Dr Niamh Mangan - Researcher Profile

Biography

Niamh is an Australian Research Fellow at the Faculty of Medicine, Nursing & Health Sciences at Monash University.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Trinity College, Dublin - Ireland

Year awarded: 2005

BSC BIOTECHNOLOGY (HONOURS)

Institution: National University of Ireland

Year awarded: 2001

Publications

Book Chapters

Smith, P., Mangan, N., Fallon, P., 2009, Generation of parasite antigens for use in Toll-like receptor research, in Methods in Molecular Biology: Toll-Like Receptors, eds Claire E McCoy & Luke A.J. O'Neill, Humana Press (Springer), New York, United States, pp. 401-413.

Journal Articles

Berry, C.M., Hertzog, P.J., Mangan, N., 2012, Interferons as biomarkers and effectors: lessons learned from animal models, Biomarkers In Medicine [P], vol 6, issue 2, Future Medicine Ltd, United Kingdom, pp. 159-176.

Bidwell, B., Slaney, C.Y., Withana, N.P., Forster, S., Cao, Y., Loi, S., Andrews, D.M., Mikeska, T., Mangan, N., Samarajiwa, S.A., De Weerd, N.A., Gould, J.A., Argani, P., Moller, A., Smyth, M., Anderson, R., Hertzog, P.J., Parker, B., 2012, Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape, Nature Medicine [P], vol 18, issue 8, Nature Publishing Group, United States, pp. 1224-1231.

Mangan, N., Fung, K.Y., 2012, Type I interferons in regulation of mucosal immunity, Immunology And Cell Biology [P], vol 90, issue 5, Nature Publishing Group, United Kingdom, pp. 510-519.

Nel, H., Hams, E., Saunders, S., Mangan, N., Smith, P., Atzberger, A., Flavell, R., Akira, S., McKenzie, A., Fallon, P., 2011, Impaired basophil induction leads to an age-dependent innate defect in type 2 immunity during helminth infection in mice, Journal Of Immunology [P], vol 186, issue 8, American Association of Immunologists, United States, pp. 4631-4639.

Amu, S., Saunders, S., Kronenberg, M., Mangan, N., Atzberger, A., Fallon, P., 2010, Regulatory B cells prevent and reverse allergic airway inflammation via FoxP3-positive T regulatory cells in a murine model, Journal Of Allergy And Clinical Immunology [P], vol 125, issue 5, Mosby Inc, United States, pp. 1114-1124.e8.

Fallon, P., Sasaki, T., Sandilands, A., Campbell, L., Saunders, S., Mangan, N., Callanan, J., Kawasaki, H., Shiohama, A., Kubo, A., Sundberg, J., Presland, R., Fleckman, P., Shimizu, N., Kudoh, J., Irvine, A., Amagai, M., McLean, W., 2009, A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming, Nature Genetics [P], vol 41, issue 5, Nature Publishing Group, United States, pp. 602-608.

Saunders, S., Walsh, C., Barlow, J., Mangan, N., Taylor, P., McKenzie, A., Smith, P., Fallon, P., 2009, The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection, Infection And Immunity [P], vol 77, issue 1, American Society for Microbiology, United States, pp. 399-404.

Cummins, E., Seeballuck, F., Keely, S., Mangan, N., Callan, J., Fallon, P.G., Taylor, C.T., 2008, The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis, Gastroenterology [P], vol 134, issue 1, Elsevier Inc, USA, pp. 156-165e.1.

Smith, P., Mangan, N., Walsh, C.M., Fallon, E., McKenzie, A.N., van Rooijen, N., Fallon, P.G., 2007, Infection with a helminth parasite prevents experimental colitis via a macrophage-mediated mechanism, Journal Of Immunology [P], vol 178, The American Association of Immunologists, Inc, US, pp. 4557-4566.

Fallon, P., Mangan, N., 2007, Suppression of TH2-type allergic reactions by helminth infection, Nature Reviews Immunology [P], vol 7, issue 3, Nature Publishing Group, United Kingdom, pp. 220-230.

Mangan, N., Dasvarma, A., McKenzie, A., Fallon, P.G., 2007, T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation, European Journal Of Immunology [P], vol 37, pp. 1302-1312.

Mangan, N., van Rooijen, N., McKenzie, A., Fallon, P., 2006, Helminth-modified pulmonary immune response protects mice from allergen-induced airway hyperresponsiveness, Journal Of Immunology [P], vol 176, issue 1, American Association of Immunologists, United States, pp. 138-147.

Fallon, P.G., Ballantyne, S., Mangan, N., Barlow, J., Dasvarma, A., Hewett, D., McIlgorn, A., Jolin, H., McKenzie, M.A., 2006, Identification of an interleukin (IL)-25-dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion, Tohoku Journal Of Experimental Medicine [P], vol 203, issue 4, pp. 1105-1116.

Hewett, D., Simons, A., Mangan, N., Jolin, H., Green, S., Fallon, P., McKenzie, A., 2005, Lethal, neonatal ichthyosis with increased proteolytic processing of filaggrin in a mouse model of Netherton syndrome, Human Molecular Genetics [P], vol 14, issue 2, Oxford University Press, United Kingdom, pp. 335-346.

Smith, P., Fallon, E., Mangan, N., Walsh, C., Saraiva, M., Sayers, J., McKenzie, A., Alcami, A., Fallon, P., 2005, Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activity, Journal of Experimental Medicine [P], vol 202, issue 10, Rockfeller University Press, United States, pp. 1319-1325.

Mangan, N., Fallon, E., Smith, P., van Rooijen, N., McKenzie, A., Fallon, P., 2004, Helminth infection protects mice from anaphylaxis via IL-10-producing B cells, Journal Of Immunology [P], vol 173, issue 10, American Association of Immunologists, United States, pp. 6346-6356.

Smith, P., Walsh, C., Mangan, N., Fallon, E., Sayers, J., McKenzie, A., Fallon, P., 2004, Schistosoma mansoni worms induce anergy of T cells via selective up-regulation of programmed death ligand 1 on macrophages, Journal Of Immunology [P], vol 173, issue 2, American Association of Immunologists, United States, pp. 1240-1248.

Grants

Title:

The role of a novel cytokine of the innate immune response in viral infection.

Investigators:

Mangan, N

Funding:

(2011 - 2015). National Health & Medical Research Council (NHMRC).

Title:

The role of a novel protein, interferon epsilon, in reproductive tract immunity.

Investigators:

Mangan, N

Funding:

(2011 - 2015). Australian Research Council (ARC).

(2011 - 2015). Monash University.