Assoc Prof David Williams - Researcher Profile

Biography

David works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as an Associate Professor.

Qualifications

PHD - NEUROSCIENCES

Institution: University of London

Year awarded: 2007

Publications

Journal Articles

Williams, D., Lee, W., 2012, Clinical features and criteria for the diagnosis of progressive supranuclear palsy, Neurodegenerative Disease Management [P], vol 2, Future Medicine Ltd, North London, UK, pp. 125-133.

Lee, W., Williams, D., Storey, E., 2012, Cognitive testing in the diagnosis of parkinsonian disorders: a critical appraisal of the literature, Movement Disorders [P], vol 27, issue 10, ohn Wiley & Sons Inc., United States, pp. 1243-1254.

Egerton, T., Williams, D., Iansek, R., 2012, Comparison of gait in progressive supranuclear palsy, Parkinson's disease and healthy older adults, BMC Neurology [P], vol 12, issue Art. No.: 116, BioMed Central Ltd, United Kingdom, pp. 1-6.

Massey, L.A., Micallef, C., Paviour, D.C., O'Sullivan, S.S., Ling, H., Williams, D., Kallis, C., Holton, J.L., Revesz, T., Burn, D.J., Yousry, T., Lees, A.J., Fox, N.C., Jager, H.R., 2012, Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy, Movement Disorders [P], vol 27, issue 14, John Wiley & Sons Inc., United States, pp. 1755-1762.

Gold, M., Lorenzl, S., Stewart, A.J., Morimoto, B.H., Williams, D., Gozes, I., 2012, Critical appraisal of the role of davunetide in the treatment of progressive supranuclear palsy, Neuropsychiatric Disease and Treatment [P], vol 8, Dove Medical Press Ltd, New Zealand, pp. 85-93.

Luk, C., Compta, Y., Magdalinou, N., Marti, M.J., Hondhamuni, G., Zetterberg, H., Blennow, K., Constantinescu, R., Pijnenburg, Y., Mollenhauer, B., Trenkwalder, C., Van Swieten, J.C., Chiu, W.Z., Borroni, B., Camara, A., Cheshire, P.A., Williams, D., Lees, A.J., de Silva, R., 2012, Development and assessment of sensitive immuno-PCR assays for the quantification of cerebrospinal fluid three- and four-repeat tau isoforms in tauopathies, Journal Of Neurochemistry [P], vol 123, issue 3, Wiley-Blackwell Publishing Ltd, United Kingdom, pp. 396-405.

Bertram, K., Williams, D., 2012, Diagnosis of dystonic syndromes--a new eight-question approach, Nature Reviews Neurology [P], vol 8, issue 5, Nature Publishing Group, New York, USA, pp. 275-283.

Cheshire, P.A., Williams, D., 2012, Serotonergic involvement in levodopa-induced dyskinesias in Parkinson's disease, Journal of Clinical Neuroscience [P], vol 19, issue 3, Churchill Livingstone, United Kingdom, pp. 343-348.

Bertram, K., Williams, D., 2012, Visual hallucinations in the differential diagnosis of parkinsonism, Journal Of Neurology Neurosurgery And Psychiatry [P], vol 83, issue 4, B M J Group, United Kingdom, pp. 448-452.

Conte, A., Belvisi, D., Bologna, M., Ottaviani, D., Fabbrini, G., Colosimo, C., Williams, D., Berardelli, A., 2011, Abnormal cortical synaptic plasticity in primary motor area in progressive supranuclear palsy, Cerebral Cortex [P], vol E, Oxford University Press, United Kingdom, pp. 1-8.

Eller, M., Williams, D., 2011, Alpha-synuclein in Parkinson disease and other neurodegenerative disorders, Clinical Chemistry And Laboratory Medicine [P], vol 49, issue 3, Walter de Gruyter, Germany, pp. 403-408.

Parkkinen, L., O'Sullivan, S., Kuoppamaki, M., Collins, C., Kallis, C., Holton, J., Williams, D., Revesz, T., Lees, A., 2011, Does levodopa accelerate the pathologic process in Parkinson disease brain?, Neurology [P], vol 77, issue 15, Lippincott Williams & Wilkins, USA, pp. 1420-1426.

Henderson, T., Georgiou-Karistianis, N., White, O., Millist, L., Williams, D., Churchyard, A., Fielding, J., 2011, Inhibitory control during smooth pursuit in Parkinson's disease and Huntington's disease, Movement Disorders [P], vol 26, issue 10, John Wiley & Sons, Inc., United States, pp. 1893-1899.

Compta, Y., Parkkinen, L., O'Sullivan, S., Vandrovcova, J., Holton, J., Collins, C., Lashley, T., Kallis, C., Williams, D., de Silva, R., Lees, A., Revesz, T., 2011, Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?, Brain [P], vol 134, issue 5, Oxford University Press, United Kingdom, pp. 1493-1505.

Duff, R., Tay, V., Hackman, P., Ravenscroft, G., McLean, C., Kennedy, P., Steinbach, A., Schoffler, W., van der Ven, P., Furst, D., Song, J., Djinovic-Carugo, K., Penttila, S., Raheem, O., Reardon, K., Malandrini, A., Gambelli, S., Villanova, M., Nowak, K., Williams, D., Landers, J., Brown, Jr., R., Udd, B., Laing, N., 2011, Mutations in the N-terminal actin-binding domain of filamin C cause a distal myopathy, American Journal Of Human Genetics [P], vol 88, issue 6, Cell Press, USA, pp. 729-740.

Cardoso, F., Hodges, J., Evans, A., Revesz, T., Williams, D., 2011, Postural instability, frontotemporal dementia, and ophthalmoplegia: clinicopathological case, Movement Disorders [P], vol 26, issue 10, John Wiley & Sons, Inc, United States, pp. 1808-1813.

Fabbrini, G., Merello, M., Evans, A., Lees, A., Holton, J., Williams, D., 2011, Progressive parkinsonism, oculomotor abnormalities and autonomic dysfunction: clinicopathological case, Movement Disorders [P], vol 26, issue 3, John Wiley & Sons, Inc, United States, pp. 424-429.

Gallagher, D., Parkkinen, L., O'Sullivan, S., Spratt, A., Shah, A., Davey, C., Bremner, F., Revesz, T., Williams, D., Lees, A., Schrag, A., 2011, Testing an aetiological model of visual hallucinations in Parkinson's disease, Brain [P], vol 134, Oxford University Press, United Kingdom, pp. 3299-3309.

Williams, D., 2010, Comment on "Association between mild parkinsonian signs and mortality in an elderly male cohort in China", Journal of Clinical Neuroscience [P], vol 17, Churchill Livingstone Elsevier, United Kingdom, p. 177.

Ling, H., O'Sullivan, S., Holton, J., Revesz, T., Massey, L., Williams, D., Paviour, D., Lees, A., 2010, Does corticobasal degeneration exist? A clinicopathological re-evaluation, Brain [P], vol 133, issue Pt 7, Oxford University Press, United Kingdom, pp. 2045-2057.

Silveira-Moriyama, L., Hughes, G., Church, A., Ayling, H., Williams, D., Petrie, A., Holton, J., Revesz, T., Kingsbury, A., Morris, H., Burn, D., Lees, A., 2010, Hyposmia in progressive supranuclear palsy, Movement Disorders [P], vol 25, issue 5, John Wiley & Sons, Inc., United States, pp. 570-577.

O'Sullivan, S., Johnson, M., Williams, D., Revesz, T., Holton, J., Lees, A., Perry, E., 2010, The effect of drug treatment on neurogenesis in Parkinson's disease, Movement Disorders [P], vol 26, issue 1, John Wiley & Sons, Inc., United States, pp. 45-50.

Williams, D., Lees, A., 2010, What features improve the accuracy of the clinical diagnosis of progressive supranuclear palsy-parkinsonism (PSP-P)?, Movement Disorders [P], vol 25, issue 3, John Wiley & Sons, Inc., United States, pp. 357-362.

Selikhova, M., Williams, D.R., Kempster, P.A., Holton, J.L., Revesz, T., Lees, A.J., 2009, A clinico-pathological study of subtypes in Parkinson's disease, Brain [P], vol 132, issue 11, Oxford University Press, United Kingdom, pp. 2947-2957.

Eller, M., Williams, D.R., 2009, Biological fluid biomarkers in neurodegenerative parkinsonism, Nature Reviews Neuroscience [E], vol 5, issue 10, Nature Publishing Group, United Kingdom, pp. 561-570.

Silveira-Moriyama, L., Gonzalez, A.M., O'Sullivan, S.S., Williams, D.R., Massey, L.A., Parkkinen, L., Ahmed, Z., de Silva, R., Chacon, J.R., Revesz, T., Lees, A.J., Holton, J.L., 2009, Concomitant progressive supranuclear palsy and multiple system atrophy: More than a simple twist of fate?, Neuroscience Letters [P], vol 467, issue 3, Elsevier Ireland Ltd, Ireland, pp. 208-211.

Song, Y.C., Halliday, G., Holton, J.L., Lashley, T., O'Sullivan, S.S., McCann, H., Lees, A.J., Ozawa, T., Williams, D.R., Lockhart, P.J., Revesz, T., 2009, Degeneration in different parkinsonian syndromes relates to astrocyte type and astrocyte protein expression, Journal of Neuropathology and Experimental Neurol..., vol 68, issue 10, Lipincott Williams & Wilkins, USA, pp. 1073-1083.

Luk, C., Giovannoni, G., Williams, D.R., Lees, A.J., de Silva, R., 2009, Development of a sensitive ELISA for quantification of three- and four-repeat tau isoforms in tauopathies, Journal of Neuroscience Methods [P], vol 180, issue 1, Elsevier BV, Netherlands, pp. 34-42.

Williams, D.R., Lees, A.J., 2009, How do patients with parkinsonism present? A clinicopathological study, Internal Medicine Journal [P], vol 39, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 7-12.

Sirisena, D., Williams, D.R., 2009, My hands shake: Classification and treatment of tremor, Australian Family Physician [P], vol 38, issue 9, Royal Australian College of General Practitioners, Australia, pp. 678-683.

Williams, D.R., Lees, A.J., 2009, Progressive supranuclear palsy: clinicopathological concepts and diagnostic challenges, Lancet Neurology [P], vol 8, issue 3, The Lancet Publishing Group, United Kingdom, pp. 270-279.

Silveira-Moriyama, L., Petrie, A., Williams, D.R., Evans, A., Katzenschlager, R., Barbosa, E.R., Lees, A.J., 2009, The use of a color coded probability scale to interpret smell tests in suspected parkinsonism, Movement Disorders [P], vol 24, issue 8, John Wiley & Sons, Inc, United States, pp. 1144-1153.

O'Sullivan, S.S., Massey, L.A., Williams, D.R., Silveira-Moriyama, L., Kempster, P.A., Holton, J.L., Revesz, T., Lees, A.J., 2008, Clinical outcomes of progressive supranuclear palsy and multiple system atrophy, Brain, vol 131, issue 5, Oxford University Press, Oxford England, pp. 1362-1372.

Williams, D.R., Lees, A.J., Wherrett, J.R., Steele, J.C., 2008, J. Clifford Richardson and 50 years of progressive supranuclear palsy, Neurology, vol 70, Lippincott Williams & Wilkins, USA, pp. 566-573.

O'Sullivan, S.S., Williams, D.R., Gallagher, D.A., Massey, L.A., Silveira-Moriyama, L., Lees, A.J., 2008, Nonmotor symptoms as presenting complaints in Parkinson's disease: A clinicopathological study, Movement Disorders, vol 23, John Wiley & Sons Inc, USA, pp. 101-106.

Healy, D.G., Falchi, M., O'Sullivan, S.S., Bonifati, V., Durr, A., Bressman, S., Brice, A., Aasly, J., Zabetian, C.P., Goldwurm, S., Ferreira, J.J., Tolosa, E., Kay, D.M., Klein, C., Williams, D.R., Marras, C., Lang, A.E., Wszolek, Z.K., Berciano, J., Schapira, A.H., Lynch, T., Bhatia, K.P., Gasser, T., Lees, A.J., Wood, N., 2008, Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study, The Lancet Neurology, vol 7, issue 7, The Lancet Publishing Group, UK, pp. 583-590.

Williams, D.R., Cowey, M., Tuck, K., Day, B.J., 2008, Psychogenic propriospinal myoclonus, Movement Disorders, vol 23, issue 9, John Wiley & Sons, Inc, Hoboken NJ USA, pp. 1312-1313.

Williams, D.R., Doyle, L.M., Lees, A.J., Brown, P., 2008, The auditory startle response in parkinsonism may reveal the extent but not type of pathology, Journal of Neurology, vol 255, Dr Dietrich Steinkopff Verlag, Germany, pp. 628-632.

Williams, D.R., Warren, J.D., Lees, A.J., 2008, Using the presence of visual hallucinations to differentiate Parkinson's disease from atypical Parkinsonism, Journal of Neurology, Neurosurgery and Psychiatry, vol 79, issue Sept 2007, BMJ Publishing Group, London, United Kingdom, pp. 652-655.

Kumaran, R., Kingsbury, A., Coulter, I., Lashley, T., Williams, D.R., de Silva, R., Mann, D., Revesz, T., Lees, A.J., Bandopadhyay, R., 2007, DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders, Neurobiology of Disease, vol 28, issue 1, Academic Press Inc Elsevier Science, USA, pp. 122-132.

Williams, D.R., Pittman, A.M., Revesz, T., Lees, A.J., de Silva, R., 2007, Genetic variation at the tau locus and clinical syndromes associated with progressive supranuclear palsy, Movement Disorders, vol 22, issue 6, John Wiley & Sons Inc, USA, pp. 895-897.

O'Sullivan, S.S., Holton, J.L., Massey, L.A., Williams, D.R., Revesz, T., Lees, A.J., 2007, Parkinson's disease with Onuf's nucleus involvement mimicking multiple system atrophy, Journal of Neurology, Neurosurgery and Psychiatry, vol 79, issue 2, BMJ Publishing Group, UK, pp. 232-234.

Williams, D.R., Holton, J.L., Strand, C., Pittman, A.M., de Silva, R., Lees, A.J., Revesz, T., 2007, Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome, Brain, vol 130, Oxford University Press, Oxford, England, pp. 1566-1576.

Kempster, P.A., Williams, D.R., Selikhova, M., Holton, J.L., Revesz, T., Lees, A.J., 2007, Patterns of levodopa response in Parkinson's disease: A clinico-pathological study, Brain, vol 130, Oxford University Press, Oxford, England, pp. 2123-2128.

Williams, D.R., Holton, J.L., Strand, K., Revesz, T., Lees, A.J., 2007, Pure akinesia with gait freezing: A third clinical phenotype of progressive supranuclear palsy, Movement Disorders, vol 22, issue 15, Wiley-Liss, Hoboken, USA, pp. 2235-2241.

Schott, J.M., Williams, D.R., Butterworth, R.J., Janssen, J.C., Larner, A.J., Holton, J.L., Rossor, M.N., 2007, Shunt responsive progressive supranuclear palsy?, Movement Disorders, vol 22, issue 6, John Wiley & Sons Inc, USA, pp. 902-903.

Williams, D.R., Watt, H.C., Lees, A.J., 2006, Predictors of falls and fractures in bradykinetic rigid syndromes: a retrospective study, Journal of Neurology, Neurosurgery and Psychiatry, vol 77, BMJ Publishing Group, London, England, pp. 468-473.

Williams, D.R., 2006, Tauopathies: classification and clinical update on neurodegenerative diseases associated with microtubule-associated protein tau, Internal Medicine Journal, vol 36, Blackwell Publishing, Oxford, England, pp. 652-660.

Williams, D.R., Reardon, K.A., Roberts, L., Dennett, X., Duff, R., Laing, N.G., Byrne, E., 2005, A new dominant distal myopathy affecting posterior leg and anterior upper limb muscles, Neurology, vol 64, issue 7, Lippincott Williams & Wilkins, Philadelphia USA, pp. 1245-1254.

Williams, D.R., de Silva, R., Paviour, D.C., Pittman, A.M., Watt, H.C., Kilford, L., Holton, J.L., Revesz, T., Lees, A.J., 2005, Characteristics of two distinct clinical phenotypes in pathologically proven progressive supranuclear palsy: Richardson's syndrome and PSP-parkinsonism, Brain, vol 128, Oxford University Press, Oxford, England, pp. 1247-1258.

Paviour, D.C., Williams, D.R., Fowler, C.J., Quinn, N.P., Lees, A.J., 2005, Is sphincter electromyography a helpful investigation in the diagnosis of multiple system atrophy? A retrospective study with pathological diagnosis, Movement Disorders, vol 20, issue 11, Wiley-Liss, Hoboken, USA, pp. 1425-1430.

Williams, D.R., Hadeed, A., Najim al-Din, A.S., Wreikat, A., Lees, A.J., 2005, Kufor Rakeb disease: Autosomal recessive, levodopa-responsive Parkinsonism with pyramidal degeneration, supranuclear gaze palsy, and dementia, Movement Disorders, vol 20, issue 10, Wiley-Liss, Hoboken, USA, pp. 1264-1271.

Pittman, A.M., Myers, A.J., Abou-Sleiman, P., Fung, H.C., Kaleem, M., Marlowe, L., Duckworth, J., Leung, D., Williams, D.R., Kilford, L., Thomas, N., Morris, C.M., Dickson, D., Wood, N., Hardy, J., Lees, A.J., de Silva, R., 2005, Linkage disequilibrium fine mapping and haplotype association analysis of the tau gene in progressive supranuclear palsy and corticobasal degeneration, Journal of Medical Genetics, vol 42, issue 11, BMJ Publishing Group, London, England, pp. 837-846.

Williams, D.R., Lees, A.J., 2005, Visual hallucinations in the diagnosis of idiopathic Parkinson's disease: A retrospective autopsy study, Lancet Neurology, vol 4, issue 10, Lancet Ltd, London, England, pp. 605-610.

Williams, D.R., 2004, Gaze-evoked brainstem myoclonus, Movement Disorders, vol 19, issue 3, Wiley-Liss, Hoboken, USA, pp. 346-349.

Williams, D.R., 2004, Psychogenic palatal tremor, Movement Disorders, vol 19, issue 3, Wiley-Liss, Hoboken, USA, pp. 333-335.

Williams, D.R., Stark, R.J., 2003, Intravenous lignocaine (lidocaine) infusion for the treatment of chronic daily headache with substantial medication overuse, Cephalalgia, vol 23, Blackwell Publishing, Oxford UK, pp. 963-971.

Other

Williams, D.R., 2007, Historical Review: James Parkinson's London, Movement Disorders, John Wiley & Sons Inc, USA.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Establishing the role of serotonergic neurons in the emergence and maintenance of dyskinesias in Parkinsons' disease..

Supervisors:

Storey, E (Main), Williams, D (Associate).