Dr Bradley Broughton - Researcher Profile

Biography

Dr Brad Broughton has an emerging profile in both the national and international cardiovascular community. Brad is currently a Foundation for High Blood Pressure Research Fellow and is a senior member of the Vascular Biology and Immunopharmacology Group in the Department of Pharmacology. He is a member of two Editorial Boards (ISRN Stroke and Physiology Journal) and is a Chief Investigator on a NHMRC Project Grant and Grant-in-aid from the National Heart Foundation.

Over the past 12 years, Brad's research has contributed to our knowledge of reactive oxygen species, calcium, apoptosis, oestrogen, Rho kinase and nitric oxide signalling in the systemic, pulmonary and cerebral circulations. His studies have elucidated physiological mechanisms in vivo and in vitro, identified gender differences, as well as abnormalities in diseases including stroke, pulmonary hypertension and atherosclerosis. The primary focus of his current research is to advance our understanding of mechanisms that contribute to brain damage after stroke, develop safe and effective stroke therapies and identify novel imaging agents that detect cell loss in the brain following stroke.

Qualifications

PHILOSOPHY

Institution: Deakin University

Year awarded: 2005

SCIENCE

Institution: Deakin University

Year awarded: 2001

Publications

Book Chapters

Resta, T.C., Broughton, B.R.S., Jernigan, N.L., 2010, Reactive oxygen species and RhoA signaling in vascular smooth muscle: role in chronic hypoxia-induced pulmonary hypertension, in Advances in Experimental Medicine and Biology, eds JX-J Yuan & JPT Ward, Humana Press, USA, pp. 355-374.

Journal Articles

Norton, C.E., Broughton, B.R., Jernigan, N.L., Walker, B.R., Resta, T.C., 2013, Enhanced Depolarization-Induced Pulmonary Vasoconstriction Following Chronic Hypoxia Requires EGFR-dependent Activation of NAD(P)H Oxidase 2, Antioxidants and Redox Signaling [P], vol E-pub, Mary Ann Liebert Inc Publishers, USA, pp. 1-54.

Broughton, B.R., Brait, V.H., Guida, E., Lee, S., Arumugam, T.V., Gardiner-Mann, C.V., Miller, A.A., Tang, S., Drummond, G.R., Sobey, C.G., 2013, Stroke Increases G Protein-Coupled Estrogen Receptor Expression in the Brain of Male but Not Female Mice, Neurosignals [P], vol E-pub, S Karger AG, Switzerland, pp. 1-11.

McCarthy, C.A., Vinh, A., Broughton, B.R., Sobey, C.G., Callaway, J.K., Widdop, R.E., 2012, Angiotensin II Type 2 receptor stimulation initiated after stroke causes neuroprotection in conscious rats, Hypertension [P], vol 60, issue 6, Lippincott Williams & Wilkins, USA, pp. 1531-1537.

Ding, A., Kalaignanasundaram, P., Ricardo, S.D., Abdelkader, A., Witting, P.K., Broughton, B.R., Kim, H.B., Wyse, B.F., Phillips, J.K., Evans, R.G., 2012, Chronic treatment with tempol does not significantly ameliorate renal tissue hypoxia or disease progression in a rodent model of polycystic kidney disease, Clinical and Experimental Pharmacology and Physiology [E], vol 39, issue 11, Wiley-Blackwell Publishing Asia, Australia, pp. 917-929.

Gardiner, B.S., Thompson, S.L., Ngo, J.P., Smith, D.W., Abdelkader, A., Broughton, B.R., Bertram, J.F., Evans, R.G., 2012, Diffusive oxygen shunting between vessels in the preglomerular renal vasculature: anatomic observations and computational modeling, American Journal of Physiology - Renal Physiology [P], vol 303, issue 5, American Physiological Society, USA, pp. F605-F618.

Brait, V.H., Martin, K.R., Corlett, A.R.I., Broughton, B.R., Kim, H., Thundyil, J., Drummond, G.R., Arumugam, T.V., Pritchard, M.A., Sobey, C.G., 2012, Over-expression of DSCR1 protects against post-ischemic neuronal injury, PLoS ONE [P], vol 7, issue 10 (Art. No.: e47841), Public Library of Science, USA, pp. 1-8.

Brait, V.H., Rivera, J., Broughton, B.R., Lee, S., Drummond, G.R., Sobey, C.G., 2011, Chemokine-related gene expression in the brain following ischemic stroke: No role for CXCR2 in outcome, Brain Research [P], vol 1372, Elzevier BV, The Netherlands, pp. 169-179.

Vlahos, R., Stambas, J., Bozinovski, S., Broughton, B.R., Drummond, G.R., Selemidis, S., 2011, Inhibition of nox2 oxidase activity ameliorates influenza a virus-induced lung inflammation, Plos Pathogens [P], vol 7, issue 2, Public Library of Scince, USA, pp. 1-12.

Broughton, B.R.S., Jernigan, N.L., Norton, C.E., Walker, B.R., Resta, T.C., 2010, Chronic hypoxia augments depolarization-induced Ca2+ sensitization in pulmonary vascular smooth muscle through superoxide-dependent stimulation of RhoA, American Journal Of Physiology-Lung Cellular And M..., vol 298, issue 2, American Physiological Society, USA, pp. 232-242.

Judkins, C.P., Diep, H., Broughton, B.R.S., Mast, A., Hooker, E.U., Miller, A.A., Selemidis, S., Dusting, G.J., Sobey, C.G., Drummond, G.R., 2010, Direct evidence of a role for Nox2 in superoxide production, reduced nitric oxide bioavailability, and early atherosclerotic plaque formation in ApoE -/- mice, American Journal Of Physiology-Heart And Circulator..., vol 298, issue 1, American Physiological Society, USA, pp. H-24-H-32.

Broughton, B.R.S., Miller, A.A., Sobey, C.G., 2010, Endothelium-dependent relaxation by G protein-coupled receptor 30 agonists in rat carotid arteries, American Journal Of Physiology-Heart And Circulatory Physiology [P], vol 298, issue 3, American Physiological Society, USA, pp. H1055-H1061.

Brait, V.H., Jackman, K.A., Walduck, A., Selemidis, S., Diep, H., Mast, A., Guida, E., Broughton, B.R., Drummond, G.R., Sobey, C.G., 2010, Mechanisms contributing to cerebral infarct size after stroke: gender, reperfusion, T lymphocytes, and Nox2-derived superoxide, Journal of Cerebral Blood Flow and Metabolism [P], vol 30, issue 7, Nature Publishing Group, USA, pp. 1306-1317.

Broughton, B.R.S., Reutens, D.C., Sobey, C.G., 2009, Apoptotic mechanisms after cerebral ischemia, Stroke, vol 40, issue 5, Lippincott Williams & Wilkins, USA, pp. 331-339.

De Silva, T.M., Broughton, B.R.S., Drummond, G.R., Sobey, C.G., Miller, A.A., 2009, Gender influences cerebral vascular responses to angiotensin II through Nox2-derived reactive oxygen species, Stroke, vol 40, issue 4, Lippincott Williams & Wilkins, USA, pp. 1091-1097.

Miller, A.A., Drummond, G.R., De Silva, T.M., Mast, A., Hickey, H., Williams, J.P., Broughton, B.R.S., Sobey, C.G., 2009, NADPH oxidase activity is higher in cerebral versus systemic arteries of four animal species: Role of Nox2, American Journal of Physiology: Heart and Circulatory Physiology, vol 296, American Physiological Society, USA, pp. H220-H225.

Broughton, B.R.S., Walker, B.R., Resta, T.C., 2008, Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 294, issue 4, American Physiological Society, USA, pp. 797-806.

Broughton, B.R.S., Donald, J.A., 2007, Dual mechanisms for nitric oxide control of large arteries in the estuarine crocodile Crocodylus porosus, Journal Of Experimental Biology [P], vol 210, issue Pt 1, The Company of Biologists Ltd, UK, pp. 129-137.

Jernigan, N.L., Broughton, B.R.S., Walker, B.R., Resta, T.C., 2006, Impaired NO-dependent inhibition of store- and receptor-operated calcium entry in pulmonary vascular smooth muscle after chronic hypoxia, American Journal Of Physiology-Lung Cellular And Molecular Physiology [P], vol 290, issue 3, American Physiological Society, USA, pp. 517-525.

Broughton, B.R.S., Donald, J.A., 2005, Nitric oxide control of large veins in the toad Bufo marinus, Comparative Biochemistry And Physiology A-Molecula..., vol 175, issue 3, Springer, Germany, pp. 157-166.

Donald, J.A., Broughton, B.R.S., 2005, Nitric oxide control of lower vertebrate blood vessels by vasomotor nerves, Comparative Biochemistry And Physiology A-Molecular & Integrative Physiology [P], vol 142, issue 2, Elsevier Inc., USA, pp. 188-197.