Assoc Prof Jeffrey Kerr - Researcher Profile

Biography

Jeff Kerr is an Associate Professor in the Department of Anatomy and Developmental Biology.  His research focuses on gene regulation of ovarian follicle development: impacts on fertility. 

• fetal/postnatal oocyte development
• strategies that delay the menopause
• rescue of fertility after chemo or radiotherapy
• cellular and molecular biology of declining oocyte quality with age

Jeff is also the Unit Co-ordinator for DEV2022.

Keywords

oocyte, fertility, menopause, gene regulation,

Qualifications

PHD IN REPRODUCTIVE BIOLOGY

Institution: Monash University

Year awarded: 1976

BACHELOR OF SCIENCE (HONS)

Institution: Flinders University, South Australia

Year awarded: 1972

Publications

Books

Kerr, J.B., 2010, Functional Histology, Mosby-Elsevier, Australia.

Book Chapters

Kerr, J.B., Loveland, K.A.L., O'Bryan, M.K., de Kretser, D.M., 2006, Cytology of the testis and intrinsic control mechanisms, in Knobil and Neill's Physiology of Reproduction, eds Jimmy D Neill, John R G Challis, David M de Kretser, Donald W Pfaff, JoAnne S Richards, Tony M Plant and Paul M Wassarman, Elsevier, London UK, pp. 827-947.

Kerr, J.B., de Kretser, D.M., 2005, Functional morphology of the testis, in Endocrinology, Volume 1, eds Leslie J DeGroot, J Larry jameson, David de Kretser, Shlomo Melmed, Ashley B Gorssman, John T Potts, Jr, Joch C Marshall, Gordon C Weir, Saunders, Philadelphia, pp. 3089-3120.

Journal Articles

Kerr, J.B., Hutt, K.J., Cook, M., Speed, T.P., Strasser, A., Findlay, J.K., Scott, C.L., 2012, Cisplatin-induced primordial follicle oocyte killing and loss of fertility are not prevented by imatinib, Nature Medicine [P], vol 18, issue 8, Nature Publishing Group, USA, pp. 1170-1172.

Kerr, J.B., Hutt, K.J., Michalak, E.M., Cook, M., Vandenberg, C., Liew, S.H., Bouillet, P., Mills, A.A., Scott, C.L., Findlay, J.K., Strasser, A., 2012, DNA damage-induced primordial follicle oocyte apoptosis and loss of fertility require TAp63-mediated induction of Puma and Noxa, Molecular Cell [P], vol 48, issue 3, Cell Press, USA, pp. 343-352.

Kerr, J.B., Brogan, L., Myers, M., Hutt, K.J., Mladenovska, T., Ricardo, S.D., Hamza, K., Scott, C.L., Strasser, A., Findlay, J.K., 2012, The primordial follicle reserve is not renewed after chemical or gamma-irradiation mediated depletion, Reproduction [P], vol 143, issue 4, BioScientifica Ltd, UK, pp. 469-476.

Aitken, R.J., Findlay, J.K., Hutt, K.J., Kerr, J.B., 2011, Apoptosis in the germ line, Reproduction [P], vol 141, issue 2, BioScientifica Ltd, UK, pp. 139-150.

Goldschlager, T., Abdelkader, A., Kerr, J.B., Boundy, I., Jenkin, G., 2010, Undecalcified bone preparation for histology, histomorphometry and fluorochrome analysis, Journal of Visualized Experiments [E], vol 35, issue 1707, Journal of Visualized Experiments, USA, pp. 1-3.

Paule, S.G., Nikolovski, B., Gray, R.E., Ludeman, J.P., Freemantle, A.L., Spark, R.A., Kerr, J.B., Ng, F.M., Zimmet, P.Z., Myers, M.A., 2009, GHTD-amide: a naturally occurring beta cell-derived peptide with hypoglycemic activity, Peptides, vol 30, issue 5, Elsevier Inc., USA, pp. 955-961.

Reddy, T., Gibbs, G.M., Merriner, D.J., Kerr, J.B., O'Bryan, M.K., 2008, Cysteine-rich secretory proteins are not exclusively expressed in the male reproductive tract, Developmental Dynamics, vol 237, issue 11, Wiley-Liss, United States, pp. 3313-3323.

Gregg, J.M., Marks, P., Silberstein, M., Schneider, T., Kerr, J.B., 2007, Histologic anatomy of the lesser metatarsophalangeal joint plantar plate, Surgical and Radiologic Anatomy, vol 29, issue 2, Springer, New York NY USA, pp. 141-147.

Huggins, R.J., Freeman, M.P., Kerr, J.B., Mendelson, B.C., 2007, Histologic and ultrastructural evaluation of sutures used for surgical fixation of the SMAS, Aesthetic Plastic Surgery, vol 31, Springer, New York NYUSA, pp. 719-724.

Kerr, J.B., Duckett, R., Myers, M.A., Britt, K.L., Mladenovska, T., Findlay, J.K., 2006, Quantification of healthy follicles in the neonatal and adult mouse ovary: evidence for maintenance of primordial follicle supply, Reproduction, vol 132, issue 1, Bioscientifica Ltd, UK, pp. 95-109.

Gregg, J.M., Silberstein, M., Schneider, T., Kerr, J.B., Marks, P., 2006, Sonography of plantar plates in cadavers: correlation with MRI and histology, American Journal of Roentgenology, vol 186, issue 12, American Roentgen Ray Society, USA, pp. 948-955.

Ebling, F.J.P., O'Nwagwu, M., Baines, H., Myers, M., Kerr, J.B., 2006, The hypogonadal (hpg) mouse as a model to investigate the estrogenic regulation of spermatogenesis, Human Fertility, vol 9, issue 3, Informa Healthcare, UK, pp. 127-135.

Myers, M., Ebling, F.J.P., Nwagwu, M., Boulton, R., Wadhwa, K., Stewart, J., Kerr, J.B., 2005, Atypical development of Sertoli cells and impairment of spermatogenesis in the hypogonadal (hpg) mouse, Journal of Anatomy, vol 207, issue 6, Blackwell Publishing, Oxford England, pp. 797-811.

Baines, H., Nwagwu, M.O., Furneaux, E., Stewart, J.M., Kerr, J.B., Mayhew, T., Ebling, F.J.P., 2005, Estrogenic induction of spermatogenesis in the hypogonadal (hpg) mouse: Role of androgens, Reproduction, vol 130, BioScientifica Ltd, Bristol England, pp. 643-654.

Nwagwu, M.O., Baines, H., Kerr, J.B., Ebling, F.J.P., 2005, Neonatal androgenization of hypogonadal (hpg) male mice does not abolish estradiol-induced FSH production and spermatogenesis, Reproductive Biology and Endocrinology, vol 3, issue 48, BioMed Central Ltd, UK, pp. 1-9.

Myers, M., Britt, K.L., Wreford, N.G.M., Ebling, F.J.P., Kerr, J.B., 2004, Methods for quantifying follicular numbers within the mouse ovary, Reproduction, vol 127, issue 5, Bio Scientifica Ltd, Bradley Stoke England, pp. 569-580.

Britt, K.L., Kerr, J.B., O'Donnell, L., Jones, M.E.E., Drummond, A.E., Davis, S.R., Simpson, E.R., Findlay, J.K., 2002, Estrogen regulates development of the somatic cell phenotype in the eutherian ovary, FASEB Journal, vol 16, issue 11, Federation of American Society of Experiment Biology, Bethesda MD USA, pp. 1389-1397.

Drummond, A.E., Britt, K.L., Dyson, M., Jones, M.E., Kerr, J.B., O'Donnell, L., Simpson, E.R., Findlay, J.K., 2002, Ovarian steroid receptors and their role in ovarian function, Molecular and Cellular Endocrinology, vol 191, Elsevier Science Ltd, Ireland, pp. 27-33.

Ebling, F.J.P., Brooks, A., Cronin, A.S., Ford, H., Kerr, J.B., 2000, Estrogenic induction of spermatogenesis in the hypogonadal mouse, Endocrinology, vol 141 issue 8, The Endocrine Society, Bethesda USA, pp. 1-9.

Fraser, H., Lunn, S., Harrison, D., Kerr, J.B., 1999, Luteal Regression in the Primate: Different Forms of Cell Death During Naturla and Gonadotropin-Releasing Hormone Antagonist or Prostaglandin Analogue-Induced Luteolysis, Biology of Reproduction, vol 61:6, Society for the Study of Reproduction, USA, pp. 1468-1479.

Fraser, H., Lunn, S., Harrison, D., Kerr, J.B., 1999, Luteal Regression in the Primate: Different forms of cell death during natural and gonadotropin-releasing hormone antagonist or prostaglandin analogue-induced luteolysis, Biology of Reproduction, vol 61, Society for the Study of Reproduction, Madison Wisconsin USA, pp. 1468-1479.

Grants

Title:

Development of Digital Imaging for High Resolution Colour Separations.

Investigators:

Kerr, J

Funding:

(1997 - 1997). Mosby International.

Title:

Digital SLR Camera (Nikon).

Investigators:

Kerr, J

Funding:

(2003 - 2007). Collier Charitable Fund.

(2003 - 2007). Monash University.

Title:

Olympus Bx50 Light Microscope With Dual Viewing Attachment for Labo.ratory Work.

Investigators:

Kerr, J

Funding:

(1998 - 1998). Collier Charitable Fund.