Dr Sebastian Furness - Researcher Profile

Biography

Position

Research Officer
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

 

Qualifications

PHD

Institution: Uni of Adelaide

Year awarded: 2004

BACEHELOR OF SCIENCE (HONS)

Institution: Uni of Adelaide

Year awarded: 2000

Publications

Journal Articles

Furness, S.G.B., Wootten, D.L., Christopoulos, A., Sexton, P.M., 2012, Consequences of splice variation on secretin family G protein-coupled receptor function, British Journal of Pharmacology [P], vol 166, issue 1, Wiley-Blackwell, Malden USA, pp. 98-109.

Harikumar, K.G., Wootten, D.L., Pinon, D.I., Koole, C.R., Ball, A.M., Furness, S.G., Graham, B., Dong, M., Christopoulos, A., Miller, L.J., Sexton, P.M., 2012, Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 109, issue 45, National Academy of Sciences, USA, pp. 18607-18612.

Sato, M., Hutchinson, D.S., Halls, M.L., Furness, S.G.B., Bengtsson, T., Evans, B.A., Summers, R.J., 2012, Interaction with caveolin-1 modulates G protein coupling of the mouse beta3-adrenoceptor, Journal Of Biological Chemistry [P], vol 287, issue 24, American Society for Biochemistry and Molecular Biology Inc., USA, pp. 20674-20688.

Willard, F.S., Wootten, D.L., Showalter, A.D., Savage, E.E., Ficorilli, J., Farb, T.B., Bokvist, K., Alsina-Fernandez, J., Furness, S.G., Christopoulos, A., Sexton, P.M., Sloop, K.W., 2012, Small molecule allosteric modulation of the glucagon-like Peptide-1 receptor enhances the insulinotropic effect of oxyntomodulin, Molecular Pharmacology [P], vol 82, issue 6, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 1066-1073.

Wookey, P.J., McLean, C.A., Hwang, P.Y.K., Furness, S.G.B., Nguyen, S., Kourakis, A., Hare, D.L., Rosenfeld, J.V., 2012, The expression of calcitonin receptor detected in malignant cells of the brain tumour glioblastoma multiforme and functional properties in the cell line A172, Histopathology [P], vol 60, issue 6, Wiley-Blackwell Publishing Ltd, UK, pp. 895-910.

Whelan, F., Hao, N., Furness, S.G., Whitelaw, M.L., Chapman-Smith, A., 2010, Amino acid substitutions in the aryl hydrocarbon receptor ligand binding domain reveal YH439 as an atypical AhR activator, Molecular Pharmacology [P], vol 77, issue 6, American Society for Pharmacology & Experimental Therapeutics, USA, pp. 1037-1046.

Dave, K.A., Whelan, F., Bindloss, C., Furness, S.G., Chapman-Smith, A., Whitelaw, M.L., Gorman, J.J., 2009, Sulfonation and phosphorylation of regions of the dioxin receptor susceptible to methionine modifications., Molecular & Cellular Proteomics [P], vol 8, issue 4, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 706-719.

Furness, S., Whelan, F., 2009, The pleiotropy of dioxin toxicity - Xenobiotic misappropriation of the aryl hydrocarbon receptor's alternative physiological roles, Pharmacology and Therapeutics [P], vol 124, issue 3, Elsevier Inc., United States, pp. 336-353.

Morfis, M., Tilakaratne, N., Furness, S.G.B., Christopoulos, G., Werry, T.D., Christopoulos, A., Sexton, P., 2008, Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors, Endocrinology, vol 149, issue 11, The Endocrine Society, United States, pp. 5423-5431.

Dave, K.A., Hamilton, B.R., Wallis, T.P., Furness, S.G.B., Whitelaw, M.L., Gorman, J.J., 2007, Identification of N,Nepsilon-dimethyl-lysine in the murine dioxin receptor using MALDI-TOF/TOF- and ESI-LTQ-Orbitrap-FT-MS, International Journal of Mass Spectrometry, vol 268, issue 2-3, Elsevier BV, Amsterdam Netherlands, pp. 168-180.

Furness, S.G.B., Lees, M.J., Whitelaw, M.L., 2007, The dioxin (aryl hydrocarbon) receptor as a model for adaptive responses of bHLH/PAS transcription factors, FEBS Letters, vol 581, issue 19, Elsevier Science BV, Amsterdam Netherlands, pp. 3616-3625.

Furness, S.G.B., McNagny, K., 2006, Beyond mere markers: Functions for CD34 family of sialomucins in hematopoiesis, Immunologic Research, vol 34, issue 1, Humana Press Inc, Totowa NJ USA, pp. 13-32.

Tan, P.C., Furness, S.G.B., Merkens, H., Lin, S., McCoy, M.L., Roskelley, C.D., Kast, J., McNagny, K.M., 2006, Na+/H+ exchanger regulatory factor-1 is a hematopoietic ligand for a subset of the CD34 family of stem cell surface proteins, Stem Cells, vol 24, issue 5, Alphamed Press, Durham USA, pp. 1150-1161.

Teaching Commitment

• Supervision of honours student in Drug Discovery Biology

Activities

Affiliations with institutes

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Proteomic approaches to characterize novel aspects of ligand-directed trafficking of receptor signal.

Supervisors:

Sexton, P (Main), Furness, S (Associate), Wootten, D (Associate).