of Steroid Biochemistry & Molecular Biology, vol 82, issue 1, Pergamon, UK, pp. 1-6.

Enriori, P., Hirsig, R., Vico, C., Etkin, A., Negri, J., Enriori, C., 2000, Effect of natural "micronized" progesterone on the chorionic gonadotropin concentrations in cyst fluids of women with gross cystic breast disease, The Journal of Steroid Biochemistry & Molecular Biology, vol 73, issue 1-2, Pergamon, UK, pp. 67-70.

Teaching Commitment

PHY3102 - Nutrition, metabolism and body weight
PHY3990 - Action in Physiology Research Project
PHY3012 - Integrative Neuroscience

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Brain control of blood glucose levels.

Supervisors:

Cowley, M (Main), Enriori, P (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Does obesity related hypertension develop as a consequence of hyperleptinaemia, through leptin's actions in the dorso medial hypothalamus.

Supervisors:

Cowley, M (Main), Enriori, P (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Examination of metabolic alterations involved in PCOS through the development of a new model.

Supervisors:

Enriori, P (Joint-co), Garcia Rudaz, M (Joint), Cowley, M (Associate).