Assoc Prof Ann Chidgey - Researcher Profile

Biography

Ann works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Qualifications

PHD IMMUNOLOGY

Institution: Monash University

Year awarded: 1998

BACHELOR OF SCIENCE

Institution: The University of Melbourne

Year awarded: 1979

DIPLOMA OF EDUCATION

Institution: The University of Melbourne

Year awarded: 1979

Publications

Book Chapters

Chidgey, A., Seach, N., Lim, R., Boyd, R., 2010, Stem Cells and Regenerative Medicine - The Evolving Story, in Stem Cell Technologies - Basics and Applications, eds S Totey & K Deb, Tata McGraw-Hill Education Private Limited, USA, pp. 1-18.

Soh, C., Lim, J.M.C., Boyd, R.L., Chidgey, A.P., 2009, Epithelial stem cells and the development of the thymus, parathyroid, and skin, in Regulatory Networks in Stem Cells, eds VK Rajasekhar & MC Vemuri, Humana Press [part of Springer Science+Business Media B.V.], Germany, pp. 405-437.

Fletcher, A.L., Reiseger, J.J., Vlahos, K., Seach, N.L., Dudakov, J.A., Chidgey, A.P., Boyd, R.L., 2009, Thymic regeneration in mice and humans following sex steroid ablation, in Handbook on Immunosensecence: Basic understanding and clinical applications, eds T Fulop, C Franceschi, K Hirokawa & G Pawelec, Springer Science+Business Media, Germany, pp. 1571-1609.

Chidgey, A.P., Boyd, R.L., Hugo, P., 2007, The Thymic Niche and Thymopoiesis, in Encyclopedia of Life Sciences, eds John Wiley & Sons Ltd, John Wiley & Sons Ltd, UK, pp. 1-12.

Journal Articles

Seach, N.L., Wong, K., Hammett, M.V., Boyd, R.L., Chidgey, A.P., 2012, Purified enzymes improve isolation and characterization of the adult thymic epithelium, Journal of Immunological Methods [P], vol 385, issue 1-2, Elsevier BV, Netherlands, pp. 23-34.

Fletcher, A., Calder, A., Hince, M., Boyd, R., Chidgey, A., 2011, The contribution of thymic stromal abnormalities to autoimmune disease, Critical Reviews in Immunology [P], vol 31, issue 3, Begell House Inc., USA, pp. 171-187.

Calder, A., Hince, M., Dudakov, J., Chidgey, A., Boyd, R., 2011, Thymic involution: Where endocrinology meets immunology, Neuroimmunomodulation [P], vol 18, issue 5, Karger, Switzerland, pp. 281-289.

Dudakov, J.A., Khong, D.M.P., Boyd, R.L., Chidgey, A.P., 2010, Feeding the fire: the role of defective bone marrow function in exacerbating thymic involution, Trends In Immunology [P], vol 31, issue 5, Elsevier Ltd, UK, pp. 191-198.

Heng, T.S.P., Chidgey, A.P., Boyd, R.L., 2010, Getting back at nature: Understanding thymic development and overcoming its atrophy, Current Opinion in Pharmacology [P], vol 10, issue 4, Elsevier Ltd, UK, pp. 425-433.

van Dommelen, S.L., Rizzitelli, A., Chidgey, A.P., Boyd, R.L., Shortman, K., Wu, L., 2010, Regeneration of dendritic cells in aged mice, Cellular & molecular immunology. [P], vol 7, issue 2, Chinese Society of Immunology, China, pp. 108-115.

Goldberg, G.L., Dudakov, J.A., Reiseger, J.J., Seach, N.L., Ueno, T., Vlahos, K., Hammett, M.V., Young, L.F., Heng, T.S.P., Boyd, R.L., Chidgey, A.P., 2010, Sex steroid ablation enhances immune reconstitution following cytotoxic antineoplastic therapy in young mice, Journal Of Immunology [P], vol 184, issue 11, American Association of Immunologists, USA, pp. 6014-6024.

Fletcher, A.L., Lowen, T.E., Sakkal, S., Reiseger, J.J., Hammett, M.V., Seach, N.L., Scott, H.S., Boyd, R.L., Chidgey, A.P., 2009, Ablation and regeneration of tolerance-inducing medullary thymic epithelial cells after cyclosporine, cyclophosphamide, and dexamethasone treatment, Journal Of Immunology [P], vol 183, issue 2, American Association of Immunologists, USA, pp. 823-831.

Barnard, A.L., Chidgey, A.P., Bernard, C.C.A., Boyd, R.L., 2009, Androgen depletion increases the efficacy of bone marrow transplantation in ameliorating experimental autoimmune encephalomyelitis, Blood, vol 113, American Society of Hematology, USA, pp. 204-213.

Alves, N.L., Richard-Le Goff, O., Huntington, N.D., Sousa, A.P., Ribeiro, V.S.G., Bordack, A., Vives, F.L., Peduto, L., Chidgey, A.P., Cumano, A., Boyd, R.L., Eberl, G., Di Santo, J.P., 2009, Characterization of the thymic IL-7 niche in vivo, Proceedings of the National Academy of Sciences of the United States of America, vol 106, issue 5, National Academy of Sciences, USA, pp. 1512-1517.

Takahama, Y., Saito, T., Kawamoto, H., Itoi, M., Boyd, R.L., Chidgey, A.P., Zamoyska, R., Hollander, G.A., Anderson, G., Taylor, N., Petrie, H.T., Nikolich-Zugich, J., 2009, EDITORIAL: The Global Thymus Network: past, present and future, Trends In Immunology [P], vol 30, issue 5, Elsevier Ltd, UK, pp. 191-192.

Goldberg, G.L., King, C.G., Nejat, R.A., Suh, D.Y., Smith, O.M., Bretz, J.C., Samstein, R.M., Dudakov, J.A., Chidgey, A.P., Chen-Kiang, S., Boyd, R.L., van den Brink, M.R.M., 2009, Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation, Journal Of Immunology [P], vol 182, issue 9, American Association of Immunologists, USA, pp. 5846-5854.

Dudakov, J.A., Goldberg, G.L., Reiseger, J.J., Vlahos, K., Chidgey, A.P., Boyd, R.L., 2009, Sex steroid ablation enhances hematopoietic recovery following cytotoxic antineoplastic therapy in aged mice, Journal Of Immunology [P], vol 183, issue 11, American Association of Immunologists, USA, pp. 7084-7094.

Heng, T.S.P., Dudakov, J.A., Khong, D.M.P., Chidgey, A.P., Boyd, R.L., 2009, Stem cells-meet immunity, Journal of Molecular Medicine [P], vol 87, issue 11, Springer, Germany, pp. 1061-1069.

Lynch, H.E., Goldberg, G.L., Chidgey, A.P., Van den Brink, M.R.M., Boyd, R.L., Sempowski, G.D., 2009, Thymic involution and immune reconstitution, Trends In Immunology [P], vol 30, issue 7, Elsevier Ltd, UK, pp. 366-373.

Cuddihy, A.R., Ge, S., Zhu, J., Jang, J., Chidgey, A.P., Thurston, G., Boyd, R.L., Crooks, G.M., 2009, VEGF-mediated cross-talk within the neonatal murine thymus, Blood, vol 113, American Society of Hematology, USA, pp. 2723-2731.

Dudakov, J.A., Goldberg, G.L., Reiseger, J.J., Chidgey, A.P., Boyd, R.L., 2009, Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis, Journal Of Immunology [P], vol 182, issue 10, American Association of Immunologists, USA, pp. 6247-6260.

Chidgey, A.P., 2008, Effects of growth hormone in enhancing thymic regrowth and T-cell reconstitution, Expert Review of Clinical Immunology, vol 4, issue 4, Expert Reviews Ltd., UK, pp. 433-439.

Sutherland, J.S., Spyroglou, L.G., Muirhead, J.L., Heng, T.S.P., Prieto-Hinojosa, A., Prince, H.M., Chidgey, A.P., Schwarer, A.P., Boyd, R.L., 2008, Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade, Clinical Cancer Research, vol 14, issue 4, American Association for Cancer Research (A AC R), USA, pp. 1138-1149.

Chidgey, A.P., Boyd, R.L., 2008, Immune privilege for stem cells: Not as simple as it looked, Cell Stem Cell, vol 3, issue 4, Cell Press, USA, pp. 357-358.

Barnard, A.L., Layton, D.S., Hince, M.N., Sakkal, S., Bernard, C.C.A., Chidgey, A.P., Boyd, R.L., 2008, Impact of the neuroendocrine system on thymus and bone marrow function, Neuroimmunomodulation, vol 15, issue 1, S. Karger AG, Switzerland, pp. 7-18.

Chidgey, A.P., Seach, N.L., Dudakov, J.A., Hammett, M.V., Boyd, R.L., 2008, Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: Pre-clinical and clinical approaches, Seminars in Immunopathology, vol 30, issue 4, Springer, Germany, pp. 457-477.

Seach, N.L., Ueno, T., Fletcher, A.L., Lowen, T.E., Mattesich, M., Engwerda, C.R., Scott, H.S., Ware, C.F., Chidgey, A.P., Gray, D.H., Boyd, R.L., 2008, The Lymphotoxin pathway regulates aire-independent expression of ectopic genes and chemokines in thymic stromal cells1, The Journal of Immunology, vol 180, issue 8, American Association of Immunologists, USA, pp. 5384-5392.

Hince, M.N., Sakkal, S., Vlahos, K., Dudakov, J.A., Boyd, R.L., Chidgey, A.P., 2008, The role of sex steroids and gonadectomy in the control of thymic involution, Cellular Immunology, vol 252, issue 1-2, Academic Press, USA, pp. 122-138.

Chidgey, A.P., Layton, D.S., Trounson, A.O., Boyd, R.L., 2008, Tolerance strategies for stem-cell-based therapies, Nature, vol 453, issue 7193, Nature Publishing Group, UK, pp. 330-337.

Gray, D.H.D., Fletcher, A., Hammett, M., Seach, N.L., Ueno, T., Young, L.F., Barbuto, J., Boyd, R.L., Chidgey, A.P., 2008, Unbiased analysis, enrichment and purification of thymic stromal cells, Journal of Immunological Methods, vol 329, Elsevier Science BV, Amsterdam, The Netherlands, pp. 56-66.

Gray, D.H.D., Tull, D., Ueno, T., Seach, N.L., Classon, B.J., Chidgey, A.P., McConville, M.J., Boyd, R.L., 2007, A unique thymic fibroblast population revealed by the monoclonal antibody MTS-15, Journal of Immunology, vol 178, issue 8, American Association of Immunologists, Bethesda MD USA, pp. 4956-4965.

Goldberg, G.L., Alpdogan, O., Muriglan, S.J., Hammett, M.V., Milton, M.K., Eng, J.M., Hubbard, V.M., Kochman, A.A., Willis, L.M., Greenberg, A.S., Tjoe, K.H., Sutherland, J.S., Chidgey, A.P., van den Brink, M.R., Boyd, R.L., 2007, Enhanced immune reconstitution by sex steroid ablation following allogeneic hemopoietic stem cell transplantation., Journal Of Immunology [P], vol 178, issue 11, American Association of Immunologists, USA, pp. 7473-7484.

Chidgey, A.P., Dudakov, J.A., Seach, N.L., Boyd, R.L., 2007, Impact of niche aging on thymic regeneration and immune reconstitution, Seminars in Immunology, vol 19, issue 5, Academic Press Elsevier Science Ltd, London, England, UK, pp. 331-340.

Rossi, S.W., Chidgey, A.P., Parnell, S.M., Jenkinson, W.E., Scott, H.S., Boyd, R.L., Jenkinson, E.J., Anderson, G., 2007, Redefining epithelial progenitor potential in the developing thymus, European Journal of Immunology, vol 37, issue 9, Wiley-V C H Verlag GMBH, Weinheim Germany, pp. 2411-2418.

Seach, N.L., Layton, D.S., Lim, J.M.C., Chidgey, A.P., Boyd, R.L., 2007, Thymic generation and regeneration: a new paradigm for establishing clinical tolerance of stem cell-based therapies, Current Opinion in Biotechnology, vol 18, issue 5, Current Biology Ltd, London, England, UK, pp. 441-447.

Chidgey, A.P., Boyd, R.L., 2006, Stemming the tide of thymic aging, Nature Immunology, vol 7, issue 10, Nature Publishing Group, New York USA, pp. 1013-1016.

Sutherland, J.S., Goldberg, G.L., Hammett, M.V., Uldrich, A.P., Berzins, S.P., Heng, T.S.P., Blazar, B.R., Millar, J.L., Malin, M., Chidgey, A.P., Boyd, R.L., 2005, Activation of thymic regeneration in mice and humans following androgen blockade, The Journal of Immunology, vol 175, issue 4, The American Association of Immunologists, USA, pp. 2741-2753.

Gray, D.H.D., Ueno, T., Chidgey, A.P., Malin, M., Goldberg, G.L., Takahama, Y., Boyd, R.L., 2005, Controlling the thymic microenvironment, Current Opinion in Immunology, vol 17, issue 2, Elsevier Ltd, Current Opinion Journals, UK, pp. 137-143.

Heng, T.S.P., Goldberg, G.L., Gray, D.H.D., Sutherland, J.S., Chidgey, A.P., Boyd, R.L., 2005, Effects of castration on thymocyte development in two different models of thymic involution, The Journal of Immunology, vol 175, issue 5, American Association of Immunologists, USA, pp. 2982-2993.

Goldberg, G.L., Sutherland, J.S., Hammett, M.V., Milton, M.K., Heng, T.S.P., Chidgey, A.P., Boyd, R.L., 2005, Sex steroid ablation enhances lymphoid recovery following autologous hematopoietic stem cell transplantation, Transplantation, vol 80, issue 11, Lippincott Williams & Wilkins, USA, pp. 1604-1613.

Gray, D.I.H., Chidgey, A., Boyd, R.L., 2002, Analysis of thymic stromal cell populations, Journal of Immunological Methods, vol 260, issue 1-2, Elsevier Science, Amsterdam Netherlands, pp. 15-28.

Boyd, R.L., Chidgey, A., 2000, T-cell development and function - a downunder experience, Immunology Today, vol 21 issue 10, Elsevier Science Ltd, Oxford England, pp. 472-474.

Katevuo, K., Imhof, B.A., Boyd, R.L., Chidgey, A., Bean, A., Dunon, D., Gobel, T.W., Vainio, O., 1999, ChT1, an Ig superfamily molecule required for T cell differentiation, Journal of Immunology, vol 162, American Association of Immunologists, Bethesda USA, pp. 5685-5694.

Chidgey, A., Pircher, H., Macdonald, H., Boyd, R.L., 1998, An adult thymic stromal-cell suspension model for invitro positive selection, Developmental Immunology, vol 6, Harwood Academic Publishers, Amsterdam Netherlands, pp. 157-170.

Chidgey, A., Boyd, R.L., 1998, Positive selection of low responsive potentially autoreactive T cells induced by high avidity, non-deleting interactions, International Immunology, vol 10 no 7, Oxford University Press, Oxford UK, pp. 999-1008.

Boyd, R.L., Kozieradzki, I., Chidgey, A., Mittrucker, H., Bouchard, D., Timms, E., Kishihara, K., Ong, C.J., Chui, D., Marth, J.D., Mak, T.W., Penninger, J.M., 1998, Receptor-specific allelic exclusion of TCRV alpha-chains during development, The Journal of Immunology, vol 161, The American Association of Immunologists, Bethesda, pp. 1718-1727.

Chidgey, A., Boyd, R.L., 1997, Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression, International Immunology, vol 9, Oxford University Press, UK, pp. 1527-1536.

Penninger, J.M., Sirard, C., Mittrucker, H.W., Chidgey, A., Kozieradzki, I., Nghiem, M., Hakem, A., Kimura, T., Timms, E., Boyd, R.L., Taniguchi, T., Matsuyama, T., Mak, T.W., 1997, The interferon regulatory transcription factor IRF-1 controls positive and negative selection of CD8+ thymocytes, Immunity, vol 7, Cell Press, USA, pp. 243-254.

Conference Proceedings

Dudakov, J.A., Goldberg, G.L., Khong, D., Chidgey, A.P., Boyd, R.L., 2008, Withdrawal of sex steroids reverses age-related defects in murine hematopoietic progenitor cell function, ISEH 37th Annual Scientific Meeting, Elsevier Inc, USA, p. S10.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Aminion membrane and placental stem cells for cutaneous wound healing.

Supervisors:

Boyd, R (Joint-co), Chidgey, A (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Amnion epithelial cells for regenerative medicine.

Supervisors:

Chidgey, A (Main), Boyd, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Developing 3D biomatrices for adult thymus reconstruction.

Supervisors:

Chidgey, A (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Development of a safe, effective and clinically relevant protocol for the induction of allogenic tolerance through mixed chimerism.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate), Heng, T (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Generation of thymic epithelial cells through microRNA-directed differentiation of mouse embryonic stem cells.

Supervisors:

Chidgey, A (Joint-co), Giudice, A (Joint), Boyd, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Phenotypic and functional characterisation of adult thymic epithelial progenitors in the mouse..

Supervisors:

Boyd, R (Joint-co), Chidgey, A (Joint), Seach, N (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Stem cell-based therapies for musculoskeletal disease.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Completed Supervision

Student:

Barnard, A.

Program of Study:

Immune regeneration as a novel approach to treat autoimmune-mediated demyelination. (PHD) 2009.

Supervisors:

Boyd, R (Main), Bernard, C (Associate), Chidgey, A (Associate).

Student:

Dudakov, J.

Program of Study:

Enhancing post-natal regeneration of hematopoietic stem cells and lymphopoiesis following immunodepletion. (PHD) 2008.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Student:

Fletcher, A.

Program of Study:

Thymic epithelial cells: post-natal maintenance, regeneration and autoimmune-associated abnormalities. (PHD) 2008.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Student:

Heng, T.

Program of Study:

Kinetics and functional impact of castration-induced thymic regeneration. (PHD) 2005.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Student:

Hince, M.

Program of Study:

Improving sex steroid ablation-induced thymic recovery for clinical application. (PHD) 2010.

Supervisors:

Boyd, R (Main), Chidgey, A (Joint).

Student:

Mathias, L.

Program of Study:

Comparative analysis of multipotent mesenchymal stromal cells from human bone marrow, umbilical cord and adipose tissue. (PHD) 2011.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate), Emmins, J (Associate).

Student:

Reiseger, J.

Program of Study:

Sex steriod ablation enhances T and B cell function in aged and immunodepleted mice. (PHD) 2008.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Student:

Sakkal, S.

Program of Study:

Regenerative potential of the female thymus in natural and induced models of involution. (PHD) 2009.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Student:

Seach, N.

Program of Study:

Medullary thymic epithelial cells: characterization, regeneration and role of the lymphotoxin beta receptor. (PHD) 2008.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).

Student:

Vlahos, K.

Program of Study:

Investigation into the hormonal influence of tolerance mechanisms following immunosenescence, thymic regeneration and bone marrow transplantation. (PHD) 2009.

Supervisors:

Boyd, R (Main), Chidgey, A (Associate).