Assoc Prof Simone Schoenwaelder - Researcher Profile

Biography

Simone is an Associate Professor (Research) at the Australian Centre for Blood Diseases and the Department of Clinical Haematology, within the Faculty of Medicine, Nursing & Health Sciences at Monash University.

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Qualifications

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1996

BACHELOR OF SCIENCE (HONOURS)

Institution: Monash University

Year awarded: 1993

Publications

Book Chapters

Jackson, S., Schoenwaelder, S., 2010, PI 3-Kinase p-110-beta regulation of platelet integrin alpha-II-beta-3, in Phosphoinositide 3-kinase in Health and Disease, eds Christian Rommel, Bart Vanhaesebroeck and Peter K Vogt, Springer, US, pp. 203-224.

Journal Articles

Nesbitt, W.S., Harper, I.S., Schoenwaelder, S.M., Yuan, Y., Jackson, S.P., 2012, A live cell micro-imaging technique to examine platelet calcium signaling dynamics under blood flow, Methods in molecular biology (Clifton, N.J.) [P], vol 788, Humana Press, USA, pp. 73-89.

Jackson, S., Schoenwaelder, S.M., 2012, Antithrombotic phosphoinositide 3-kinase ? inhibitors in humans: A 'shear' delight!, Journal Of Thrombosis And Haemostasis [P], vol 10, issue 10, Wiley-Blackwell Publishing Ltd, Chichester, West Sussex PO19 8SQ United Kingdom, pp. 2123-2126.

Schoenwaelder, S., Jackson, S., 2012, Bcl-xL–inhibitory BH3 mimetics (ABT-737 or ABT-263) and the modulation of cytosolic calcium flux and platelet function, Blood [P], vol 119, issue 5, American Society of Hematology, United States, pp. 1320-1321.

White, M., Schoenwaelder, S., Josefsson, E., Jarman, K., Henley, K., James, C., Debrincat, M., Jackson, S., Huang, D., Kile, B., 2012, Caspase-9 mediates the apoptotic death of megakaryocytes and platelets, but is dispensable for their generation and function, Blood [P], vol 119, issue 18, American Society of Hematology, United States, pp. 4283-4290.

Guerreiro, A., Fattet, S., Kulesza, D., Atamer, A., Elsing, A., Shalaby, T., Jackson, S., Schoenwaelder, S., Grotzer, M., Delattre, O., Arcaro, A., 2011, A sensitized RNA interference screen identifies a novel role for the PI3K p110I-gamma isoform in medulloblastoma cell proliferation and chemoresistance, Molecular Cancer Research [P], vol 9, issue 7, American Association for Cancer Research, USA, pp. 925-935.

Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., Andrews, R., Mason, K., Salem, H., Huang, D., Kile, B., Roberts, A., Jackson, S., 2011, Bcl-x L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets, Blood [P], vol 118, issue 6, American Society of Hematology, USA, pp. 1663-1674.

Wen, P., Osborne, S., Zanin, M., Low, P., Wang, H., Schoenwaelder, S., Jackson, S., Wedlich-Soldner, R., Vanhaesebroeck, B., Keating, D., Meunier, F., 2011, Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells, Nature Communications [E], vol 2, issue 1, Nature Publishing Group, UK, pp. 491-502.

De Laurentiis, A., Pardo, O., Palamidessi, A., Jackson, S., Schoenwaelder, S., Reichmann, E., Scita, G., Arcaro, A., 2011, The catalytic class IA PI3K isoforms play divergent roles in breast cancer cell migration, Cellular Signalling [P], vol 23, issue 3, Elsevier Inc., USA, pp. 529-541.

Qiu, M., Jiang, L., Matthaei, K.I., Schoenwaelder, S.M., Kuffner, T., Mangin, P., Joseph, J.E., Low, J., Connor, D., Valenzuela, S., Curmi, P.M., Brown, L.J., Mahaut-Smith, M., Jackson, S., Breit, S.N., 2010, Generation and characterization of mice with null mutation of the chloride intracellular channel 1 gene, Genesis [P], vol 48, issue 2, John Wiley & Sons, Inc., USA, pp. 127-136.

Schoenwaelder, S.M., Ono, A., Nesbitt, W.S., Lim, J.M.C., Jarman, K.E., Jackson, S., 2010, Phosphoinositide 3-kinase p110beta regulates integrin alphaIIbbeta3 avidity and the cellular transmission of contractile forces, Journal Of Biological Chemistry [P], vol 285, issue 4, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 2886-2896.

Jackson, S., Schoenwaelder, S., 2010, Procoagulant platelets: are they necrotic?, Blood [P], vol 116, issue 12, American Society of Hematology, United States, pp. 2011-2018.

Garcia, A., Kim, S., Bhavaraju, K., Schoenwaelder, S.M., Kunapuli, S.P., 2010, Role of phosphoinositide 3-kinase beta in platelet aggregation and thromboxane A2 generation mediated by Gi signalling pathways, Biochemical Journal [P], vol 429, issue 2, Portland Press Ltd., United Kingdom, pp. 369-377.

Wei, A., Schoenwaelder, S.M., Andrews, R.K., Jackson, S., 2009, New insights into the haemostatic function of platelets, British Journal Of Haematology [P], vol 147, issue 4, Wiley-Blackwell Publishing Ltd, UK, pp. 415-430.

Gilio, K., Munnix, I.C.A., Mangin, P., Cosemans, J.M.E., Feijge, M.A.H., van der Meijden, P.E.J., Olieslagers, S., Chrzanowska-Wodnicka, M., Lillian, R., Schoenwaelder, S.M., Koyasu, S., Sage, S.O., Jackson, S., Heemskerk, J.W.M., 2009, Non-redundant roles of phosphoinositide 3-kinase isoforms alpha and beta in glycoprotein VI-induced platelet signaling and thrombus formation, Journal Of Biological Chemistry [P], vol 284, issue 49, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 33750-33762.

Calkin, A., Drew, B.G., Ono, A., Duffy, S.J., Gordon, M., Schoenwaelder, S.M., Sviridov, D., Cooper, M.E., Kingwell, B.A., Jackson, S., 2009, Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol efflux, Circulation [P], vol 120, issue 21, Lippincott Williams & Wilkins, USA, pp. 2095-2104.

Schoenwaelder, S.M., Yuan, Y., Josefsson, E.C., White, M.J., Yao, Y., Mason, K.D., O'Reilly, L.A., Henley, K.J., Ono, A., Hsiao, S.T., Willcox, A.E.H., Roberts, A.W., Huang, D.C.S., Salem, H.H., Kile, B., Jackson, S., 2009, Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function, Blood [P], vol 114, issue 3, American Society of Hematology, USA, pp. 663-666.

van der Meijden, P.E.J., Schoenwaelder, S.M., Feijge, M.A.H., Cosemans, J.M.E., Munnix, I.C.A., Wetzker, R., Heller, R., Jackson, S., Heemskerk, J.W.M., 2008, Dual P2Y12 receptor signaling in thrombin-stimulated platelets - involvement of phosphoinositide 3-kinase beta but not gamma isoform in Ca2+ mobilization and procoagulant activity, The FEBS Journal, vol 275, issue 2, Wiley-Blackwell Publishing Ltd., UK, pp. 371-385.

Ono, A., Westein, E., Hsiao, S.T., Nesbitt, W.S., Hamilton, J.R., Schoenwaelder, S.M., Jackson, S., 2008, Identification of a fibrin-independent platelet contractile mechanism regulating primary hemostasis and thrombus growth, Blood, vol 112, issue 1, American Society of Hematology, United States, pp. 90-99.

Heller, R., Chang, Q., Ehrlich, G., Hsieh, S.N., Schoenwaelder, S.M., Kuhlencordt, P.J., Preissner, K.T., Hirsch, E., Wetzker, R., 2008, Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells, Cardiovascular Research, vol 80, issue 1, Oxford University Press, UK, pp. 96-105.

Straub, A., Wendel, H.P., Dietz, K., Schiebold, D., Peter, K., Schoenwaelder, S.M., Ziemer, G., 2008, Selective inhibition of the platelet phosphoinositide 3-kinase p110beta as promising new strategy for platelet protection during extracorporeal circulation, Thrombosis and Haemostasis, vol 99, issue 3, Schattauer GmbH, Germany, USA, pp. 609-615.

Guerreiro, A.S., Fattet, S., Fischer, B., Shalaby, T., Jackson, S.P., Schoenwaelder, S.M., Grotzer, M.A., Delattre, O., Arcaro, A., 2008, Targeting the PI3K p110alpha isoform inhibits medulloblastoma proliferation, chemoresistance, and migration, Clinical Cancer Research, vol 14, issue 21, American Association for Cancer Research (A AC R), United States, pp. 6761-6769.

Schoenwaelder, S.M., Ono, A., Sturgeon, S.A., Chan, S.M., Mangin, P., Maxwell, M.J., Turnbull, S., Mulchandani, M., Anderson, K.E., Kauffenstein, G., Rewcastle, G.W., Kendall, J., Gachet, C., Salem, H.H., Jackson, S., 2007, Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin aIIb?3 adhesive function in platelets, The Journal of Biological Chemistry, vol 282, issue 39, The American Society for Biochemistry and Molecular Biology Inc, USA, pp. 28648-28658.

Arcaro, A., Doepfner, K.T., Boller, D., Guerreiro, A.S., Shalaby, T., Jackson, S., Schoenwaelder, S.M., Delattre, O., Grotzer, M.A., Fischer, B., 2007, Novel role for insulin as an autocrine growth factor for malignant brain tumour cells, Biochemical Journal, vol 406, issue 1, Portland Press Ltd, UK, pp. 57-66.

McCormack, M.P., Hall, M.A., Schoenwaelder, S.M., Zhao, Q., Ellis, S., Prentice, J.A., Clarke, A.J., Slater, N.J., Salmon, J.M., Jackson, S.P., Jane, S.M., Curtis, D.J., 2006, A critical role for the transcription factor Scl in platelet production during stress thrombopoiesis, Blood, vol 108, issue 7, American Society of Hematology, Washington DC USA, pp. 2248-2256.

Mangin, P., Yap, C.L.S., Nonne, C., Sturgeon, S.A., Goncalves, I., Yuan, Y., Schoenwaelder, S.M., Wright, C.E., Lanza, F., Jackson, S., 2006, Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency, Blood, vol 107, issue 11, American Society of Hematology, Washington USA, pp. 4346-4353.

Jackson, S., Schoenwaelder, S.M., 2006, Type I phosphoinositide 3-kinases: potential antithrombotic targets?, Cellular and Molecular Life Sciences, vol 63, issue 10, Birkhauser Verlag AG, Basel Switzerland, pp. 1085-1090.

Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V.B., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H., 2005, PI 3-kinase p110beta: A new target for antithrombotic therapy, Nature Medicine, vol 11, issue 5, Nature Publishing Group, New York USA, pp. 507-514.

Chrzanowska-Wodnicka, M., Smyth, S.S., Schoenwaelder, S.M., Fischer, T.H., White 11, G.C., 2005, Rap1b is required for normal platelet function and hemostasis in mice, The Journal of Clinical Investigation, vol 115, Amer Soc Clinical Investigation Inc, Michigan USA, pp. 680-687.

Jackson, S.P., Schoenwaelder, S.M., 2003, Antiplatelet Therapy: In search of the 'Magic Bullet', Nature Reviews Drug Discovery, vol 2, issue 10, Nature Publishing Group, London UK, pp. 1-15.

Goncalves, I., Hughan, S.C., Schoenwaelder, S.M., Yap, C.L.S., Yuan, Y., Jackson, S.P., 2003, Integrin IIb3-dependent calcium signals regulate platelet-fribrinogen interactions under flow, The Journal of Biological Chemistry, vol 278, issue 37, The American Society for Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 34812-34822.

Lawrenson, I.D., Wimmer-Kleikamp, S.H., Lock, P., Schoenwaelder, S.M., Down, M., Boyd, A.W., Alewood, P.F., Lackmann, M., 2002, Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling, Journal of Cell Science, vol 115, issue 5, Company of Biologists Ltd, Cambridge England, pp. 1059-1072.

Lawrenson, I.D., Wimmer-Kleikamp, S.H., Lock, P., Schoenwaelder, S.M., Down, M., Boyd, A.W., Alewood, P., Lackmann, M., 2002, Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by Crkll and Rho-mediated signalling, Journal of Cell Science, vol 115, The Company of Biologists Ltd, UK, pp. 1059-1072.

Schoenwaelder, S.M., Hughan, S.C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P.E., Salem, H., Jackson, S.P., 2002, RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear, Journal of Biological Chemistry, vol 277, issue 17, Amer Soc for Biochemistry and Molecular Biology, Inc, Bethesda MD USA, pp. 14738-14746.

Schoenwaelder, S.M., Yuan, Y., Jackson, S.P., 2000, Calpain regulation of integrin alphaIIbbeta3 signaling in human platelets, Platelets, vol 11, Taylor & Francis Ltd, London UK, pp. 189-198.

Schoenwaelder, S.M., Petch, L.A., Williamson, D., Shen, R., Feng, G., Burridge, K., 2000, The protein tyrosine phosphatase Shp-2 regulates RhoA activity, Current Biology, vol 10, Elsevier Science Ltd, London UK, pp. 1523-1526.

Schoenwaelder, S.M., Burridge, K., 1999, Bidirectional signalling between the cytoskeleton and integrins, Current Opinion in Cell Biology, vol 11, Current Biology Ltd., London England, pp. 274-286.

Schoenwaelder, S.M., Burridge, K., 1999, Evidence for a calpeptin-sensitive protein-tyrosine phosphatase upstream of the small GTPase Rho. A novel role for the calpain inhibitor calpeptin in the inhibition of protein-tyrosine phosphatases, Journal of Biological Chemistry, vol 274 issue 20, American Soc. Biochemistry and Molecular Biology, Bethesda MD USA, pp. 14359-14367.

Schoenwaelder, S.M., Yuan, Y., Cooray, P., Salem, H.H., Jackson, S.P., 1997, Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytosskeletal Attachment of Integrin aPb b3(Platelet Glyoprotein IIb/IIIa and the Cellular Retraction of Fibrin Clots, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 1694-1702.

Schoenwaelder, S.M., Kulkarni, S., Salem, H.H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T.C., Jackson, S.P., 1997, Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 24876-24884.

Other

Abbott, B., Anderson, K., Goncalves, I., Jackson, S., Vijaya, K., Warwick, N., Hishani, P., Robertson, A.D., Saylik, D., Schoenwaelder, S.M., Thompson, P., 2009, Inhibition of phosphoinositide 3-kinase-beta (AU), Australia.

Jackson, S., Robertson, A.D., Kenche, V., Thompson, P., Prabaharan, H., Anderson, K., Abbott, B.M., Goncalves, I., Nesbitt, W.S., Schoenwaelder, S.M., Saylik, D., 2007, Inhibition of phosphoinositide 3-kinase beta, New Zealand.

Jackson, S., Robertson, A.D., Kenche, V., Thompson, P., Prabaharan, H., Anderson, K., Abbott, B., Goncalves, I., Nesbitt, W.S., Schoenwaelder, S.M., Saylik, D., 2004, Inhibition of phosphoinositide 3-kinase beta.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

PI3 Kinase Inhibitors as adjunct thrombolytic therapies.

Supervisors:

Jackson, S (Main), Schoenwaelder, S (Associate), Yuan, Y (Associate).

Completed Supervision

Student:

Ono, A.

Program of Study:

Investigation of novel mechanisms regulating platelet contractile function. (PHD) 2009.

Supervisors:

Jackson, S (Main), Schoenwaelder, S (Associate).