Prof Franklin Rosenfeldt - Researcher Profile

Biography

Franklin works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

FELLOW - FRACS

Institution: Royal Australian College of Surgeons

Year awarded: 1980

FELLOW - FRCSE

Institution: Royal College of Surgeons - Edinburgh

Year awarded: 1970

MBBS - MEDICINE AND SURGERY

Institution: Adelaide University

Year awarded: 1962

Publications

Book Chapters

Rosenfeldt, F.L., Marasco, S., Leong, J.Y., Pepe, S., 2006, Oxidative stress and coenzyme Q10 therapy, in Oxidative Stress, Disease and Cancer, eds Keshav K Singh, Imperial College Press, London UK, pp. 965-994.

Journal Articles

Chaudhuri, K., Storey, E., Lee, G.A., Bailey, M.J., Chan, J.C.Y., Rosenfeldt, F.L., Pick, A., Negri, J., Gooi, J., Zimmet, A., Esmore, D.S., Merry, C., Rowland, M., Lin, E., Marasco, S., 2012, Carbon dioxide insufflation in open-chamber cardiac surgery: A double-blind, randomized clinical trial of neurocognitive effects, Journal of Thoracic and Cardiovascular Surgery [P], vol 144, Mosby, Inc, USA, pp. 646-653.

Rosenfeldt, F., Wilson, M., Buxton, B., Marasco, S., 2012, Coronary Artery Bypass Surgery Provides Long-Term Results Superior to Percutaneous Coronary Intervention, Heart Lung and Circulation [P], vol 21, issue 1, Elsvier Australia, Australia, pp. 1-11.

Braun, L.A., Stanguts, C., Casanelia, L., Spitzer, O., Paul, E., Vardaxis, N.J., Rosenfeldt, F.L., 2012, Massage therapy for cardiac surgery patients - a randomized trial, Journal of Thoracic and Cardiovascular Surgery [P], vol 144, issue 6, Mosby, Inc., United States, pp. 1453-1459.

Blum, M.L., Esser, M.P., Richardson, M.D., Paul, E., Rosenfeldt, F.L., 2012, Negative pressure wound therapy reduces deep infection rate in open tibial fractures, Journal of Orthopaedic Trauma [P], vol 26, issue 9, Lippincott Williams & Wilkins, United States, pp. 499-505.

Rosenfeldt, F., Braun, L., Spitzer, O., Bradley, S., Shepherd, J., Bailey, M., van der Merwe, J., Leong, J.Y., Esmore, D., 2011, Physical conditioning and mental stress reduction - a randomised trial in patients undergoing cardiac surgery, BMC Complementary and Alternative Medicine [P], vol 11, issue Art. No: 20, BioMed Central Ltd, United Kingdom, pp. 1-7.

Rosenfeldt, F., 2011, The Early History of the Australasian Society of Cardiac and Thoracic Surgeons, Heart Lung and Circulation Journal and the ASCTS Database, Heart Lung and Circulation [P], vol 20, issue 3, Heart, Lung and Circulation, Australia, pp. 145-148.

Chew, P., Yuen, D., Stefanovic, N., Pete, J., Coughlan, M., Jandeleit-Dahm, K., Thomas, M., Rosenfeldt, F., Cooper, M., de Haan, J., 2010, Antiatherosclerotic and renoprotective effects of ebselen in the diabetic apolipoprotein E/GPx1-double knockout mouse, Diabetes [P], vol 59, issue 12, Amercian Diabetes Association, USA, pp. 3198-3207.

Repse, S.E., Pepe, S., Anderson, J., McLean, C., Rosenfeldt, F.L., 2010, Cardiac reanimation for donor heart transplantation after cardiocirculatory death, Journal of Heart and Lung Transplantation [P], vol 29, issue 7, Elsevier Inc., USA, France, pp. 747-755.

van den Brink, O., Cochrane, A., Rosenfeldt, F., Penny, D., Pepe, S., 2010, Increased myocardial methionine-enkephalin with reduced arterial oxygenation in congenital heart disease, Journal Of Paediatrics And Child Health [P], vol E, Wiley-Blackwell Publishing Ltd, UK, Australia, pp. 1-5.

Leong, J.Y., Van Der Merwe, J., Pepe, S., Bailey, M.J., Perkins, T., Lymbury, R., Esmore, D.S., Marasco, S., Rosenfeldt, F.L., 2010, Perioperative metabolic therapy improves redox status and outcomes in cardiac surgery patients: A randomised trial, Heart Lung and Circulation [P], vol 19, issue 10, Elsevier Australia, Australia, pp. 584-591.

Lim, H.K., Jayaweera, S., Calderone, A., Pepe, S., Rosenfeldt, F., Marasco, S., 2010, Protective role of coenzyme Q10 in two models of rat lung injury, ANZ Journal of Surgery [P], vol 80, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 265-270.

Markman, P.L., Rowland, M., Leong, J., Van Der Merwe, J., Storey, E., Marasco, S., Negri, J., Bailey, M.J., Rosenfeldt, F.L., 2010, Skeletonized internal thoracic artery harvesting reduces chest wall dysesthesia after coronary bypass surgery, Journal of Thoracic and Cardiovascular Surgery [P], vol 139, issue 3, Mosby, Inc., United States, pp. 674-679.

Ashton, E., Windebank, E., Skiba, M., Reid, C., Schneider, H., Rosenfeldt, F., Tonkin, A., Krum, H., 2010, Why did high-dose rosuvastatin not improve cardiac remodeling in chronic heart failure? Mechanistic insights from the UNIVERSE study, International Journal of Cardiology [P], vol 146, issue 3, Elsevier Ireland Ltd, Ireland, pp. 404-407.

Miller, F.J., Nagley, P., Mariani, J., Ou, R., Liu, V.W.S., Zhang, C., Linnane, A.W., Pepe, S., Rosenfeldt, F.L., 2009, Age-related decline in stress responses of human myocardium may not be explained by changes in mtDNA, Mechanisms of Ageing and Development [P], vol 130, issue 11-12, Elsevier Ireland Ltd, Ireland, pp. 742-747.

Adamides, A.A., Rosenfeldt, F.L., Winter, C.D., Pratt, N.M., Tippett, N.J., Lewis, P.M., Bailey, M.J., Cooper, D.J., Rosenfeld, J.V., 2009, Brain tissue lactate elevations predict episodes of intracranial hypertension in patients with traumatic brain injury, Journal of the American College of Surgeons [P], vol 209, issue 4, Elsevier Inc, United States, pp. 531-539.

Adamides, A.A., Cooper, D.J., Rosenfeldt, F.L., Bailey, M.J., Pratt, N.M., Tippett, N.J., Vallance, S., Rosenfeld, J.V., 2009, Focal cerebral oxygenation and neurological outcome with or without brain tissue oxygen-guided therapy in patients with traumatic brain injury, Acta Neurochirurgica [P], vol 151, issue 11, Springer Wien, Austria, pp. 1399-1409.

Marasco, S., Rosenfeldt, F.L., Lim, H., Mennen, M., Cairo, S., Bain, C., 2008, Correction of posteromedial papillary muscle displacement in repair of ischemic mitral regurgitation., The Journal of Heart Valve Disease, vol 17, issue 6, ICR Publishers Ltd, United Kingdom, pp. 620-627.

Snell, G.I., Levvey, B., Oto, T., McEgan, R., Pilcher, D.V., Davies, A.R., Marasco, S., Rosenfeldt, F.L., 2008, Early lung transplantation success utilizing controlled donation after cardiac death donors, American Journal of Transplantation, vol 8, issue 6, Wiley-Blackwell Publishing Ltd., UK, USA, pp. 1282-1289.

Snell, G.I., Levvey, B., Oto, T., McEgan, R., Mennan, M., Eriksson, L., Williams, T.J., Rosenfeldt, F.L., 2008, Effect of multiorgan donation after cardiac death retrieval on lung performance, ANZ Journal of Surgery, vol 78, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 262-265.

Esmore, D.S., Kaye, D., Salamonsen, R.F., Buckland, M., Begg, J.R., Negri, J., Ayre, P., Woodard, J., Rosenfeldt, F.L., 2008, Initial clinical experience with the VentrAssist left ventricular assist device: The pilot trial, The Journal of Heart and Lung Transplantation, vol 27, issue 5, Elsevier Inc., USA, pp. 479-485.

Lymbury, R., Tinggi, U., Griffiths, L., Rosenfeldt, F.L., Perkins, A.V., 2008, Selenium status of the Australian population : Effect of age, gender and cardiovascular disease, Biological Trace Element Research, vol 126, issue 1, Humana Press, Inc., USA, pp. 1-10.

Pepe, S., Leong, J.Y., Van Der Merwe, J., Marasco, S., Hadj, A., Lymbury, R., Perkins, A., Rosenfeldt, F.L., 2008, Targeting oxidative stress in surgery: Effects of ageing and therapy, Experimental Gerontology, vol 43, issue 7, Elsevier Inc., United States, pp. 653-657.

Chand, V., Rosenfeldt, F.L., Pepe, S., 2008, The Publication Rate and Impact of Abstracts Presented at the Cardiac Society of Australia and New Zealand (1999-2005), Heart, Lung and Circulation, vol 17, issue 5, Elsevier Australia, Australia, pp. 375-379.

Van den Brink, O.W., Delbridge, L.M.D., Pedrazzini, T., Rosenfeldt, F.L., Pepe, S., 2007, Augmented myocardial methionine-enkephalin in a murine model of cardiac angiotensin II-overexpression, Journal of the Renin-Angiotensin-Aldosterone, vol 8, issue 4, JRAAS, UK, pp. 153-159.

Pepe, S., Marasco, S., Haas, S.J., Sheeran, F.L., Krum, H., Rosenfeldt, F.L., 2007, Coenzyme Q10 in cardiovascular disease, Mitochondrion, vol 7, Elsevier BV, The Netherlands & USA, pp. S154-S167.

Rosenfeldt, F.L., Haas, S.J., Krum, H., Hadj, A., Ng, K., Leong, J.Y., Watts, G.F., 2007, Coenzyme Q10 in the treatment of hypertension: a meta-analysis of the clinical trials, Journal of Human Hypertension, vol 21, issue 4, Nature Publishing Group, UK, pp. 297-306.

Hadj, A., Pepe, S., Rosenfeldt, F.L., 2007, The clinical application of metabolic therapy for cardiovascular disease, Heart, Lung and Circulation, vol 16, issue Supplement 3, Wiley-Blackwell Publishing Asia, Australia, pp. 56-64.

Lim, H.K., Anderson, J., Leong, J., Pepe, S., Salamonsen, R.F., Rosenfeldt, F.L., 2007, What is the role of leukocyte depletion in cardiac surgery?, Heart Lung and Circulation, vol 16, issue 4, Wiley-Blackwell Publishing Asia, Australia, pp. 243-253.

Van den Brink, O.W., Rowland, M., Marasco, S., Esmore, D.S., Rosenfeldt, F.L., Pepe, S., 2006, Complex regional pain syndrome and methionine-enkephalin, Clinical Chemistry, vol 52, issue 3, American Association for Clinical Chemistry, Inc., USA, p. 535.

Snell, G.I., Oto, T., Levvey, B., McEgan, R., Eriksson, L., Williams, T.J., Rosenfeldt, F.L., 2006, Evaluation of techniques for lung transplantation following donation after cardiac death, The Annals of Thoracic Surgery, vol 81, issue 6, Elsevier, USA, pp. 2014-2019.

Oto, T., Calderone, A., Pepe, S., Snell, G.I., Rosenfeldt, F.L., 2006, High-flow endobronchial cooled humidified air protects non-heart-beating donor rat lungs against warm ischemia, Journal of Thoracic and Cardiovascular Surgery, vol 132, issue 2, Mosby-Elsevier, USA, pp. 413-419.

Hadj, A., Esmore, D.S., Rowland, M., Pepe, S., Schneider, L., Lewin, J., Rosenfeldt, F.L., 2006, Pre-operative preparation for cardiac surgery utilising a combination of metabolic, physical and mental therapy, Heart Lung and Circulation, vol 15, issue 3, Blackwell Publishing Asia, Australia, pp. 172-181.

Oto, T., Rabinov, M., Negri, J., Marasco, S., Rowland, M., Pick, A., Snell, G.I., Rosenfeldt, F.L., Esmore, D.S., 2006, Techniques of reconstruction for inadequate donor left atrial cuff in lung transplantation, The Annals of Thoracic Surgery, vol 81, issue 4, Elsevier Science Inc., USA, pp. 1199-1204.

Rosenfeldt, F.L., Marasco, S., Lyon, W., Wowk, M., Sheeran, F.L., Bailey, M.J., Esmore, D.S., Davis, B., Pick, A., Rabinov, M., Smith, J.A., Nagley, P., Pepe, S., 2005, Coenzyme Q10 therapy before cardiac surgery improves mitochondrial function and in vitro contractility of myocardial tissue, Journal of Thoracic and Cardiovascular Surgery, vol 129, issue 1, Mosby, Inc., St Louis USA, pp. 25-32.

Marasco, S., Esmore, D.S., Negri, J., Rowland, M., Newcomb, A., Rosenfeldt, F.L., Bailey, M.J., Richardson, M., 2005, Early institution of mechanical support improves outcomes in primary cardiac allograft failure, The Journal of Heart and Lung Transplantation, vol 24, issue 12, Elsevier Inc., USA, pp. 2037-2042.

Oto, T., Rabinov, M., Rosenfeldt, F.L., Esmore, D.S., 2005, Extended pericardiotomy avoids cardiopulmonary bypass during bilateral sequential lung transplantation, The Journal of Thoracic and Cardiovascular Surgery, vol 129, issue 2, Mosby, Inc., St Louis USA, pp. 466-467.

Esmore, D.S., Kaye, D., Salamonsen, R.F., Buckland, M., Rowland, M., Negri, J., Rowley, Y., Woodard, J., Begg, J.R., Ayre, P., Rosenfeldt, F.L., 2005, First clinical implant of the VentrAssist left ventricular assist system as destination therapy for end-stage heart failure, The Journal of Heart and Lung Transplantation, vol 24, issue 8, Elsevier Inc., USA, pp. 1150-1154.

Rosenfeldt, F.L., Mijch, A.M., McCrystal, G., Sweeney, C., Pepe, S., Nicholls, M., Dennett, X., 2005, Skeletal myopathy associated with nucleoside reverse transciptase inhibitor therapy: potential benefit of coenzyme Q10 therapy, International Journal of STD & AIDS, vol 16, Royal Society of Medicine Press Ltd, London England, pp. 827-829.

Esmore, D.S., Markman, P.L., Agrawal, S., Burton, P.R., Rosenfeldt, F.L., 2005, The split radial technique: an alternative to the Y-graft for total arterial myocardial revascularisation, Heart, Lung and Circulation, vol 14, issue 1, Blackwell Publishing Asia, Australia, pp. 32-35.

Salamonsen, R.F., Anderson, J., Anderson, M., Bailey, M.J., Magrin, G., Rosenfeldt, F.L., 2005, Total leukocyte control for elective coronary bypass surgery does not improve short-term outcome, The Annals of Thoracic Surgery, vol 79, issue 6, Elsevier Inc., USA, pp. 2032-2038.

Takahiho, O., Rosenfeldt, F.L., Rowland, M., Pick, A., Rabinov, M., Preovolos, A., Snell, G.I., Williams, T.J., Esmore, D., 2004, Extracorporeal membrane oxygenation after lung transplantation: evolving technique improves outcomes, Annals of Thoracic Surgery, vol 78, issue 4, Elsevier, New York USA, pp. 1230-1235.

Rosenfeldt, F.L., Miller, F., Nagley, P., Hadj, A., Marasco, S., Quick, D., Sheeran, F., Wowk, M., Pepe, S., 2004, Response of the senescent heart to stress. Clinical therapeutic strategies and quest for mitochondrial predictors of biological age, Annals of the New York Academy of Sciences, vol 1019, New York Academy of Sciences, New York USA, pp. 78-84.

Miller, F.J., Rosenfeldt, F.L., Zhang, C., Linnane, A.W., Nagley, P., 2003, Precise determination of mitochondrial DNA copy number in human skeletal and cardiac muscle by a PCR-based assay: lack of change of copy number with age, Nucleic Acids Research, vol 31, issue 11, Oxford University Press, Oxford England, pp. e61-e67.

Keogh, A., Fenton, S., Leslie, C., Aboyoun, C., Macdonald, P.S., Zhao, Y., Bailey, M.J., Rosenfeldt, F.L., 2003, Randomised double-blind, placebo-controlled trial of coenzyme Q[10] therapy in class II and III systolic heart failure, Heart, Lung and Circulation (Print), vol 12, issue 3, Elsevier, Australia, pp. 135-141.

Rosenfeldt, F.L., Hilton, D.J., Pepe, S., Krum, H., 2003, Systematic review of effect of coenzyme Q10 in physical exercise, hypertension and heart failure, BioFactors, vol 18, IOS Press, Netherlands, Australia, pp. 91-100.

Rosenfeldt, F.L., Pepe, S., Linnane, A.W., Nagley, P., Rowland, M.A., Ou, R., Marasco, S., Lyon, W., Esmore, D.S., 2002, Coenzyme Q10 protects the ageing heart against stress, Annals of the New York Academy of Sciences, vol 959, issue 1, New York Academy of Sciences, New York NY USA, pp. 355-359.

Rosenfeldt, F.L., Pepe, S., Linnane, A.W., Nagley, P., Rowland, M.A., Ou, R., Marasco, S., Lyon, W., 2002, The effects of ageing on the response to cardiac surgery: protective strategiess for the ageing myocardium, Biogerontology, vol 3, issue 12, Klumer Academic Publishing, Dordecht Netherland, pp. 37-40.

Reid, C.M., Solterbeck, A., Buxton, B.F., Skillington, P.D., Shardey, G.C., Smith, J.A., Rosenfeldt, F.L., 2001, Developing performance indicators for cardiac surgery: A demonstration project in Victoria, Heart, Lung and Circulation, vol 10, issue 1, Elsevier Ltd, Australia, pp. S29-S33.

Gahan, M.E., Miller, F., Lewin, S.R., Cherry, C., Hoy, J., Mijch, A.M., Rosenfeldt, F.L., Wesselingh, S.L., 2001, Quantification of mitochondrial DNA in peripheral blood mononuclear cells and subcutaneous fat using real-time polymerase chain reaction, Journal of Clinical Virology, vol 22, Elsevier Science BV, Amsterdam Netherlands, pp. 241-247.

Mariani, J.A., Ou, R., Bailey, M., Rowland, M.A., Nagley, P., Rosenfeldt, F.L., Pepe, S., 2000, Tolerance to ischemia and hypoxia is reduced in aged human myocardium, Journal of Thoracic and Cardiovascular Surgery, vol 120 issue 4, Mosby-Year Book Inc, St Louis USA, pp. 660-667.

Rosenfeldt, F.L., Pepe, S., Ou, R., Mariani, J.A., Rowland, M.A., Nagley, P., Linnane, A.W., 1999, Coenzyme Q<10 improves the tolerance of the senescent myocardium to aerobic and ischemic stress: studies in rats and in human atrial tissue, Biofactors, vol . 9 issues 2-4, IOS Press, Amsterdam Netherlands, pp. 291-299.

Zhang, C., Lee, A., Liu, V.W., Pepe, S., Rosenfeldt, F.L., Nagley, P., 1999, Mitochondrial DNA deletions in human cardiac tissue show a gross mosaic distribution, Biochemical and Biophysical Research Communications, vol . 254 issue 1, Academic Press, San Diego CA USA, pp. 152-157.

Rowland, M.A., Nagley, P., Linnane, A.W., Rosenfeldt, F.L., 1998, Coenzyme Q10 treatment improves the tolerance of the senescent myocardium to pacing stress in the rat, Cardiovascular Research, vol 40 no 1, Elsevier Science BV, Amsterdam Netherlands, pp. 165-173.

Conference Proceedings

Pepe, S., Ou, R., Lew, R., Mariani, J.A., Nagley, P., Linnane, A.W., Rosenfeldt, F.L., 1998, Age-associated reduction in post-ischemic functional recovery of human myocardium in vitro is abolished by coenzyme Q10, Proceedings, XVI World Congress of the International Society for Heart Research: Cardiovascular Biology and Medicine into the 21st Century, Rhodes Greece 27-31 May 1998, Academic Press, London UK, p. A320.

Mariani, J.A., Liu, V.W., Pepe, S., Nagley, P., Rosenfeldt, F.L., 1998, Atrial fibrillation after cardiac surgery is associated with mitochondrial DNA mutations, Proceedings, XVI World Congress of the International Society for Heart Research: Cardiovascular Biology and Medicine into the 21st Century, Rhodes Greece 27-31 May 1998, Academic Press, London UK, p. A320.

Mariani, J.A., Ou, R., Pepe, S., Nagley, P., Liu, V.W., Linnane, A.W., Rosenfeldt, F.L., 1998, Response of the human muocardium to hypoxia and ischaemia declines with age and correlates with increased mitochondrial DNA deletions, Proceedings, Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth WA February 1998, Adis International Pty Limited, Frenchs Forest NSW, p. 91.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Comparison of Long-term Outcomes and Cost Effectiveness of Coronary Bypass Surgery versus Percutaneous Coronary Interventions in the Australian context..

Supervisors:

Reid, C (Main), Ademi, Z (Associate), Billah, B (Associate), Rosenfeldt, F (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Exercise haemodynamics in patients with a centrifugal (non-pulsatile) flow pump and the need for a physiological controller to adjust pump speed during exercise.

Supervisors:

Rosenfeldt, F (Main), Kaye, D (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Methodological considerations in cerebral autoregulation assessment.

Supervisors:

Rosenfeldt, F (Main), Rosenfeld, J (Associate).

Completed Supervision

Student:

Adamides, A.

Program of Study:

Multimodality neuromonitoring in severe traumatic brain injury. (PHD) 2009.

Supervisors:

Rosenfeldt, F (Main), Rosenfeld, J (Associate).

Student:

Blum, M.

Program of Study:

Effect of Negative Pressure Wound Therapy on Outcomes in Open Tibial Fractures. (Masters) 2010.

Supervisors:

Rosenfeldt, F (Main), Esser, M (Associate).

Student:

Chaudhuri, K.

Program of Study:

The Role of Carbon Dioxide Insufflation of the pericardial field in open chamber cardiac surgery to prevent neurocognitive decline. (Masters) 2011.

Supervisors:

Marasco, S (Main), Rosenfeldt, F (Associate).

Student:

Lim, H.

Program of Study:

Therapeutic Strategies To Ameliorate Ischemia-Reperfusion Injury In Heart and Lung Transplantation. (Masters) 2008.

Supervisors:

Rosenfeldt, F (Main), Marasco, S (Associate), Pepe, S (Associate).

Student:

Miller, F.

Program of Study:

THE MOLECULAR AND PHYSIOLOGICAL CHANGES OF mtDNA IN THE AGEING HUMAN HEART. (PHD) 2003.

Supervisors:

Rosenfeldt, F (Main), Nagley, P (Associate).

Student:

Sheeran, F.

Program of Study:

The role of mitochondrial function in human heart failure. (PHD) 2008.

Supervisors:

Pepe, S (Main), Rosenfeldt, F (Associate).

Student:

Van Den Brink, O.

Program of Study:

The novel role of enkephalins in the heart. (PHD) 2005.

Supervisors:

Pepe, S (Main), Rosenfeldt, F (Associate).