Dr Bimbil Graham - Researcher Profile

Biography

Position

Senior Lecturer
Faculty of Pharmacy and Pharmaceutical Sciences

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

 

 

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Keywords

Synthetic chemistry, coordination chemistry, bioconjugation, molecular imaging, nanotechnology

Qualifications

BACHELOR OF SCIENCE (HONOURS)

Institution: Monash University

Year awarded: 1999

DOCTOR OF PHILOSOPHY

Institution: Monash University

Year awarded: 1999

Publications

Journal Articles

Desbouis, D., Troitsky, I.P., Belousoff, M.J., Spiccia, L., Graham, B., 2012, Copper(II), zinc(II) and nickel(II) complexes as nuclease mimetics, Coordination Chemistry Reviews [P], vol 256, issue 11-12, Elsevier Science, Lausanne Switzerland, pp. 897-937.

Lau, S., Graham, B., Cao, N., Boyd, B.J., Pouton, C.W., White, P.J., 2012, Enhanced extravasation, stability and in vivo cardiac gene silencing via in situ siRNA-albumin conjugation, Molecular Pharmaceutics [P], vol 9, issue 1, American Chemical Society, USA, pp. 71-80.

Pathberiya, L.G., Barlow, N., Nguyen, T.B.T., Graham, B., Tuck, K.L., 2012, Facile, divergent route to bis-Zn(II)dipicolylamine type chemosensors for pyrophosphate, Tetrahedron [P], vol 68, issue 46, Pergamon, Oxford UK, pp. 9435-9439.

Harikumar, K.G., Wootten, D.L., Pinon, D.I., Koole, C.R., Ball, A.M., Furness, S.G., Graham, B., Dong, M., Christopoulos, A., Miller, L.J., Sexton, P.M., 2012, Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 45, National Academy of Sciences, USA, pp. 18607-18612.

Tjioe, L., Joshi, T., Forsyth, C.M., Moubaraki, B., Murray, K.S., Brugger, J., Graham, B., Spiccia, L., 2012, Phosphodiester cleavage properties of copper(II) complexes of 1,4,7-triazacyclononane ligands bearing single alkyl guanidine pendants, Inorganic Chemistry [P], vol 51, issue 2, American Chemical Society, Washington DC USA, pp. 939-953.

Kamaruddin, M., Ung, P., Hossain, M., Jarasrassamee, B., O'Malley, W., Thompson, P., Scanlon, D., Cheng, H., Graham, B., 2011, A facile, click chemistry-based approach to assembling fluorescent chemosensors for protein tyrosine kinases, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 1, Pergamon, United Kingdom, pp. 329-331.

Piantavigna, S., McCubbin, G., Boehnke, S., Graham, B., Spiccia, L., Martin, L., 2011, A mechanistic investigation of cell-penetrating Tat peptides with supported lipid membranes, Biochimica et Biophysica Acta - Biomembranes [P], vol 1808, issue 7, Elsevier Science BV, Netherlands, pp. 1811-1817.

Swarbrick, J., Ung, P., Chhabra, S., Graham, B., 2011, An iminodiacetic acid based lanthanide binding tag for paramagnetic exchange NMR spectroscopy, Angewandte Chemie - International Edition [P], vol 50, issue 19, WILEY-BLACKWELL, USA, pp. 4403-4406.

de la Cruz, L., Nguyen, T., Ozawa, K., Shin, J., Graham, B., Huber, T., Otting, G., 2011, Binding of low molecular weight inhibitors promotes large conformational changes in the dengue virus NS2B-NS3 protease: fold analysis by pseudocontact shifts, Journal Of The American Chemical Society [P], vol 133, issue 47, AMER CHEMICAL SOC, USA, pp. 19205-19215.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Commercially supplied amine-modified siRNAs may require ultrafiltration prior to conjugation with amine-reactive compounds, Journal of Nucleic Acids [E], vol 2011, issue 154609, SAGE-Hindawi Access to Research, England, pp. 1-5.

Graham, B., Spiccia, L., Hearn, M., 2011, Comparison of the binding behavior of several histidine-containing proteins with immobilized copper(II) complexes of 1,4,7-triazacyclononane and 1,4-bis(1,4,7-triazacyclononan-1-yl)butane, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences [P], vol 879, issue 13-14, Elsevier Science BV, Netherlands, pp. 844-852.

Graham, B., Loh, C., Swarbrick, J., Ung, P., Shin, J., Yagi, H., Jia, X., Chhabra, S., Barlow, N., Pintacuda, G., Huber, T., Otting, G., 2011, DOTA-amide lanthanide tag for reliable generation of pseudocontact shifts in protein NMR spectra, Bioconjugate Chemistry [P], vol 22, issue 10, American Chemical Society, United States, pp. 2118-2125.

Lim, Z., Forsyth, C., Graham, B., 2011, Di-mu(2)-methoxo-bis{[mu-3,10,18,25-tetraazapentacyclo[17.4.4.3.1.1]triconta-1(31),2,4(9),5,7,10,12,14,16(32),17,19(24),20,22,25,27,29-hexadecaene-31,32-diolato]dizinc(II)} bis(perchlorate) N,N-dimethylformamide disolvate, Acta Crystallographica Section E: Structure Reports Online [P], vol 67, issue Part 3, WILEY-BLACKWELL, USA, pp. 1-11.

Tjioe, L., Meininger, A., Joshi, T., Spiccia, L., Graham, B., 2011, Efficient plasmid DNA cleavage by copper(II) complexes of 1,4,7-triazacyclononane ligands featuring Xylyl-linked guanidinium groups, Inorganic Chemistry [E], vol 50, issue 10, American Chemical Society, United States, pp. 4327-4339.

Swarbrick, J., Ung, P., Su, X., Maleckis, A., Chhabra, S., Huber, T., Otting, G., Graham, B., 2011, Engineering of a bis-chelator motif into a protein alpha-helix for rigid lanthanide binding and paramagnetic NMR spectroscopy, Chemical Communications [P], vol 47, ROYAL SOC CHEMISTRY, England, pp. 7368-7370.

Yagi, H., Banerjee, D., Graham, B., Huber, T., Goldfarb, D., Otting, G., 2011, Gadolinium tagging for high-precision measurements of 6 nm distances in protein assemblies by EPR., Journal of the American Chemical Society [E], vol 133, issue 27, AMERICAN CHEMICAL SOCIETY, USA, pp. 10418-10421.

Barreto Solano, J., O'Malley, W., Kubeil, M., Graham, B., Stephan, H., Spiccia, L., 2011, Nanomaterials: applications in cancer imaging and therapy, Advanced Materials [P], vol 23, issue 12, Wiley-Blackwell, USA, pp. 18-40.

Barreto Solano, J., Matterna, M., Graham, B., Stephan, H., Spiccia, L., 2011, Synthesis, colloidal stability and (64)Cu labeling of iron oxide nanoparticles bearing different macrocyclic ligands, New Journal Of Chemistry [P], vol 35, issue 11, ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, England, pp. 2705-2712.

Tjioe, L., Joshi, T., Brugger, J., Graham, B., Spiccia, L., 2011, Synthesis, structure, and DNA cleavage properties of copper(II) complexes of 1,4,7-triazacyclononane ligands featuring pairs of guanidine pendants, Inorganic Chemistry [P], vol 50, issue 2, American Chemical Society, USA, pp. 621-635.

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of SiRNA across the vascular endothelium, Journal Of Gene Medicine [P], vol 13, issue 7-8, WILEY-BLACKWELL, USA, p. 438.

Belousoff, M.J., Gasser, G.A., Graham, B., Tor, Y., Spiccia, L., 2009, Binding of HIV-1 TAR mRNA to a peptide nucleic acid oligomer and its conjugates with metal-ion-binding multidentate ligands, Journal Of Biological Inorganic Chemistry [P], vol 14, SpringerLink, Germany, pp. 287-300.

Belousoff, M.J., Graham, B., Spiccia, L., Tor, Y., 2009, Cleavage of RNA oligonucleotides by aminoglycosides, Organic & Biomolecular Chemistry [P], vol 7, Royal Society of Chemistry, UK, pp. 30-33.

Belousoff, M.J., Ung, P., Forsyth, C.M., Tor, Y., Spiccia, L., Graham, B., 2009, New macrocyclic terbium(III) complex for use in RNA footprinting experiments, Journal Of The American Chemical Society [P], vol 131, American Chemical Society, USA, pp. 1106-1114.

Vivian, J., Scoullar, J., Rimmer, K., Bushell, S.R., Beddoe, T.C., Wilce, M.C.J., Byres, E., Boyle, T.P., Doak, B.C., Simpson, J.S., Graham, B., Heras, B., Kahler, C.M., Rossjohn, J., Scanlon, M., 2009, Structure and function of the oxidoreductase DsbA1 from Neisseria meningitidis, Journal of Molecular Biology [P], vol 394, issue 5, Academic Press, UK, pp. 931-943.

Belousoff, M.J., Graham, B., Spiccia, L., 2008, Copper(II) complexes of N-methylated derivatives of ortho- and meta-xylyl-bridged bis(1,4,7-triazacyclononane) ligands: Synthesis, X-ray structure and reactivity as artificial nucleases, European Journal of Inorganic Chemistry, issue 26, Wiley-VCH Verlag, Germany, pp. 4133-4139.

Graham, B., Spiccia, L., Hearn, M.T.W., 2008, Examination of the binding behaviour of several proteins with the immobilized copper(II) complexes of o-, m- and p-xylylene bridged bis(1,4,7-triazacyclononane) macrocycles, Journal of Chromatography A, vol 1194, Elsevier, The Netherlands, pp. 30-37.

Belousoff, M.J., Tjioe, L., Graham, B., Spiccia, L., 2008, Synthesis, X-Ray Crystal Structures, and Phosphate Ester Cleavage Properties of bis(2-Pyridylmethyl)amine Copper(II) Complexes with Guanidinium Pendant Groups, Inorganic Chemistry, vol 47, issue 19, American Chemical Society, USA, pp. 8641-8651.

Gasser, G.A., Tjioe, L., Graham, B., Belousoff, M.J., Juran, S., Walther, M., Kunstler, J., Bergmann, R., Stephan, H., Spiccia, L., 2008, Synthesis, copper(II) complexation, 64Cu-labeling, and bioconjugation of a new bis(2-pyridylmethyl) derivative of 1,4,7- triazacyclononane, Bioconjugate Chemistry, vol 19, Americal Chemiscal Society, USA, pp. 719-730.

Graham, B., Comba, P., Hearn, M.T.W., Spiccia, L., 2007, An examination of the binding behavior of histidine-containing peptides with immobilized metal complexes derived from the macrocyclic ligand, 1,4,7-triazacyclononane, Journal of Biological Inorganic Chemistry, vol 12, issue 1, Springer, Germany, pp. 11-21.

Belousoff, M.J., Battle, A.R., Graham, B., Spiccia, L., 2007, Syntheses, structures and hydrolytic properties of copper(II) complexes of asymmetrically N-functionalised 1,4,7-triazacyclononane ligands, Polyhedron, vol 26, issue 2, Pergamon, UK, pp. 344-355.

Belousoff, M.J., Graham, B., Moubaraki, B., Murray, K.S., Spiccia, L., 2006, Oxalato-bridged dinuclear copper(II) complexes of N-alkylated derivatives of 1,4,7-triazacyclononane: synthesis, X-ray crystal structures and magnetic properties, European Journal of Inorganic Chemistry, issue 23, Wiley-VCH, Germany, pp. 4872-4878.

Battle, A.R., Graham, B., Spiccia, L., Moubaraki, B., Murray, K.S., Skelton, B.W., White, A.H., 2006, Structure and magnetic properties of polynuclear chloro- and hydroxo-bridged copper(II) complexes formed by a tetramacrocyclic derivative of 1,4,7-triazacyclononane, Inorganica Chimica Acta, vol 359, issue 1, Elsevier BV, Netherlands, pp. 289-297.

Belousoff, M.J., Duriska, M., Graham, B., Batten, S.R., Moubaraki, B., Murray, K.S., Spiccia, L., 2006, Synthesis, X-ray crystal structures, magnetism, and phosphate ester cleavage properties of copper(II) complexes of N-substituted derivatives of 1,4,7-triazacyclononane, Inorganic Chemistry, vol 45, issue 9, Wiley, Germany, pp. 3746-3755.

Wang, W., Kourtchev, I., Graham, B., Cafmeyer, J., Maenhaut, W., Claeys, M., 2005, Characterization of oxygenated derivatives of isoprene related to 2-methyltetrols in Amazonian aerosols using trimethylsilylation and gas chromatography/ion trap mass spectrometry, Rapid Communications in Mass Spectrometry, vol 19, issue 10, Wiley InterScience, USA, pp. 1343-1351.

Graham, B., Spiccia, L., Skelton, B.W., White, A.H., Hockless, D.C.R., 2005, Imidazole derivatives of binuclear copper (II) and nickel (II) complexes incorporating bis(1,4,7-triazacyclononan-1-yl) ligands, Inorganica Chimica Acta, vol 358, issue 358, Elsevier BV, Netherlands, pp. 3974-3982.

Graham, B., Spiccia, L., Batten, S.R., Skelton, B.W., White, A.H., 2005, Polynuclear nickel (II) and copper (II) complexes of hexaazamacrocycles incorporating pairs of diethylenetriamine subunits separated by aromatic spacers, Inorganica Chimica Acta, vol 358, issue 13, Elsevier BV, Netherlands, pp. 3983-3994.

Graham, B., Claeys, M., Vas, G., Wang, W., Vermeylen, R., Pashynska, V., Cafmeyer, J., Guyon, P., Andreae, M.O., Artaxo, P., Maenhaut, W., 2004, Formation of Secondary Organic Aerosols Through Photooxidation of Isoprene, Science, vol 303, Highwire Press, USA, pp. 1173-1176.

Graham, B., Falkovich, A.H., Rudich, Y., Maenhaut, W., Guyon, P., Andreae, M.O., 2004, Local and regional contributions to the atmospheric aerosol over Tel Aviv, Israel:a case study using elemental, ionic and organic tracers, Atmospheric Environment, vol 38, issue 11, Elsevier Ltd, The Netherlands, pp. 1593-1604.

Guyon, P., Graham, B., Roberts, G.C., Mayol-Bracero, O.L., Maenhaut, W., Artaxo, P., Andreae, M.O., 2004, Sources of optically active aerosol particles over the Amazon forest, Atmospheric Environment, vol 38, issue 7, Elsevier Science Ltd, Netherlands, pp. 1039-1051.

Graham, B., Hearn, M.T.W., Spiccia, L., Skelton, B.W., White, A.H., 2003, Amino acid binding to copper(II) in (1,4,7-triazacyclononane) (L-histidine)copper(II) hexafluorophosphate monohydrate, Australian Journal of Chemistry, vol 56, CSIRO Publishing, Collingwood Vic Australia, pp. 1259-1261.

Graham, B., Guyon, P., Maenhaut, W., Taylor, P.E., Ebert, M., Matthias-Maser, S., Mayol-Bracero, O.L., Godoi, R.H., Artaxo, P., Meixner, F.X., Lima Moura, M.A., Eca D'Almeida Rocha, C.H., Van Grieken, R., Glovsky, M.M., Flagan, R.C., Andreae, M.O., 2003, Composition and diurnal variability of the natural Amazonian aerosol, Journal of Geophysical Research, vol 108, issue D24, American Geophysical Union, USA, pp. AAC5.1-AAC5.16.

Guyon, P., Graham, B., Roberts, G.C., Mayol-Bracero, O.L., Maenhaut, W., Artaxo, P., Andreae, M.O., 2003, In-canopy gradients, composition, and sources of optically active aerosols over the Amazon forest, Journal of Geophysical Research, vol 108, issue D18, AGU Journals, USA, pp. AAC9.1-AAC9.16.

Graham, B., Guyon, P., Taylor, P.E., Artaxo, P., Maenhaut, W., Glovsky, M.M., Flagan, R.C., Andreae, M.O., 2003, Organic compounds present in the natural Amazonian aerosol: Characterization by gas chromatography-mass spectrometry, Journal of Geophysical Research, vol 108, issue D24, American Geophysical Union, USA, pp. AAC6.1-AAC6.13.

Guyon, P., Graham, B., Beck, J., Boucher, O., Gerasopoulos, E., Mayol-Bracero, O.L., Roberts, G.C., Artaxo, P., Andreae, M.O., 2003, Physical properties and concentration of aerosol particles over the Amazon tropical forest during background and biomass burning conditions, Atmospheric Chemistry and Physics Discussions, vol 3, issue 5, Copernicus Publications, Germany, pp. 1367-1414.

Guyon, P., Boucher, O., Graham, B., Beck, J., Mayol-Bracero, O.L., Roberts, G.C., Maenhaut, W., Artaxo, P., Andreae, M.O., 2003, Refractive Index of aerosol particles over the Amazon tropical forest during LBA-EUSTACH 1999, Jounral of Aerosol Science, vol 34, issue 7, Elsevier Science Ltd, Netherlands, pp. 883-907.

Levin, Z., Teller, A., Ganor, E., Graham, B., Andreae, M.O., Maenhaut, W., Falkovich, A.H., Rudich, Y., 2003, Role of aerosol size and composition in nucleation scavenging within clouds in a shallow cold front, Journal of Geophysical Research, vol 108, issue D22, American Geophysical Union, USA, pp. AAC5.1-AAC5.14.

Blazso, M., Janitsek, S., Gelencser, A., Artaxo, P., Graham, B., Andreae, M.O., 2003, Study of tropical organic aerosol by thermally assisted alkylation-gas chromatography mass spectrometry, Journal of Analytical and Applied Pyrolysis, vol 68-69, Elsevier Science Ltd, Netherlands, pp. 351-369.

Graham, B., Spiccia, L., Fallon, G.D., Hearn, M.T.W., Mabbs, F.E., Moubaraki, B., Murray, K.S., 2002, Structure and magnetic properties of tri- and hexa-nuclear hydroxo-bridged copper(II) complexes formed by a trimacrocyclic derivative of 1,4,7-triazacyclononane, Journal of the Chemical Society - Dalton Transactions, vol 6, Royal Society of Chemistry, Cambridge England, pp. 1226-1232.

Graham, B., Mayol-Bracero, O.L., Guyon, P., Roberts, G.C., Decesari, S., Facchini, M.C., Artaxo, P., Maenhaut, W., Koll, P., Andreae, M.O., 2002, Water-soluble organic compounds in biomass burning aerosols over Amazonia 1. Characterization by NMR abd GC-MS, Jounral of Geophysical Research, vol 107, issue D20, American Geophysical Union, USA, pp. LB14.1-LB14.16.

Mayol-Bracero, O.L., Guyon, P., Graham, B., Roberts, G., Andreae, M.O., 2002, Water-soluble organic compounds in biomass burning aerosols over Amazonia 2. Apportionment of the chemical composition and importance of the polyacidic fraction, Journal of Geophysical Research, vol 107, issue D20, The American Geophysical Union, USA, pp. LBA59.1-LBA59.15.

Graham, B., Spiccia, L., Bond, A.M., Hearn, M.T., Kepert, C.M., 2001, Structural, spectroscopic and electrochemical studies of nickel(II) "sandwich" complexes with ligands featuring tethered 1,4,7-triazacyclononane macrocycles, Dalton Transactions: an international journal of inorganic chemistry, vol 15, issue 15, Royal Society of Chemistry, UK, pp. 2232-2238.

Graham, B., Hearn, M.W., Junk, P.C., Kepert, C.M., Mabbs, F.E., Moubaraki, B., Murray, K.S., Spiccia, L., 2001, Syntheses, crystal structures, magnetic properties, and EPR spectra of tetranuclear copper(II) complexes featuring pairs of "roof-shaped" Cu2X2 dimers with hydroxide, methoxide, and azide bridges, Inorganic Chemistry, vol 40, issue 7, American Chemical Society, USA, pp. 1536-1543.

Warden, A.C., Graham, B., Hearn, M.T.W., Spiccia, L., 2001, Synthesis of novel derivatives of 1,4,7-triazacyclononane, Organic Letters, vol 3, issue 18, American Chemical Society, USA, pp. 2855-2858.

Graham, B., Grannas, M.J., Hearn, M.T.W., Kepert, C., Spiccia, L., Skelton, B.W., White, A.H., 2000, Coordination Chemistry of a Novel Tetramacrocyclic Ligand Derived from 1,4,7-Triazacyclononane: Synthesis, Structure, and Properties of Nickel(II) and Copper(II) Complexes, Inorganic Chemistry, vol 39, American Chemical Society, Washington DC USA, pp. 1092-1099.

Jiang, W., Graham, B., Spiccia, L., Hearn, M.T., 1998, Protein selectivity with immobilized metal ion-tacn sorbents: Chromatographic studies with human serum proteins and several other globular proteins, Analytical Biochemistry, vol 255, Academic Press, USA, pp. 47-58.

Jiang, W., Graham, B., Spiccia, L., Hearn, M.T., 1998, Protein selectivity with immobilized metal ion-tacn sorbents: chromatographic studies with human serum proteins and several other globular proteins, Analytical Biochemistry, vol 225 no 1, Academic Press, San Diego USA, pp. 47-58.

Fry, F., Graham, B., Spiccia, L., Hockless, D.C.R., Tiekink, E.R.T., 1997, Binuclear copper complexes of bis(1,4,7-triazacyclonon-1-yl) ligands incorporating acetate pendant arms, Journal of the Chemical Society, Dalton Transactions, Royal Society of Chemistry, UK, pp. 827-831.

Graham, B., Fallon, G.D., Hearn, M.T., Hockless, D.C.R., Lazarev, G., Spiccia, L., 1997, Coordination modes of a series of xylylene-bridged bis(1,4,7-triazacyclonon-1-yl) ligands: Synthesis, structure and properties of nickel(II) and copper(II) complexes, Inorganic Chemistry, vol 36, American Chemical Society, USA, pp. 6366-6373.

Graham, B., Fallon, G.D., Hearn, M.T., Hockless, D.C.R., Lazarev, G., Spiccia, L., 1997, Coordination modes of a series of xylylene-bridged bis(1,4,7-triazacyclonon-1-yl) ligands: synthesis, structure, and properties of nickel(II) and copper(II) complexes, Journal of Inorganic Chemistry, vol 36, The American Chemical Society, Washington DC USA, pp. 6366-6373.

Graham, B., Moubaraki, B., Murray, K.S., Spiccia, L., Cashion, J.D., Hockless, D.C.R., 1997, Syntheses and characterization of mono - and di - nuclear iron(III) complexes of 1,4,7 - triazacyclononane - N - acetate (L). Crystal structures of [FeCl2L] and [Fe2(m - O)(m - O2CMe)L2]CIO4 . NaClO4 . 2H2O, Journal of the Chemical Society, Dalton Transactions, vol no, Royal Society of Chemistry, UK, pp. 887-893.

Graham, B., Spiccia, L., Moubaraki, B., Murray, K.S., Cashion, J.D., Hockless, D.C.R., 1997, Synthesis and characterisation of mononuclear and dinuclear iron (III) Complexes of 1,4,7 - Triazacyclononane - N - Acetate(L). Crystal structures of [FeCl2L[ and [Fe2(m - O) (m - O2CMe)L2]CIO4 NaCIO4. 2H2O, Journal of the Chemical Society-Dalton Transactions, vol jsdtbi, Royal Society of Chemistry, UK, pp. 887-893.

Spiccia, L., Graham, B., Hearn, M.T., Lazarev, G., Moubaraki, B., Murray, K.S., Tiekink, E.R.T., 1997, Towards synthetic models for trinuclear copper active sites of ascorbate oxidase and laccase: self-assembly, crystal structure and magnetic properties of the copper (II) complexes of 1,3,5-tris(1,4,7-triazacyclonon-1-ylmethyl)benzene, Journal of the Chemical Society-Dalton Transactions, vol -, Royal Society of Chemistry, Cambridge UK, pp. 4089-4097.

Spiccia, L., Graham, B., Hearn, M.T., Lazarev, G., Moubaraki, B., Murray, K.S., Tiekink, E.R.T., 1997, Towards synthetic models for trinuclear copper active sites of ascorbate oxidase and laccase: self-assembly, crystal structure and magnetic properties of the copper(II) complexes of 1,3,5-tris(1,4,7-triazacyclonon-1-ylmethyl)benzene, Journal of the Chemical Society, Dalton Transactions, vol no, Royal Society of Chemistry, UK, pp. 4089-4097.

Conference Proceedings

Lau, S., Graham, B., Boyd, B., Pouton, C., White, P., 2011, Utilisation of albumin to enhance in vivo delivery of sirna across the vascular endothelium, The Journal of Gene Medicine, 04-06 Mat 2011, John Wiley & Sons, England, p. e1.

Gasser, G., Bond, A.M., Graham, B., Kosowski, Z., Spiccia, L., 2005, Synthesis of new metal complex - biomolecule hybrids as redox ensors for specific nucleobases, NSTI-Nanotech 2005, 08 May 2005 to 12 May 2005, Nano Science and Technolgy Institute, USA, pp. 412-415.

Wei, J., Graham, B., Wirth, H.-., Boysen, R.I., Spiccia, L., Hearn, M.T., 1997, Engineering ligands for the high resolution analysis and purification of recombinant proteins, 17th International Symposium on the Separation of Proteins, Peptides and Polynucleotides, Rockvile, Maryland USA, Oct. 26-29, 1997, Barr Enterprises, Rockville MD USA, p. 41.

Other

Graham, B., Mooney, J., Jiang, W., Hearn, M., Christensen, T., Spiccia, L., 2009, Peptide purification by means of metal ion affinity chromatography, Japan.

Christensen, T., Hearn, M.T.W., Spiccia, L., Jiang, W., Mooney, J.T., Graham, B., 2008, Peptide purification by means of metal ion affinity chromatography.

Christensen, T., Hearn, M.T.W., Spiccia, L., Jiang, W., Mooney, J.T., Graham, B., 2003, Peptide Purification by Means of Metal Ion Affinity Chromatography, Europe.

Christensen, T., Hearn, M.T.W., Spiccia, L., Jiang, W., Mooney, J.T., 2003, Peptide Purification by Means of Metal Ion Affinity Chromatography, Worldwide.

Graham, B., Mooney, J., Jiang, W., Hearn, M., Christensen, T., Spiccia, L., 2002, Peptide purification by means of metal ion affinity chromatography, Sydney, NSW, Australia.

Graham, B., Grannas, M.J., Spiccia, L., Fallon, G.D., Hearn, M.T., Tiekink, E.R.T., Hockless, D.C.R., Skelton, B.W., White, A.H., 1997, Synthesis and application of polynuclear metal complexes in immobilised metal affinity chromatography (IMAC), RACI 3rd Annual Postgraduate Symposium on Inorganic Chemistry, RACI, Australia.

Teaching Commitment

Organic Chemistry I and II (unit coordinator and lecturer)

Chemistry of Biomolecules (unit coordinator and lecturer)

Chemical Technologies for the Pharmaceutical Sciences (lecturer

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Aminoglycoside - Metal Complexes as Novel RNA Cleaving Agents.

Supervisors:

Spiccia, L (Main), Graham, B (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

LRET based assay employing luminescent metal chelates and nanoparticles.

Supervisors:

Graham, B (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Lanthanide tags for luminescent cellular imaging and paramegnetic structural NMR.

Supervisors:

Graham, B (Main), Swarbrick, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Lanthanide-based artificial ribonucleases targetting therapeutically-significant RNA motifs.

Supervisors:

Graham, B (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Luminescent Bivalent GPCR-Binding Ligands.

Supervisors:

Graham, B (Joint), Scammells, P (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Nanomaterials as Cancer Imaging and Therapeutic Agents.

Supervisors:

Spiccia, L (Main), Graham, B (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Nanoparticle-based agents for cancer imaging and therapy.

Supervisors:

Swarbrick, J (Main), Graham, B (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Novel anti-cancer agents for stabilising g-quadruplex DNA.

Supervisors:

Graham, B (Main), Chalmers, D (Associate), Swarbrick, J (Associate).

Completed Supervision

Student:

Tjioe, L.

Program of Study:

Catalytic cleavage agents for phosphate esters hydrolysis. (PHD) 2010.

Supervisors:

Spiccia, L (Main), Graham, B (Associate).