Dr Lisa Ooms - Researcher Profile

Biography

Lisa works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Senior Research Fellow.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Melbourne

Year awarded: 2005

Publications

Book Chapters

Ooms, L.M., Dyson, J.M., Kong, A.M., Mitchell, C.A., 2009, Analysis of phosphatidylinositol 3,4,5 trisphosphate 5-phosphatase activity by in vitro and in vivo assays, in Lipid Signaling Protocols, eds B Larijani, R Woscholski, C A rosser, Humana Press, USA, pp. 223-239.

Journal Articles

Manji, S.S.M., Williams, L.L., Miller, K.A., Ooms, L.M., Bahlo, M., Mitchell, C.A., Dahl, H.M., 2011, A mutation in synaptojanin 2 causes progressive hearing loss in the ENU-mutagenised mouse strain Mozart, PLoS ONE [P], vol 6, issue 3, Public Library of Science, USA, pp. e17607.1-e17607.11.

Nguyen, N., Maxwell, M., Ooms, L., Davies, E.M., Hilton, A., Collinge, J., Hilton, D., Kile, B., Mitchell, C., Hibbs, M., Jane, S., Curtis, D., 2011, An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation, Blood [P], vol 117, issue 20, American Society of Hematology, United States, pp. 5362-5371.

Astle, M., Ooms, L., Cole, A., Binge, L., Dyson, J., Layton, M., Petratos, S., Sutherland, C., Mitchell, C., 2011, Identification of a proline-rich inositol polyphosphate 5-phosphatase (PIPP) collapsin response mediator protein 2 (CRMP2) complex that regulates neurite elongation, Journal Of Biological Chemistry [P], vol 286, issue 26, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 23407-23418.

Rahman, P., Huysmans, R., Wiradjaja, F., Gurung, R., Ooms, L., Sheffield, D., Dyson, J., Layton, M., Sriratana, A., Takada, H., Tiganis, T., Mitchell, C., 2011, Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton, Journal Of Biological Chemistry [P], vol 286, issue 34, American Society of Biochemistry and Molecular Biology Inc., USA, pp. 29758-29770.

Fedele, C.G., Ooms, L.M., Ho, M., Vieusseux, J.L., O'Toole, S.A., Millar, E.K., Lopez-Knowles, E., Sriratana, A., Gurung, R., Baglietto, L., Giles, G., Bailey, C.G., Rasko, J.E., Shields, B.J., Price, J.T., Majerus, P.W., Sutherland, R.L., Tiganis, T., McLean, C., Mitchell, C.A., 2010, Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers, Proceedings Of The National Academy Of Sciences O..., vol 107, issue 51, National Academy of Sciences, USA, pp. 22231-22236.

Loh, K.Y., Deng, H., Fukushima, A., Cai, X., Boivin, B., Galic, S., Bruce, C., Shields, B.J., Skiba, B., Ooms, L.M., Stepto, N.K., Wu, B.J., Mitchell, C.A., Tonks, N., Watt, M.J., Febbraio, M.A., Crack, P.J., Andrikopoulos, S., Tiganis, T., 2009, Reactive oxygen species enhance insulin sensitivity, Cell Metabolism [P], vol 10, issue 4, Cell Press, USA, pp. 260-272.

Ooms, L.M., Horan, K.A., Rahman, P., Seaton, G., Gurung, R., Kethesparan, D.S., Mitchell, C.A., 2009, The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease, Biochemical Journal, vol 419, issue 1, Portland Press Ltd, UK, pp. 29-49.

Waters, J.E., Astle, M.V., Ooms, L.M., Balamatsias, D., Gurung, R., Mitchell, C.A., 2008, P-Rex1 - a multidomain protein that regulates neurite differentiation, Journal of Cell Science, vol 121, issue 17, The Company of Biologists Ltd., United Kingdom, pp. 2892-2903.

Wiradjaja, F., Ooms, L.M., Tahirovic, S., Kuhne, E.S., Devenish, R.J., Munn, A.L., Piper, R.C., Mayinger, P., Mitchell, C.A., 2007, Inactivation of the phosphoinositide phosphatases Sac1p and Inp54p leads to accumulation of phosphatidylinositol 4,5-Bisphosphate on vacuole membranes and vacuolar fusion defects, Journal of Biological Chemistry, vol 282, issue 22, American Society of Biochemistry & Molecular Biology Inc, Bethesda MD USA, pp. 16295-16307.

Ramshaw, H.S., Guthridge, M.A., Stomski, F.C., Barry, E.F., Ooms, L.M., Mitchell, C.A., Begley, C.G., Lopez, A.F., 2007, The Shc-binding site of the ?c subunit of the GM-CSF/IL-3/IL-5 receptors is a negative regulator of hematopoiesis, Blood, vol 110, issue 10, American Society of Hematology, Washington DC USA, pp. 3582-3590.

Astle, M.V., Horan, K.A., Ooms, L.M., Mitchell, C.A., 2007, The inositol polyphosphate 5-phosphatases: traffic controllers, waistline watchers and tumour suppressors?, Biochemical Society Symposium, vol 3.324, Portland Press Ltd, London England UK, pp. 161-181.

Ooms, L.M., Fedele, C.G., Astle, M.V., Ivetac, I., Cheung, V., Pearson, R.B., Layton, M.J., Forrai, A., Nandurkar, H., Mitchell, C.A., 2006, The inositol polyphosphate 5-phosphatase, PIPP, is a novel regulator of phosphoinositide 3-kinase-dependent neurite elongation, Molecular Biology of the Cell, vol 17, issue 2, American Society for Cell Biology, Bethesda USA, pp. 607-622.

Gurung, R., Tan, A., Ooms, L.M., Mcgrath, M.J., Huysmans, R.D., Munday, A.D., Prescott, M., Whisstock, J.C., Mitchell, C.A., 2003, Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: the inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following, Journal of Biological Chemistry, vol 278, issue 13, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 11376-11385.

Mitchell, C.A., Gurung, R., Kong, A.M., Dyson, J.M., Tan, A., Ooms, L.M., 2002, Inositol polyphosphate 5-phospatases: Lipid phosphatases with flair, IUBMB Life, vol 25, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 25-36.

Dyson, J.M., O'Malley, C.J., Becanovic, J., Munday, A.D., Berndt, M.C., Coghill, I.D., Nandurkar, H., Ooms, L.M., Mitchell, C.A., 2001, The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin, Journal of Cell Biology, vol 155, issue 6, Rockefeller University Press, New York NY USA, pp. 1065-1079.

Wiradjaja, F., Ooms, L.M., Whisstock, J.C., Mccoll, B.K., Helfenbaum, L., Sambrook, J., Gething, M., Mitchell, C.A., 2001, The yeast inositol polyphosphate 5-phosphatase Inp54p localizes to the endoplasmic reticulum via a C-terminal hydrophobic anchoring tail, Journal of Biological Chemistry, vol 276, issue 10, American Society for Biochemsitry and Molecular Biology Inc, Bethesda MD USA, pp. 7643-7653.

Kong, A.M., Speed, C.J., O'Malley, C., Layton, M.J., Meehan, T., Loveland, K.L., Cheema, S.S., Ooms, L.M., Mitchell, C.A., 2000, Cloning and characterization of a 72-kDa inositol-polyphosphate 5-phosphatase localized to the Golgi network, Journal of Biological Chemistry, vol 275, American Soc for Biochem & Molecular Biology, Inc, Bethesda USA, pp. 24052-24064.

Whisstock, J.C., Romero, S., Gurung, R., Nandurkar, H., Ooms, L.M., Bottomley, S.P., Mitchell, C.A., 2000, The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis, Journal of Biological Chemistry, vol 275 issue 47, Amer Soc for Biochem & Molecular Biology, Bethesda USA, pp. 37055-37061.

Ooms, L.M., McColl, B.K., Wiradjaja, F., Wijayaratnam, A.P.W., Gleeson, P.A., Gething, M., Sambrook, J., Mitchell, C.A., 2000, The yeast inositol polyphosphate 5-phosphatases Inp52p and Inp53p translocate to actin patches following hyperosmotic stress: Mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations, Molecular and Cellular Biology, vol 20 issue 24, American Society for Microbiology, Washington USA, pp. 9376-9390.

Brown, S., Mcgrath, M.J., Ooms, L.M., Gurung, R., Maimone, M.M., Mitchell, C.A., 1999, Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1, Journal of Biological Chemistry, vol 274, no 38, American Soc. for Biochem. and Mol. Biol. Inc., www.jbc.org, pp. 27083-27091.

Brown, S., Biben, C., Ooms, L.M., Maimone, M.M., Mcgrath, M.J., Gurung, R., Harvey, R.P., Mitchell, C.A., 1999, The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart, Journal of molecular and cellular cardiology, vol 31, Academic Press Ltd., London England, pp. 837-843.

Sun, J., Ooms, L.M., Bird, C., Sutton, V.R., Trapani, J.A., Bird, P.I., 1997, A New Family of 10 Murine Ovalbumin Serpins Includes Two Homologs of Proteinase Inhibitor 8 and Two Homologs of the Granzyme B Inhibitor (Proteinase Inhibitor 9), Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 15434-15441.

Scott, F.L., Eyre, H.J., Ooms, L.M., Sun, J., Bird, P.I., Sutherland, G.R., 1997, Proteinases inhibitor 8 Map position 18q21.3, Chromosome Research, vol 5, Thomson Rapid Science Publisher, USA, p. 279.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Molecular mechanisms of P-Rex1 acts as an oncogene in breast cancer..

Supervisors:

Mitchell, C (Joint-co), Ooms, L (Joint).

Completed Supervision

Student:

Astle, M.

Program of Study:

The 5-phosphatase PIPP binds CRMP proteins and is a novel regulator of neuron differentiation. (PHD) 2008.

Supervisors:

Mitchell, C (Main), Ooms, L (Associate).

Student:

Binge, L.

Program of Study:

The proline-rich inositol polyphosphate 5-phosphatase (PIPP) is a negative regulator of phosphoinositide 3-kinase/Akt signalling in breast cancer. (PHD) 2010.

Supervisors:

Mitchell, C (Main), Ooms, L (Associate).

Student:

Dyson, J.

Program of Study:

THE SH2-CONTAINING INOSITOL POLYPHOSPHATE 5-PHOSPHATASE-2 (SHIP-2) REGULATES THE ACTIN CYTOSKELETON. (PHD) 2003.

Supervisors:

Mitchell, C (Main), Ooms, L (Joint).

Student:

Fedele, C.

Program of Study:

Type II inositol polyphosphate 4-phosphatase is a novel tumour suppressor in human breast cancer. (PHD) 2009.

Supervisors:

Mitchell, C (Main), Ooms, L (Associate).

Student:

Ivetac, I.

Program of Study:

The multifunctional role of the type I inositol polyphosphate 4-phosphatase in the cellular signalling and trafficking pathways. (PHD) 2007.

Supervisors:

Mitchell, C (Main), Ooms, L (Associate).

Student:

Nasa, C.

Program of Study:

. 2007.

Supervisors:

Mitchell, C (Main), Ooms, L (Associate).

Student:

Naughtin, M.

Program of Study:

MTMR4, a novel regulator of endocytic trafficking. (PHD) 2008.

Supervisors:

Mitchell, C (Main), Ooms, L (Associate).

Student:

Wiradjaja, F.

Program of Study:

INP45P REGULATES SECRETION FROM THE ENDOPLASMIC RETICULUM IN SACCHAROMYCES CEREVISIAE. (PHD) 2003.

Supervisors:

Mitchell, C (Joint-Co), Ooms, L (Joint).