Tel: +61 3 990 24712
Fax: +61 3 9594 7439
Email: Caroline.Gargett@med.monash.edu.au
Email: Caroline.Gargett@monash.edu
Postal address:
Caroline works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow. She is a Deputy Director of the Ritchie Centre in the Monash Institute for Medical Research and heads the Women's Health Theme, where she leads the Endometrial Stem Cell Group. Her research focuses on characterising epithelial progenitor cells and mesenchymal stem cells (MSC) she discovered in the highly regenerative lining of the uterus (endometrium) and examining their role in endometriosis and endometrial cancer. She leads a collaboration with CSIRO to develop a tissue engineering approach as a cell based therapy to treat pelvic organ prolapse using endometrial MSC and novel scaffold materials.
Caroline has received a number of national and international awards for her research. She was recently honoured for her pioneering research in Endometriosis by the Endometriosis Foundation of America (2011) in New York. She was awarded a British Council Early Career Research Exchange Award to undertake a sabbatical at Cambridge University, UK in 2007, the European Society for Human Reproduction and Embryology Established Investigator Award in 2005, the prestigous Society for Reproductive Biology Research Centre for Reproductive Health Award for Excellence in Reproductive Biology Research in 2011.
She was featured in Australia’s National Health and Medical Research Council’s (NHMRC) “10 of the Best Research Projects in 2008” and was a NHMRC RD Wright Fellow (2007-11). Caroline has received numerous invitations to speak at international conferences on her piorneering work on endometrial stem/progenitor cells and their role in gynaecological disease.
Caroline has been funded by NHMRC since 2004 and currently holds 2 NHMRC Project grants that commenced in 2012. She is also a Chief Investigator on a Research Infrastructure Support Services (RISS) grant to develop endometrial MSC for cell production for translation into the clinic. She is a CI of the lead organisation (MIMR) of the Victorial Consortium for Cell Therapies which raised $2M from Therapeutic Innovations Australia (TIA) for establishing closed systems for production of cells under clinical grade Good Manufacturing Practice.
Caroline has organised Symposia for international conferences including World Congress of Endometriosis (2011), Tissue Engineering and Regenerative Medicine International Society (2012) and Society for Gynecological Investigation (2011, 2013). She also engages the community through the media, writes for The Conversation, as well as hosting a well attened Public Forum on "Childbirth and the Pelvic Floor - new solutions to age old problems" in 2012.
She serves on the Editorial Boards of Fertility and Sterility and Reproductive Sciences and was Associate Editor for Human Reproduction (2005-8). She is Vice President of the Australasian Society for Stem Cell Research and was Secretary for the Society for Reproductive Biology (2005-7).
Gargett, C.E., Masuda, H., Weston, G.C., 2012, Stem cells in endometriosis, in Endometriosis: Science and Practice, eds Linda C Giudice, Johannes L H Evers, David L Healy, Wiley-Blackwell, West Sussex, UK, pp. 130-139.
Gargett, C.E., 2011, Stem cells of the human uterus: derivation, characterisation and uses of endometrial stem cells, in Stem cells: From Bench to Bedside, eds Ariff Bongso and Eng Hin Lee, World Scientific, Singapore, pp. 583-609.
Gargett, C., Guo, S., 2010, Stem cells and clonality in endometriosis, in Endometriosis - Current Management and Future Trends, eds Juan A Garcia-Velasco and Botros RMB Rizk, Jaypee Brothers, India, pp. 307-316.
Gargett, C.E., Cervello, I., Hubbard, S., Simon, C., 2009, Adult stem cells in the human endometrium, in Stem Cells in Human Reproduction - Basic Science and Therapeutic Potential, eds Carlos Simon and Antonio Pellicer, Informa Healthcare, UK, pp. 160-176.
Gargett, C.E., Schwab, K., 2009, The endometrium: A novel source of adult stem / progenitor cells, in Regulatory Networks in Stem Cells, eds Vinagolu K. Rajasekhar and Mohan C. Vemuri, Humana Press, USA, pp. 391-404.
Gargett, C.E., 2008, Endometrial stem cells, in The Endometrium, eds John D Aplin, Asgerally T Fazleabas, Stanley R Glasser, Linda C Giudice, Informa Healthcare, London UK, pp. 135-153.
Gargett, C.E., 2007, Adult stem cells in the human endometrium - basic science and therapeutic potential, in Stem Cells in Human Reproduction, eds Carlos Simon & Antonio Pellicer, Informa Healthcare, UK, pp. 105-120.
Weston, G.C., Girling, J.E., Gargett, C.E., Rogers, P.A.W., 2005, Hormonal effects on endometrial angiogenesis, in Trends in Angiogenesis Research, eds Roberta V. Zubar, Nova Science Publishers, New York USA, pp. 71-102.
Rogers, P.A.W., Gargett, C.E., 2001, The vascular system in the endometrium: introduction and overview, in Vascular Morphogenesis in the Female Reproductive System, eds Hellmut G. Augustin, M. Luisa Iruela-Arispe, Peter A.W. Rogers and Stephen K. Smith, Birkhauser, Boston USA, pp. 209-222.
Masuda, H., Anwar, S.S., Buhring, H., Rao, J.R., Gargett, C.E., 2012, A novel marker of human endometrial mesenchymal stem-like cells, Cell Transplantation [P], vol 21, issue 10, Cognizant Communication Corporation, United States, pp. 2201-2214.
Ulrich, D., Edwards, S.L., White, J.F., Supit, T., Ramshaw, J., Lo, C.Y., Rosamilia, A., Werkmeister, J., Gargett, C.E., 2012, A preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model, PLoS ONE [P], vol 7, issue 11 (Art. No.: e50044), Public Library of Science, United States, pp. 1-12.
Nguyen, H.P.T., Sprung, C.N., Gargett, C.E., 2012, Differential expression of Wnt signaling molecules between pre- and postmenopausal endometrial epithelial cells suggests a population of putative epithelial stem/progenitor cells reside in the basalis layer, Endocrinology [P], vol 153, issue 6, The Endocrine Society, United States, pp. 2870-2883.
Gargett, C.E., Ye, P.L., 2012, Endometrial reconstruction from stem cells, Fertility and Sterility [P], vol 98, issue 1, Elsevier Inc., United States, pp. 11-20.
Gargett, C.E., Nguyen, H.P.T., Ye, P.L., 2012, Endometrial regeneration and endometrial stem/progenitor cells, Reviews In Endocrine & Metabolic Disorders [P], vol 13, issue 4, Springer New York LLC, United States, pp. 235-251.
Kaituu, T.J., Ye, P.L., Salamonsen, L.A., Girling, J.E., Gargett, C.E., 2012, Identification of label-retaining perivascular cells in a mouse model of endometrial decidualization, breakdown, and repair, Biology Of Reproduction [P], vol 86, issue 6 (Art. No: 184), Society for the Study of Reproduction, United States, pp. 1-8.
Ye, P., Evans, J., Gargett, C., 2012, Lim1/LIM1 is expressed in developing and adult mouse and human endometrium, Histochemistry And Cell Biology [P], vol 137, issue 4, Springer, Germany, pp. 527-536.
Chan, R., Kaituu, T., Gargett, C., 2012, Role of label-retaining cells in estrogen-induced endometrial regeneration, Reproductive Sciences [P], vol 19, issue 1, Sage Publications, Inc., United States, pp. 102-114.
Pratama, G., Vaghjiani, V., Tee, J., Liu, Y., Chan, M., Tan, C., Murthi, P., Gargett, C., Manuelpillai, U., 2011, Changes in culture expanded human amniotic epithelial cells: Implications for potential therapeutic applications, PLoS ONE [P], vol 6, issue 11 (Art. No: e26136), Public Library of Science, United States, pp. 1-12.
Gargett, C., Healy, D., 2011, Generating receptive endometrium in Asherman's syndrome, Journal of Human Reproductive Sciences [P], vol 4, issue 1, Medknow Publications and Media Pvt. Ltd., India, pp. 49-52.
Ye, P., Mayberry, R., Lo, C., Britt, K., Stanley, E., Elefanty, A., Gargett, C., 2011, Generation of human female reproductive tract epithelium from human embryonic stem cells, PLoS ONE [P], vol 6, issue 6 (Art. No: e21136), Public Library of Science, United States, pp. 1-11.
Hubbard, S., Gargett, C.E., 2010, A cancer stem cell origin for human endometrial carcinoma?, Reproduction [P], vol 140, issue 1, Bio Scientifica, Bristol, United Kingdom, pp. 23-32.
Gargett, C.E., Masuda, H., 2010, Adult Stem Cells in the Endometrium, Molecular Human Reproduction [P], vol 16, issue 11, Oxford University Press, Oxford, United Kingdom, pp. 818-834.
Kaitu'u-Lino, T.J., Ye, P.L., Gargett, C.E., 2010, Reepithelialization of the uterine surface arises from endometrial glands: evidence from a functional mouse model of breakdown and repair, Endocrinology [P], vol 151, issue 7, The Endocrine Society, USA, pp. 3386-3395.
Gargett, C.E., 2010, Stem cells in Human Reproduction, Reproduction [P], vol 140, issue 1, Bio Scientifica, Bristol, United Kingdom, pp. 1-2.
Sobiesiak, M., Sivasubramaniyan, K., Hermann, C., Tan, C.S.C., Orgel, M., Treml, S., Cerabona, F., de Zwart, P., Ochs, U., Muller, C.A., Gargett, C.E., Kalbacher, H., Buhring, H., 2010, The mesenchymal stem cell antigen MSCA-1 is identical to tissue non-specific alkaline phosphatase, Stem Cells and Development [P], vol 19, issue 5, Mary Ann Liebert, Inc. Publishers, USA, pp. 669-677.
Hubbard, S., Friel, A.M., Kumar, B., Zhang, L., Rueda, B.R., Gargett, C.E., 2009, Evidence for cancer stem cells in human endometrial carcinoma, Cancer Research [P], vol 69, issue 21, American Association for Cancer Research, USA, pp. 8241-8248.
Gargett, C.E., Schwab, K.E., Zillwood, R.M., Nguyen, H., Wu, D., 2009, Isolation and culture of epithelial progenitors and mesenchymal stem cells from human endometrium, Biology Of Reproduction [P], vol 80, issue 6, Society for the Study of Reproduction, USA, pp. 1136-1145.
Rogers, P.A.W., Da??Hooghe, T., Fazleabas, A., Gargett, C.E., Giudice, L., Montgomery, G., Rombauts, L., Salamonsen, L.A., Zonderwan, K., 2009, Priorities for endometriosis research: recommendations from an international consensus workshop, Reproductive Sciences [P], vol 16, issue 4, Sage Publications, Inc., USA, pp. 335-346.
Gargett, C.E., Chan, R.W.S., Schwab, K.E., 2008, Hormone and growth factor signaling in endometrial renewal: Role of stem/progenitor cells, Molecular and Cellular Endocrinology, vol 288, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 22-29.
Ponnampalam, A.P., Gargett, C.E., Rogers, P.A.W., 2008, Identification and hormonal regulation of a novel form of NKp30 in human endometrial epithelium, European Journal of Immunology, vol 38, issue 1, Wiley - VCH Verlag GmbH & Co. KGaA, Germany, pp. 216-226.
Schwab, K.E., Hutchinson, P.E., Gargett, C.E., 2008, Identification of surface markers for prospective isolation of human endometrial stromal colony-forming cells., Human Reproduction, vol 23, issue 4, Oxford University Press, Oxford UK, pp. 934-943.
Hemberger, M., Yang, W., Natale, D., Brown, T.L., Dunk, C., Gargett, C.E., Tanaka, S., 2008, Stem cells from fetal membranes - a workshop report, Placenta [P], vol 29, issue Suppl A, WB Saunders Co, UK, pp. S17-S19.
Schwab, K.E., Gargett, C.E., 2007, Co-expression of two perivascular cell markers isolates mesenchymal stem-like cells from human endometrium, Human Reproduction, vol 22, issue 11, Oxford University Press, UK & Belgium, pp. 2903-2911.
Gargett, C.E., Chan, R.W.S., Schwab, K.E., 2007, Endometrial stem cells, Current Opinion in Obstetrics & Gynecology, vol 19, issue 4, Lippincott Williams & Wilkins, USA, pp. 377-383.
Gargett, C.E., 2007, Review article: Stem cells in human reproduction, Reproductive Sciences, vol 14, issue 5, Sage Science Press (US), USA, pp. 405-424.
Gargett, C.E., 2007, Uterine stem cells: what is the evidence?, Human Reproduction Update, vol 13, issue 1, Oxford University Press, UK & Belgium, pp. 87-101.
Gargett, C.E., Chan, R.W.S., 2006, Endometrial stem/progenitor cells and proliferative disorders of the endometrium, Minerva Ginecologica, vol 58, issue 5, Edizioni Minerva Medica, Italy, pp. 511-526.
Gargett, C.E., 2006, Identification and characterisation of human endometrial stem/progenitor cells, Australian and New Zealand Journal of Obstetrics and Gynaecology, vol 46, issue 3, Blackwell Publishing, Oxford UK, pp. 250-253.
Chan, R.W.S., Gargett, C.E., 2006, Identification of label-retaining cells in mouse endometrium, Stem Cells, vol 24, issue 6, AlphaMed Press, Durham USA, pp. 1529-1538.
Hussein-Fikret, S., Fuller, P.J., Gargett, C.E., 2005, Expression of steroid receptor coactivators in cultured cells from paired myometrial and fibroid tissues, Journal of the Society for Gynecologic Investigation [P], vol 12, issue 6, Elsevier, USA, pp. 445-451.
Schwab, K.E., Chan, R.W.S., Gargett, C.E., 2005, Putative stem cell activity of human endometrial epithelial and stromal cells during the menstrual cycle, Fertility and Sterility, vol 84, issue 2, Elsevier, USA, pp. 1124-1130.
Chan, R.W.S., Schwab, K.E., Gargett, C.E., 2004, Clonogenicity of human endometrial epithelial and stromal cells, Biology of Reproduction, vol 70, The Society for the Study of Reproduction, Inc, Madison USA, pp. 1738-1750.
Zaitseva, M., Sam Yue, D., Katzenellenbogen, J.A., Rogers, P.A.W., Gargett, C.E., 2004, Estrogen receptor-agonists promote angiogenesis in human myometrial microvascular endothelial cells, Journal of the Society for Gynecologic Investigation, vol 11, issue 8, Elsevier, New York USA, pp. 529-535.
Gargett, C.E., 2004, Stem cells in gynaecology, Australian and New Zealand Journal of Obstetrics and Gynaecology, vol 44, Royal Australian and New Zealand College of Obstetricians and Gynaecologists, East Melbourne Vic Australia, pp. 380-386.
Weston, G.C., Trajstman, A.C., Gargett, C.E., Manuelpillai, U.C., Vollenhoven, B.J., Rogers, P.A.W., 2003, Fibroids display an anti-angiogenic gene expression profile when compared with adjacent myometrium, Molecular Human Reproduction, vol 9, issue 9, Oxford University Press, Oxford England, pp. 541-549.
Gargett, C.E., Zaitseva, M., Bucak, K., Chu, S., Fuller, P.J., Rogers, P., 2002, 17Up-Regulates Vascular Endothelial Growth Factor Receptor-2 Expression in Human Myometrial Microvascular Endothelial Cells: Role of Estrogen Receptor-and -, The Journal of Clinical Endocrinology & Metabolism, vol 87, issue 9, Endocrine Society, Bethesda Maryland USA, pp. 4341-4349.
Gargett, C.E., Bucak, K., Zaitseva, M., Chu, S., Taylor, N., Fuller, P.J., Rogers, P.A.W., 2002, Estrogen receptor-and -expression in microvascular endothelial cells and smooth muscle cells of myometrium and leiomyoma, Human Reproduction, vol 8, issue 8, Oxford University Press, Oxford UK, pp. 770-775.
Gargett, C.E., Weston, G.C., Rogers, P., 2002, Mechanisms and Regulation of Endometrial Angiogenesis, Reproductive Medicine Review, vol 10, issue 1, Cambridge University Press, Cambridge UK, pp. 45-61.
Schneider-Kolsky, M.E., Manuelpillai, U.C., Gargett, C., Wallace, E.M., 2001, Activin bA-subunit and activin receptors in human myometrium at term and during labour, British Journal of Obstetrics and Gynaecology, vol 108, issue 8, Elsevier Science BV, Amsterdam Netherlands, pp. 869-874.
Gargett, C., Lederman, F., Heryanto, B.B., Gambino, L.S., Rogers, P., 2001, Focal vascular endothelial growth factor correlates with angiogenesis in human endometrium. Role of intravascular neutrophils, Human Reproduction, vol 16, issue 6, Oxford University Press, Oxford UK, pp. 1065-1075.
Gargett, C., Rogers, P., 2001, Human endometrial angiogenesis, Reproduction, vol 121, issue 2, Journals of Reproduction & Fertility Ltd, Cambridge UK, pp. 181-186.
Gargett, C., Bucak, K., Rogers, P.A.W., 2000, Isolation, characterization and long-term culture of human myometrial microvascular endothelial cells, Human Reproduction, vol 15 issue 2, Oxford University Press, Oxford UK, pp. 293-301.
Rogers, P.A., Gargett, C., 1999, Endometrial angiogenesis, Angiogenesis, vol 2;4, Kluwer Academic Publishers, Netherland, pp. 287-294.
Gargett, C., Lederman, F., Lau, T.M., Taylor, N., Rogers, P.A., 1999, Lack of correlation between vascular endothelial growth factor production and endothelial cell proliferation in the human endometrium, Human Reproduction, vol 14;8, Oxford Univ Press, Oxford England, pp. 2080-2088.
Tsaltas, J., Rogers, P.A., Gargett, C., Healy, D.W., 1998, Excessive angiogenesis: a new thoery for endometriosis, Current Obstetrics & Gynaecology Mini symposium - endometriosis, vol professor em symonds, Churchill Livingstone, UK, pp. 186-190.
Schwab, K., Gargett, C.E., 2006, Prospective isolation of putative human endometrial mesenchymal stem cells using CD146 and platelet-derived growth factor receptor beta, Journal of The Society for Gynecologic Investigation, 22-25 March 2006, Elsevier Science Inc, New York NY USA, p. 186A.
Heffernan, C., Gargett, C., Rogers, P.A., 1998, Angiogenesis inhibitors in human endometrium, The Australian Society for Medical Research 37th National Scientific Conference, Hobart, 22-25 November 1998, The Australian Society for Medical Research, Australia, p. 41.
Bucak, K., Gargett, C., Rogers, P.A., 1998, Isolation and culture of human myometrial microvascular endothelial cells, The Australian Society for Medical Research 37th National Scientific Conference, Hobart, 22-25 November 1998, The Australian Society for Medical Research, Australia, p. 67.
Rogers, P.A., Gargett, C., Lederman, F., Taylor, N., Lau, T.M., 1998, Lack of correlation between VEGF production and angiogenesis in human endometrium, The Fertility Society of Australia, Hobart '98, Hobart, 28-31 October 1998, The Fertility Society of Australia, Australia, p. 72.
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