Prof Magdalena Plebanski - Researcher Profile

Biography

Magdalena works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: Bristol University United Kingdom

Year awarded: 1993

BACHELOR OF SCIENCE (HONOURS)

Institution: National Autonomous University of Mexico

Year awarded: 1988

Publications

Book Chapters

Xiang, S.D., Fuchsberger, M., Karlson, T., Hardy, C.L., Selomulya, C., Plebanski, M., 2013, Nanoparticles, Immunomodulation and Vaccine Delivery, in Frontiers in Nanobiomedical Research: Volume 1 Handbook of Immunological Properties of Engineered Nanomaterials, eds Marina A Dobrovolskaia and Scott E McNeil, World Scientific, USA, pp. 449-476.

Journal Articles

Al-deen, F.M.N., Ma, C.W.C., Xiang, S.D., Selomulya, C., Plebanski, M., Coppel, R.L., 2013, On the efficacy of malaria DNA vaccination with magnetic gene vectors, Journal of Controlled Release [P], vol 168, issue 1, Elsevier Science BV, Netherlands, pp. 10-17.

Li, S., Roberts, S., Plebanski, M., Gouillou, M., Spelman, T., Latour, P.A., Jackson, D.C., Brown, L.E., Sparrow, R., Prince, M., Hart, D., Loveland, B.E., Gowans, E., 2012, Induction of multi-functional T cells in a phase I clinical trial of dendritic cell immunotherapy in hepatitis C virus infected individuals, PLoS ONE [P], vol 7, issue 8 (Art. No.: e39368 ), Public Library of Science, United States, pp. 1-7.

Hardy, C., LeMasurier, J., Belz, G., Scalzo-Inguanti, K., Yao, J., Xiang, S., Kanellakis, P., Bobik, A., Strickland, D.H., Rolland, J., O'Hehir, R., Plebanski, M., 2012, Inert 50-nm polystyrene nanoparticles that modify pulmonary dendritic cell function and inhibit allergic airway inflammation, Journal of Immunology [E], vol 188, issue 3, American Association of Immunologists, USA, pp. 1431-1441.

Park, A., Govindaraj, C., Xiang, S.D., Halo, J., Quinn, M., Scalzo-Inguanti, K., Plebanski, M., 2012, Substantially modified ratios of effector to regulatory T cells during chemotherapy in ovarian cancer patient return to pre-treatment levels at completion: implications for immunology, Cancers [E], vol 4, M D P I AG, Switzerland, pp. 581-600.

Hardy, C.L., Nguyen, H.T., Mohamud, R., Yao, J.J., Oh, D.Y., Plebanski, M., Loveland, K.A.L., Harrison, C., Rolland, J.M., O'Hehir, R.E., 2012, The activin A antagonist follistatin inhibits asthmatic airway remodelling., Thorax [P], B M J Group, United Kingdom, pp. 1-10.

Scalzo-Inguanti, K., Plebanski, M., 2011, CD38 identifies a hypo-proliferative IL-13-secreting CD4 (+) T-cell subset that does not fit into existing naive and memory phenotype paradigms, European Journal Of Immunology [P], vol 41, issue 5, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 1298-1308.

Salwati, E., Minigo, G., Woodberry, T., Piera, K., De Silva, H., Kenangalem, E., Tjitra, E., Coppel, R., Price, R., Anstey, N., Plebanski, M., 2011, Differential cellular recognition of antigens during acute Plasmodium falciparum and Plasmodium vivax malaria, Journal Of Infectious Diseases [P], vol 203, issue 8, Oxford University Press, USA, pp. 1192-1199.

De Silva, H.D., Saleh, S.M., Kovacevic, S., Wang, L., Black, C.G., Plebanski, M., Coppel, R.L., 2011, The antibody response to Plasmodium falciparum Merozoite Surface Protein 4: Comparative assessment of specificity and growth inhibitory antibody activity to infection-acquired and immunization-induced epitopes, Malaria Journal [P], vol 10, issue Art. No: 266, BioMed Central Ltd, UK, pp. 1-12.

Gartlan, K., Belz, G.T., Tarrant, J.M., Minigo, G., Katsara, M., Sheng, K., Sofi, M., van Spriel, A.B., Apostolopoulos, V., Plebanski, M., Robb, L.M., Wright, M.D., 2010, A complementary role for the tetraspanins CD37 and Tssc6 in cellular immunity, Journal Of Immunology [P], vol 185, American Association of Immunologists, US, pp. 3158-3166.

Xiang, S.D., Selomulya, C., Ho, J., Apostolopoulos, V., Plebanski, M., 2010, Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetic nanoparticles, Wiley Interdisciplinary Reviews:Nanomedicine and Nanobiotechnology [P], vol 2, issue 3, John Wiley & Sons, United States, pp. 205-218.

Murhandarwati, E.E.H., Wang, L., De Silva, H.D., Ma, C.W.C., Plebanski, M., Black, C.G., Coppel, R.L., 2010, Growth-inhibitory antibodies are not necessary for protective immunity to malaria infection, Infection And Immunity [P], vol 78, American Society for Microbiology, USA, pp. 680-687.

Scholzen, A., Minigo, G., Plebanski, M., 2010, Heroes or villains? T regulatory cells in malaria infection, Trends in Parasitology [P], vol 26, Elseview Ltd., United Kingdom, pp. 16-25.

Hardy, C.L., LeMasurier, J., Olsson, F.P., Dang, T., Yao, J.J., Yang, M., Plebanski, M., Phillips, D.J., Mollard, R.A., Rolland, J.M., O'Hehir, R.E., 2010, Interleukin-13 regulates secretion of the tumor growth factor - ? superfamily cytokine activin A in allergic airway inflammation, American Journal Of Respiratory Cell And Molecular ..., vol 42, issue 6, Amercan Thoracic Society, United States, pp. 667-675.

Plebanski, M., Katsara, M., Sheng, K., Xiang, S., Apostolopoulos, V., 2010, Methods to measure T-cell responses, Expert Review of Vaccines [P], vol 9, issue 6, Expert Review Ltd, UK, pp. 595-600.

Ho, J., Al-deen, F., Al-Abboodi, A., Selomulya, C., Xiang, S., Plebanski, M., Forde, G., 2010, N,N'-Carbonyldiimidazole-mediated functionalization of superparamagnetic nanoparticles as vaccine carrier, Colloids and Surfaces B: Biointerfaces [P], vol 83, issue 1, Elsevier Science BV, Netherlands, pp. 83-90.

Li, S., Floess, S., Hamann, A., Gaudiei, S., Lucas, A., Hellard, M., Roberts, S., Paukovics, G., Plebanski, M., Loveland, B.E., Aitken, C., Barry, S., Schofield, L., Gowans, E.J., 2009, Analysis of FOXP3+ regulatory T cells that display apparent viral antigen specificity during chronic hepatitis C virus infection, Plos Pathogens [P], vol 5, issue 12 (e1000707), Public Library of Science, United States, pp. 1-13.

Minigo, G., Woodberry, T., Piera, K.A., Salwati, E., Tjitra, E., Kenangalem, E., Price, R.N., Engwerda, C.R., Anstey, N.M., Plebanski, M., 2009, Parasite-dependent expansion of TNF receptor II-positive regulatory T cells with enhanced suppressive activity in adults with severe malaria, Plos Pathogens [P], vol 5, issue 4 (e1000402), Public Library of Science, United States, pp. 1-10.

Scholzen, A., Mittag, D., Rogerson, S., Cooke, B.M., Plebanski, M., 2009, Plasmodium falciparum-mediated induction of human CD25hiFoxp3hi CD4 T cells is independent of direct TCR stimulation and requires IL-2, IL-10 and TGFbeta, Plos Pathogens [P], vol 5, issue 8 (e1000543), Public Library of Science, United States, pp. 1-20.

Woodberry, T., Minigo, G., Piera, K.A., Hanley, J., De Silva, H.D., Salwati, E., Kenangalem, E., Tjitra, E., Coppel, R.L., Price, R.N., Anstey, N.M., Plebanski, M., 2008, Antibodies to Plasmodium falciparum and Plasmodium vivax merozoite surface protein 5 in Indonesia: Species-specific and cross-reactive responses, Thr Journal of Infectious Diseases, vol 198, issue 1, University of Chisago Press, United States, pp. 134-142.

Todryk, S.M., Bejon, P., Mwangi, T., Plebanski, M., Urban, B., Marsh, K., Hill, A.V., Flanagan, K.L., 2008, Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4+ CD25high T cells with susceptibility in Kenyans, PLoS ONE [P], vol 3, issue 4 (e2027), Public Library of Science, United States, pp. 1-7.

Von Itzstein, M., Plebanski, M., Cooke, B.M., Coppel, R.L., 2008, Hot, sweet and sticky: The glycobiology of Plasmodium falciparum, Trends in Parasitology, vol 24, issue 5, Elsevier Ltd., Trends Journals, United Kingdom, pp. 210-218.

Proudfoot, O., Drew, N., Scholzen, A., Xiang, S.D., Plebanski, M., 2008, Investigation of a novel approach to scoring Giemsa-stained malaria-infected thin blood films, Malaria Journal, vol 7, issue 62, BioMed Central Ltd, United Kingdom, pp. 1-6.

Plebanski, M., Locke, E., Kazura, J.W., Coppel, R.L., 2008, Malaria vaccines: into a mirror, darkly?, Trends in Parasitology, vol 24, issue 12, Elsevier Ltd., Trends Journals, United Kingdom, pp. 532-536.

Li, S., Gowans, E.J., Chougnet, C., Plebanski, M., Dittmer, U., 2008, Natural regulatory T cells and persistent viral infection, Journal of Virology, vol 82, American Society of Microbiology, Washington DC USA, pp. 21-30.

Xiang, S.D., Scalzo-Inguanti, K., Minigo, G., Park, A., Hardy, C.L., Plebanski, M., 2008, Promising particle-based vaccines in cancer therapy, Expert Review of Vaccines, vol 7, issue 7, Expert Reviews Ltd., United Kingdom, pp. 1103-1119.

Katsara, M., Minigo, G., Plebanski, M., Apostolopoulos, V., 2008, The good, the bad and the ugly: How altered peptide ligands modulate immunity, Expert Opinion on Biological Therapy [P], vol 8, issue 12, Informa Healthcare, United Kingdom, pp. 1873-1884.

Greenwood, D.L., Dynon, K., Kalkanidis, M., Xiang, S.D., Plebanski, M., Scheerlinck, J., 2008, Vaccination against foot-and-mouth disease virus using peptides conjugated to nano-beads, Vaccine, vol 26, issue 22, Elsevier Ltd, United Kingdom, pp. 2706-2713.

Li, S., Jones, K.L., Woollard, D.J., Dromey, J., Paukovics, G., Plebanski, M., Gowans, E.J., 2007, Defining target antigens for CD25+FOXP3+IFN-gamma- regulatory T cells in chronic hepatitis C virus infection, Immunology and Cell Biology, vol 85, issue 3, Nature Press Group, UK, pp. 197-204.

Tang, C., Lodding, J., Minigo, G., Pouniotis, D., Plebanski, M., Scholzen, A., McKenzie, I., Pietersz, G.A., Apostolopoulos, V., 2007, Mannan-mediated gene delivery for cancer immunotherapy, Immunology, vol 120, issue 3, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 325-335.

Minigo, G., Scholzen, A., Tang, C.K., Hanley, J., Kalkanidis, M., Pietersz, G.A., Apostolopoulos, V., Plebanski, M., 2007, Poly-L-lysine-coated nanoparticles: a potent delivery system to enhance DNA vaccine efficacy, Vaccine, vol 25, issue 7, Elsevier Science, UK, pp. 1316-1327.

Minigo, G., Scalzo, K., Flanagan, K.L., Plebanski, M., 2007, Predicting memory: a prospective readout for malaria vaccines?, Trends in Parasitology, vol 23, issue 8, Elsevier science, UK, pp. 341-343.

Mottram, P.L., Leong, D., Crimeen-Irwin, B., Gloster, S., Xiang, S.D., Meanger, J., Ghildyal, R., Vardaxis, N.J., Plebanski, M., 2007, Type 1 and 2 immunity following vaccination is influenced by nanoparticle size: formulation of a model vaccine for respiratory syncytial virus, Molecular Pharmaceutics, vol 4, issue 1, American Chemical Society, USA, pp. 73-84.

Pouniotis, D., Plebanski, M., Apostolopoulos, V., McDonald, C.F., 2006, Alveolar macrophage function is altered in patients with lung cancer, Clinical And Experimental Immunology [P], vol 143, issue 2, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 363-372.

Flanagan, K.L., Plebanski, M., Odhiambo, K., Sheu, E., Mwangi, T., Gelder, C., Hart, K., Kortok, M., Lowe, B., Robson, K.J., Marsh, K., Hill, A.V.S., 2006, Cellular reactivity to the p. Falciparum protein trap in adult kenyans: Novel epitopes, complex cytokine patterns, and the impact of natural antigenic variation, American Journal of Tropical Medicine and Hygiene [P], vol 74, issue 3, American Society of Tropical Medicine and Hygiene, United States, pp. 367-375.

Lee, E.A., Flanagan, K.L., Minigo, G., Reece, W.H., Bailey, R., Pinder, M., Hill, A.V., Plebanski, M., 2006, Dimorphic Plasmodium falciparum merozoite surface protein-1 epitopes turn off memory T cells and interfere with T cell priming, European Journal Of Immunology [P], vol 36, issue 5, Wiley - V C H Verlag GmbH & Co. KGaA, Germany, pp. 1168-1178.

Plebanski, M., Lopez, E., Proudfoot, O., Cooke, B.M., Von Itzstein, M., Coppel, R.L., 2006, Economic and practical challenges to the formulation of vaccines against endemic infectious diseases such as malaria, Methods, vol 40, issue 1, Academic Press Inc Elsevier Science, SAN DIEGO USA, pp. 77-85.

Kalkanidis, M., Pietersz, G.A., Xiang, S.D., Mottram, P.L., Crimeen-Irwin, B., Ardipradja, K., Plebanski, M., 2006, Methods for nano-particle based vaccine formulation and evaluation of their immunogenicity, Methods [P], vol 40, issue 1, Academic Press, United States, pp. 20-29.

Xiang, S.D., Scholzen, A., Minigo, G., David-Shields, C., Apostolopoulos, V., Mottram, P.L., Plebanski, M., 2006, Pathogen recognition and development of particulate vaccines: Does size matter?, Methods [P], vol 40, issue 1, Academic Press, United States, pp. 1-9.

Apostolopoulos, V., Pietersz, G.A., Tsibanis, A., Tsikkinis, A., Drakaki, H., Loveland, B.E., Piddlesden, S.J., Plebanski, M., Pouniotis, D., Alexis, M., McKenzie, I., Vassilaros, S., 2006, Pilot phase III immunotherapy study in early-stage breast cancer patients using oxidized mannan-MUC1 [ISRCTN71711835], Breast Cancer Research [P], vol 8, issue 3 (R27), Current Medicine Group Ltd, United Kingdom, pp. 1-11.

Scheerlinck, J.Y., Gloster, S., Gamvrellis, A., Mottram, P.L., Plebanski, M., 2006, Systemic immune responses in sheep, induced by a novel nano-bead adjuvant, Vaccine [P], vol 24, issue 8, Elsevier Ltd, United Kingdom, pp. 1124-1131.

Pouniotis, D., Proudfoot, O., Bogdanoska, V., Scalzo, K., Kovacevic, S., Coppel, R.L., Plebanski, M., 2005, Selectively impaired CD8+ but not CD4+ T cell cycle arrest during priming as a consequence of dendritic cell interaction with plasmodium-infected red cells, Journal of Immunology, vol 175, issue 6, American Association of Immunologists, USA, pp. 3525-3533.

Reece, W.H., Pinder, M., Gothard, P.K., Milligan, P., Bojang, K., Doherty, T., Plebanski, M., Akinwunmi, P., Everaere, S., Watkins, K.R., Voss, G., Tornieporth, N., Alloueche, A., Greenwood, B.M., Kester, K.E., McAdam, K.P.W., Cohen, J., Hill, A.V.S., 2004, A CD4{+} T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease, Nature Medicine [P], vol 10, issue 4, Nature Publishing Group, United States, pp. 406-410.

Pouniotis, D., Proudfoot, O., Minigo, G., Hanley, J.C., Plebanski, M., 2004, A new boost for malaria vaccines, Trends in Parasitology [P], vol 20, issue 4, Elsevier Ltd., Trends Journals, United Kingdom, pp. 157-160.

van Spriel, A.B., Puls, K.L., Sofi, M., Pouniotis, D., Hochrein, H., Orinska, Z., Knobeloch, K., Plebanski, M., Wright, M.D., 2004, A regulatory role for CD37 in T cell proliferation, Journal Of Immunology [P], vol 172, issue 5, American Association of Immunologists, United States, pp. 2953-2961.

Pouniotis, D., Proudfoot, O., Bogdanoska, V., Apostolopoulos, V., Fifis, T., Plebanski, M., 2004, Dendritic cells induce immunity and long-lasting protection against blood-stage malaria despite an in vitro parasite-induced maturation defect, Infection And Immunity [P], vol 72, issue 9, American Society for Microbiology, United States, pp. 5331-5339.

Fifis, T., Mottram, P.L., Bogdanoska, v., Hanley, J., Plebanski, M., 2004, Short peptide sequences containing MHC class I and/or class II epitopes linked to nano-beads induce strong immunity and inhibition of growth of antigen-specific tumour challenge in mice, Vaccine [P], vol 23, issue 2, Elsevier Ltd, United Kingdom, pp. 258-266.

Fifis, T., Gamvrellis, A., Crimeen-Irwin, B., Pietersz, G.A., Li, J., Mottram, P.L., McKenzie, I., Plebanski, M., 2004, Size-dependent immunogenicity: Therapeutic and protective properties of nano-vaccines against tumors, Journal Of Immunology [P], vol 173, issue 5, American Association of Immunologists, United States, pp. 3148-3154.

Gamvrellis, A., Leong, D., Hanley, J.C., Xiang, S.D., Mottram, P.L., Plebanski, M., 2004, Vaccines that facilitate antigen entry into dendritic cells, Immunology And Cell Biology [P], vol 82, issue 5, Nature Publishing Group, United Kingdom, pp. 506-516.

Apostolopoulos, V., Yuriev, E., Ramsland, P.A., Halton, J., Osinski, C., Li, W., Plebanski, M., Paulsen, H., McKenzie, I.F., 2003, A glycopeptide in complex with MHC class 1 uses the GaINAc residue as an anchor, Proceedings of the National Academy of Sciences of the United States of America, vol 100, issue 25, National Academy of Sciences, USA, pp. 15029-15034.

McKenzie, I., Apostolopoulos, V., Plebanski, M., Pietersz, G.A., Loveland, B.E., 2003, Aspects of cancer immunotherapy, Immunology And Cell Biology [P], vol 81, issue 1, Nature Publishing Group, United Kingdom, pp. 79-85.

Plebanski, M., Proudfoot, O., Pouniotis, D., Coppel, R.L., Apostolopoulos, V., Flannery, G., 2002, Immunogenetics and the design of Plasmodium falciparum vaccines for use in malaria-endemic populations, The Journal of Clinical Investigation, vol 110, issue 3, American Society for Clinical Investigation, Ann Arbor USA, pp. 295-301.

Conference Proceedings

Pietersz, G.A., Proudfoot, O., Meanger, J., Plebanski, M., 2005, Development of mucosal vaccines for respiratory syncytial virus, bacillus anthracis and rotavirus based on oxidised mannan, Tissue Antigens, Blackwell Publishing, Oxford England, pp. 512-513.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Biodegradable Immuno-theraputic Nanoparticles.

Supervisors:

Plebanski, M (Joint), Selomulya, C (Joint-co).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Developing a therapeutic nano-vaccine against ovarian cancer.

Supervisors:

Plebanski, M (Joint-co), Xiang, S (Joint).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Effects of cancer cells on the cells of the dendritic cell lineage.

Supervisors:

Plebanski, M (Main).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Role of MHC class I expression in the pathogenesis of type 1 diabetes.

Supervisors:

Slattery, R (Main), Plebanski, M (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The effects of nanoparticles on regulatory T cells in lungs: implication for asthma development and immunotherapy..

Supervisors:

Plebanski, M (Main), O''Hehir, R (Associate), Hardy, C (Associate), Rolland, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of TMFR2+ regulatory T cells in cancer.

Supervisors:

Plebanski, M (Main), Spencer, A (Associate), Wei, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of TNFR2 T cells in human disease.

Supervisors:

Plebanski, M (Main), Xiang, S (Associate).

Completed Supervision

Student:

Kong, Y.

Program of Study:

. 2010.

Supervisors:

Plebanski, M (Main), Apostolopoulos, V (External).