Prof Hatem Salem - Researcher Profile

Professor Hatem Salem

Address

Medicine
Monash Medical School Building, The Alfred Hospital

Biography

Hatem works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Related Links:

Qualifications

Unknown
Institution: Royal Australasian College of Physicians
Year awarded: 1984
Unknown
Institution: Royal College of Pathologists of Australasia
Year awarded: 1984
Unknown
Institution: Royal Collge of Physicians of England
Year awarded: 1984
Unknown
Institution: Royal Collge of Physicians of England
Year awarded: 1977
Unknown
Institution: Royal College of Surgeons of England
Year awarded: 1977
Unknown
Institution: Royal College of Physicians of UK
Year awarded: 1976
Unknown
Institution: Mosul, Iraq
Year awarded: 1974

Publications

Journal Articles

Low, M., Lee, D., Coutsouvelis, J., Patil, S., Opat, S., Walker, P.A., Schwarer, A., Salem, H.H., Avery, S., Spencer, A., Wei, A., 2013, High-dose cytarabine (24g/m2) in combination with idarubicin (HiDAC-3) results in high first-cycle response with limited gastrointestinal toxicity in adult acute myeloid leukaemia, Internal Medicine Journal [P], vol 43, issue 3, Wiley-Blackwell Publishing Asia, Richmond, VIC 3121 Australia, pp. 294-297.

Fitzgerald, M., Chan, J., Ross, A., Liew, S., Butt, W., Baguley, D., Salem, H., Russ, M., Deasy, C., Martin, K., Mathew, J., Rosenfeld, J., 2011, A synthetic haemoglobin-based oxygen carrier and the reversal of cardiac hypoxia secondary to severe anaemia following trauma, Medical Journal Of Australia [P], vol 194, issue 9, Australasian Medical Publishing Company Pty Ltd.,, Australia, pp. 471-473.

Schoenwaelder, S., Jarman, K., Gardiner, E., Hua, M., Qiao, J., White, M., Josefsson, E., Alwis, I., Ono, A., Willcox, A., Andrews, R., Mason, K., Salem, H., Huang, D., Kile, B., Roberts, A., Jackson, S., 2011, Bcl-x L-inhibitory BH3 mimetics can induce a transient thrombocytopathy that undermines the hemostatic function of platelets, Blood [P], vol 118, issue 6, American Society of Hematology, USA, pp. 1663-1674.

Tran, H., Collecutt, M., Whitehead, S., Salem, H.H., 2011, Prothrombin complex concentrates used alone in urgent reversal of warfarin anticoagulation, Internal Medicine Journal [P], vol 41, issue 4, Wiley-Blackwell Publishing Asia, Victoria, Australia, pp. 337-343.

Teh, T., Grigoriadis, G., Salem, H., 2010, Clinical Scientific notes, Internal Medicine Journal [E], vol 40, Wiley-Blackwell Publishing Asia, Australia, pp. 667-670.

Woollard, K.J., Sturgeon, S.A., Chin-Dusting, J.P., Salem, H.H., Jackson, S., 2009, Erythrocyte hemolysis and hemoglobin oxidation promote ferric chloride-induced vascular Injury, Journal Of Biological Chemistry [P], vol 284, issue 19, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 13110-13118.

Schoenwaelder, S.M., Yuan, Y., Josefsson, E.C., White, M.J., Yao, Y., Mason, K.D., O'Reilly, L.A., Henley, K.J., Ono, A., Hsiao, S.T., Willcox, A.E.H., Roberts, A.W., Huang, D.C.S., Salem, H.H., Kile, B., Jackson, S., 2009, Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function, Blood [P], vol 114, issue 3, American Society of Hematology, USA, pp. 663-666.

Schoenwaelder, S.M., Ono, A., Sturgeon, S.A., Chan, S.M., Mangin, P., Maxwell, M.J., Turnbull, S., Mulchandani, M., Anderson, K.E., Kauffenstein, G., Rewcastle, G.W., Kendall, J., Gachet, C., Salem, H.H., Jackson, S., 2007, Identification of a unique co-operative phosphoinositide 3-kinase signaling mechanism regulating integrin aIIb?3 adhesive function in platelets, The Journal of Biological Chemistry, vol 282, issue 39, The American Society for Biochemistry and Molecular Biology Inc, USA, pp. 28648-28658.

Nesbitt, W.S., Mangin, P., Salem, H.H., Jackson, S., 2006, The impact of blood rheology on the molecular and cellular events underlying arterial thrombosis., Journal of Molecular Medicine, vol 84, issue 12, Springer-Verlag, Germany, pp. 989-995.

Cranmer, S.L., Pikovski, I., Mangin, P.H., Thompson, P.E., Domagala, T., Frazzetto, M., Salem, H.H., Jackson, S.P., 2005, Identification of a unique filamin A binding region within the cytoplasmic domain of glycoprotein Ibalpha, Biochemical Journal, vol 387, issue 3, Portland Press Ltd, London UK, pp. 849-858.

Jackson, S.P., Schoenwaelder, S.M., Goncalves, I., Nesbitt, W.S., Yap, C.L., Wright, C.E., Kenche, V.B., Anderson, K.E., Dopheide, S.M., Yuan, Y., Sturgeon, S.A., Prabaharan, H., Thompson, P.E., Smith, G.D., Shepherd, P.R., Daniele, N., Kulkarni, S., Abbott, B., Saylik, D., Jones, C., Lu, L., Giuliano, S., Hughan, S.C., Angus, J.A., Robertson, A.D., Salem, H.H., 2005, PI 3-kinase p110beta: A new target for antithrombotic therapy, Nature Medicine, vol 11, issue 5, Nature Publishing Group, New York USA, pp. 507-514.

Maxwell, M.J., Yuan, Y., Anderson, K.E., Hibbs, M.L., Salem, H.H., Jackson, S.P., 2004, SHIP1 and Lyn kinase negatively regulate integrin IIb3 signaling in platelets, The Journal of Biological Chemistry, vol 279, issue 31, The American Society for Biochemistry and Molecular Biology,c, USA, pp. 32196-32204.

Baker, R.I., Coughlin, P.B., Gallus, A.s., Harper, P.L., Salem, H.H., Wood, E.M., 2004, Warfarin reversal: consensus guidelines, on behalf of the Australasian Society of Thrombosis and Haemostasis, Medical Journal of Australia, vol 181, issue 9, Australasian Medical Publishing co Pty Ltd, Australila, pp. 492-497.

Nesbitt, W.S., Kulkarni, S., Giuliano, S., Goncalves, I., Dopheide, S.M., Yap, C.L., Harper, I.S., Salem, H., Jackson, S.P., 2002, Distinct Glycoprotein Ib/V/IX and Integrin IIb3-dependent Calcium Signals Cooperatively Regulate Platelet Adhesion under Flow, The Journal of Biological Chemistry, vol 277, issue 4, The Amer Society for Biochemistry and Molecular Biology Inc, USA, pp. 2965-2972.

Yap, C.L., Anderson, K.E., Hughan, S.C., Dopheide, S.M., Salem, H., Jackson, S.P., 2002, Essential role for phosphoinositide 3-kinase in shear-dependent signaling between platelet glycoprotein Ib/V/IX and integrin IIb3, BLOOD, vol 99, issue 1, The American Society of Hematology, USA, pp. 151-158.

Williamson, D., Pikovski, I., Cranmer, S.L., Mangin, P., Mistry, N., Domagala, T., Chehab, S., Lanza, F., Salem, H., Jackson, S.P., 2002, Interaction between Platelet Glycoprotein Ib and Filamin-1 Is Essential for Glycoprotein Ib/IX Receptor Anchorage at High Shear, The Journal of Biological Chemistry, vol 277, issue 3, The Amer Society for Biochemistry and Molecular Biolog Inc, Bethesda MD USA, pp. 2151-2159.

Schoenwaelder, S.M., Hughan, S.C., Boniface, K., Fernando, S., Holdsworth, M., Thompson, P.E., Salem, H., Jackson, S.P., 2002, RhoA Sustains Integrin IIb3 Adhesion Contacts under High Shear, Journal of Biological Chemistry, vol 277, issue 17, Amer Soc for Biochemistry and Molecular Biology, Inc, Bethesda MD USA, pp. 14738-14746.

Mistry, N., Cranmer, S.L., Yuan, Y., Mangin, P., Dopeide, S.M., Harper, I., Giuliano, S., Dunstan, D.E., Lanza, F., Salem, H.H.H., Jackson, S.P., 2000, Cytoskeletal regulation of the platelet glycoprotein Ib/V/IX-von Willebrand factor interaction, Blood, vol 96 issue 10, The American Society of Hematology, Washington DC USA, pp. 3480-3489.

Yap, C.L., Hughan, S.C., Cranmer, S.L., Nesbitt, W.S., Rooney, M.M., Giuliano, S., Kulkarni, S., Dopeide, S.M., Yuan, Y., Salem, H.H.H., Jackson, S.P., 2000, Synergistic adhesive interactions and signaling mechanisms operating between platelet glycoprotein Ib.IX and intergrin alphaIIbBeta3, The Journal of Biological Chemistry, vol 275 issue 52, Amer Soc for Biochemistry and Molecular Biology, Bethesda UK, pp. 41377-41388.

Cranmer, S.L., Ulsemer, P., Cooke, B.M., Salem, H.H., De La Salle, C., Lanza, F., Jackson, S.P., 1999, Glycoprotein (GP) Ib-IX-transfected cells roll on a von Willebrand factor matrix under flow. Importance of the GPIb/actin-binding protein (ABP-280) interaction in maintaining adhesion under high shear, The Journal of Biological Chemistry, vol 274 issue 10, Amer Soc for Biochemistry & Molecular Biology Inc, Bethesda USA, pp. 6097-6106.

Yuan, Y., Kulkarni, S., Ulsemer, P., Cranmer, S.L., Yap, C.L., Nesbitt, W.S., Harper, I., Mistry, N., Dopheide, S.M., Hughan, S.C., Williamson, D., De La Salle, C., Salem, H.H., Lanza, F., Jackson, S.P., 1999, The von Willebrand factor-glycoprotein Ib/V/IX interaction induces actin polymerisation and cytoskeletal reorganisation in rolling platelets and glycoprotein Ib/V/IX-transfected cells, Journal of Biological Chemistry, vol 274 issue 51, American Society for Molecular Biology Inc., Rockville Pike Bethesda MD USA, pp. 36241-36251.

Bird, P.I., Cerruti, L., Scott, F.L., Coughlin, P.B., Salem, H.H., Paddle-Ledinek, J.E., 1998, Proteinase inhibitor 6 (PI-6) expression in human skin: Induction of PI-6 and a PI-6/Proteinase complex during keratinocyte differentiation, Experimental cell research, vol 245, Academic Press, USA, pp. 263-271.

Schoenwaelder, S.M., Yuan, Y., Cooray, P., Salem, H.H., Jackson, S.P., 1997, Calpain Cleavage of Focal Adhesion Proteins Regulates the Cytosskeletal Attachment of Integrin aPb b3(Platelet Glyoprotein IIb/IIIa and the Cellular Retraction of Fibrin Clots, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 1694-1702.

Yuan, Y., Dopeide, S.M., Ivanidis, C., Salem, H.H., Jackson, S.P., 1997, Calpain Regulation of Cytoskeletal Signaling Complexes in Von Willbrand Factor-stimulated Platelets, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 21847-21854.

Schoenwaelder, S.M., Kulkarni, S., Salem, H.H., Imajoh-Ohmi, S., Yamao-Harigaya, W., Saido, T.C., Jackson, S.P., 1997, Distinct Substrate Specificites and Functional Roles for the 78 - and 76 - kDa Forms of m-Calpain in Human Platelets, Journal of Biological Chemistry, vol 272, Am. Soc. Biochem. and Mol. Biol., USA, pp. 24876-24884.

Castelino, D.J., Salem, H.H., 1997, Natural anticoagulants and the liver, Journal of Gastroenterology and Hepatology, vol 12, Blackwell Science, USA, pp. 77-83.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Determining the role of GPIb binding to thrombin specifically pertaining to its effect on fibrin generation and impact on leukocyte - platelet interaction.
Supervisors:
Jackson, S (Main), Salem, H (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Management of distal DVT-A treatment paradigm.
Supervisors:
Salem, H (Main), Tran, H (Associate).

Completed Supervision

Student:
Abbott, B.
Program of Study:
SYNTHESIS AND STRUCTURE-ACTIVITY STUDIES OF ANTIPLATELET 2-MORPHOLINOCHROMONES. (PHD) 2003.
Supervisors:
Salem, H (Main), Thompson, P (Associate).
Student:
Frazzetto, M.
Program of Study:
Studies of phosphoinositide 3-kinase isoform function using selective inhibitors and site directed mutagenesis. (PHD) 2007.
Supervisors:
Salem, H (Joint-Co), Thompson, P (Joint).
Student:
Ghasemzadeh, M.
Program of Study:
Investigation of signalling cross-talk between platelets and neutrophils. (PHD) 2009.
Supervisors:
Jackson, S (Main), Salem, H (Associate).
Student:
Hosseini, E.
Program of Study:
HLA-E polymorphisms and NK cell reconstitution after allogeneic hematopoietic stem cell transplantation. (PHD) 2010.
Supervisors:
Schwarer, A (Main), Salem, H (Associate).
Student:
Kosta, M.
Program of Study:
REGULATION OF TISSUE-TYPE PLASMINOGEN ACTIVATOR. (PHD) 2000.
Supervisors:
Medcalf, R (Main), Salem, H (Associate).
Student:
Kulkarni, S.
Program of Study:
Investigation of Mechanisms Regulating Platelet Aggregation Under Flow. (PHD) 2002.
Supervisors:
Salem, H (Main), Jackson, S (Associate).
Student:
Maxwell, M.
Program of Study:
INVESTIGATION OF MECHANISMS REGULATING PLATELET ADHESION DYNAMICS UNDER FLOW. (PHD) 2005.
Supervisors:
Jackson, S (Main), Salem, H (Associate).
Student:
Mistry, N.
Program of Study:
INVESTIGATION OF THE ROLE OF THE PLATELET CYTOSKELETON IN REGULATING THE INTERACTION BETWEEN GLYCOPROTEIN IB/V/IX AND VON WILLEBRAND FACTOR. (PHD) 2003.
Supervisors:
Salem, H (Main), Jackson, S (Associate).
Student:
Scott, F.
Program of Study:
MOLECULAR CELL BIOLOGY. (PHD) 2000.
Supervisors:
Salem, H (Main), Bird, P (Associate).
Student:
Tierney, M.
Program of Study:
POST-TRANSCRIPTIONAL REGULATION OF PLASMINOGEN ACTIVATOR INHIBITOR TYPE 2. (PHD) 2002.
Supervisors:
Medcalf, R (Main), Salem, H (Associate).
Student:
Yap, C.
Program of Study:
INVESTIGATION OF SHEER DEPENDENT SIGNALLING BETWEEN PLATELET GLYCOPROTEIN Ib/V/IX AND INTEGRIN IIb/IIla. (PHD) 2002.
Supervisors:
Salem, H (Main), Jackson, S (Associate).