Dr Paul White - Researcher Profile

Biography

Position

Senior Lecturer
Alternate Associate Dean (Teaching)
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

GRADUATE CERTIFICATE IN HIGHER EDUCATION

Institution: Monash University

Year awarded: 2001

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1997

Publications

Book Chapters

White, P., Duncan, G., 2009, A faculty approach to implementing advanced e-learning dependent, formative and summative assessment practices, in E-Learning Technologies and Evidence-Based Assessment Approaches, eds Christine Spratt and Paul Lajbycgier, IGI Publishing, United States, pp. 76-96.

Journal Articles

White, P.J., Hickey, P.L., Tu, L.S., Headey, S.J., Scanlon, M., Boyd, B.J., Pouton, C.W., 2012, Colloidal characteristics and formulation of pure protein particulate vaccines, Journal of Pharmacy and Pharmacology [P], vol 64, issue 10, John Wiley & Sons Ltd, United Kingdom, pp. 1386-1393.

Lau, S., Graham, B., Cao, N., Boyd, B.J., Pouton, C.W., White, P.J., 2012, Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation, Molecular Pharmaceutics [P], vol 9, issue 1, American Chemical Society, USA, pp. 71-80.

Gosling, J.I., Baker, S.P., Haynes, J.M., Kassiou, M., Pouton, C.W., Warfe, L., White, P.J., Scammells, P.J., 2012, Synthesis and biological evaluation of adenosines with heterobicyclic and polycyclic N6-substituents as adenosine A1 receptor agonists, Chemmedchem [P], vol 7, issue 7, Wiley-V C H Verlag GMBH, Germany, pp. 1191-1201.

Hausler, N., Devine, S., McRobb, F.M., Warfe, L., Pouton, C.W., Haynes, J.M., Bottle S.E., White, P.J., Scammells, P.J., 2012, Synthesis and pharmacological evaluation of dual acting antioxidant A2A adenosine receptor agonists, Journal of Medicinal Chemistry [P], vol 55, issue 7, American Chemical Society, USA, pp. 3521-3534.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds, Journal of Nucleic Acids [E], vol 2011, issue 154609, SAGE-Hindawi Access to Research, England, pp. 1-5.

Walker, J., Fairfull-Smith, K., Anzai, K., Lau, S., White, P., Scammells, P., Bottle, 2011, Edaravone containing isoindoline nitroxides for the potential treatment of cardiovascular ischaemia, MedChemComm [P], vol 2, issue 5, ROYAL SOC CHEMISTRY, England, pp. 436-441.

Megersa, T., White, P., Coupar, I., Irving, H., 2011, Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract, Biochemical Pharmacology [P], vol 81, issue 1, Elsevier Inc., United States, pp. 123-133.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of SiRNA across the vascular endothelium, Journal Of Gene Medicine [P], vol 13, issue 7-8, WILEY-BLACKWELL, USA, p. 438.

Urmaliya, V., Pouton, C., Devine, S., Haynes, J., Warfe, L., Scammells, P., White, P., 2010, A novel highly selective adenosine A1 receptor agonist VCP28 reduces ischemia injury in a cardiac cell line and ischemia-reperfusion injury in isolated rat hearts at concentrations that do not affect heart rate, Journal Of Cardiovascular Pharmacology [P], vol 56, issue 3, Lippincott Williams & Wilkins, United States, pp. 282-292.

Neale, D., Thompson, P., White, P., Chalmers, D., Yuriev, E., Manallack, D., 2010, Binding mode prediction of PDE4 inhibitors: a comparison of modelling methods, Australian Journal of Chemistry [E], vol 63, issue 3, C S I R O Publishing, Australia, pp. 396-404.

Urmaliya, V., Pouton, C., Ledent, C., Short, J., White, P., 2010, Cooperative cardioprotection through adenosine A1 and A 2A receptor agonism in ischemia-reperfused isolated mouse heart, Journal Of Cardiovascular Pharmacology [P], vol 56, issue 4, Lippincott Williams & Wilkins, Inc., USA, pp. 379-388.

Valant, C., Aurelio, L., Urmaliya, V., White, P., Scammells, P., Sexton, P., Christopoulos, A., 2010, Delineating the mode of action of adenosine A1 receptor allosteric modulators, Molecular Pharmacology [P], vol 78, issue 3, American Society for Pharmacology and Experimental Therapeutics, United States, pp. 444-455.

Hsieh, M.J., White, P.J., Pouton, C.W., 2010, Interaction of viruses with host cell molecular motors, Current Opinion in Biotechnology [P], vol 21, Elsevier Ltd, United Kingdom, pp. 633-639.

Devine, S.M., Gregg, A., Figler, H., McIntosh, K., Urmaliya, V., Linden, J., Pouton, C.W., White, P.J., Bottle, S.E., Scammells, P.J., 2010, Synthesis and evaluation of new N6-substituted adenosine-5'-N-methylcarboxamides as A3 adenosine receptor agonists, Bioorganic & Medicinal Chemistry Letters [P], vol 18, issue 9, Pergamon, United Kingdom, pp. 3078-3087.

Nguyen, W., Neale, D., Howard, B., Thompson, P., White, P., Wulff, H., Manallack, D., 2010, Use of Kv1.3 blockers for inflammatory skin conditions, Current Medicinal Chemistry [P], vol 17, issue 26, Bentham Science Publishers Ltd., Netherlands, pp. 2882-2896.

Urmaliya, V., Church, J.E., Coupar, I.M., Rose'Meyer, R., Pouton, C.W., White, P.J., 2009, Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine, Journal Of Cardiovascular Pharmacology [P], vol 53, issue 5, Lippincott Williams & Wilkins, United States, pp. 424-433.

White, P.J., Anastasopoulos, F., Pouton, C.W., Boyd, B.J., 2009, Overcoming biological barriers to in vivo efficacy of antisense oligonucleotides., Expert Reviews in Molecular Medicine [P], vol 11, issue e10, Cambridge University Press, UK, pp. 1-19.

White, P.J., 2008, Barriers to successful delivery of short interfering RNA after systemic administration, Clinical and Experimental Pharmacology and Physiology, vol 35, issue 11, Blackwell Publishing Asia Pty Ltd, Australia, pp. 1371-1376.

White, P.J., Anastasopoulos, F., Church, J.E., Kuo, C.(., Boyd, B.J., Hickey, P.L., Sze Tu, L., Burns, P., Lew, A.M., Heath, W.R., Davey, G.M., Pouton, C.W., 2008, Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants, Vaccine, vol 26, issue 52, Elsevier Ltd, Netherlands, pp. 6824-6831.

Gregg, A.D., Bottle S.E., Devine, S., Figler, H., Linden, J., White, P.J., Pouton, C.W., Urmaliya, V., Scammells, P.J., 2007, Dual acting antioxidant A1 adenosine receptor agonists, Bioorganic & Medicinal Chemistry Letters, vol 17, issue 19, Pergamon, England, pp. 5437-5441.

Cao, N., Lau, S., Nguyen, T.T., White, P.J., 2006, Characterization of the acute cardiovascular effects of intravenously administered insulin-like growth factor-I in conscious Sprague-Dawley rats, Clinical and Experimental Pharmacology and Physiology, vol 33, issue 12, Blackwell Publishing, Oxford UK, pp. 1190-1195.

Gray, A.C., Coupar, I.M., White, P.J., 2006, Comparison of opioid receptor distributions in the rat central nervous system, Life Sciences, vol 79, issue 7, Elsevier, USA, pp. 674-685.

Gray, A.C., Coupar, I.M., White, P.J., 2006, Comparison of opioid receptor distributions in the rat ileum, Life Sciences, vol 78, issue 14, Elsevier Inc., USA, pp. 1610-1616.

Nguyen, T.T., Cao, N., Short, J.L., White, P.J., 2006, Intravenous insulin-like growth factor-I receptor antisense treatment reduces angiotensin receptor expression and function in spontaneously hypertensive rats, The Journal of Pharmacology and Experimental Therapeutics, vol 318, issue 3, The American Society Pharmacology Experimental Therapeutics, Bethesda MD USA, pp. 1171-1177.

Gray, A.C., White, P.J., Coupar, I.M., 2005, Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum, British Journal of Pharmacology, vol 144, issue 5, Nature Publishing Group, UK, pp. 687-694.

Nguyen, T.T.L., White, P.J., 2005, Intravenous IGF-I receptor antisense reduces IGF-IR expression and diminishes pressor responses to angiotensin II in conscious normotensive rats, British Journal of Pharmacology, vol 146, issue 7, Nature Publishing Group, UK, pp. 935-941.

White, P.J., Atley, L.M., Wraight, C., 2004, Antisense oligonucleotide treatments for psoriasis, Expert Opinion on Biological Therapy [P], vol 4, issue 1, Informa Healthcare, UK, pp. 75-81.

White, P.J., Gray, A.C., Fogarty, R.D., Sinclair, R.D., Thumiger, S.P., Werther, G.A., Wraight, C.J., 2002, C-5 propyne-modified oligonucleotides penetrate the epidermis in psoriatic and not normal human skin after topical application, The Journal of Investigative Dermatology: An International Journal for Research in Cutaneous Biology, vol 118, issue 6, Blackwell Publishing, Inc., USA, pp. 1003-1007.

White, P.J., Nguyen, T.T.L., 2002, Chronic caffeine treatment causes changes in cardiac adenosine receptor function in rats, Pharmacology: International Journal of Experimental and Clinical Pharmacology, vol 65, issue 3, S. Karger AG, Switzerland, pp. 129-135.

Fogarty, R.D., McKean, S.C., White, P.J., Atley, L.M., Werther, G.A., Wraight, C.J., 2002, Sequence dependence of C5-propynyl-dU, dC-phosphorothioate oligonucleotide inhibition of the human IGF-I receptor: mRNA, protein, and cell growth, Antisense and Nucleic Acid Drug Development, vol 12, issue 6, Mary Ann Liebert, Inc. Publishers, USA, pp. 369-377.

Wraight, C.J., White, P.J., 2001, Antisense oligonucleotides in cutaneous therapy, Pharmacology & Therapeutics, vol 90, Elsevier, USA, pp. 89-104.

White, P.J., Fogarty, R.D., Werther, G.A., Wraight, C.J., 2000, Antisense inhibition of IGF receptor expression in HaCaT keratinocytes: A model for antisense strategies in keratinocytes, Antisense & Nucleic Acid Drug Development, vol 10 issue 3, Mary Ann Liebert, Larchmont NY USA, pp. 195-203.

Wraight, C.J., White, P.J., McKean, S.C., Fogarty, R.D., Venables, D.J., Liepe, I.J., Edmondson, S., Werther, G.A., 2000, Reversal of epidermal hyperproliferation in psoriasis by insulin-like growth factor I receptor antisense oligonucleotides, Nature Biotechnlogy, vol 18 issue 5, Nature America Inc, New York NY USA, pp. 521-526.

White, P.J., Fogarty, R.D., Liepe, I.J., Delaney, P.M., Werther, G.A., Wraight, C.J., 1999, Live confocal microscopy of oligonucleotide uptake by keratinocytes in human skin grafts on nude mice, Journal of Investigative Dermatology, vol 112 issue 6, Blackwell Science, USA, pp. 887-892.

White, P.J., Fogarty, R.D., McKean, S.C., Venables, D.J., Werther, G.A., Wraight, C.J., 1999, Oligonucleotide uptake in cultured keratinocytes: Influence of confluence, cationic liposomes, and keratinocyte cell type, Journal of Investigative Dermatology, vol 112 issue 5, Blackwell Science, USA, pp. 699-705.

Conference Proceedings

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of sirna across the vascular endothelium, The Journal of Gene Medicine, 04-06 Mat 2011, John Wiley & Sons, England, p. e1.

White, P.J., Nguyen, T.T., Lau, S., Cao, N., 2006, Antisense oligonucleotides and short interfering RNA as tools for in vivo evaluation of protein function in the cardiovascular system, Proceedings of the Australian Health & Medical Research Congress 2006, 26 Nov - 1 Dec 2006, Australian Health & Medical Research Congress, Melbourne Vic Australia, p. 398.

Lau, S., White, P.J., 2006, Characterisation of the acute effects of exogenous insulin-like growth factor-I infusion on cardiovascular system of conscious rats, Proceedings of the Australian Health & Medical Research Congress 2006, 26 Nov - 1 Dec 06, Australian Health & Medical Research Congress 2006, Melbourne Vic Australia, p. 397.

White, P.J., Nguyen, T.T., Cao, N., Lau, S., 2006, Chimeric IGF-I receptor antisense treatment reduces vascular target expression, Acta Pharmacologica Sinica, p. 133.

Cao, N., Nguyen, T.T., White, P.J., 2006, Comparison of the pharmacokinetic and pharmacodynamic properties of antisense oligonucleotide and small interfering RNA, Proceedings of the Australian Health & Medical Research Congress 2006, 26 Nov - 1 Dec 2006, Australian Health & Medical Research Congress 2006, Melbourne Vic Australia, p. 402.

Short, J.L., Exintaris, B., White, P.J., Ventura, S., 2006, How do we improve skills required for critical thinking in pharmacy students?, Chinese Pharmacologist, 29 June - 1 July 2006, Chinese Pharmacological Society, Beijing China, p. 9.

Lau, S., White, P.J., 2006, Use of insulin-like growth factor-I antisense oligonucleotides in rat cardiovascular system, Proceedings of the joint meeting of Ascept and APSA, December 4 - 7 2005.

Gray, A., Fogarty, R.D., Edmondson, S., Wraight, C.J., Werther, G.A., White, P.J., 1999, Antisense gene therapy for the skin: a study of oligonucleotide topical delivery, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 126.

Other

Binks, P., Critchley, M., Irving, R.A., Pouton, C.W., White, P.J., 2007, Microarray Device, Australia.

White, P.J., 2007, Vaccine composition, method for production and using same, Australia.

Teaching Commitment

Alternate Associate Dean (Teaching)

51 lectures per year

Unit Coordinator: Basis of drug action II, Bachelor of Pharmacy

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

A study of Adenovirus proteins as a DNA delivery vehicle to the nucleus.

Supervisors:

Pouton, C (Joint-co), White, P (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Biased adenosine receptor agonists as cardioprotective agents - in vivo evaluation.

Supervisors:

White, P (Main), May, L (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Biosynthesis of nanoparticles using Solanum lycopersicum: optimisation, characterisation and their potential in formulation of plant-made pharmaceuticals.

Supervisors:

Webster, D (Main), Piedrafita, D (Associate), White, P (Associate), Walmsley, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Improving the efficiency of DNA delivery in non-virtal gene therapy.

Supervisors:

White, P (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigating the modulation of adenosine A1 receptor-mediated cardioprotection by A2 receptors.

Supervisors:

May, L (Joint), White, P (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Validation of the Cannabinoid Receptor Interacting Protein (CRIP1a) as a novel therapeutic target.

Supervisors:

Malone, D (Main), White, P (Associate).

Completed Supervision

Student:

Cao, N.

Program of Study:

Investigation of the cardiovascular effects of IGF-IR knockdown following systemic delivery of antisense oligonucleotides and small interfering RNA. (PHD) 2010.

Supervisors:

White, P (Main).

Student:

Gray, A.

Program of Study:

Pharmacological and histological investigations into opioid receptors. (PHD) 2006.

Supervisors:

White, P (Main), Coupar, I (Associate).

Student:

Hsieh, M.

Program of Study:

Intracellular trafficking of adenovirus protein II (hexon) and its significance with respect to design of non-viral gene delivery systems. (PHD) 2012.

Supervisors:

White, P (Main), Mantamadiotis, T (Joint).

Student:

Nedi Megersa, T.

Program of Study:

Investigations into the regulation of the desensitization of 5-HT4 receptors in the rat gastrointestinal tract. (PHD) 2011.

Supervisors:

White, P (Main), Irving, H (Associate), Coupar, I (Associate).

Student:

Nguyen, T.

Program of Study:

Use of IGF-IR antisense therapy to identify the role of IGF-I in hypertension. (PHD) 2005.

Supervisors:

White, P (Main), Coupar, I (Associate).

Student:

Nguyen, W.

Program of Study:

Development of novel Kv1.3 ion channel blockers based upon diphenoxylate. (PHD) 2012.

Supervisors:

Manallack, D (Main), Thompson, P (Associate), White, P (Associate).

Student:

Urmaliya, V.

Program of Study:

Adenosine receptor-mediated cardioprotection. (PHD) 2010.

Supervisors:

White, P (Main), Coupar, I (Associate), Pouton, C (Associate).