Dr Stephanie Gras - Researcher Profile

Biography

Stephanie works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD

Institution: Joseph Fouier University FRANCE

Year awarded: 2006

Publications

Book Chapters

McCluskey, J., Gras, S., Bharadwaj, M., Kjer-Nielsen, L., Macdonald, W.A., Saunders, P.M., Rossjohn, J., 2010, HLA Molecules of the Major Histocompatibility Complex, in The HLA Complex in Biology and Medicine: A Resource Book, eds NK Mehra, DK Agencies (P) Ltd, India, pp. 86-118.

Journal Articles

Gras, S., Wilmann, P., Chen, Z., Abd Halim, N., Liu, Y.C., Kjer-Nielsen, L., Purcell, A.W., Burrows, S.R., McCluskey, J., Rossjohn, J., 2012, A structural basis for varied alphabeta TCR usage against an immunodominant EBV antigen restricted to a HLA-B8 molecule, Journal Of Immunology [P], vol 188, issue 1, American Association of Immunologists, USA, pp. 311-321.

Gras, S., Burrows, S.R., Turner, S.J., Sewell, A.K., McCluskey, J., Rossjohn, J., 2012, A structural voyage toward an understanding of the MHC-I-restricted immune response: lessons learned and much to be learned, Immunological Reviews [P], vol 250, issue 1, Wiley-Blackwell Publishing Inc., USA, pp. 61-81.

Smith, C., Elhassen, D., Gras, S., Wynn, K.K., Dasari, V., Tellam, J., Tey, S., Liu, Y.C., Rossjohn, J., Burrows, S.R., Khanna, R., 2012, Endogenous antigen presentation impacts on T-box transcription factor expression and functional maturation of CD8(+)T cells, Blood [P], vol 120, issue 16, American Society of Hematology, USA, pp. 3237-3245.

Illing, P.T., Vivian, J.P., Dudek, N.L., Kostenko, L., Chen, Z., Bharadwaj, M., Miles, J.J., Kjer-Nielsen, L., Gras, S., Williamson, N.A., Burrows, S.R., Purcell, A.W., Rossjohn, J., McCluskey, J., 2012, Immune self-reactivity triggered by drug-modified HLA-peptide repertoire, Nature [P], vol 486, issue 7404, Nature Publishing Group, UK, pp. 554-558.

Chen, A.T., Cornberg, M., Gras, S., Guillonneau, C., Rossjohn, J., Trees, A., Emonet, S., de la Torre, J.C., Welsh, R.M., Selin, L.K., 2012, Loss of anti-viral immunity by infection with a virus encoding a cross-reactive pathogenic epitope, PLoS Pathogens [E], vol 8, issue 4 (Art. ID: e1002633), Public Library of Science, USA, pp. 1-12.

Patel, O.G., Pellicci, D.G., Gras, S., Sandoval Romero, M.L., Uldrich, A.P., Mallevaey, T., Clarke, A.J., Le Nours, J., Theodossis, A., Cardell, S.L., Gapin, L., Godfrey, D.I., Rossjohn, J., 2012, Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor, Nature Immunology [P], vol 13, issue 9, Nature Publishing Group, USA, pp. 857-863.

Bulek, A.M., Cole, D.K., Skowera, A., Dolton, G., Gras, S., Madura, F., Fuller, A., Miles, J.J., Gostick, E., Price, D.A., Drijfhout, J.W., Knight, R.R., Huang, G.C., Lissin, N., Molloy, P.E., Wooldridge, L., Jakobsen, B.K., Rossjohn, J., Peakman, M., Rizkallah, P.J., Sewell, A.K., 2012, Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes, Nature Immunology [P], vol 13, issue 3, Nature Publishing Group, USA, pp. 283-289.

Liu, Y.C., Chen, Z., Burrows, S.R., Purcell, A.W., McCluskey, J., Rossjohn, J., Gras, S., 2012, The energetic basis underpinning T-cell receptor recognition of a super-bulged peptide bound to a major histocompatibility complex class I molecule, Journal Of Biological Chemistry [P], vol 287, issue 15, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 12267-12276.

Denton, A., Wesselingh, R., Gras, S., Guillonneau, C., Olson, M.R., Mintern, J.D., Zeng, W., Jackson, D.C., Rossjohn, J., Hodgkin, P.D., Doherty, P.C., Turner, S.J., 2011, Affinity thresholds for naive CD8{+} CTL activation by peptides and engineered influenza A viruses, Journal Of Immunology [P], vol 187, issue 11, American Association of Immunologists, USA, pp. 5733-5744.

Iglesias, M., Almeida, J., Fastenackels, S., van Bockel, D., Hashimoto, M., Venturi, V., Gostick, E., Urrutia, A., Wooldridge, L., Clement, M., Gras, S., Wilmann, P., Autran, B., Moris, A., Rossjohn, J., Davenport, M., Takiguchi, M., Brander, C., Douek, D., Kelleher, A., Price, D., Appay, V., 2011, Escape from highly effective public CD8+ T-cell clonotypes by HIV, Blood [P], vol 118, issue 8, American Society of Hematology, USA, pp. 2138-2149.

Vivian, J.P., Duncan, R.C., Berry, R., O'Connor, G.M., Reid, H.H., Beddoe, T.C., Gras, S., Saunders, P.M., Olshina, M.A., Widjaja, J.M., Harpur, C.M., Lin, J., Maloveste, S.M., Price, D.A., Lafont, B.A., McVicar, D.W., Clements, C.S., Brooks, A.G., Rossjohn, J., 2011, Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B, Nature [P], vol 479, issue 7373, Nature Publishing Group, UK, pp. 401-405.

Day, E., Guillonneau, C., Gras, S., La Gruta, N., Vignali, D., Doherty, P., Purcell, A., Rossjohn, J., Turner, S., 2011, Structural basis for enabling T-cell receptor diversity within biased virus-specific CD8+ T-cell responses, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 108, issue 23, National Academy of Sciences, USA, pp. 9536-9541.

Gras, S., Kjer-Nielsen, L., Chen, Z., Rossjohn, J., McCluskey, J., 2011, The structural bases of direct T-cell allorecognition: Implications for T-cell-mediated transplant rejection, Immunology And Cell Biology [P], vol 89, issue 3, Nature Publishing Group, UK, Australia, pp. 388-395.

Gras, S., Chen, Z., Miles, J.J., Liu, Y.C., Bell, M.J., Sullivan, L.C., Kjer-Nielsen, L., Brennan, R.M., Burrows, J.M., Neller, M.A., Khanna, R., Purcell, A.W., Brooks, A.G., McCluskey, J., Rossjohn, J., Burrows, S.R., 2010, Allelic polymorphism in the T cell receptor and its impact on immune responses, Journal of Experimental Medicine [P], vol 207, issue 7, Rockefeller University Press, USA, pp. 1555-1567.

Gras, S., Kedzierski, L., Valkenburg, S.A., Laurie, K.L., Liu, Y.C., Denholm, J.T., Richards, M.J., Rimmelzwaan, G.F., Kelso, A., Doherty, P.C., Turner, S.J., Rossjohn, J., Kedzierska, K., 2010, Cross-reactive CD8+ T-cell immunity between the pandemic H1N1-2009 and H1N1-1918 influenza A viruses, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 28, National Academy of Sciences, USA, pp. 12599-12604.

Burrows, S.R., Chen, Z., Archbold, J.K., Tynan, F.E., Beddoe, T.C., Kjer-Nielsen, L., Miles, J.J., Khanna, R., Moss, D.J., Liu, Y.C., Gras, S., Kostenko, L., Brennan, R.M., Clements, C.S., Brooks, A.G., Purcell, A.W., McCluskey, J., Rossjohn, J., 2010, Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 23, National Academy of Sciences, USA, pp. 10608-10613.

Valkenburg, S.A., Gras, S., Guillonneau, C., La Gruta, N.L., Thomas, P.G., Purcell, A.W., Rossjohn, J., Doherty, P.C., Turner, S.J., Kedzierska, K., 2010, Protective efficacy of cross-reactive CD8+ T cells recognising mutant viral epitopes depends on peptide-MHC-I structural interactions and T cell activation threshold, Plos Pathogens [P], vol 6, issue 8 (e1001039), Public Library of Science, USA, pp. 1-15.

Bade-Doeding, C., Theodossis, A., Gras, S., Kjer-Nielsen, L., Eiz-Vesper, B., Seltsam, A., Huyton, T., Rossjohn, J., McCluskey, J., Blasczyk, R., 2010, The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family, Haematologica-The Hematology Journal [P], vol 96, issue 1, Fondazione Ferrata Storti, Italy, pp. 110-118.

Pellicci, D.G., Patel, O., Kjer-Nielsen, L., Pang, S.S., Sullivan, L.C., Kyparissoudis, K., Brooks, A.G., Reid, H.H., Gras, S., Lucet, I.S., Koh, R., Smyth, M.J., Mallevaey, T., Matsuda, J.L., Gapin, L., McCluskey, J., Godfrey, D.I., Rossjohn, J., 2009, Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the Vbeta8.2 and Vbeta7 Semi-invariant NKT T Cell Receptors, Immunity [P], vol 31, issue 1, Cell Press, USA, pp. 47-59.

Archbold, J.K., Macdonald, W.A., Gras, S., Ely, L.K., Miles, J.J., Bell, M.J., Brennan, R.M., Beddoe, T.C., Wilce, M.C.J., Clements, C.S., Purcell, A.W., McCluskey, J., Burrows, S.R., Rossjohn, J., 2009, Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition, The Journal of Experimental Medicine, vol 206, issue 1, Rockefeller University Press, USA, pp. 209-219.

Gras, S., Saulquin, X., Reiser, J., Debeaupuis, E., Echasserieau, K., Kissenpfennig, A., Legoux, F., Chouquet, A., Le Gorrec, M., Machillot, P., Neveu, B., Thielens, N.M., Malissen, B., Bonneville, M., Housset, D., 2009, Structural bases for the affinity-driven selection of a public TCR against a dominant human cytomegalovirus epitope, Journal Of Immunology [P], vol 183, issue 1, American Association of Immunologists, USA, pp. 430-437.

Macdonald, W.A., Chen, Z., Gras, S., Archbold, J.K., Tynan, F.E., Clements, C.S., Bharadwaj, M., Kjer-Nielsen, L., Saunders, P.M., Wilce, M.C.J., Crawford, F., Stadinsky, B., Jackson, D., Brooks, A., Purcell, A.W., Kappler, J., Burrows, S.R., Rossjohn, J., McCluskey, J., 2009, T cell allorecognition via molecular mimicry, Immunity [P], vol 31, issue 6, Cell Press, USA, pp. 897-908.

Gras, S., Burrows, S.R., Kjer-Nielsen, L., Clements, C.S., Liu, Y.C., Sullivan, L.C., Bell, M.J., Brooks, A.G., Purcell, A.W., McCluskey, J., Rossjohn, J., 2009, The shaping of T cell receptor recognition by self-tolerance, Immunity, vol 30, issue 2, Cell Press, USA, pp. 193-203.

Kedzierska, K., Guillonneau, C., Gras, S., Hatton, L.A., Webby, R., Purcell, A.W., Rossjohn, J., Doherty, P.C., Turner, S.J., 2008, Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy, Proceedings of the National Academy of Sciences, vol 105, issue 49, National Academy of Sciences, United States, pp. 19408-19413.

Wynn, K.K., Fulton, Z.J., Cooper, L., Silins, S.L., Gras, S., Archbold, J.K., Tynan, F.E., Miles, J.J., McCluskey, J., Burrows, S.R., Rossjohn, J., Khanna, R., 2008, Impact of clonal competition for peptide-MHC complexes on the CD8 + T-cell repertoire selection in a persistent viral infection, Blood, vol 111, issue 8, American Society of Hematology, United States, pp. 4283-4292.

Gras, S., Kjer-Nielsen, L., Burrows, S.R., McCluskey, J., Rossjohn, J., 2008, T-cell receptor bias and immunity, Current Opinion in Immunology, vol 20, issue 1, Elsevier Ltd., United Kingdom, pp. 119-125.

Gras, S., Chaumont, V., Fernandez, B., Carpentier, P., Charrier-Savournin, F., Schmitt, S., Pineau, C., Flament, D., Hecker, A., Forterre, P., Armengaud, J., Housset, D., 2007, Structural insights into a new homodimeric self-activated GTPase family, Embo Reports [P], vol 8, issue 6, Nature Publishing Group, UK, Germany, pp. 569-575.

Gras, S., Fernandez, B., Chaumont, V., Carpentier, P., Armengaud, J., Housset, D., 2005, Expression, purification, crystallization and preliminary crystallographic analysis of the PAB0955 gene product, Acta Crystallographica Section F: Structural Biology and Crystallization Communications [P], vol 61, issue Pt 2, Wiley-Blackwell Publishing, Inc., USA, pp. 208-211.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structural and biophysical investigations into super-bulged antigen and its recognition by T cell receptors..

Supervisors:

Rossjohn, J (Main), Gras, S (Associate).