Prof Ian Coupar - Researcher Profile

Publications

Journal Articles

Coupar, I.M., Irving, H.R., Manallack, D.T., Tan, Y.Y., Ayad, F., Di Iulio, J.L., Tochon-Danguy, N., Iskander, M.N., 2012, Assessment of the pharmacological properties of 5-methoxyindole derivatives at 5-HT4 receptors, Journal of Pharmacy and Pharmacology [P], vol 64, issue 8, John Wiley & Sons Ltd, UK, pp. 1099-1106.

Megersa, T., White, P., Coupar, I., Irving, H., 2011, Tissue dependent differences in G-protein coupled receptor kinases associated with 5-HT4 receptor desensitization in the rat gastro-intestinal tract, Biochemical Pharmacology [P], vol 81, issue 1, Elsevier Inc., United States, pp. 123-133.

Irving, H.R., Tochon-Danguy, N., Chinkwo, K.A., Li, J.G., Grabbe, C., Shapiro, M., Pouton, C.W., Coupar, I.M., 2010, Investigations into the binding affinities of different human 5-HT 4 receptor splice variants, Pharmacology [P], vol 85, issue 4, S. Karger AG, Switzerland, pp. 224-233.

Hanna-Elias, A., Manallack, D., Berque-Bestel, I., Irving, H., Coupar, I., Iskander, M., 2010, Synthesis and preliminary screening of novel tryptamines as 5-HT4 receptor ligands, Current Medicinal Chemistry [P], vol 17, Bentham Science Publishers Ltd, Chicago Illinois USA, pp. 2775-2787.

Hanna-Elias, A., Manallack, D.T., Levit, A., Nguyen, W., Ayad, F., Perera, G., Shapiro, M., Coupar, I.M., Iskander, M.N., Irving, H.R., 2010, Synthesis, testing and structure-activity studies on a library of 5-HT 4 ligands, Medicinal Chemistry [P], vol 6, issue 6, Bentham Science Publishers Ltd, Oak Park Illinois USA, pp. 344-354.

Urmaliya, V., Church, J.E., Coupar, I.M., Rose'Meyer, R., Pouton, C.W., White, P.J., 2009, Cardioprotection induced by adenosine A1 receptor agonists in a cardiac cell ischemia model involves cooperative activation of adenosine A2A and A2B receptors by endogenous adenosine, Journal Of Cardiovascular Pharmacology [P], vol 53, issue 5, Lippincott Williams & Wilkins, United States, pp. 424-433.

Chetty, N., Coupar, I.M., Tan, Y.Y., Desmond, P.V., Irving, H.R., 2009, Distribution of serotonin receptors and interacting proteins in the human sigmoid colon, Neurogastroenterology and Motility, vol 21, issue 5, Blackwell Publishing Ltd, UK, pp. 551-e15.

Hanna-Elias, A., Manallack, D.T., Berque-Bestel, I., Irving, H.R., Coupar, I.M., Iskander, M.N., 2009, Synthesis and preliminary screening of novel indole-3-methanamines as 5-HT4 receptor ligands, European Journal of Medicinal Chemistry [P], vol 44, issue 7, Elsevier Masson, France, pp. 2952-2959.

Hanna-Elias, A., Manallack, D.T., Berque-Bestel, I., Irving, H.R., Coupar, I.M., Iskander, M.N., 2009, Synthesis of quinoline derivatives as 5-HT4 receptor ligands, Australian Journal of Chemistry [E], vol 62, issue 2, CSIRO Publishing, Australia, pp. 150-156.

Hanna-Elias, A., Thompson, P., Manallack, D.T., Irving, H.R., Coupar, I.M., Berque-Bestel, I., Iskander, M.N., 2009, The Use of Tripeptides for Lead Discovery of 5-HT4 Receptor Ligands, Protein and Peptide Letters [P], vol 16, issue 7, Bentham Science Publishers Ltd., Netherlands, pp. 805-809.

Chetty, N., Irving, H.R., Coupar, I.M., 2008, Effects of the novel 5-HT3 agonist MKC-733 on the rat, mouse and guinea pig digestive tract, Pharmacology, vol 81, S Karger AG, Switzerland, pp. 104-109.

Irving, H.R., Tan, Y.Y., Tochon-Danguy, N., Liu, H., Chetty, N., Desmond, P.V., Pouton, C.W., Coupar, I.M., 2007, Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon, Life Sciences, vol 80, issue 13, Elsevier Inc, USA, pp. 1198-1205.

Chetty, N., Coupar, I.M., Chess-Williams, R., Kerr, K.P., 2007, Demonstration of 5-HT3 receptor function and expression in the mouse bladder, Naunyn-Schmiedeberg's Archives of Pharmacology, vol 375, issue 6, Springer-Verlag, Germany, pp. 359-368.

Coupar, I.M., Desmond, P.V., Irving, H.R., 2007, Human 5-HT4 and 5-HT7 splice variants: are they important?, Current Neuropharmacology, vol 5, issue 4, Bentham Science Publishers Ltd, United Arab Emirates, pp. 224-231.

Chetty, N., Irving, H.R., Coupar, I.M., 2006, Activation of 5-HT3 receptors in the rat and mouse intestinal tract: a comparative study, British Journal of Pharmacology, vol 148, issue 7, Nature Publishing Group, UK, pp. 1012-1021.

Hsu, B., Coupar, I.M., Ng, K., 2006, Antioxidant activity of hot water extract from the fruit of the Doum palm, Hyphaene thebaica, Food Chemistry, vol 98, issue 2, Elsevier BV, Netherlands, pp. 317-328.

Gray, A.C., Coupar, I.M., White, P.J., 2006, Comparison of opioid receptor distributions in the rat central nervous system, Life Sciences, vol 79, issue 7, Elsevier, USA, pp. 674-685.

Gray, A.C., Coupar, I.M., White, P.J., 2006, Comparison of opioid receptor distributions in the rat ileum, Life Sciences, vol 78, issue 14, Elsevier Inc., USA, pp. 1610-1616.

Poole, D.P., Xu, B., Koh, S.L., Hunne, B., Coupar, I.M., Irving, H.R., Shinjo, K., Furness, J.B., 2006, Identification of neurons that express 5-hydroxytryptamine4 receptors in intestine, Cell and Tissue Research, vol 325, issue 3, Springer, New York USA, pp. 413-422.

Iskander, M.N., Leung, L.M., Buley, T., Ayad, F., Di Iulio, J.L., Tan, Y.Y., Coupar, I.M., 2006, Optimization of a pharmacophore model for 5-HT4 agonists using CoMFA and receptor based alignment, European Journal of Medicinal Chemistry, vol 41, issue 1, Elsevier France, France, pp. 16-26.

Gray, A.C., White, P.J., Coupar, I.M., 2005, Characterisation of opioid receptors involved in modulating circular and longitudinal muscle contraction in the rat ileum, British Journal of Pharmacology, vol 144, issue 5, Nature Publishing Group, UK, pp. 687-694.

Liu, H., Irving, H.R., Tan, Y.Y., Meng, L., Chetty, N., Coupar, I.M., 2004, Influences of gender and region on reponses to 5-HT in the rat small intestine, Pharmacology, vol 72, issue 4, S. Karger AG, Switzerland, pp. 220-224.

Liu, H., Coupar, I.M., Irving, H.R., 2003, Effects of some antidepressant drugs on tryptaminergic responses of the rat jejunum, Pharmacology, vol 69, issue 2, S.Karger AG, Switzerland, pp. 88-92.

Coupar, I.M., Di Iulio, J.L., 2003, Effects of tachykinins and 5-hydroxytryptamine on intestinal secretion, Clinical and Experimental Pharmacology and Physiology, vol 30, issue 10, Blackwell Publishing Asia, Australia, pp. 764-768.

Iskander, M., Song, Y., Coupar, I., Jiratchariyakul, W., 2002, Antiinflammatory screening of the medicinal plant Gynura procumbens, Plant Foods for Human Nutrition, vol 57, issue 3-4, Kluwer Academic Publishers Group, The Netherlands, pp. 233-244.

Coupar, I., Tran, B.L.T., 2002, Effects of adenosine agonists on consumptive behaviour and body temperature, Journal of Pharmacy and Pharmacology: An International Journal of Pharmaceutical Science, vol 54, issue 2, Pharmaceutical Press, UK, pp. 289-294.

Liu, H., Irving, H.R., Coupar, I.M., 2001, Expression patterns of 5-HT7 receptor isoforms in the rat digestive tract, Life Sciences, vol 69, Elsevier, USA, pp. 2467-2475.

Hemedah, M., Loiacono, R.E., Coupar, I., Mitchelson, F., 2001, Lack of evidence for histamine H3 receptor function in rat ileum and human colon, Naunyn-Schmeideberg's Archives of Pharmacology, vol 363, Springer-Verlag, Germany, pp. 133-138.

Song, Y., Coupar, I.M., Iskander, M.N., 2001, Structural predictions of adenosine 2B antagonist affinity using molecular field analysis, Quantitative Structure-Activity Relationships, vol 20, Wiley-VCH, Germany, pp. 23-30.

Coupar, I., Tran, B.L.T., 2001, Withdrawal and bidirectional cross-withdrawal responses in rats treated with adenosine agonists and morphine, Life Sciences, vol 69, Elsevier Science, USA, pp. 779-790.

Hemedah, M., Coupar, I.M., Mitchelson, F.J., 2000, Characterisation of a 5-HT7 binding site in mouse ileum, European Journal of Pharmacology, vol 387 issue 3, Elsevier Science B.V., Amsterdam Netherlands, pp. 265-272.

Kerr, K.P., Thai, B., Coupar, I.M., 2000, Tachykinin-induced contraction of the guinea-pig isolated oesophageal mucosa is mediated by NK2 receptors, British Journal of Pharmacology, vol 131 issue 7, Nature Publishing Group, Basingstoke England, pp. 1461-1467.

Kerr, K.P., Mitchelson, F.J., Coupar, I.M., 2000, Tachykinins play a minor role in mediating the third phase of the contractile response to vagal nerve stimulation of the guinea-pig oesophagus, Neuropeptides, vol 34 issue 1, Churchill Livingstone, Edinburgh Scotland, pp. 12-17.

Coupar, I.M., 1999, Characterization and tissue location of the neural adenosine receptor in the rat ileum, British Journal of Pharmacology, vol 126 issue 5, Stockton Press, UK, pp. 1269-1275.

Iskander, M.N., Coupar, I.M., Winkler, D.A., 1999, Investigation of 5 - HT4 agonist activities using molecular field analysis, Journal of the Chemical Society Perkin Transactions 2, vol issue 2, Royal Society of Chemistry, Cambridge UK, pp. 153-158.

Iskander, M.N., Coupar, I.M., Winkler, D.A., 1999, Investigation of 5 - HT4 agonist activities using molecular field analysis, Journal of the Chemical Society: Perkin Transactions 2, vol issue 2, Royal Society of Chemistry, Cambridge UK, pp. 153-158.

Hemedah, M., Coupar, I.M., Mitchelson, F.J., 1999, [3H]-mesulergine labels5 -HT7 sites in rat brain and guinea pig ileum but not rat jejunum, British Journal of Pharmacology, vol 126 issue 1, Stockton Press, UK, pp. 179-188.

Hemedah, M., Mitchelson, F.J., Coupar, I.M., 1998, Evidence of H3 receptor inhibition by iodoaminopotentidine in the guinea pig ileum, Life Sciences, vol 63 issue 15, Elsevier Science, USA, pp. 1371-1376.

McLean, P.G., Coupar, I.M., 1998, Investigation into the effect of 5-Hydroxytryptamine on fluid transport in the rat small intestine, General Pharmacology, vol 30 issue 2, Elsevier Science, USA, pp. 227-231.

Liu, L., Coupar, I.M., 1997, Characterisation of pre- and post- synaptic a-adrenoceptos in modulation of the rat ilium longitudinal and circular muscle activities, Naunyn-Schmiedeberg's Archives of Pharmacology, vol 356, Springer-Verlag, Germany, pp. 248-256.

Liu, L., Coupar, I.M., 1997, Involvement of Alpha - 2 adrenoceptors in the effects of moxonidine on intestinal motility and fluid transport, Journal of Pharmacology and Experimental Therapeutics, vol 283, Am Soc for Pharmacol & Experimental Therapeutics, USA, pp. 1367-1374.

Liu, L., Coupar, I.M., 1997, Role of a2 - adrenoceptors in the regulation of intestinal water transport, British Journal of Pharmacology, vol 120, Stockton Press, UK, pp. 892-898.

Hancock, D.L., Coupar, I.M., 1997, Studies investigating the possible involvement of adenosine in the antisecretory action of morphine, General Pharmacology, vol 28, Elsevier Science Inc, USA, pp. 709-713.

Kerr, K.P., Mitchelson, F.J., Coupar, I.M., 1997, Tachykinin receptors in the guinea-pig isolated oesophagus: a complex system, British Journal of Pharmacology, vol 120, Stockton Press, UK, pp. 1021-1028.

Conference Proceedings

Chetty, N., Coupar, I.M., Chess-Williams, R., Kerr, K.P., 2006, Characterisation of 5-HT receptors in the mouse bladder, 3rd Annual meeting on Advances in Urogenital Research, 29 September 2006, Griffith University, Gold Coast Qld Australia.

Irving, H.R., Tan, Y.Y., Tochon-Danguy, N., Liu, H., Chetty, N., Desmond, P.V., Pouton, C.W., Coupar, I.M., 2006, Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon, Proceedings of the Australian Society for Biochemistry and Molecular Biology, 25-28 September 06, p. 109.

Irving, H.R., Chetty, N., Desmond, P.V., Tan, Y.Y., Tochon-Danguy, N., Liu, H., Pouton, C.W., Coupar, I.M., 2006, Comparison of 5-HT4 and 5-HT7 receptor expression and function in the circular muscle of the human colon, Proceedings of the Australian Health & Medical Research Congress, 26 Nov - 1 Dec 2006, pp. 404-405.

Chetty, N., Coupar, I.M., Chess-Williams, R., Kerr, K.P., 2006, Demonstration of 5-HT3 receptors in the mouse bladder, Proceedings of the Australian Health & Medical Research Congress 2006, 26 Nov 06 - 1 Dec 06, p. 159.

Chetty, N., Irving, H.R., Coupar, I.M., 2006, Effect of 5-HT3 mediated responses in two different preparations of the rat intestine, Proceedings of the Australian Health & Medical Research Congress 2006, 26th Nov 06 - 1st Dec 06, Australian Health & Medical Research Congress 2006, Melbourne Vic Australia, p. 404.

Chetty, N., Coupar, I.M., Chess-Williams, R., Kerr, K.P., 2006, Investigation of the effects of 5-HT on the neurogenic contractions in the mouse bladder, VCPPA Symposium, 24 October 2006, Melbourne Vic Australia.

Chetty, N., Irving, H.R., Coupar, I.M., 2006, Regional effects of MKC-733, a novel 5-HT3 receptor agonist, in the rat digestive tract, VCPPA Symposium, Melbourne Vic Australia.

Hemedah, M., Coupar, I.M., Mitchelson, F.J., 1999, Absence of histamine H3 receptors in rat ileum and human colon, British Journal of Pharmacology, Nottingham UK 14-16 July 1999, Stockton Press, Basingstoke UK, p. 100P.

Song, Y., Iskander, M.N., Coupar, I.M., 1999, Anti-inflammatory activity of extracts and fractions from Gynura procumbens, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 121.

Song, Y., Iskander, M.N., Coupar, I.M., 1999, Anti-inflammatory activity of extracts and fractions from Gynura procumbens, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 121.

Hemedah, M., Coupar, I.M., Mitchelson, F.J., 1999, Characterization of a 5-HT2 binding site in the mouse ileum, Fundamental & Clinical Pharmacology, Budapest Hungary 3-7 July 1999, Elsevier Science, Paris France, p. 281s.

Tran, B.L.T., Coupar, I.M., 1999, Investigation into the withdrawal and bidirectional cross-withdrawal responses between adenosine agonists and morphine, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 166.

Leung, L., Iskander, M.N., Coupar, I.M., 1999, Synthesis and pharmacological evaluation of novel 5-HT4 agonists, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 75.

Leung, L., Iskander, M.N., Coupar, I.M., 1999, Synthesis and pharmacological evaluation of novel5-HT4 agonists, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 75.

Thai, B., Kerr, K.P., Coupar, I.M., 1999, The isolated mucosa of the guinea-pig oesophagusis a mono NK2 receptor system, Proceedings of the Australasian Society of Clinical & Experimental Pharmacologists & Toxicologists, Sydney NSW 4-8 December 1999, Aust. Soc. of Clin. & Exp. Pharmacol. & Toxicol., Sydney NSW Australia, p. 79.

Coupar, I.M., 1998, Characterisation and function of the neural adenosine receptor in the rat ileum, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 173.

Iskander, M.N., Coupar, I.M., Winkler, D.A., 1998, Investigation of 5 - HT4 agonist activities using molecular field analysis, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 173.

Iskander, M.N., Coupar, I.M., Winkler, D.A., 1998, Investigation of 5 - HT4 agonist activities using molecular field analysis, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 173.

Kerr, K.P., Mitchelson, F.J., Coupar, I.M., 1998, Putative neurotransmitters in the mediation of a capsaicin-sensitive, hexamethinium-resistant cholinergic contractile response, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 130.

Haas, S.J., Coupar, I.M., 1998, Some effects of the adenosine agonist, NECA, in comparison to morphine, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Hobart Tas, 13-16 December 1998, Australasian Soc of Clinical & Exp Pharm & Toxicol, Sydney NSW Australia, p. 126.

Hemedah, M., Coupar, I.M., Mitchelson, F.J., 1998, [3H] - mesulergine labels 5-HT7 sites in rat brain and guinea - pig ileum but not rat jejunum, Naunyn-Schmiedeberg's Archives of Pharmacology, Munchen Germany, 26-31 July 1998, Springer Verlag, Germany, p. R108.

Hemedah, M., Mitchelson, F.J., Coupar, I.M., 1997, Evidence of histamine H3 receptor blockade by iodoaminopentidine in the guinea - pigileum, Proceedings of ASCEPT: Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists, Canberra Australia, 30 November-3 December, ASCEPT, Australia, p. 100.

Liu, L., Coupar, I.M., 1997, Involvement of a2 - adrenoceptors in the effects of moxonidine and rilmenidine on intestinal motility, Journal of the Autonomic Nervous System, Cairns Australia, 14-19 September, Elsevier, Netherlands, p. 134.

Liu, L., Coupar, I.M., 1997, Involvement of a2 - adrenoceptors in the effects of moxonidine on intestinal fluid transport, Journal of Autonomic Nervous System, Cairns Australia, 14-19 September, Elsevier Science, Netherlands, p. 135.

Grants

Title:

5-ht4 receptors: A target for treating the irritable bowels syndrome?.

Investigators:

Coupar, I, Irving, H

Funding:

(1998 - 1998). Australian Research Council (ARC).

Title:

Biotage Flash Chromatography System including refractive index detector and integrator.

Investigators:

Iskander, M, Coupar, I

Funding:

(2003 - 2007). National Health & Medical Research Council (NHMRC).

Title:

Evc 4000-2 Apparatus for Measuring Fluid and Electrolyte Transport Across Epithelia, Such As Intenstinal Mucosa.

Investigators:

Coupar, I, Iskander, M

Funding:

(2000 - 2000). National Health & Medical Research Council (NHMRC).

(2000 - 2004). Monash University.

Title:

ML750 PowerLab/4SP, Adaptor Cables and PC to be used in research projects aimed at gaining a better understanding of the irritable bowel syndrome (IBS).

Investigators:

Coupar, I, Tan, Y

Funding:

(2004 - 2008). Collier Charitable Fund.

(2004 - 2009). Monash University.

Title:

Pipettes from John Morris; 3 x Starter Kits and 3 x Pipetman.

Investigators:

Kerr, K, Irving, H, Exintaris, B, Thompson, P, Coupar, I

Funding:

(2008 - 2011). Collier Charitable Fund.

Title:

Potential Roles of 5-hydroxytryptamine in Diseases Affecting the Colon.

Investigators:

Coupar, I, Iskander, M

Funding:

(2001 - 2003). National Health & Medical Research Council (NHMRC).

Title:

Powerlab system.

Investigators:

Coupar, I

Funding:

(2002 - 2006). Monash University.

(2002 - 2006). National Health & Medical Research Council (NHMRC).

Title:

Rainin PS3 Peptide Synthesizer and Mettler-Toldeo compact parallel synthesizer.

Investigators:

Thompson, P, Iskander, M, Scanlon, M, Coupar, I

Funding:

(2004 - 2008). National Health & Medical Research Council (NHMRC).

Title:

The Effects of Opioid Peptides on the Rat Intestine.

Investigators:

Coupar, I

Funding:

(1994 - 1998). Australian Research Council (ARC).

Title:

Tissue electrophysiology Rig I.D. 264650.

Investigators:

Exintaris, B, Ventura, S, Haynes, J, Pouton, C, Coupar, I, Short, J

Funding:

(2005 - 2009). National Health & Medical Research Council (NHMRC).

Title:

High Resolution Cellular and Molecular Imaging System.

Investigators:

Furness, J, Donald, J, Coupar, I, Lithgow, T, Hime, G, Young, H, Anderson, C, Irving, H, Whitington, P, Fletcher, E

Funding:

(2006 - 2010). Australian Research Council (ARC).

(2006 - 2010). Monash University.