Prof Robert Pike - Researcher Profile

Biography

Robert works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Keywords

complement system; c1s; c1r; masp-2; protease; serpin; c1-inhibitor

Qualifications

PHD

Institution: University of Natal

Year awarded: 1991

Publications

Book Chapters

Horvath, A.J., Lu, B.G., Pike, R.N., Bottomley, S.P., 2011, Methods to measure the kinetics of protease inhibition by serpins, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whisstock and Phillip I Bird, Academic Press, USA, pp. 223-235.

Song, J., Matthews, A., Reboul, C.F., Kaiserman, D., Pike, R.N., Bird, P.I., Whisstock, J.C., 2011, Predicting serpin/protease interactions, in Methods in Enzymology, Volume 501: Serpin Structure and Evolution, eds James C Whisstock and Philip I Bird, Academic Press, USA, pp. 237-273.

Beinrohr, L., Murray-Rust, T., Dyksterhuis, L., Zavodszky, P., Gal, P., Pike, R., Wijeyewickrema, L., 2011, Serpins and the complement system, in Methods in Enzymology, Volume 499: Biology of Serpins, eds James C Whisstock and Phillip I Bird, Academic Press, UK, pp. 55-75.

Yongqing, T., Potempa, J., Pike, R., Wijeyewickrema, L., 2011, The lysine-specific gingipain of porphyromonas gingivalis : Importance to pathogenicity and potential strategies for inhibition, in Cysteine Proteases of Pathogenic Organisms, eds Mark W Robinson & John P Dalton, Springer Science+Business Media, USA, pp. 15-29.

Grigoryev, S.A., Bulynko, Y.A., Pike, R.N., Whisstock, J., 2007, MENT a chromatin-associated serpin from avian blood cells: structure and function, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds G.A. Silverman & D.A. Lomas, World Scientific, Singapore, pp. 243-259.

Church, F., Pike, R.N., Tollefsen, D.M., Buckle, A.M., Ciaccia, A.V., Olson, S.T., 2007, Regulation of hemostasis by heparin-binding serpins, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds G.A. Silverman & D.A. Lomas, World Scientific, Singapore, pp. 509-554.

Pearce, M.C., Pike, R.N., Lesk, A.M., Bottomley, S.P., 2007, Serpin Conformations, in Molecular and Cellular Aspects of the Serpinopathies and Disorders in Serpin Activity, eds G.A. Silverman & D.A. Lomas, World Scientific, Singapore, pp. 35-66.

Potempa, J., Pike, R.N., 2005, Bacterial peptidases, in Concepts in Bacterial Virulence, eds Wayne Russell and Heiko Herwald (Volume Editors)Axel Schmidt and Heiko Herwald (Series Editors), Karger, Basel Switzerland, pp. 132-180.

Journal Articles

Dunstan, R.A., Heinz, E., Wijeyewickrema, L.C., Pike, R.N., Purcell, A.W., Evans, T.J., Praszkier, J., Robins-Browne, R.M., Strugnell, R.A., Korotkov, K.V., Lithgow, T.J., 2013, Assembly of the type II secretion system such as found in Vibrio cholerae depends on the novel Pilotin AspS, PLoS ONE [P], vol 9, issue 1, Public Library of Science, USA, pp. 1-14.

Langendorf, C.G., Tuck, K.L., Key, T., Fenalti, G., Pike, R.N., Rosado, C.J., Wong, A.S., Buckle, A.M., Law, R.H.P., Whisstock, J., 2013, Structural characterization of the mechanism through which human glutamic acid decarboxylase auto-activates, Bioscience Reports [P], vol 33, issue 1, Portland Press Ltd, UK, pp. 137-149.

Norbury, L.J., Hung, A., Beckham, S.A., Pike, R.N., Spithill, T.W., Craik, C.S., Choe, Y., Fecondo, J.V., Smooker, P.M., 2012, Analysis of Fasciola cathepsin L5 by S2 subsite substitutions and determination of the P1-P4 specificity reveals an unusual preference, Biochimie [P], vol 94, issue 5, Elsevier Masson, France, pp. 1119-1127.

Hsieh, Y.S., Taleski, D., Wilkinson, B., Wijeyewickrema, L.C., Adams, T.E., Pike, R.N., Payne, R.J., 2012, Effect of O-glycosylation and tyrosine sulfation of leech-derived peptides on binding and inhibitory activity against thrombin, Chemical Communications [P], vol 48, issue 10, Royal Society of Chemistry Publications, UK, pp. 1547-1549.

Duncan, R.C., Mohlin, F.C., Taleski, D., Coetzer, T.H., Huntington, J.A., Payne, R.J., Blom, A.M., Pike, R.N., Wijeyewickrema, L.C., 2012, Identification of a catalytic exosite for complement component c4 on the serine protease domain of c1s, Journal Of Immunology [P], vol 189, issue 5, American Association of Immunologists, USA, pp. 2365-2373.

Yongqing, T., Drentin, N., Duncan, R.C., Wijeyewickrema, L.C., Pike, R.N., 2012, Mannose-binding lectin serine proteases and associated proteins of the lectin pathway of complement: two genes, five proteins and many functions?, Biochimica et Biophysica Acta - Proteins and Proteomics [P], vol 1824, issue 1, Elsevier Science BV, The Netherlands, pp. 253-262.

Mika, A., Reynolds, S.L., Mohlin, F.C., Willis, C., Swe, P.M., Pickering, D.A., Halilovic, V., Wijeyewickrema, L.C., Pike, R.N., Blom, A.M., Kemp, D.J., Fischer, K., 2012, Novel scabies mite serpins inhibit the three pathways of the human complement system, PLoS ONE [P], vol 7, issue 7 (Art. No.: e40489), Public Library of Science, USA, pp. 1-15.

Song, J., Tan, H., Perry, A.J., Akutsu, T., Webb, G.I., Whisstock, J.C., Pike, R.N., 2012, PROSPER: an integrated feature-based tool for predicting protease substrate cleavage sites, PLoS ONE [P], vol 7, issue 11 (Art. No.: e50300), Public Library of Science, USA, pp. 1-23.

Georgy, S., Pagal, C., Ghasem-Zadeh, A., Zebaze, R., Pike, R., Sims, N., Mackie, E., 2012, Proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair, Bone [P], vol 50, issue 3, Elsevier Inc., United States, pp. 704-712.

Law, R.H., Caradoc-Davies, T.T., Cowieson, N.P., Horvath, A.J., Quek, A.J., Amarante Da Encarnacao, J., Steer, D.L., Cowan, A.D., Zhang, Q., Lu, B.G., Pike, R.N., Smith, A.I., Coughlin, P.B., Whisstock, J.C., 2012, The x-ray crystal structure of full-length human plasminogen, Cell Reports [E], vol 1, issue 3, Cell Press, USA, pp. 185-190.

Norbury, L.J., Beckham, S.A., Pike, R.N., Grams, R., Spithill, T.W., Fecondo, J.V., Smooker, P.M., 2011, Adult and juvenile Fasciola cathepsin L proteases: Different enzymes for different roles, Biochimie [P], vol 93, issue 3, Elsevier Masson, France, pp. 604-611.

Song, J., Tan, H., Boyd, S.E., Shen, H., Mahmood, K., Webb, G., Akutsu, T., Whisstock, J., Pike, R., 2011, Bioinformatic approaches for predicting substrates of proteases, Journal of Bioinformatics and Computational Biology [P], vol 9, issue 1, Imperial College Press, UK, pp. 149-178.

Ng, N., Pierce, M.J., Webb, G., Ratnikov, B., Wijeyewickrema, L.C., Duncan, R., Robertson, A.L., Bottomley, S.P., Boyd, S.E., Pike, R.N., 2011, Discovery of amino acid motifs for thrombin cleavage and validation using a model substrate, Biochemistry [P], vol 50, issue 48, American Chemical Society, USA, pp. 10499-10507.

Duncan, R.C., Bergstrom, F.C., Coetzer, T.H., Blom, A.M., Wijeyewickrema, L.C., Pike, R.N., 2011, Multiple domains of MASP-2, an initiating complement protease, are required for interaction with its substrate C4, Molecular Immunology [P], vol E, Pergamon, UK, pp. 1-8.

Wong, W., Wijeyewickrema, L.C., Kennan, R.M., Reeve, S.B., Steer, D.L., Reboul, C., Smith, A.I., Pike, R.N., Rood, J.I., Whisstock, J.C., Porter, C.J., 2011, S1 pocket of a bacterially derived subtilisin-like protease underpins effective tissue destruction, Journal Of Biological Chemistry [P], vol 286, issue 49, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 42180-42187.

Smooker, P.M., Jayaraj, R., Pike, R.N., Spithill, T.W., 2010, Cathepsin B proteases of flukes: The key to facilitating parasite control?, Trends in Parasitology [P], vol 26, issue 10, Elsevier Ltd, UK, pp. 506-514.

Peddie, V., Pietsch, M., Bromfield, K.M., Pike, R.N., Duggan, P.J., Abell, A.D., 2010, Fluorinated beta2- and beta3-amino acids: Synthesis and inhibition of alpha-chymotrypsin, Synthesis-Stuttgart [P], issue 11, Georg Thieme Verlag KG, Germany, pp. 1845-1859.

Pike, R.N., Whisstock, J., 2010, Highlight: The Biology of Proteolytic Systems, Biological Chemistry [P], vol 391, issue 8, Walter de Gruyter GmbH & Co KG, Germany, p. 837.

Wong, D.M., Tam, V., Lam, R., Walsh, K.A., Tatarczuch, L., Pagel, C.N., Reynolds, E.C., O'Brien-Simpson, N.M., Mackie, E.J., Pike, R.N., 2010, Protease-activated receptor 2 has pivotal roles in cellular mechanisms involved in experimental periodontitis, Infection And Immunity [P], vol 78, Amercian Society of Microbiology, USA, pp. 629-638.

Georgy, S.R., Pagel, C.N., Wong, D.M., Sivagurunathan, S., Loh, L.H., Myers, D.E., Hollenberg, M.D., Pike, R.N., Mackie, E.J., 2010, Proteinase-activated receptor-2 (PAR2) and mouse osteoblasts: Regulation of cell function and lack of specificity of PAR2- activating peptides, Clinical And Experimental Pharmacology And Physiology [P], vol 37, issue 3, Wiley-Blackwell Publishing Asia, Australia, pp. 328-336.

Northfield, S., Roberts, K., Mountford, S., Hughes, R., Kaiserman, D., Mangan, M., Pike, R., Bird, P., Thompson, P., 2010, Synthesis of "difficult" fluorescence quenched substrates of granzyme C, International Journal of Peptide Research and Therapeutics [E], vol 16, Springer, New York New York USA, pp. 159-165.

Kennan, R.M., Wong, W., Dhungyel, O., Han, X., Wong, D.M., Parker, D., Rosado, C.J., Law, R.H., McGowan, S., Reeve, S.B., Levina, V., Powers, G.A., Pike, R.N., Bottomley, S.P., Smith, A.I., Marsh, I., Whittington, R.J., Whisstock, J., Porter, C.J., Rood, J.I., 2010, The subtilisin-like protease AprV2 is required for virulence and uses a novel disulphide-tethered exosite to bind substrates, Plos Pathogens [P], vol 6, issue 11, Public Library of Science, USA, pp. 1-12.

Tchoubrieva, E.B., Ong, P.C., Pike, R.N., Brindley, P.J., Kalinna, B.H., 2010, Vector-based RNA interference of cathepsin B1 in Schistosoma mansoni, Cellular And Molecular Life Sciences [P], vol 67, issue 21, Birkhaeuser Verlag AG, Switzerland, pp. 3739-3748.

Beckham, S.A., Piedrafita, D.M., Phillips, C.I., Samarawickrema, N., Law, R.H.P., Smooker, P.M., Quinsey, N.S., Irving, J.A., Greenwood, D.L., Verhelst, S.H.L., Bogyo, M., Turk, B., Coetzer, T.H., Wijeyewickrema, L.C., Spithill, T.W., Pike, R.N., 2009, A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites, International Journal of Biochemistry and Cell Biolog..., vol 41, issue 7, Pergamon, UK, pp. 1601-1612.

Beckham, S.A., Boyd, S.E., Reynolds, S., Willis, C., Johnstone, M., Mika, A., Simerska, P., Wijeyewickrema, L.C., Smith, A.I., Kemp, D.J., Pike, R.N., Fischer, K., 2009, Characterization of a serine protease homologous to house dust mite group 3 allergens from the scabies mite sarcoptes scabiei, Journal Of Biological Chemistry [P], vol 284, issue 49, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 34413-34422.

Ong, P.C., Golding, S.J., Pearce, M.C., Irving, J.A., Grigoryev, S.A., Pike, D., Langendorf, C.G., Bashtannyk-Puhalovich, T.A., Bottomley, S.P., Whisstock, J.C., Pike, R.N., McGowan, S., 2009, Conformational change in the chromatin remodelling protein MENT, PL o S One, vol 4, issue 3 (e4727), Public Library of Science, USA, pp. 1-5.

Boyd, S.E., Kerr, F.K., Albrecht, D.W., Garcia De La Banda, M.J., Ng, N., Pike, R.N., 2009, Cooperative effects in the substrate specificity of the complement protease C1s, Biological Chemistry [P], vol 390, issue 5/6, Walter De Gruyter & Co, Berlin Germany, pp. 503-507.

Potempa, J., Pike, R.N., 2009, Corruption of innate immunity by bacterial proteases, Journal of Innate Immunity [P], vol 1, issue 12, S Karger AG, Switzerland, pp. 70-87.

McAlister, A.D., Sroka, A., Fitzpatrick, R.E., Quinsey, N.S., Travis, J., Potempa, J., Pike, R.N., 2009, Gingipain enzymes from Porphyromonas gingivalis preferentially bind immobilized extracellular proteins: A mechanism favouring colonization?, Journal of Periodontal Research, vol 44, Wiley-Blackwell Munksgaard, Denmark, pp. 348-353.

Murray-Rust, T.A., Kerr, F.K., Thomas, A.R., Wu, T.J., Yongqing, T., Ong, P.C., Quinsey, N.S., Whisstock, J.C., Wagenaar-Bos, I.C., Freeman, C., Pike, R.N., 2009, Modulation of the proteolytic activity of the complement protease C1s by polyanions: Implications for polyanion-mediated acceleration of interaction between C1s and SERPING1, Biochemical Journal [P], vol 422, issue 2, Portland Press Ltd, UK, pp. 295-303.

Bergstrom, F.C., Reynolds, S., Johnstone, M., Pike, R.N., Buckle, A.M., Kemp, D.J., Fischer, K., Blom, A.M., 2009, Scabies mite inactivated serine protease paralogs inhibit the human complement system, Journal Of Immunology [P], vol 182, issue 12, American Association of Immunologists, USA, pp. 7809-7817.

Fischer, K., Langendorf, C., Irving, J.A., Reynolds, S., Willis, C., Beckham, S.A., Law, R.H.P., Yang, S., Bashtannyk-Puhalovich, T.A., McGowan, S., Whisstock, J., Pike, R.N., Kemp, D.J., Buckle, A.M., 2009, Structural mechanisms of inactivation in scabies mite serine protease paralogues, Journal of Molecular Biology [P], vol 390, issue 4, Academic Press, UK, pp. 635-645.

Ng, N.M., Pike, R.N., Boyd, S.E., 2009, Subsite cooperativity in protease specificity, Biological Chemistry, vol 390, issue 5-6, Walter de Gruyter GmbH & Co. KG, Germany, pp. 401-407.

Ng, N.M., Quinsey, N.S., Matthews, A.Y., Kaiserman, D., Wijeyewickrema, L.C., Bird, P.I., Thompson, P.E., Pike, R.N., 2009, The effects of exosite occupancy on the substrate specificity of thrombin, Archives Of Biochemistry And Biophysics [P], vol 489, issue 1-2, Academic Press, USA, pp. 48-54.

Fitzpatrick, R.E., Campbell, P.D., Sivagurunathan, S., Pagel, C.N., Potempa, J., Mackie, E.J., Pike, R.N., 2009, The gingipains from Porphyromonas gingivalis do not directly induce osteoclast differentiation in primary mouse bone marrow cultures, Journal of Peridontal Research, vol 44, Wiley-Blackwell Munksgaard, Denmark, pp. 565-567.

Fitzpatrick, R.E., Wijeyewickrema, L.C., Pike, R.N., 2009, The gingipains: scissors and glue of the periodontal pathogen, Porphyromonas gingivalis, Future Microbiology [P], vol 4, issue 4, Future Medicine Ltd, UK, pp. 471-487.

Pagel, C.N., Song, S., Loh, L.H., Tudor, E.M., Murray-Rust, T.A., Pike, R.N., Mackie, E.J., 2009, Thrombin-stimulated growth factor and cytokine expression in osteoblasts is mediated by protease-activated receptor-1 and prostanoids, Bone, vol 44, issue 5, Elsevier Inc., USA, pp. 813-821.

Kerr, F.K., Thomas, A.R., Wijeyewickrema, L.C., Whisstock, J., Boyd, S.E., Kaiserman, D., Matthews, A.Y., Bird, P.I., Thielens, N.M., Rossi, V., Pike, R.N., 2008, Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor, Molecular Immunology, vol 45, Pergamon-Elsevier Science Ltd, Oxford England UK, pp. 670-677.

Smith, R., Spithill, T.W., Pike, R.N., Meeusen, E.N.T., Piedrafita, D.M., 2008, Fasciola hepatica and Fasciola gigantica: Cloning and characterisation of 70 kDa heat-shock proteins reveals variation in HSP70 gene expression between parasite species recovered from sheep, Experimental Parasitology, vol 118, Academic Press Inc Elsevier Science, San Diego, CA, USA, pp. 536-542.

Uaesoontrachoon, K., Yoo, H., Tudor, E.M., Pike, R.N., Mackie, E.J., Pagel, C.N., 2008, Osteopontin and skeletal muscle myoblasts: Association with muscle regeneration and regulation of myoblast function in vitro, The International Journal of Biochemistry & Cell Biology, vol 40, issue 10, Pergamon, United Kingdom, pp. 2303-2314.

Duncan, R.C., Wijeyewickrema, L.C., Pike, R.N., 2008, The initiating proteases of the complement system: controlling the cleavage, Biochimie, vol 90, Elsevier France-Editions Scientifiquers Medicales Elsevier, Paris France, pp. 387-395.

Rosado, C.J., Buckle, A.M., Law, R.H.P., Butcher, R.E., Kan, W., Bird, C.H., Ung, K., Browne, K.A., Baran, K., Bashtannyk-Puhalovich, T.A., Faux, N.G., Wong, W., Porter, C.J., Pike, R.N., Ellisdon, A.M., Pearce, M.C., Bottomley, S.P., Emsley, J., Smith, A.I., Rossjohn, J., Hartland, E.L., Voskoboinik, I., Trapani, J.A., Bird, P.I., Dunstone, M.A., Whisstock, J., 2007, A common fold mediates vertebrate defense and bacterial attack, Science, vol 317, issue 5844, American Association of Advancement in Science, Washington, DC, USA, pp. 1548-1551.

Ong, P.C., McGowan, S., Pearce, M.C., Irving, J.A., Kan, W., Grigoryev, S.A., Turk, B., Silverman, G.A., Brix, K., Bottomley, S.P., Whisstock, J., Pike, R.N., 2007, DNA accelerates the inhibition of human cathepsin V by serpins, Journal of Biological Chemistry, vol 282, issue 51, American Society of Biochemistry & Molecular Biology Inc, Bethesda MD USA, pp. 36980-36986.

Fenalti, G., Law, R.H.P., Buckle, A.M., Langendorf, C., Tuck, K.L., Rosado, C.J., Faux, N.G., Mahmood, K., Hampe, C.S., Banga, J.P., Wilce, M.C.J., Schmidberger, J., Rossjohn, J., El-Kabbani, O., Pike, R.N., Smith, A.I., Mackay, I.R., Rowley, M.J., Whisstock, J., 2007, GABA production by glutamic acid decarboxylase is regulated by a dynamic catalytic loop, Nature Structural & Molecular Biology, vol 14, issue 4, Nature Publishing Group, New York NY USA, pp. 280-286.

Paterson, M.A., Horvath, A.J., Pike, R.N., Coughlin, P.B., 2007, Molecular characterization of centerin, a germinal centre cell serpin, Biochemical Journal, vol 405, issue 3, Portland Press Ltd, UK, pp. 489-494.

Law, R.H.P., Zhang, Q., McGowan, S., Buckle, A.M., Silverman, G.A., Wong, W., Rosado, C.J., Langendorf, C., Pike, R.N., Bird, P.I., Whisstock, J., 2006, An overview of the serpin superfamily, Genome Biology, vol 7, issue 5, Biomed Central Ltd, London UK, pp. 216-1-216-11.

Bromfield, K.M., Quinsey, N.S., Duggan, P.J., Pike, R.N., 2006, Approaches to selective peptidic inhibitors of factor Xa, Chemical Biology & Drug Design, vol 68, issue 1, Blackwell Publishing, Oxford England, pp. 11-19.

Pagel, C.N., Sivagurunathan, S., Loh, L.H., Tudor, E.M., Pike, R.N., Mackie, E.J., 2006, Functional responses of bone cells to thrombin, Biological Chemistry, vol 387, issue 8, Walter de Gruyter & Co., Berlin Germany, pp. 1037-1041.

Beckham, S.A., Law, R.H., Smooker, P.M., Quinsey, N.S., Caffrey, C.R., McKerrow, J.H., Pike, R.N., Spithill, T.W., 2006, Production and processing of a recombinant Fasciola hepatica cathepsin B-like enzyme (FhcatB1) reveals potential processing mechanisms in the parasite, Biological Chemistry, vol 387, issue 8, Walter de Gruyter & Co., Berlin Germany, pp. 1053-1061.

McGowan, S., Buckle, A.M., Irving, J.A., Ong, P.C., Bashtannyk-Puhalovich, T.A., Kan, W., Henderson, K., Bulynko, Y.A., Popova, E.Y., Smith, A.I., Bottomley, S.P., Rossjohn, J., Grigoryev, S.A., Pike, R.N., Whisstock, J.C., 2006, X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation, The EMBO Journal, vol 25, issue 13, Nature Publishing Group, New York USA, pp. 3144-3155.

O'Brien-Simpson, N.M., Pathirana, R.D., Paolini, R.A., Chen, Y., Veith, P.D., Tam, V., Ally, N., Pike, R.N., Reynolds, E.C., 2005, An Immune Response Directed to Proteinase and Adhesin Functional Epitopes Protects against Porphyromonas gingivalis-Induced Periodontal Bone loss, Journal of Immunology, vol 175, issue 6, American Association of Immunologists, Bethesda USA, pp. 3980-3989.

Pike, R.N., Buckle, A.M., Le Bonniec, B., Church, F., 2005, Control of the coagulation system by serpins: getting by with a little help from glycosaminoglycans, FEBS Journal, vol 272, issue 19, Blackwell Publishing, Oxford UK, pp. 4842-4851.

Kerr, F.K., O'Brien, G., Quinsey, N.S., Whisstock, J., Boyd, S.E., Garcia De La Banda, M.J., Kaiserman, D., Matthews, A.Y., Bird, P.I., Pike, R.N., 2005, Elucidation of the substrate specificity of the C1s protease of the classical complement pathway, Journal of Biological Chemistry, vol 280, issue 47, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 39510-39514.

Boyd, S.E., Pike, R.N., Rudy, G.B., Whisstock, J., Garcia De La Banda, M.J., 2005, PoPS: A computational tool for modeling and predicting protease specificity, Journal of Bioinformatics and Computational Biology, vol 3, issue 3, Imperial College Press, London UK, pp. 551-585.

Whisstock, J., Bottomley, S.P., Bird, P.I., Pike, R.N., Coughlin, P.B., 2005, Serpins 2005 - fun between the beta-sheets : Meeting report based upon presentations made at the 4th International Symposium on Serpin Structure, Function and Biology (Cairns, Australia), FEBS Journal, vol 272, issue 19, Blackwell Publishing, Oxford UK, pp. 4868-4873.

Song, S.J., Pagel, C.N., Pike, R.N., Mackie, E.J., 2005, Studies on the receptors mediating responses of osteoblasts to thrombin, International Journal of Biochemistry & Cell Biology, vol 37, issue 1, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 206-213.

Quinsey, N.S., Pike, R.N., 2005, Substrate specificity of mannose lectin binding associated serine proteinase 3, Febs Journal, vol 272, Blackwell Publishing, Oxford England, p. 174.

Horvath, A.J., Irving, J.A., Rossjohn, J., Law, R.H.P., Bottomley, S.P., Quinsey, N.S., Pike, R.N., Coughlin, P.B., Whisstock, J., 2005, The murine orthologue of human antichymotrypsin: a structural paradigm for CLADE A3 serpins, Journal of Biological Chemistry, vol 280, issue 52, American Society for Biochemistry and Molecular Biology, Inc., Bethesda USA, pp. 43168-43178.

Song, S.J., Pagel, C.N., Campbell, T.M., Pike, R.N., Mackie, E.J., 2005, The role of protease-activated receptor-1 in bone healing, American Journal of Pathology, vol 166, issue 3, American Society for Investigative Pathology, Inc., Bethesda USA, pp. 857-868.

Smith, R.A., Ransjo, M., Tatarczuch, L., Song, S., Pagel, C.N., Morrison, J.R., Pike, R.N., Mackie, E.J., 2004, Activation of protease-activated receptor-2 leads to inhibition of osteoclast differentiation, Journal of Bone and Mineral Research, vol 19, issue 3, American Society for Bone and Mineral Research, Washington USA, pp. 507-516.

Quinsey, N.S., Greedy, A.L., Bottomley, S.P., Whisstock, J.C., Pike, R.N., 2004, Antithrombin: in control of coagulation, The International Journal of Biochemistry & Cell Biology, vol 36, issue 3, Pergamon-Elsevier Science Ltd, Kidlington England, pp. 386-389.

Dafforn, T.R., Pike, R.N., Bottomley, S.P., 2004, Physical characterization of serpin conformations, Methods, vol 32, issue 2, Academic Press Inc. Elsevier Science, San Diego USA, pp. 150-158.

Sztukowska, M., Sroka, A., Bugno, M., Banbula, A., Takahashi, Y., Pike, R.N., Genco, C.A., Travis, J., Potempa, J., 2004, The C-terminal domains of the gingipain K polyprotein are necessary for assembly of the active enzyme and expression of associated activities, Molecular Microbiology, vol 54, issue 5, Blackwell Publishing Ltd, Oxford England, pp. 1393-1408.

Ally, N., Whisstock, J.C., Sieprawskalupa, M., Potempa, J., Le Bonniec, B.F., Travis, J., Pike, R.N., 2003, Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes, Biochemistry, vol 42, issue 40, American Chemical Society, Washington USA, pp. 11693-11700.

Law, R.H.P., Smooker, P.M., Irving, J.A., Piedrafita, D., Ponting, R., Kennedy, N.J., Whisstock, J.C., Pike, R.N., Spithill, T.W., 2003, Cloning and expression of the major secreted cathepsin B-Iike protein from juvenile Fasciola hepatica and analysis of immunogenicity following liver fluke infection, Infection and Immunity, vol 71, issue 12, American Society for Microbiology, Washington USA, pp. 6921-6932.

Ludeman, J.P., Pike, R.N., Bromfield, K.M., Duggan, P.J., Cianci, J., Le Bonniec, B., Whisstock, J.C., Bottomley, S.P., 2003, Determination of the P'1, P'2 and P'3 subsite-specificity of factor Xa, International Journal of Biochemistry & Cell Biology, vol 35, issue 2, Pergamon-Elsevier Science Ltd, Oxford England, pp. 221-225.

Hodder, A.N., Drew, D.R., Epa, C., Delorenzi, M., Bourgon, R., Miller, S.K., Moritz, R.L., frecklington, D.F., Simpson, R.J., Speed, T.P., Pike, R.N., Crabb, B.S., 2003, Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5, Journal of Biological Chemistry, vol 278, issue 48, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 48169-48177.

Welss, T., Sun, J., Irving, J.A., Blum, R., Smith, A.I., Whisstock, J.C., Pike, R.N., Von Mikecz, A., Ruzicka, T., Bird, P.I., Abts, H., 2003, Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from ultraviolet-induced apoptosis, Biochemistry, vol 42, issue 24, American Chemical Society, Washington USA, pp. 7381-7389.

O'Brien, G., Quinsey, N.S., Whisstock, J.C., Pike, R.N., 2003, Importance of the prime subsites of the C1s protease of the classical complement pathway for recognition of substrates, Biochemistry, vol 42, issue 50, American Chemical Society, Washington USA, pp. 14939-14945.

Pagel, C.N., De Niese, M.R., Abraham, L.A., Chinni, C., Song, S., Pike, R.N., Mackie, E.J., 2003, Inhibition of osteoblast apoptosis by thrombin, Bone, vol 33, issue 4, Elsevier Science Inc., New York USA, pp. 733-743.

Quinsey, N.S., Fitton, H.L., Coughlin, P.B., Whisstock, J.C., Dafforn, T.R., Carrell, R.W., Bottomley, S.P., Pike, R.N., 2003, Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability, Biochemistry, vol 42, issue 34, American Chemical Society, Washington USA, pp. 10169-10173.

Irving, J.A., Cabrita, L.D., Rossjohn, J., Pike, R.N., Bottomley, S.P., Whisstock, J.C., 2003, The 1.5 crystal structure of a prokaryote serpin: controlling conformational change in a heated environment, Structure, vol 11, issue 4, Cell Press, Cambridge USA, pp. 387-397.

Bianchini, E.P., Pike, R.N., Le Bonniec, B.F., 2003, The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions, Journal of Biological Chemistry, vol e-pub, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 1-41.

Irving, J.A., Spithill, T.W., Pike, R.N., Whisstock, J.C., Smooker, P.M., 2003, The evolution of enzyme specificity in Fasciola spp., Journal of Molecular Evolution, vol 57, issue 1, Springer-Verlag, New York USA, pp. 1-15.

Nuttall, S.N., Krishnan, U.V., Doughty, L., Nathanielsz, A., Ally, N., Pike, R.N., Hudson, P.J., Kortt, A.A., Irving, R.A., 2002, A naturally occurring NAR variable domain binds the Kgp protease from Porphyromonas gingivalis, FEBS Letters, vol 516, issue 1-3, Elsevier Science BV, Amsterdam Netherlands, pp. 80-86.

De Niese, M.R., Chinni, C., Pike, R.N., Bottomley, S., Mackie, E.J., 2002, Dissection of protease-activated receptor-1-dependent and -independent responses to thrombin in skeletal myoblasts, Experimental Cell Research, vol 274, issue 1, Academic Press Inc Elsevier Science, San Diego CA USA, pp. 149-156.

Irving, J., Pike, R.N., Dai, W., Bromme, D., Worrall, M.D., Silverman, G.A., Coetzer, T.H., Dennison, C., Bottomley, S., Whisstock, J.C., 2002, Evidence that serpin architecture intrinsically supports papain-like cystein protease inhibition: Engineering 1- abutrypsin to inhibit acathepsin proteases, Biochemistry, vol 41, issue 15, American Chemical Society, Washington DC USA, pp. 4998-5004.

Irving, J.A., Shushanov, S., Pike, R.N., Popova, E.Y., Bromme, D., Coetzer, T.H., Bottomley, S., Boulynko, I.A., Grigoreyev, S.A., Whisstock, J.C., 2002, Inhibitory activity of a heterchromatin-associated serpin (MENT) against papain like cystein proteinases affects chromatin structure and blocks cell proliferation, The Journal of Biological Chemistry, vol 277, issue 15, American Society Biochemistry Molecular Biology Inc, Bethesda MD USA, pp. 13192-13201.

Quinsey, N.S., Whisstock, J.C., Le Bonniec, B., Louvain, V., Bottomley, S.P., Pike, R.N., 2002, Molecular determinants of the mechanisms underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide, The Journal of Biological Chemistry, vol 277, issue 18, American Society of Biochemistry and Molecular Biology, Bethesda MS USA, pp. 15971-15978.

Mackie, E.J., Pagel, C.N., Smith, R., De Niese, M.R., Song, S., Pike, R.N., 2002, Protease-activated receptors: A means of converting extracellular proteolysis into intracellular signals, IUBMB Life, vol 53, issue 6, Taylor & Francis, Philadelphia PA USA, pp. 277-281.

Irving, J., Steenbakkers, P.J., Lesk, A.M., Op Den Camp, H.J., Pike, R.N., Whisstock, J.C., 2002, Serpins in Prokaryotes, Molecular Biology and Evolution, vol 19, issue 11, Society Molecular Biology Evolution, Lawrence KS USA, pp. 1881-1890.

Pike, R.N., Bottomley, S., Irving, J., Bird, P.I., Whisstock, J.C., 2002, Serpins: finely balanced conformational traps, IUBMB Life, vol 54, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 1-7.

Lourbakos, A., Yuan, Y., Jenkins, A.L., Travis, J., Andrade-Gordon, P., Santulli, R., Potempa, J., Pike, R.N., 2001, Activation of protease-activated receptors by gingipains from porphyromonas gingivalis leads to platelet aggregation: a new trait in micobial pathogenicity, Blood, vol 97, issue 12, American Society of Hematology, Washington DC USA, pp. 3790-3797.

Lourbakos, A., Potempa, J., Travis, J., D'Andrea, M., Andrade-Gordon, P., Santulli, R., Pike, R.N., 2001, Arginine-specific protease from porphyromonas gingivalis activates protease-activated receptors on human oral epithelial cells and induces interleukin-6 secretion, Infection and Immunity, vol 69, issue 8, American Society for Microbiology, Washington DC USA, pp. 5121-5130.

Bottomley, S., Lawrenson, I.D., Tew, D.J., Dai, W., Whisstock, J.C., Pike, R.N., 2001, The role of strand 1 of the C b-sheet in the structure and function of a1- antitrypsin, Protein Science, vol 10, Cold Spring Harbor Laboratory Press, Plainview New York NY USA, pp. 2518-2524.

Smooker, P.M., Whisstock, J.C., Irving, J., Siyaguna, S., Spithill, T.W., Pike, R.N., 2000, A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica, Protein Science, vol 9, Cambridge University Press, New York NY USA, pp. 1-6.

Dunstone, M.A., Dai, W., Whisstock, J.C., Rossjohn, J., Pike, R.N., Feil, S.C., Le Bonniec, B., Parker, M.W., Bottomley, S.P., 2000, Cleaved antitrypsin polymers at atominc resolution, Protein Science, vol 9, Cambridge University Press, New York NY USA, pp. 417-420.

Whisstock, J.C., Pike, R.N., Jin, L., Skinner, R., Pei, X.Y., Carrell, R.W., Lesk, A.M., 2000, Conformational changes in serpins: II. The mechanism of activation of antithrombin by heparin, Journal of Molecular Biology, vol 301, Academic Press Ltd, London UK, pp. 1287-1305.

Smith, R., Jenkins, A.L., Lourbakos, A., Thompson, P.E., Ramakrishnan, V., Tomlinson, J., Deshpande, U., Johnson, D.A., Jones, R., Mackie, E.J., Pike, R.N., 2000, Evidence for the activation of PAR-2 by the sperm protease, acrosin: expression of the receptor on oocytes, FEBS Letters, vol 484 issue 1, Elsevier Science BV, Amsterdam Netherlands, pp. 285-290.

Hopkins, P., Pike, R.N., Stone, S.R., 2000, Evolution of serpin specificity: cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C, Journal of Molecular Evolution, vol 51, Springer-Verlag, New York NY USA, pp. 507-515.

Abraham, L.A., Chinni, C., Jenkins, A.L., Lourbakos, A., Ally, N., Pike, R.N., Mackie, E.J., 2000, Expression of proteas-activated receptor-2 by osteoblasts, Bone, vol 26 issue 1, Elsevier Science Inc, New York NY USA, pp. 7-14.

Irving, J., Pike, R.N., Lesk, A.M., Whisstock, J.C., 2000, Phylogeny of the serpin superfamily: Implications of patterns of amino acid conservation for structure and function, Genome Research, vol 10 issue 12, Cold Sprin Harbor Laboratory Press, Plainview USA, pp. 1845-1864.

Osicka, T.M., Yu, Y., Panagiotopoulos, S., Clavant, S.P., Kiriazis, Z., Pike, R.N., Pratt, L.M., Russo, L.M., Kemp, B.E., Comper, W.D., Jerums, G., 2000, Prevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C, Diabetes, vol 49 issue 1, American Diabetes Association, Alexandria USA, pp. 87-93.

Chinni, C., De Niese, M.R., Jenkins, A.L., Pike, R.N., Bottomley, S.P., Mackie, E.J., 2000, Protease-activated receptor-2 mediates proliferative responses in skeletal myoblasts, Journal of Cell Science, vol 113, Company of Biologists Ltd, Cambridge UK, pp. 4427-4433.

Troeberg, L., Morty, R.E., Pike, R.N., Lonsdale-Eccles, J.D., Palmer, J.T., McKerrow, J.H., Coetzer, T.H., 1999, Cysteine proteinase inhibitors kill cultured bloodstream forms of "Trypanosoma brucei brucei", Experimental Parasitology, vol 91, Academic Press, www.idealibrary.com, pp. 349-355.

Whisstock, J.C., Irving, J., Bottomley, S.P., Pike, R.N., Lesk, A.M., 1999, Serpins in the "Caenorhabditis elegans" genome, Proteins-Structure Function and Genetics, vol 36, Wiley-Liss, Inc., URL:http://www.sanger.ac.uk/Projects/C_elegans/wo/, pp. 31-41.

Morty, R.E., Troeberg, L., Pike, R.N., Jones, R., Nickel, P., Lonsdale-Eccles, J.D., Coetzer, T.H., 1998, A trypanosome oligopeptidase as a target for the trypanocidal agents pentamidine, diminazene and suramin, FEBS Letters, vol 433 no 3, Elsevier Science B.V., Netherland, pp. 251-256.

Streatfeild-James, R.M., Williamson, D., Pike, R.N., Tewksbury, D., Carrell, R.W., Coughlin, P.B., 1998, Angiotensinogen cleavage by renin: importance of a structurally constrained N-terminus, FEBS Letters, vol 436 no 2, Elsevier B.V., Netherland, pp. 267-270.

Lourbakos, A., Chinni, C., Thompson, P.E., Potempa, J., Travis, J., Mackie, E.J., Pike, R.N., 1998, Cleavage and activation of preinase-activated receptor-2 on human neutrphil s by gingpain -R from Porphyromonas gingivilis, FEBS Letters, vol 435 no 1, Elsevier B.V., Amsterdam Netherlands, pp. 45-48.

Conference Proceedings

Ng, N., Boyd, S.E., Bird, P.I., Thompson, P., Matthews, A.Y., Kaiserman, D., Pike, R.N., 2007, The effects of thrombomodulin on the substrate specificity of thrombin, 5th General Meeting of the International Proteolysis Society Book of Abstracts, 20 October 2007 to 24 October 2007, Novartis Pharma A, Basel Switzerland, p. 375.

Sommerhoff, C.P., Dunn, B.M., Pike, R.N., 2006, Guest Editorial Protease Inhibitors, 4th General Meeting of the International Proteolysis Society/International Conference on Protease Inhibitors, 19-25 October 2005, Walter De Gruyter & Co, Berlin Germany, p. 825.

Boyd, S.E., Garcia De La Banda, M.J., Pike, R.N., Whisstock, J., Rudy, G.B., 2004, PoPS: a computational tool for modeling and predicting protease specificity, Proceedings of the 2004 IEEE Computational Systems Bioinformatics Conference, 16 August 2004 to 19 August 2004, IEEE Computer Society Press, Los Alamitos USA, pp. 372-381.

Ally, N., Pike, R.N., 1999, Binding affinity of gingipain proteinase-adhesins to a range of proteins, Proceedings, 24th Annual Lorne Conference on Protein Structure and Function, Lorne, Vic 7-11 February 1999, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. A4.

Smith, S.R., Whisstock, J.C., Lawrenson, I.D., Hopkins, P., Ludeman, J., Bottomley, S.P., Pike, R.N., 1999, Engineering a novel factor Xa inhibitor, Proceedings, 24th Annual Conference on Protein Structure and Function, Lorne Vic 7-11 February 1999, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. B12.

Irving, J., Pike, R.N., Whisstock, J.C., 1999, Substitution of the reactive centre loop of antitrypsin with that of SCCA1 yields a chimeric protein capable of inhibiting cysteine proteinases of the papain superfamily, Proceedings, 24th Annual Lorne Conference on Protein Structure and Function, Lorne Vic 7-11 February 1999, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. A8.

Lawrenson, I.D., Whisstock, J.C., Pike, R.N., Bottomley, S.P., 1999, The importance of strand 1C in the inhibitory mechanism of alpha1-antitrypsin, Proceedings, 24th Annual Conference on Protein Structure and Function, Lorne Vic 7-11 February 1999, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. C38.

Whisstock, J.C., Lesk, A.M., Pike, R.N., 1999, The mechanism of anticoagulant activation of antithrombin by heparin, Proceedings, 24th Annual Lorne Conference on Protein Structure and Function, Lorne Vic 7-11 February 1999, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. C39.

Irving, J., Boyd, S., Pike, R.N., Whisstock, J.C., 1999, The phylogeny of the serpin superfamily, Proceedings, 24th Annual Lorne Conference on Protein Structure and Function, Lorne Vic 7-11 February 1999, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. C40.

Lourbakos, A., Chinni, C., Mackie, E.J., Pike, R.N., 1998, Activation ofproteinase activated receptor - 2 on human neutrophils by arginine gingpain from Porphyromonas gingivalis, Proceedings, 23rd Annual Lorne Conference on Protein Structure and Function, Lorne VIC 8-12 February 1998, Lorne Protein Workshop, Inc., Melbourne Vic Australia, p. 51.

Pike, R.N., Smooker, P.M., Irving, J., Whisstock, J.C., Spithill, T.W., 1998, Characterization of a recombinant Fasciola Hepatica cathepsin L, The Australian Society for Parasitology, Melbourne VIC, 27 Sept - 1 Oct 1998, Australian Society for Parasitology, Melbourne Vic Australia, p. 63.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The kinetic mechanism of interaction between the complement porteases C1s and MASP-2 and the substrate C4?.

Supervisors:

Pike, R (Main), Wijeyewickrema, L (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The structure and function of the human conplement protease, MASP-3.

Supervisors:

Pike, R (Main), Wijeyewickrema, L (Associate).

Completed Supervision

Student:

Ally, N.

Program of Study:

THE SPECIFICITY OF PROTEINASE-ADHESINS FROM PORPHYROMONAS GINGIVALIS. (PHD) 2003.

Supervisors:

Pike, R (Main), Spithill, T (Associate).

Student:

Beckham, S.

Program of Study:

CHARACTERISATION OF A CATHEPSIN B-LIKE CYSTEINE PROTEASE FROM JUVENILE FASCIOLA HEPATICA. (PHD) 2005.

Supervisors:

Pike, R (Main), Spithill, T (Associate).

Student:

Boyd, S.

Program of Study:

COMPUTATIONAL MODELLING AND PREDICTION OF PROTEASE SPECIFICITY. (PHD) 2005.

Supervisors:

Garcia De La Banda, M (Main), Pike, R (Associate), Whisstock, J (Associate).

Student:

Bromfield, K.

Program of Study:

APPROACHES TOWARD FACTOR Xa INHIBITION. (PHD) 2005.

Supervisors:

Langford, S (Main), Pike, R (Associate).

Student:

Bugarin, M.

Program of Study:

PRODUCTION OF RECOMBINANT FASCIOLA HEPATIZA PROCATHEPSIN B: PRUIFICATION AND CHARACTERISATION. (Masters) 2000.

Supervisors:

Pike, R (Main), Spithill, T (Associate).

Student:

Duncan, R.

Program of Study:

The molecular mechanisms of the interaction between complement proteases and substrates. (PHD) 2011.

Supervisors:

Pike, R (Main).

Student:

Faux, N.

Program of Study:

The role of single amino acid repeats in protein function and evolution. (PHD) 2008.

Supervisors:

Whisstock, J (Main), Garcia De La Banda, M (Associate), Pike, R (Associate).

Student:

Fitzpatrick, R.

Program of Study:

Functional analysis of the gingipains from Porphyromonas gingivalis and their role in periodontal disease. (PHD) 2011.

Supervisors:

Pike, R (Main).

Student:

Irving, J.

Program of Study:

SERPINS: EVOLUTION AND CYSTEINE PROTEINASE INHIBITION. (PHD) 2002.

Supervisors:

Pike, R (Main), Spithill, T (Associate), Whisstock, J (Associate).

Student:

Kennedy, N.

Program of Study:

Assessment and enhancement of protein and DNA vaccines using candidate Fasciola antigens. (PHD) 2005.

Supervisors:

Pike, R (Main), Piedrafita, D (Associate), Spithill, T (Associate).

Student:

Kerr, F.

Program of Study:

Regulation of the complement proteases: C1s and MASP-2. (PHD) 2007.

Supervisors:

Pike, R (Main).

Student:

Lourbakos, A.

Program of Study:

ACTIVATION OF HUMAN PROTEASE-ACTIVATED RECEPTORS BY PROTEASES FROM A PERIODONTAL PATHOGEN. (PHD) 2001.

Supervisors:

Pike, R (Main).

Student:

Ng, N.

Program of Study:

Determinants of thrombin specificity. (PHD) 2010.

Supervisors:

Pike, R (Main), Boyd, S (Associate).

Student:

O'Brien, G.

Program of Study:

THE INTERACTION OF PROTEASES OF THE COMPLEMENT SYSTEM WITH PHYSIOLOGICAL SUBSTRATES. (PHD) 2003.

Supervisors:

Pike, R (Main), Spithill, T (Associate).

Student:

Ong, P.

Program of Study:

Investigation of the chromatin condensation mechanism of the nuclear serpin, MENT. (PHD) 2008.

Supervisors:

Pike, R (Main), Whisstock, J (Joint).

Student:

Rainczuk, A.

Program of Study:

EVALUATION OF DNA VACCINE TARGETING STRATEGIES AND EXPRESSION LIBRARY IMMUNISATION AGAINST LETHAL ERYTHROCYTIC STAGE MALARIA. (PHD) 2003.

Supervisors:

Pike, R (Main), Piedrafita, D (Associate), Spithill, T (Associate).

Student:

Smith, R.

Program of Study:

Differential gene expression studies in Fasciola species. (PHD) 2006.

Supervisors:

Pike, R (Main), Piedrafita, D (Associate), Spithill, T (Associate).

Student:

Smith, R.

Program of Study:

PROTEASE-ACTIVATED RECEPTOR-2 ON OSTEOBLASTS: THE EFFECT OF RECEPTOR ACTIVATION ON MODULATION OF BONE HOMEOSTASIS. (PHD) 2004.

Supervisors:

Pike, R (Main).

Student:

Wu, T.

Program of Study:

PRODUCTION AND CHARACTERIZATION OF RECOMBINANT ALPHA 1 - ANTITRYPSIN VARIANTS WITH SPECIFICITY FOR COMPLEMENT PROTEASES C1s AND C1r. (Masters) 2006.

Supervisors:

Pike, R (Main).