Ms Betty Exintaris - Researcher Profile

Biography

Position

Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Research & Supervision Interests

General Research Interests

• Role of membrane potential in regulating peristalsis in the urinary system
• Intracellular mechanisms underlying spontaneous activity of the urinary tract and prostate gland
• Modulating effects of autonomic and sensory nerves on the electrical and contractile activity of spontaneously active smooth muscle preparations

Current Research Areas

• Intracellular mechanisms underlying spontaneous electrical and contractile activity in the smooth muscle of the prostate gland
• Role of the autonomic nervous system in the regulation of the spontaneous activity recorded in the isolated prostate gland

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION

Institution: Monash University

Year awarded: 2005

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 2000

SCIENCE (HONS)

Institution: Monash University

Year awarded: 1994

Publications

Journal Articles

Dey, A., Lang, R.J., Exintaris, B., 2012, Nitric oxide signaling pathways involved in the inhibition of spontaneous activity in the guinea pig prostate, Journal Of Urology [P], vol 187, issue 6, Elsevier Inc., USA, pp. 2254-2260.

Nguyen, D., Dey, A., Lang, R., Ventura, S., Exintaris, B., 2011, Contractility and pacemaker cells in the prostate gland, Journal Of Urology [P], vol 185, issue 1, Elsevier Inc., United States, pp. 347-351.

Lam, M., Kerr, K., Ventura, S., Exintaris, B., 2011, Extracellular Ca2+ entry and mobilization of inositol trisphosphate-dependent Ca2+ stores modulate histamine and electrical field stimulation induced contractions of the guinea-pig prostate, Pharmacological Research [P], vol E, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, United Kingdom, pp. 1-7.

Yaakob, N., Malone, D., Exintaris, B., Irving, H., 2011, Heterogeneity amongst 5-HT3 receptor subunits: is this significant?, Current Molecular Medicine [P], vol 11, issue 1, Bentham Science Publishers Ltd., Netherlands, pp. 57-88.

Ventura, S., Oliver, V., White, C., Xie, A., Haynes, J., Exintaris, B., 2011, Novel drug targets for the pharmacotherapy of benign prostatic hyperplasia (BPH), British Journal of Pharmacology [P], vol 163, issue 5, John Wiley & Sons Ltd., United Kingdom, pp. 891-907.

Lam, M., Shigemasa, Y., Exintaris, B., Lang, R., Hashitani, H., 2011, Spontaneous Ca(2+) signaling of interstitial cells in the guinea pig prostate, Journal Of Urology [P], vol 186, issue 6, ELSEVIER SCIENCE INC, USA, pp. 2478-2486.

Tokanovic, S., White, C., Malone, D.T., Exintaris, B., Ventura, S., 2010, Characterisation of the prostanoid receptor mediating inhibition of smooth muscle contractility in the rat prostate gland, Naunyn-Schmiedeberg's Archives of Pharmacology [P], vol 381, Springer, Germany, pp. 321-328.

Dey, A., Kusljic, S., Lang, R., Exintaris, B., 2010, Role of connexin 43 in the maintenance of spontaneous activity in the guinea pig prostate gland, British Journal of Pharmacology [P], vol 161, issue 8, John Wiley & Sons Ltd., United Kingdom, pp. 1692-1707.

Kusljic, S., Exintaris, B., 2010, The effect of estrogen supplementation on cell proliferation and expression of c-kit positive cells in the rat prostate, Prostate [P], vol 70, issue 14, John Wiley & Sons, Inc., United States, pp. 1555-1562.

Exintaris, B., Nguyen, D., Lam, M., Lang, R.J., 2009, Inositol trisphosphate-dependent Ca2+ stores and mitochondria modulate slow wave activity arising from the smooth muscle cells of the guinea pig prostate gland, British Journal of Pharmacology [P], vol 156, issue 7, John Wiley and Sons Ltd, UK, pp. 1098-1106.

Dey, A., Nguyen, D., Lang, R.J., Exintaris, B., 2009, Spontaneous electrical waveforms in aging guinea pig prostates, Journal Of Urology [P], vol 181, issue 6, Elsevier Inc., USA, pp. 2797-2805.

Nguyen, D., Lang, R.J., Exintaris, B., 2009, alpha1-Adrenoceptor modulation of spontaneous electrical waveforms in the guinea-pig prostate, European Journal of Pharmacology [P], vol 608, issue 1-3, Elsevier B.V., Netherlands, pp. 62-70.

Patak, E., Pennefather, J.N., Gozali, M., Candenas, M.L., Kerr, K.P., Exintaris, B., Ziccone, S., Potteck, H., Chetty, N., Page, N.M., Pinto, F., 2008, Functional characterisation of hemokinin-1 in mouse uterus, European Journal of Pharmacology, vol 601, issue 1-3, Elsevier B.V., Netherlands, pp. 148-153.

Kusljic, S., Dey, A., Nguyen, D., Lang, R.J., Exintaris, B., 2008, Prostatic interstitial cells in ageing guinea pig prostates, Current Urology, vol 1, issue 3, S. Karger AG, Switzerland, pp. 141-144.

Nguyen, D., Lang, R.J., Exintaris, B., 2007, K+ channel modulation of slow wave activity in the guinea-pig prostate, British Journal of Pharmacology, vol 151, issue 6, Nature Publishing Group, UK, pp. 828-836.

Lang, R.J., Nguyen, D., Matsuyama, H., Takewaki, T., Exintaris, B., 2006, Characterization of spontaneous depolarizations in smooth muscle cells of the guinea pig prostate, The Journal of Urology, vol 175, issue 1, Elsevier, Inc, New York NY USA, pp. 370-380.

Exintaris, B., Nguyen, D.T., Dey, A., Lang, R.J., 2006, Spontaneous electrical activity in the prostate gland, Autonomic Neuroscience: Basic and Clinical, vol 126-127, Elsevier, Netherlands, pp. 371-379.

Lang, R.J., Mulholland, E.L., Exintaris, B., 2004, Characterization of the ion channel currents in single myocytes of the guinea pig prostate, The Journal of Urology, vol 172, issue 3, Lippincott, Williams & Wilkins, Philadelphia USA, pp. 1179-1187.

Exintaris, B., Klemm, M.F., Lang, R.J., 2004, Re: Spontaneous slow wave and contractile activity of the guinea-pig prostate, Journal of Urology, vol 171, issue 4, Lippincott Williams & Wilkins, USA, pp. 1637-1638.

Lang, R.J., Davidson, M.E., Exintaris, B., 2002, Pyeloureteral motility and ureteral peristalsis: essential role of sensory nerves and endogenous prostaglandins, Experimental Physiology, vol 87, issue 2, Cambridge University Press, New York NY USA, pp. 129-146.

Exintaris, B., Klemm, M.F., Lang, R.J., 2002, Spontaneous slow wave and contractile activity of the guinea-pig prostate, Journal of Urology, vol 168, issue 1, Lippincott, Williams and Wilkins, USA, pp. 315-322.

Exintaris, B., Lang, R.J., 1999, Effects of nerve stimulation on spontaneously active preparations of the guinea-pig upper ureter, Urological Research, vol 27 issue 5, Springer, Heidelberg Germany, pp. 328-335.

Klemm, M.F., Exintaris, B., Lang, R.J., 1999, Identification of the cells underlying pacemaker activity in the guinea-pig upper urinary tract, Journal of Physiology, vol 519 issue 3, Cambridge University Press, Cambridge UK, pp. 867-884.

Exintaris, B., Lang, R.J., 1999, K^+ channel blocker modulation of the refractory period in spontaneously active guinea-pig ureters, Urological Research, vol 27 issue 5, Springer, Heidelberg Germany, pp. 319-327.

Conference Proceedings

Exintaris, B., Dey, A., Lam, M., Udakis, M., Lang, R., 2011, Contractility and pacemaker cells in the prostate gland, Contractility and pacemaker cells in the prostate gland, 22/03/2011-24/03/2011, Nihon Yakuri Gakkai Henshuubu, Japan, p. 267P.

Dey, A., Udakis, M., Exintaris, B., 2011, Role of NO/cGMP in the regulation of spontaneous activity in the guinea pig prostate gland, 11th Southeast asian western pacific regional meeting of pharmacologists, 22/03/2011-24/03/2011, Japanese pharmacological society, Japan, p. 267.

Exintaris, B., Dey, A., Kusljic, S., Lam, M., Nguyen, D., Lang, R., 2010, Pacemaker cells and contractility in the prostate gland, Pacemaker cells and contractility in the prostate gland, 17/07/2010-23/07/2010, Danish society for pharmacology, Denmark, p. 179.

Dey, A., Kusljic, S., Lang, R., Exintaris, B., 2010, Role of CX43 in the maintenance of spontaneous activity in the guinea pig prostate, Role of CX43 in the maintenance of spontaneous activity in the guinea pig prostate, 17/07/2010-23/07/2010, Danish society for pharmacology, Denmark, p. 179.

Kusljic, S., Exintaris, B., 2010, The effect of estrogen supplementation on cell proliferation and distribution of prostatic interstitial cells in the rat prostate, The effect of estrogen supplementation on cell proliferation and distribution of prostatic interstitial cells in the rat prostate, 17/07/2010-23/07/2010, Danish society for pharmacology, Denmark, p. 235.

Lam, M., Dey, A., Exintaris, B., 2010, The effect of imatinib mesylate on spontaneous activity in the guinea-pig prostate, The effect of imatinib mesylate on spontaneous activity in the guinea-pig prostate, 17/07/2010-23/07/2010, Danish society for pharmacology, Denmark, p. 180.

Nguyen, D., Dey, A., Lang, R.J., Exintaris, B., 2006, Effects of sodium nitroprusside (SNP) on the spontaneous electrical activity in the guinea-pig prostate, Australian Neuroscience Society.

Short, J.L., Exintaris, B., White, P.J., Ventura, S., 2006, How do we improve skills required for critical thinking in pharmacy students?, Chinese Pharmacologist, 29 June - 1 July 2006, Chinese Pharmacological Society, Beijing China, p. 9.

Exintaris, B., Dey, A., Nguyen, D., Lang, R.J., 2006, Spontaneous electrical activity in guinea-pig prostates, The Athenian EuroAmerican Congress of Urology.

Dey, A., Nguyen, D., Kusljic, S., Lang, R.J., Exintaris, B., 2006, Spontaneous electrical activity in guinea-pig prostates, Proceedings of the Australian Health & Medical Research Congress 2006, 26 Nov - 1 Dec 06, Australian Health & Medical Research Congress, Melbourne Vic Australia.

Dey, A., Nguyen, D., Lang, R.J., Exintaris, B., 2006, Spontaneous electrical activity in young and aged guinea-pig prostates, Australian Neuroscience Society, 31 January to 3 February 2006, p. 31.

Nguyen, D., Dey, A., Lang, R.J., Exintaris, B., 2006, Spontaneous electrical activity of the prostate, The Athenian EuroAmerican Congress of Urology.

Exintaris, B., Dey, A., Nguyen, D., Lang, R.J., 2006, Spontaneous electrical waveforms in immature and older guinea-pig prostates, Acta Pharmacologica Sinica, 2-7 July 2006, Blackwell Publishing, Beijing China, p. 374.

Dey, A., Nguyen, D., Lang, R.J., Exintaris, B., 2006, Spontaneous electrical waveforms in immature and older guinea-pig prostates, Advances in Urinogenital Research, 29 September 2006, Griffith University, Gold Coast Qld Australia.

Exintaris, B., Nguyen, D., Dey, A., Lang, R.J., 2006, Spontaneous electrical waveforms in the prostate gland, Advances in Urinogenital Research, 29 September 2006, Griffith University, Griffith University Queensland.

Pennefather, J.N., Patak, E., Gozali, M., Exintaris, B., Kerr, K.P., Ziccone, S., 2006, Stimulant responses to hemokinins in pregnant mouse uterus, Proceedings of the Australian Health & Medical Research Congress, 26 Nov 06 - 1 Dec 06, p. 158.

Lang, R.J., Exintaris, B., Klemm, M.F., 1999, Identification of the cells generating the 'pacemaker' action potentials in the upper urinary tract of the guinea pig, Proceedings of International Symposium on New Developments in Smooth Muscle and Endothelial Cell Signalling, Nagoya Japan 17-19 May 1999, Nagoya Japan, p. 34P.

Exintaris, B., Lang, R.J., 1999, Identification of the cells underlying myogenic peristalsis in the upper urinary tract, Proceedings of the Australian Physiological and Pharmacological Society, Newcastle NSW 27-29 September 1999, Australian Physiological and Pharmacological Soc, Melbourne Vic Australia, p. 104P.

Klemm, M.F., Exintaris, B., Lang, R.J., 1998, Morphological basis of peristalsis in the guinea pig upper urinary tract, Proceedings of the Australian Physiological and Pharmacological Society, Brisbane Queensland 27 September 1998, Aust Physiological and Pharmacological Society, Vic Australia, p. 202P.

Exintaris, B., Lang, R.J., 1998, Nerve-mediated modulation of action potential discharge in a wholemount preparation of the guinea-pig urinary tract, Proceedings of the Australian Physiological and Pharmacological Society, Brisbane Queensland 27 September 1998, Aust Physiological and Pharmacological Society, Vic Australia, p. 48P.

Lang, R.J., Exintaris, B., 1998, The effects of potassium-channel blockers on the spontaneous action potentials recorded from the ureter of the guinea-pig, Proceedings of the Australian Physiological and Pharamcological Society, Brisbane Queensland 27 September 1998, Aust Physiological and Pharmacological Society, Vic Australia, p. 324P.

Exintaris, B., Lang, R.J., 1997, Regional variation in the nature of the spontaneous action potentials recorded in the upper urinary tract of the guinea pig, Journal of the Autonomic Nervous System, Cairns, September 14-19 1997, Elsevier, Amsterdam Netherlands, p. 144.

Other

Lang, R.J., Exintaris, B., Teele, M.E., Harvey, J.R., Klemm, M.F., 1998, Electrical basis of peristalsis in the mammalian upper urinary tract, Clinical and Experimental Pharmacology and Physiology, vol 25, issue 5, Blackwell Science Asia, Melbourne Vic Australia, pp. 310-321.

Teaching Commitment

Bachelor of Pharmacy and Bachelor of Pharmaceutical Science: physiology, pharmacology and coursework.

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Grants

Title:

Pipettes from John Morris; 3 x Starter Kits and 3 x Pipetman.

Investigators:

Kerr, K, Irving, H, Exintaris, B, Thompson, P, Coupar, I

Funding:

(2008 - 2011). Collier Charitable Fund.

Title:

Role of interstitial cells in the generation of slow wave activity in the prostate gland.

Investigators:

Exintaris, B

Funding:

(2004 - 2010). Monash University.

Title:

Role of pacemaker cells in the generation of slow wave activity in the prostate gland.

Investigators:

Exintaris, B, Ventura, S

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

Title:

Tissue electrophysiology Rig I.D. 264650.

Investigators:

Exintaris, B, Ventura, S, Haynes, J, Pouton, C, Coupar, I, Short, J

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).