Dr Kit-Ling Cheung - Researcher Profile

Biography

Kit-Ling works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2000

Publications

Book Chapters

Cheung, K.J., McGowan, S., Rood, J.I., 2005, Two-component signal transduction systems in Clostridia, in Handbook on Clostridia, eds Peter Duerre, CRC Press, Boca Raton USA, pp. 545-560.

Journal Articles

Yan, X., Porter, C.J., Hardy, S.P., Steer, D.L., Smith, A.I., Quinsey, N.S., Hughes, V.A., Cheung, K.J., Keyburn, A., Kaldhusdal, M., Moore, R., Bannam, T.L., Whisstock, J., Rood, J.I., 2013, Structural and Functional Analysis of the Pore-Forming Toxin NetB from Clostridium perfringens, mBio [E], vol 4, issue 1, American Society for Microbiology, USA, pp. 1-9.

Bannam, T.L., Yan, X., Harrison, P.F., Seemann, T., Keyburn, A.L., Stubenrauch, C., Weeramantri, L.H., Cheung, J.K., McClane, B.A., Boyce, J.D., Moore, R.J., Rood, J.I., 2011, Necrotic enteritis-derived Clostridium perfringens strain with three closely related independently conjugative toxin and antibiotic resistance plasmids, mBio [E], vol 2, issue 5 (Art. No: e00190), American Society for Microbiology, USA, pp. 1-9.

Hiscox, T.J., Chakravorty, A., Choo, J.M.F., Ohtani, K., Shimizu, T., Cheung, K.J., Rood, J.I., 2011, Regulation of virulence by the RevR response regulator in Clostridium perfringens, Infection And Immunity [P], vol 79, issue 6, American Society for Microbiology, USA, pp. 2145-2153.

Chakravorty, A., Awad, M., Hiscox, T., Cheung, K., Carter, G., Choo, J., Lyras, D., Rood, J., 2011, The cysteine protease alpha-clostripain is not essential for the pathogenesis of Clostridium perfringens-mediated myonecrosis, PLoS ONE [P], vol 6, issue 7 (Art. No: e22762), Public Library of Science, USA, pp. 1-7.

Cheung, J.K., Keyburn, A.L., Carter, G.P., Lanckriet, A.L., Van Immerseel, F., Moore, R.J., Rood, J.I., 2010, The VirSR two-component signal transduction system regulates NetB toxin production in Clostridium perfringens, Infection And Immunity [P], vol 78, issue 7, American Society for Microbiology, USA, pp. 3064-3072.

Kennedy, C.L., Lyras, D., Cheung, K.J., Hiscox, T.J., Emmins, J.J., Rood, J.I., 2009, Cross-complementation of Clostridium perfringens PLC and Clostridium septicum alpha-toxin mutants reveals PLC is sufficient to mediate gas gangrene, Microbes and Infection, vol 11, issue 3, Elsevier Masson, France, pp. 413-418.

Cheung, K.J., Awad, M.M., McGowan, S., Rood, J.I., 2009, Functional analysis of the VirSR phosphorelay from Clostridium perfringens, PLoS ONE [P], vol 4, issue 6 (e5849), Public Library of Science, USA, pp. 1-11.

O'Connor, J.R., Lyras, D., Farrow, K.A., Adams, V.M., Powell, D.R., Hinds, J., Cheung, K.J., Rood, J.I., 2006, Construction and analysis of chromosomal Clostridium difficile mutants, Molecular Microbiology, vol 61, issue 5, Blackwell Publishing, UK, pp. 1335-1351.

Myers, G.S., Rasko, D.A., Cheung, K.J., Ravel, J., Seshadri, R., DeBoy, R.T., Ren, Q., Varga, J., Awad, M.M., Brinkac, L.M., Daugherty, S.C., Haft, D.H., Dodson, R.J., Madupu, R., Nelson, W.C., Rasovitz, M.J., Sullivan, S.A., Khouri, H., Dimitrov, G.I., Watkins, K.L., Mulligan, S., Benton, J., Radune, D., Fisher, D.J., Atkins, H.S., Hiscox, T.J., Jost, B., Billington, S.J., Songer, J., McClane, B.E., Titball, R.W., Rood, J.I., Melville, S.B., Paulsen, I.T., 2006, Skewed genomic variability in strains of the toxigenic bacterial pathogen, Clostridium perfringens, Genome Research, vol 16, issue 8, Cold Spring Harbor Lab Press, Publications Dept, USA, pp. 1031-1040.

Cheung, K.J., Rood, J.I., 2006, Two-component signal transduction systems: The adapt and survive response, Microbiology Australia [P], vol 27, issue 3, The Australian Society for Microbiology Inc., Australia, pp. 102-104.

Cheung, K.J., Dupuy, B., Deveson, D.S., Rood, J.I., 2004, The spatial organization of the VirR boxes is critical for VirR-mediated expression of the perfringolysin O gene, pfoA, from Clostridium perfringens, Journal of Bacteriology, vol 186, issue 11, American Society for Microbiology, Washington USA, pp. 3321-3330.

McGowan, S., O'Connor, J.R., Cheung, J.K., Rood, J.I., 2003, The SKHR motif is required for biological function of the VirR response regulator from Clostridium perfringens, Journal of Bacteriology, vol 185, issue 20, American Society for Microbiology, Washington USA, pp. 6205-6208.

McGowan, S., Lucet, I.S., Cheung, J.K., Awad, M.M., Whisstock, J.C., Rood, J.I., 2002, The FxRxHrS motif: a conserved region essential for DNA binding of the VirR response regulator from Clostridium perfringens, Journal of Molecular Biology, vol 322, issue 5, Academic Press Ltd Elsevier Science Ltd, London England, pp. 997-1011.

Cheung, J., Rood, J.I., 2000, Glutamate residues in the putative transmembrane region are required for the function of the VirS sensor histidine kinase from Clostridium perfringens, Microbiology, vol 146, Society for General Microbiology, Reading UK, pp. 517-525.

Cheung, J., Rood, J.I., 2000, The VirR response regulator from Clostridium perfringens binds independently to two imperfect direct repeats located upstream of the pfoA promoter, Journal of Bacteriology, vol 182 issue 1, American Society for Microbiology, Washington USA, pp. 57-66.

Billington, S.J., Huggins, A.S., Johanesen, P.A., Crellin, P.K., Cheung, J., Katz, M.E., Wright, C.L., Haring, V., Rood, J.I., 1999, Complete nucleotide sequence of the 27-kilobase virulence related locus ("vrl") of "Dichelobacter nodosus": evidence for extrachromosomal origin, Infection and Immunity, vol 67 issue 3, American Society for Microbiology, Washington USA, pp. 1277-1286.

Conference Proceedings

Cheung, J., Rood, J.I., 1997, Genetic regulation of virulence in Clostridium perfringens, Reviews in Medical Microbiology, Cambridge, UK, 09-11/07/97, Chapman & Hall, London UK, pp. S25-S27.

Cheung, J., Rood, J.I., 1997, Two - component regulation of toxin production in Clostridium perfringens: functional analysis of the VirR and VirS proteins, Clostridia 97 - Pathogenesis, Onzain, France, 22-25/06/97, Societe Francaise de Microbiologie, Paris France, p. 55.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Comparative transcriptome analysis of Clostridium perfringens cultured in vivo an in vitro.

Supervisors:

Cheung, K (Joint), Rood, J (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Regulation of binary toxin production in Clostridium difficile.

Supervisors:

Rood, J (Joint-co), Cheung, K (Joint), Lyras, D (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of conjugative plasmids of clostridium perfringens in toxin production and virulence.

Supervisors:

Rood, J (Main), Adams, V (Associate), Cheung, K (Associate).

Completed Supervision

Student:

Hiscox, T.

Program of Study:

Functional analysis of signal transduction systems in Clostridium perfringens. (PHD) 2012.

Supervisors:

Cheung, K (Joint), Rood, J (Joint-Co).