Dr Ian Jennings - Researcher Profile

Biography

Position

Research Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Qualifications

SCIENCE

Institution: University of Melbourne

Year awarded: 2002

SCIENCE

Institution: University of Melbourne

Year awarded: 1977

Publications

Journal Articles

Zheng, Z., Amran, S.I., Zhu, J., Schmidt-Kittler, O., Kinzler, K., Vogelstein, B., Shepherd, P.R., Thompson, P., Jennings, I., 2012, Definition of the binding mode of a new class of phosphoinositide 3-kinase alpha-selective inhibitors using in vitro mutagenesis of non-conserved amino acids and kinetic analysis, Biochemical Journal [P], vol 444, Portland Press Ltd., UK, pp. 529-535.

Pinson, J., Schmidt-Kittler, O., Frazzetto, M., Zheng, Z., Jennings, I., Kinzler, K., Vogelstein, B., Chalmers, D.K., Thompson, P., 2012, Synthesis and pharmacological evaluation of 4-iminothiazolidinones for inhibition of PI3 kinase, Australian Journal of Chemistry [E], vol 65, issue 10, CSIRO Publishing, Australia, pp. 1396-1404.

Zheng, Z., Amran, S., Thompson, P., Jennings, I., 2011, Isoform-selective inhibition of phosphoinositide 3-kinase: identification of a new region of nonconserved amino acids critical for p110 alpha inhibition, Molecular Pharmacology [P], vol 80, issue 4, AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS, USA, pp. 657-664.

Pinson, J., Schmidt-Kittler, O., Zhu, J., Jennings, I., Kinzler, K., Vogelstein, B., Chalmers, D., Thompson, P., 2011, Thiazolidinedione-based PI3K alpha inhibitors: an analysis of biochemical and virtual screening methods, Chemmedchem [P], vol 6, issue 3, WILEY-BLACKWELL, USA, pp. 514-522.

Nankervis, J., Feil, S., Hancock, N., Zheng, Z., Ng, H., Morton, C., Holien, J., Ho, P., Frazzetto, M., Jennings, I., Manallack, D., Martin, T., Thompson, P., Parker, M., 2011, Thiophene inhibitors of PDE4: crystal structures show a second binding mode at the catalytic domain of PDE4D2, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 23, PERGAMON-ELSEVIER SCIENCE LTD, ENGLAND, pp. 7089-7093.

Giraud, A., Dumesny, C., Whitley, J., Parker, L., Jennings, I., Kemp, B., Moody, T., Sancho, V., Jensen, R., Shulkes, A., 2010, Isolation, identification and biological activity of gastrin-releasing peptide 1-46 (oGRP1-46), the primary GRP gene-derived peptide product of the pregnant ovine endometrium, Peptides [P], vol 31, issue 2, Elsevier Inc., United States, pp. 284-290.

Frazzetto, M., Suphioglu, C., Zhu, J., Schmidt-Kittler, O., Jennings, I., Cranmer, S.L., Jackson, S., Kinzler, K., Vogelstein, B., Thompson, P., 2008, Dissecting isoform selectivity of P13K inhibitors: The role of non-conserved residues in the catalytic pocket, Biochemical Journal, vol 414, issue 3, Portland Press Ltd., UK, pp. 383-390.

Kemp, B.E., Stapleton, D., Campbell, D.J., Chen, Z., Murthy, S., Walter, M., Gupta, A., Adams, J.J., Katsis, F., van Denderen, B.J., Jennings, I.G., Iseli, T.J., Michell, B., Witters, L.A., 2003, AMP-activated protein kinase, super metabolic regulator, Biochemical Society Transactions, vol 31, issue Pt 1, Portland Press Ltd, London England, pp. 162-168.

Polekhina, G., Gupta, A., Michell, B., van Denderen, B.J., Murthy, S., Feil, S.C., Jennings, I.G., Campbell, D.J., Witters, L.A., Parker, M.W., Kemp, B.E., Stapleton, D.I., 2003, AMPK beta subunit targets metabolic stress sensing to glycogen, Current Biology [P], vol 13, issue 10, Cell Press, United States, pp. 867-871.

Catimel, B., Teh, T., Fontes, M.R., Jennings, I.G., Jans, D.A., Howlett, G.J., Nice, E., Kobe, B., 2001, Biophysical characterization of interactions involving importin-alpha during nuclear import, Journal Of Biological Chemistry [P], vol 276, issue 36, American Society for Biochemistry & Molecular Biology Inc, USA, pp. 34189-34198.

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Identifying the role of specific non-conserved residues on PI3K in the discovery of isoform-selective PI3K inhibitors..

Supervisors:

Thompson, P (Main), Jennings, I (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural studies of PI3 kinase catalysis and inhibitor binding.

Supervisors:

Thompson, P (Main), Jennings, I (Associate).