Prof David Copolov - Researcher Profile

Biography

David works in the Office of the DVC (Education) at Monash University as a PVC.

Qualifications

Unknown

Institution: Monash University

Year awarded: 1986

PHD

Institution: Monash University

Year awarded: 1983

MBBS

Institution: University of Melbourne

Year awarded: 1974

Publications

Book Chapters

Walterfang, M., Mocellin, R., Copolov, D., Velakoulis, D., 2010, Secondary hallucinations, in Secondary Schizophrenia, eds Perminder S. Sachdev and Matcheri S. Keshavan, Cambridge University Press, Cambridge, UK, pp. 21-43.

Sundram, S., Dean, B., Copolov, D.L., 2004, The endogenous cannabinoid system in schizophrenia, in Marijuana and Madness, eds David Castle and Robin Murray, Cambridge University Press, Cambridge UK, pp. 127-141.

Keks, N., Hill, C., Opeskin, K., Copolov, D.L., Dean, B., 1999, Psychiatric diagnosis after death: the problems of accurate diagnosis from case history review and relative Interviews, in The Use of CNS Autopsy Tissue in Psychiatric Research: A Practical Guide, Gordon and Breach Science Publishers, Amsterdam Netherlands, pp. 19-37.

Journal Articles

McCarthy-Jones, S., Trauer, T., Mackinnon, A.J., Sims, E., Thomas, N., Copolov, D.L., 2012, A new phenomenological survey of auditory hallucinations: Evidence for subtypes and implications for theory and practice, Schizophrenia Bulletin [E], Oxford University Press, United Kingdom, pp. 1-11.

Shawyer, F., Farhall, J., Mackinnon, A.J., Trauer, T., Sims, E., Ratcliff, K., Larner, C., Thomas, N.A., Castle, D.J., Mullen, P.E., Copolov, D.L., 2012, A randomised controlled trial of acceptance-based cognitive behavioural therapy for command hallucinations in psychotic disorders, Behaviour Research and Therapy [P], vol 50, Elsevier Ltd, UK, pp. 110-121.

Dean, O., Bush, A.I., Copolov, D.L., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Berk, M., 2012, Effects of N-acetyl cysteine on cognitive function in bipolar disorder, Psychiatry and Clinical Neurosciences [E], vol 66, issue 6, Wiley-Blackwell Publishing Asia, Australia, pp. 514-517.

Henshall, K., Sergejew, A., McKay, C., Rance, G., Shea, T.L., Hayden, M.J., Innes-Brown, H., Copolov, D.L., 2012, Interhemispheric transfer time in patients with auditory hallucinations: An auditory event-related potential study, International Journal of Psychophysiology [P], vol 80, Elsevier Science Ltd, England, pp. 130-139.

Henshall, K., Sergejew, A., McKay, C., Rance, G., Shea, T., Hayden, M., Innes-Brown, H., Copolov, D., 2012, Interhemispheric transfer time in patients with auditory hallucinations: An auditory event-related potential study, International Journal of Psychophysiology [P], vol 84, issue 2, Elsevier Science Ltd, Netherlands, pp. 130-139.

Magalhaes, P.V., Dean, O., Bush, A.I., Copolov, D.L., Malhi, G.S., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Berk, M., 2011, N-acetylcysteine for major depressive episodes in bipolar disorder, Revista Brasileira de Psiquiatria [P], vol 33, issue 4, Associacao Brasileira de Psiquiatria, Brazil, pp. 374-378.

Dean, O., Bush, A., Berk, M., Copolov, D., van den Buuse, M., 2010, Interaction of glutathione depletion and psychotropic drug treatment in prepulse inhibition in rats and mice, Pharmacology, Biochemistry & Behavior [P], vol 97, issue 2, Elsevier Inc., USA, pp. 293-300.

Magalhaes, P., Dean, O., Bush, A., Copolov, D., Malhi, G., Kohlmann, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Berk, M., 2010, N-acetyl cysteine add-on treatment for bipolar II disorder: A subgroup analysis of a randomized placebo-controlled trial, Journal of Affective Disorders [P], vol 129, issue 1-3, Elsevier BV, Netherlands, pp. 317-320.

Berk, M., Munib, A., Dean, O., Malhi, G., Kohlmann, K., Schapkaitz, I., Jeavons, S., Katz, F., Anderson-Hunt, M., Conus, P., Hanna, B., Otmar, R., Ng, F., Copolov, D., Bush, A., 2010, Qualitative methods in early-phase drug trials: Broadening the scope of data and methods from an RCT of N-acetylcysteine in schizophrenia, Journal of Clinical Psychiatry [P], vol 72, Physicians Postgraduate Press, Inc., USA, pp. 909-913.

Gavrilescu, M., Rossell, S.L., Stuart, G.W., Shea, T., Innes-Brown, H., Henshall, K., McKay, C., Sergejew, A., Copolov, D.L., Egan, G.F., 2010, Reduced connectivity of the auditory cortex in patients with auditory hallucinations: A resting state functional magnetic resonance imaging study, Psychological Medicine [P], vol 40, Cambridge University Press, UK, pp. 1149-1158.

Keks, N.A., Hill, C., Sundram, S., Graham, A., Bellingham, K., Dean, B., Opeskin, K., Dorissa, A., Copolov, D.L., 2009, Evaluation of treatment in 35 cases of bipolar suicide, Australian And New Zealand Journal Of Psychiatry [P], vol 43, issue 6, Informa Healthcare, UK, Australia, pp. 503-508.

Shawyer, F., Mackinnon, A.J., Farhall, J., Sims, E., Blaney, S., Yardley, P., Daley, M., Mullen, P.E., Copolov, D.L., 2008, Acting on harmful command hallucinations in psychotic disorders: An integrative approach, Journal Of Nervous And Mental Disease [P], vol 196, issue 5, Lippincott Williams & Wilkins, USA, pp. 390-398.

Mann, C., Croft, R.J., Scholes, K.E., Dunne, A., O'Neill, B.V., Leung, S., Copolov, D.L., Phan, K.L., Nathan, P.J., 2008, Differential effects of acute serotonin and dopamine depletion on prepulse inhibition and P50 suppression measures of sensorimotor and sensory gating in humans, Neuropsychopharmacology, vol 33, Nature Publishing Group, London UK, pp. 1653-1666.

Gavrilescu, M., Stuart, G.W., Rossell, S.L., Henshall, K., McKay, C., Sergejew, A., Copolov, D.L., Egan, G.F., 2008, Functional connectivity estimation in fMRI data: Influence of preprocessing and time course selection, Human Brain Mapping, vol 29, issue 9, John Wiley & Sons, Inc., USA, pp. 1040-1052.

Lavoie, S., Murray, M.M., Deppen, P., Knyazeva, M.G., Berk, M., Boulat, O., Bovet, P., Bush, A.I., Conus, P., Copolov, D.L., Fornari, E., Meuli, R., Solida, A., Vianin, P., Cuenod, M., Buclin, T., Do, K.Q., 2008, Glutathione precursor, N-acetyl-cysteine, improves mismatch negativity in schizophrenia patients, Neuropsychopharmacology [P], vol 33, issue 9, Nature Publishing Group, UK, pp. 2187-2199.

Berk, M., Copolov, D.L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Judd, F., Katz, F., Katz, P., Ording-Jespersen, S., Little, J.D., Conus, P., Cuenod, M., Do, K.Q., Bush, A.I., 2008, N-Acetyl Cysteine as a Glutathione Precursor for Schizophrenia-A Double-Blind, Randomized, Placebo-Controlled Trial, Biological Psychiatry [P], vol 64, issue 5, Elsevier Inc., USA, pp. 361-368.

Berk, M., Copolov, D.L., Dean, O., Lu, K., Jeavons, S., Schapkaitz, I., Anderson-Hunt, M., Bush, A.I., 2008, N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder-A Double-Blind Randomized Placebo-Controlled Trial, Biological Psychiatry [P], vol 64, issue 6, Elsevier Inc., USA, pp. 468-475.

Dodd, S., Dean, O., Copolov, D.L., Malhi, G.S., Berk, M., 2008, N-acetylcysteine for antioxidant therapy: Pharmacology and clinical utility, Expert Opinion on Biological Therapy [P], vol 8, issue 12, Informa Healthcare, UK, pp. 1955-1962.

Keks, N.A., Burrows, G.D., Copolov, D.L., Newton, R., Paoletti, N., Schweitzer, I., Tiller, J., 2007, Beyond the evidence: is there a place for antidepressant combinations in the pharmacotherapy of depression?, Medical Journal of Australia, vol 186, issue 3, Australasian Medical Publishing Company Pty Ltd, Australia, pp. 142-144.

Shea, T., Sergejew, A., Burnham, D., Jones, C., Rossell, S.L., Copolov, D.L., Egan, G.F., 2007, Emotional prosodic processing in auditory hallucinations, Schizophrenia Research [P], vol 90, issue 1, Elsevier, Netherlands, pp. 214-220.

Brewer, W.J., Wood, S.J., Pantelis, C., Berger, G.E., Copolov, D.L., McGorry, P.D., 2007, Olfactory sensitivity through the course of psychosis: relationships to olfactory identification, symptomatology and the schizophrenia odour, Psychiatry Research, vol 149, issue 1-3, Elsevier Ireland Ltd, East Park Shannon Ireland, pp. 97-104.

Shawyer, F., Ratcliff, K., Mackinnon, A.J., Farhall, J., Hayes, S.C., Copolov, D.L., 2007, The Voices Acceptance and Action Scale (VAAS): Pilot data, Journal of Clinical Psychology, vol 63, issue 6, John Wiley & Sons Inc, USA, pp. 593-606.

Raedler, T.J., Bymaster, F.P., Tandon, R., Copolov, D.L., Dean, B., 2007, Towards a muscarinic hypothesis of schizophrenia, Molecular Psychiatry, vol 12, issue 3, Nature Publishing Group, London UK, pp. 232-246.

Sundram, S., Copolov, D.L., Dean, B., 2005, Clozapine decreases [3H] CP 55940 binding to the cannabinoid1 receptor in the rat nucleus accumbens, Naunyn-Schmiedeberg's Archives of Pharmacology, vol 371, Springer, New York USA, pp. 428-433.

Howe, V., Foister, K., Jenkins, K.D., Skene, L., Copolov, D.L., Keks, N.A., 2005, Competence to give informed consent in acute psychosis is associated with symptoms rather than diagnosis, Schizophrenia Research [P], vol 77, issue 2, Elsevier, Netherlands, pp. 211-214.

Walterfang, M., Wood, S.J., Velakoulis, D., Copolov, D.L., Pantelis, C., 2005, Diseases of white matter and schizophrenia-like psychosis, Australian And New Zealand Journal Of Psychiatry [P], vol 39, issue 9, Informa Healthcare, New York, USA, pp. 746-756.

Sritharan, A., Line, P., Sergejew, A., Silberstein, R., Egan, G., Copolov, D., 2005, EEG coherence measures during auditory hallucinations in schizophrenia, Psychiatry Research [P], vol 136, Elsevier Ireland Ltd, Ireland, pp. 189-200.

Rehn, A.H., van den Buuse, M., Copolov, D.L., Briscoe, T., Lambert, G.W., Rees, S.M., 2004, An animal model of chronic placental insufficiency: Relevance to neurodevelopmental disorders including schizophrenia, Neuroscience [P], vol 129, issue 2, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 381-391.

Collinson, S.L., Copolov, D.L., 2004, Challenges and opportunities for mental health research in Australia, Journal of Mental Health [P], vol 13, issue 1, Informa Healthcare, London, England, pp. 29-36.

Copolov, D.L., Mackinnon, A.J., Trauer, T., 2004, Correlates of the affective impact of auditory hallucinations in psychotic disorders, Schizophrenia Bulletin, vol 30, issue 1, US Government Printing Office, Washington USA, pp. 163-171.

Mackinnon, A.J., Copolov, D.L., Trauer, T., 2004, Factors associated with compliance and resistance to command hallucinations, The Journal of Nervous and Mental Disease, vol 192, issue 5, Lippincott Williams & Wilkins, Philadelphia USA, pp. 357-362.

Scarr, E., Pavey, G., Copolov, D.L., Dean, B., 2004, Hippocampal 5-hydroxytryptamine receptors: abnormalities in postmortem brain from schizophrenic subjects, Schizophrenia Research, vol 71, issue 2-3, Elsevier, The Netherlands, pp. 383-392.

Dean, B., Pavey, G., Scarr, E., Goeringer, K.E., Copolov, D.L., 2004, Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: differential regional changes in schizophrenia, Life Sciences, vol 74, issue 25, Elsevier, USA, pp. 3115-3131.

Singh, B.S., Copolov, D.L., Grainger, D., Goh, J., 2004, Partnerships between academic psychiatry and the pharmaceutical industry: The Lilly MAP Initiative, Australasian Psychiatry [E], vol 12, issue 3, Blackwell Publishing, USA, pp. 220-224.

Dean, B., Bradbury, R., Copolov, D.L., 2003, Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia, Biological Psychiatry, vol 53, issue 7, Elsevier, USA, pp. 585-592.

Shawyer, F., Mackinnon, A.J., Farhall, J., Trauer, T., Copolov, D.L., 2003, Command hallucinations and violence: implications for detention and treatment, Psychiatry, Psychology and Law, vol 10, issue 1, Australian Academic Press Pty Ltd, Australia, pp. 97-107.

Howe, V., Foister, K., Jenkins, K.D., Skene, L., Copolov, D.L., Keks, N.A., 2003, Competence to give informed consent to research participation in persons with schizophrenia and related psychosis, Psychiatry, Psychology and Law [P], vol 10, issue 1, Routledge, UK, pp. 85-90.

Copolov, D.L., Seal, M.L., Maruff, P., Ulusoy, R., Wong, M.T.H., Tochon-Danguy, H., Egan, G.F., 2003, Cortical activation associated with the experience of auditory hallucinations and perception of human speech in schizophrenia: a PET correlation study, Psychiatry Research [P], vol 122, issue 3, Elsevier Ireland Ltd, Ireland, pp. 139-152.

Thomas, E.A., Dean, B., Scarr, E., Copolov, D.L., Sutcliffe, J.G., 2003, Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder, Molecular Psychiatry, vol 8, issue 2, Nature Publishing Group, London England, pp. 167-175.

Kusljic, S., Copolov, D.L., van den Buuse, M., 2003, Differential Role of Serotonergic Projections Arising from the Dorsal and Median Raphe Nuclei in Locomotor Hyperactivity and Prepulse Inhibition, Neuropsychopharmacology [P], vol 28, issue 12, Nature Publishing Group, London, England, pp. 2138-2147.

Thomas, E.A., Copolov, D.L., Sutcliffe, J.G., 2003, From pharmacotherapy to pathophysiology: emerging mechanisms of apolipoprotein D in psychiatric disorders, Current Molecular Medicine [P], vol 3, issue 5, Bentham Science Publ Ltd, United Arab Emirates, pp. 408-418.

Freckleton, I., Keks, N.A., Howe, V., Foister, K., Jenkins, K.D., Copolov, D.L., Sullivan, D., 2003, How can valid informed consent be obtained from a psychotic patient for research into psychosis? Three perspectives., Monash bioethics review [P], vol 22, issue 4, Monash University ePress, Clayton, Victoria, pp. 60-75.

Brewer, W.J., Wood, S.J., McGorry, P.D., Francey, S.M., Phillips, L., Yung, A., Anderson, V.A., Copolov, D.L., Singh, B., Velakoulis, D., Pantelis, C., 2003, Impairment of Olfactory Identification Ability in Individuals at Ultra-High Risk for Psychosis Who Later Develop Schizophrenia, American Journal of Psychiatry [P], vol 160, issue 10, American Psychiatric Publishing Inc, Arlington, Virginia, pp. 1790-1794.

Copolov, D.L., Trauer, T., Mackinnon, A.J., 2003, On the non-significance of internal versus external auditory hallucinations, Schizophrenia Research, vol electronic, Elsevier, The Netherlands, pp. 1-6.

Pereira, A., McLaren, A., Bell, W.R., Copolov, D.L., Dean, B., 2003, Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow, The Pharmacogenomics Journal, vol 3, issue 4, Nature Publishing Group, UK, pp. 227-234.

Dean, B., Scarr, E., Pavey, G., Copolov, D.L., 2003, Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder, Journal of Affective Disorders, vol 75, issue 1, Elsevier, The Netherlands, pp. 65-69.

Pavey, G., Copolov, D.L., Dean, B., 2002, High-resolution phosphor imaging: validation for use with human brain tissue sections to determine the affinity and density of radioligand binding, Journal of Neuroscience Methods, vol 116, issue 2, Elsevier Science BV, Netherlands, pp. 157-163.

Yucel, M., Stuart, G.W., Maruff, P., Wood, S.J., Savage, G.R., Smith, D.J., Crowe, S.F., Copolov, D., Velakoulis, D., Pantelis, C., 2002, Paracingulate morphologic differences in males with established schizophrenia: a magnetic resonance imaging morphometric study, Biological Psychiatry, vol 52, Elsevier Inc., USA, pp. 15-23.

McLeod, M., Pralong, D., Copolov, D.L., Dean, B., 2002, The heterogeneity of cental benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H] flumazenil and zolpidem, Molecular Brain Research, vol 104, issue 2, Elsevier Science BV, Netherlands, pp. 203-209.

McLeod, M., Pralong, D., Copolov, D.L., Dean, B., 2002, [3H] Flumazenil binding in the hyman hippocampal formation, frontal cortex and cerebellum detected by high-resolution phosphorimaging, Brain Research, vol 926, issue 1, Elsevier Science, BV, Netherlands, pp. 27-32.

Dean, B., Pavey, G., McLeod, M., Opeskin, K., Keks, N., Copolov, D.L., 2001, A change in the density of [3H]flumazenil, but not [3H]muscimol binding, in Brodmann's Area 9 fromsubjects with bipolar disorder, Journal of Affective Disorders, vol 66, Elsevier Science BV, Netherlands, pp. 147-158.

Scarr, E., Copolov, D.L., Dean, B., 2001, A proposed pathological model in the hippocampus of subjects with schizophrenia, Clinical and experimental pharmacology and physiology, vol 28, Blackwell Science Asia Pty Ltd, Carlton Vic Australia, pp. 70-73.

Dean, B., Hussain, T., Scarr, E., Pavey, G., Copolov, D.L., 2001, Extended treatment with typical and atypical antipsychotic drugs. Differential effects on the densities of dopamine D2-like and GABA A receptors in rat striatum, Life Sciences, vol 69, Elsevier Science, USA, pp. 1257-1268.

Crook, J., Tomaskovic-Crook, E., Copolov, D.L., Dean, B., 2001, Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment, American Journal of Psychiatry, vol 158, issue 6, 0002-953X, USA, pp. 918-925.

Dean, B., Sundram, S., Bradbury, R., Scarr, E., Copolov, D.L., 2001, Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use, Neuroscience, vol 103, issue 1, Pergamon, UK, pp. 9-15.

Lee, D., Dong, P., Copolov, D.L., Lim, A., 1999, D5 Dompamine Receptors Mediate E2-induced Stimulation of Hypothalamic ANF Neurons, Molecular Endocrinology, vol 13, The Endocrine Society of America, USA, pp. 344-352.

Dean, B., Tomaskovic-Crook, E., Opeskin, K., Keks, N., Copolov, D.L., 1999, No change in the density of the serotonin1A receptor, the serotonin4 receptor or the serotonin transporter in the dorsolateral prefrontal cortex from subjects with schizophrenia, Neurochemistry International, vol 34, Pergamon-Elsevier Science, Oxford UK, pp. 109-115.

Copolov, D.L., Bell, W.R., Benson, W.J., Keks, N.A., Strazzeri, D.C., Johnson, G.F., 1998, Clozapine treatment in Australia: a review of haematological monitoring, Medical Journal of Australia, vol 168 no 10, Australasian Medical Publishing Co. Ltd, North Sydney NSW Australia, pp. 495-497.

Roberts, S.B., Hill, C., Dean, B., Keks, N., Opeskin, K., Copolov, D.L., 1998, Confirmation of the diagnosis of schizophrenia after death using DSM-IV: a Victorian experience, Australian and New Zealand Journal of Psychiatry, vol 32 no 1, Blackwell Science Asia Pty. Ltd, Carlton Vic Australia, pp. 73-76.

Roberts, S., Hill, C., Dean, B., Keks, N., Opeskin, K., Copolov, D.L., 1998, Confirmation of the diagnosis of schizophrenia after death using DSMIV: A Victorian experience, Australian and New Zealand Journal of Psychiatry, vol 32:73-76, Aust & NZ College of Psychiatry, Carlton Vic Australia, pp. 73-76.

Naylor, L., Dean, B., Pereira, A.M., Mackinnon, A.J., Kouzmenko, A., Copolov, D.L., 1998, No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus, Molecular Medicine, vol 4 no 10, Picower Inst Press & Springer-Verlag New York Inc., New York NY USA, pp. 671-674.

Keks, N.A., Copolov, D.L., Burrows, G.D., 1997, Discontinuing antipsychotic therapy, Current Therapeutics, vol 38, Adis International, Frenchs Forest NSW, pp. 41-48.

Marzella, P.L., Hill, C., Keks, N., Singh, B., Copolov, D.L., 1997, The binding of both [3H]Nemonapride and [3H]Raclopride is increased in schizophrenia, Biological Psychiatry, vol 42, Elsevier Science, New York NY USA, pp. 648-654.

Conference Proceedings

Shawyer, F., Farhall, J., Sims, E., Copolov, D.L., 2005, Command hallucinations in psychosis: Acceptance and disengagement as a focus of treatment, Theory and Practice in Contemporary Australian Cognitive Behaviour Therapy: Proceedings of the 28th National AACBT Conference, 16/04/2005 - 20/04/2005, Australian Association for Cognitive and Behaviour Therapy, Victoria, Melbourne, Australia, pp. 5-14.

Copolov, D.L., Crook, J., Opeskin, K., Hill, C., Keks, N., Dean, B., 1997, Muscarinic M1 receptors in the caudate putamen of patients with schizophrenia: decreased receptor density is not accompanied by decreased receptor mRNA, Schizophrenia Research, Colorado Springs USA, 12-16 April 1998, Elsevier Science, Amsterdam Netherlands, p. 32.