Prof Nadia Rosenthal - Researcher Profile

Biography

Nadia works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

BIOCHEMISTRY

Institution: Harvard University

Year awarded: 1981

BIOLOGY

Institution: Harvard University

Year awarded: 1975

Publications

Books

Rosenthal, N.A., Harvey, R.P. (eds), 2010, Heart Development and Regeneration, Academic Press, UK.

Book Chapters

Brand, N.J., Lara-Pezzi, E., Rosenthal, N.A., Barton, P.J., 2010, Analysis of cardiac myocyte biology in transgenic mice: a protocol for preparation of neonatal mouse cardiac myocyte cultures, in Methods in Molecular Biology, eds A Ward & D Tosh, Humana Press Inc, USA, pp. 113-124.

Lara-Pezzi, E., Rosenthal, N.A., 2010, Genetic enhancement of cardiac regeneration, in Heart Development and Regeneration, Volume 1, eds N Rosenthal & RP Harvey, Academic Press, UK, pp. 981-997.

Vinciguerra, M., Musaro, A., Rosenthal, N.A., 2010, Regulation of muscle atrophy in aging and disease, in Protein Metabolism and Homeostasis in Aging, eds N Tavernarakis, Springer Science+Business Media, USA, pp. 211-233.

Journal Articles

Pinto, A.R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J.W., Rosenthal, N.A., 2012, An abundant tissue macrophage population in the adult murine heart with a distinct alternatively-activated macrophage profile, PLoS ONE [P], vol 7, issue 5 (e36814), Public Library of Science, USA, pp. 1-11.

Chandras, C., Zouberakis, M., Salimova, E., Smedley, D., Rosenthal, N.A., Aidinis, V., 2012, CreZOO--the European virtual repository of Cre and other targeted conditional driver strains, Database: The Journal of Biological Databases and Curation [E], vol 2012, issue bas029, Oxford University Press, UK, pp. 1-5.

Hede, M., Salimova, E., Piszczek, A., Perlas, E., Winn, N., Nastasi, T., Rosenthal, N.A., 2012, E-peptides control bioavailability of IGF-1, PLoS ONE [P], vol 7, issue 12 (Art. No.: e5112), Public Library of Science, USA, pp. 1-11.

Rosenthal, N.A., Stewart, C., 2012, In search of a wide-angle perspective, Differentiation [P], vol 83, issue 3, Elsevier Ltd, UK, pp. 3-4.

Prele, C., Reichelt, M., Mutsaers, S., Davies, M., Delbridge, L., Headrick, J., Rosenthal, N., Bogoyevitch, M., Grounds, M., 2012, Insulin-like growth factor-1 overexpression in cardiomyocytes diminishes ex vivo heart functional recovery after acute ischemia, Cardiovascular Pathology [P], vol 21, issue 1, Elsevier Science Inc, USA, pp. 17-27.

Tourvon, M., Escoubet, B., Mericskay, M., Angelini, A., Lamotte, L., Santini, M.P., Rosenthal, N.A., Daegelen, D., Tuil, D., Decaux, J., 2012, Locally expressed IGF1 propeptide improves mouse heart function in induced dilated cardiomyopathy by blocking myocardial fibrosis and SRF-dependent CTGF induction, Disease Models and Mechanisms [P], vol 5, issue 4, The Company of Biologists Ltd, UK, pp. 481-491.

Santini, M.P., Rosenthal, N.A., 2012, Myocardial regenerative properties of macrophage populations and stem cells, Journal of Cardiovascular Translational Research [P], vol 5, issue 5, Springer New York LLC, USA, pp. 700-712.

Felkin, L., Narita, T., Germack, R., Shintani, Y., Takahashi, K., Sarathchandra, P., Lopez-Olaneta, M., Gomez-Salinero, J., Suzuki, K., Barton, P.J.R., Rosenthal, N.A., Lara-Pezzi, E., 2011, Calcineurin splicing variant calcineurin A{beta}1 improves cardiac function after myocardial infarction without inducing hypertrophy, Circulation [P], vol 123, issue 24, Lippincott Williams & Wilkins, USA, pp. 2838-2847.

Da Costa, M., Lee, S., Furtado, M., Xin, L., Sparrow, D., Martinez, C., Dunwoodie, S., Kurtenbach, E., Mohun, T., Rosenthal, N., Harvey, R., 2011, Complex SUMO-1 regulation of cardiac transcription factor Nkx2-5, PLoS ONE [P], vol 6, issue 9 (Art. No: e24812), Public Library of Science, USA, pp. 1-13.

Smedley, D., Salimova, E., Rosenthal, N., 2011, Cre recombinase resources for conditional mouse mutagenesis, Methods [P], vol 53, issue 4, Academic Press Inc Elsevier Science, USA, pp. 411-416.

Santini, M., Lexow, J., Borsellino, G., Slonimski, E., Zarrinpashneh, E., Poggioli, T., Rosenthal, N., 2011, IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines, Biochemical And Biophysical Research Communications [P], vol 410, issue 2, Academic Press Inc. Elsevier Science, USA, pp. 201-207.

Poudel, B., Bilbao, D., Sarathchandra, P., Germack, R., Rosenthal, N.A., Santini, M.P., 2011, Increased cardiogenesis in P19-GFP teratocarcinoma cells expressing the propeptide IGF-1Ea, Biochemical And Biophysical Research Communications [P], vol 416, issue 3-4, Academic Press, USA, pp. 293-299.

Boon, R., Seeger, T., Heydt, S., Fischer, A., Hergenreider, E., Horrevoets, A., Vinciguerra, M., Rosenthal, N., Sciacca, S., Pilato, M., Van Heijningen, P., Essers, J., Brandes, R., Zeiher, A., Dimmeler, S., 2011, MicroRNA-29 in aortic dilation: Implications for aneurysm formation, Circulation Research [P], vol 109, issue 10, Lippincott Williams & Wilkins, USA, pp. 1115-1119.

Vinciguerra, M., Santini, M.P., Martinez, C., Pazienza, V., Claycomb, W.C., Giuliani, A., Rosenthal, N.A., 2011, mIGF-1/JNK1/SirT1 signaling confers protection against oxidative stress in the heart, Aging Cell [P], vol E, Wiley-Blackwell Publishing Ltd, UK, pp. 1-11.

Shavlakadze, T., Chai, J., Maley, K., Cozens, G., Grounds, G., Winn, N., Rosenthal, N.A., Grounds, M.D., 2010, A growth stimulus is needed for IGF-1 to induce skeletal muscle hypertrophy in vivo, Journal Of Cell Science [P], vol 123, issue Pt 6, The Company of Biologists Ltd, UK, pp. 960-971.

Kratsios, P., Huth, M., Temmerman, L., Salimova, E., Al Banchaabouchi, M., Sgoifo, A., Manghi, M., Suzuki, K., Rosenthal, N.A., Mourkioti, F., 2010, Antioxidant amelioration of dilated cardiomyopathy caused by conditional deletion of NEMO/IKKgamma in cardiomyocytes, Circulation Research [P], vol 106, issue 1, Lippincott Williams & Wilkins, USA, pp. 133-144.

Temmerman, L., Slonimsky, E., Rosenthal, N.A., 2010, Class 2 IGF-1 isoforms are dispensable for viability, growth and maintenance of IGF-1 serum levels, Growth Hormone and IGF Research [P], vol 20, issue 3, Churchill Livingstone, UK, Germany, pp. 255-263.

Vinciguerra, M., Hede, M., Rosenthal, N.A., 2010, Comments on Point:Counterpoint: IGF is/is not the major physiological regulator of muscle mass. IGF-1 is a major regulator of muscle mass during growth but not for adult myofiber hypertrophy, Journal Of Applied Physiology [P], vol 108, issue 6, American Physiological Society, USA, pp. 1829-1830.

Kratsios, P., Catela, C., Salimova, E., Huth, M., Berno, V., Rosenthal, N.A., Mourkioti, F., 2010, Distinct roles for cell-autonomous notch signaling in cardiomyocytes of the embryonic and adult heart, Circulation Research [P], vol 106, Lippincott Williams & Wilkins, USA, pp. 559-572.

Smedley, D., Schofield, P., Chen, C., Aidinis, V., Ainali, C., Bard, J., Balling, R., Birney, E., Blake, A., Bongcam-Rudloff, E., Brookes, A.J., Cesareni, G., Chandras, C., Eppig, J., Flicek, P., Gkoutos, G., Greenaway, S., Gruenberger, M., Heriche, J., Lyall, A., Mallon, A., Muddyman, D., Reisinger, F., Ringwald, M., Rosenthal, N.A., Schughart, K., Swertz, M., Thorisson, G.A., Zouberakis, M., Hancock, J.M., 2010, Finding and sharing: New approaches to registries of databases and services for the biomedical sciences, Database: The Journal of Biological Databases and Curation [E], vol 2010, issue Art. No: baq014, Oxford University Press, UK, pp. 1-5.

Castillo, H.A., Cravo, R.M., Azambuja, A.P., Simoes-Costa, M.S., Sura-Trueba, S., Gonzalez, J., Slonimsky, E., Almeida, K., Abreu, J.G., Afonso de Almeida, M.A., Sobreira, T.P., de Oliveira, S.H.P., de Oliveira, P.S.L., Signore, I.A., Colombo, A., Concha, M.L., Spengler, T.S., Bronner-Fraser, M., Nobrega, M., Rosenthal, N., Xavier-Neto, J., 2010, Insights into the organization of dorsal spinal cord pathways from an evolutionarily conserved raldh2 intronic enhancer, Development [P], vol 137, issue 3, The Company of Biologists Ltd, UK, pp. 507-518.

Vinciguerra, M., Santini, M.P., Claycomb, W.C., Ladurner, A., Rosenthal, N.A., 2010, Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity, Aging [E], vol 2, issue 1, Impact Journals LLC, USA, pp. 43-62.

Zouberakis, M., Chandras, C., Swertz, M., Smedley, D., Gruenberger, M., Bard, J., Schughart, K., Rosenthal, N.A., Hancock, J.M., Schofield, P.N., Kollias, G., Aidinis, V., 2010, Mouse Resource Browser-a database of mouse databases, Database: The Journal of Biological Databases and Curation [E], vol 2010, issue Art. No: baq010, Oxford University Press, UK, pp. 1-7.

Schofield, P.N., Bubela, T., Weaver, T.A., Portilla, L., Brown, S.D., Hancock, J.D., Einhorn, D., Tocchini-Valentini, G., de Angelis, M.H., Rosenthal, N.A., CASIMIR Rome Meeting Participa, 2010, Post-publication sharing of data and tools, Nature [P], vol 461, issue 7261, Nature Publishing Group, UK, pp. 171-173.

Bochmann, L., Sarathchandra, P., Mori, F., Lara-Pezzi, E., Lazzaro, D., Rosenthal, N.A., 2010, Revealing new mouse epicardial cell markers through transcriptomics, PLoS ONE [P], vol 5, issue 6 (Art. No: e11429), Public Library of Science, USA, pp. 1-13.

Catela, C., Kratsios, P., Hede, M., Lang, F., Rosenthal, N.A., 2010, Serum and glucocorticoid-inducible kinase 1 (SGK1) is necessary for vascular remodeling during angiogenesis, Developmental Dynamics [P], vol 239, issue 8, John Wiley & Sons, Inc., USA, pp. 2149-2160.

Vinciguerra, M., Fulco, M., Ladurner, A., Sartorelli, V., Rosenthal, N.A., 2010, SirT1 in muscle physiology and disease: Lessons from mouse models, Disease Models and Mechanisms [P], vol 3, issue 5-6, The Company of Biologists Ltd, UK, pp. 298-303.

Ruffell, D., Mourkioti, F., Gambardella, A., Kirstetter, P., Lopez, R.G., Rosenthal, N.A., Nevlov, C., 2009, A CREB-C/EBPbeta cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 106, issue 41, National Academy of Sciences, USA, pp. 17475-17480.

Chandras, C., Weaver, T.A., Zouberakis, M., Smedley, D., Schughart, K., Rosenthal, N.A., Hancock, J.M., Kollias, G., Schofield, P.N., Aidinis, V., 2009, Models for financial sustainability of biological databases and resources, Database: The Journal of Biological Databases and Curation [E], vol bap017, Oxford University Press, UK, pp. 1-9.

Catela, C., Bilbao-Cortes, D., Slonimsky, E., Kratsios, P., Rosenthal, N.A., te Welscher, P., 2009, Multiple congenital malformations of Wolf-Hirschhorn syndrome are recapitulated in Fgfrl1 null mice, Disease Models and Mechanisms [P], vol 2, issue 5-6, The Company of Biologists Ltd, UK, pp. 283-294.

Mourkioti, F., Slonimsky, E., Huth, M., Berno, V., Rosenthal, N.A., 2008, Analysis of CRE-mediated recombination driven by myosin light chain 1/3 regulatory elements in embryonic and adult skeletal muscle: a tool to study fiber specification, Genesis: The Journal of Genetics and Development, vol 46, issue 8, John Wiley & Sons, Inc., USA, pp. 424-430.

Lara-Pezzi, E., Felkin, L.E., Birks, E.J., Sarathchandra, P., Panse, K.D., George, R., Hall, J.L., Yacoub, M.H., Rosenthal, N.A., Barton, P.J.R., 2008, Expression of follistatin-related genes is altered in heart failure, Endocrinology, vol 149, issue 11, The Endocrine Society, USA, pp. 5822-5827.

Burchfield, J.S., Iwasaki, M., Koyanagi, M., Urbich, C., Rosenthal, N.A., Zeiher, A.M., Dimmeler, S., 2008, Interleukin-10 from transplanted bone marrow mononuclear cells contributes to cardiac protection after myocardial infarction, Circulation Research, vol 103, issue 2, Lippincott Williams & Wilkins, USA, pp. 203-211.

Mourkioti, F., Rosenthal, N.A., 2008, NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases, Journal of Molecular Medicine, vol 86, issue 7, Springer, Germany, pp. 747-759.

Semenova, E., Koegel, H., Hasse, S., Klatte, J.E., Slonimsky, E., Bilbao, D., Paus, R., Werner, S., Rosenthal, N.A., 2008, Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice, The American Journal of Pathology, vol 173, issue 5, American Society for Investigative Pathology, USA, pp. 1295-1310.

Mandillo, S., Tucci, V., Holter, S.M., Meziane, H., Al Banchaabouchi, M., Kallnik, M., Lad, H.V., Nolan, P.M., Ouagazzal, A., Coghill, E.L., Gale, K., Golini, E., Jacquot, S., Krezel, W., Parker, A., Riet, F., Schneider, I., Marazziti, D., Auwerx, J., Brown, S.D.M., Chambon, P., Rosenthal, N.A., Tocchini-Valentini, G., Wurst, W., 2008, Reliability, robustness, and reproducibility in mouse behavioral phenotyping: A cross-laboratory study, Physiological Genomics, vol 34, issue 3, American Physiological Society, USA, pp. 243-255.

Santini, M.P., Tsao, L., Monassier, L., Theodoropoulos, C., Carter, J., Lara-Pezzi, E., Slonimsky, E., Salimova, E., Delafontaine, P., Song, Y., Bergmann, M., Freund, C., Suzuki, K., Rosenthal, N.A., 2007, Enhancing repair of the mammalian heart, Circulation Research, vol 100, issue 12, Lippincott Williams & Wilkins, USA, pp. 1732-1740.

Mirabeau, O., Perlas, E., Severini, C., Audero, E., Gascuel, O., Possenti, R., Birney, E., Rosenthal, N.A., Gross, C., 2007, Identification of novel peptide hormones in the human proteome by hidden Markov model screening, Genome Research, vol 17, issue 3, Cold Spring Harbor Laboratory Press, USA, pp. 320-327.

Batten, P., Rosenthal, N.A., Yacoub, M.H., 2007, Immune response to stem cells and strategies to induce tolerance, Philosophical Transactions of the Royal Society of London - Biological Sciences, vol 362, issue 1484, Royal Society Publishing, UK, pp. 1343-1356.

Pelosi, L., Giacinti, C., Nardis, C., Borsellino, G., Rizzuto, E., Nicoletti, C., Wannenes, F., Battistini, L., Rosenthal, N.A., Molinaro, M., Musaro, A., 2007, Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines, The FASEB Journal, vol 21, issue 7, Federation of American Societies for Experimental Biology, USA, pp. 1393-1402.

Reuveni, E., Carola, V., Banchaabouchi, M.A., Rosenthal, N.A., Hancock, J.M., Gross, C., 2007, Phenostat: Visualization and statistical tool for analysis of phenotyping data, Mammalian Genome, vol 18, issue 9, Springer, USA, pp. 677-681.

Pelosi, M., Marampon, F., Zani, B.M., Prudente, S., Perlas, E., Caputo, V., Cianetti, L., Berno, V., Narumiya, S., Kang, S.W., Musaro, A., Rosenthal, N.A., 2007, ROCK2 and its alternatively spliced isoform ROCK2m positively control the maturation of the myogenic program, Molecular and Cellular Biology, vol 27, issue 17, American Society for Microbiology, USA, pp. 6163-6176.

Rosenthal, N.A., Brown, S., 2007, The mouse ascending: perspectives for human-disease models, Nature Cell Biology, vol 9, issue 9, Nature Publishing Group, UK, pp. 993-999.

Musaro, A., Dobrowolny, G., Rosenthal, N.A., 2007, The neuroprotective effects of a locally acting IGF-1 isoform, Experimental Gerontology, vol 42, issue 1-2, Pergamon-Elsevier Science Ltd, UK, pp. 76-80.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of cardiac tissue macrophages in the ageing heart.

Supervisors:

Rosenthal, N (Main), Pinto, R (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Understanding the role of cardiac fibroblasts in homeostasis and disease.

Supervisors:

Rosenthal, N (Main), Godwin, J (Main).