Prof Jennifer Wilkinson-Berka - Researcher Profile

Biography

Jennifer works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Professor.

Qualifications

DOCTOR OF PHILOSOPHY

Institution: University of Melbourne

Year awarded: 1992

Publications

Journal Articles

Deliyanti, D., Miller, A.G., Tan, G., Binger, K., Samson, A.L., Wilkinson-Berka, J.L., 2012, Neovascularization is attenuated with aldosterone synthase inhibition in rats with retinopathy, Hypertension [P], vol 59, issue 3, Lippincott Williams & Wilkins, USA, pp. 607-613.

Sedeek, M., Montezano, A.C., Hebert, R.L., Gray, S., Di Marco, E., Jha, J.C., Cooper, M., Jandeleit-Dahm, K.A.M., Schiffrin, E.L., Wilkinson-Berka, J., Touyz, R.M., 2012, Oxidative stress, nox isoforms and complications of diabetes-potential targets for novel therapies, Journal of Cardiovascular Translational Research [P], vol 5, issue 4, Springer New York LLC, United States, pp. 509-518.

Wilkinson-Berka, J., Agrotis, A., Deliyanti, D., 2012, The retinal renin–angiotensin system: roles of angiotensin II and aldosterone, Peptides [P], vol 36, issue 1, Elsevier Inc., United States, pp. 142-150.

Wilkinson-Berka, J., Tan, G., Binger, K., Sutton, L., McMaster, K., Deliyanti, D., Perera, G., Campbell, D., Miller, A., 2011, Aliskiren reduces vascular pathology in diabetic retinopathy and oxygen-induced retinopathy in the transgenic (mRen-2)27 rat, Diabetologia [P], vol 54, issue 10, Springer, Germany, pp. 2724-2735.

Vessey, K., Wilkinson-Berka, J., Fletcher, E., 2011, Characterization of Retinal Function and Glial Cell Response in a Mouse Model of Oxygen-Induced Retinopathy, Journal of Comparative Neurology [P], vol 519, issue 3, John Wiley & Sons, Inc, US, pp. 506-527.

Wilkinson-Berka, J., Miller, A., Binger, K., 2011, Prorenin and the (pro)renin receptor: recent advances and implications for retinal development and disease, Current Opinion In Nephrology And Hypertension [P], vol 20, issue 1, Lippincott Williams & Wilkins, USA, pp. 69-76.

Downie, L., Hatzopoulos, K., Pianta, M., Vingrys, A., Wilkinson-Berka, J., Kalloniatis, M., Fletcher, E., 2010, Angiotensin type-1 receptor inhibition is neuroprotective to amacrine cells in a rat model of retinopathy of prematurity, Journal of Comparative Neurology [P], vol 518, issue 1, John Wiley & Sons, Inc, United States, pp. 41-63.

Miller, A., Tan, G., Binger, K., Pickering, R., Thomas, M., Nagaraj, R., Cooper, M.E., Wilkinson-Berka, J., 2010, Candesartan attenuates diabetic retinal vascular pathology by restoring glyoxalase-I function, Diabetes [P], vol 59, issue 12, American Diabetes Association, United States, pp. 3208-3215.

Wilkinson-Berka, J., Miller, A., Fletcher, E., 2010, Prorenin and the (pro)renin receptor: do they have a pathogenic role in the retina?, Frontiers in Bioscience [P], vol 2, Frontiers in Bioscience, United States, pp. 1054-1064.

Wilkinson-Berka, J., Heine, R.D., Tan, G., Cooper, M.E., Hatzopoulos, K., Fletcher, E.L., Binger, K., Campbell, D.J., Miller, A., 2010, RILLKKMPSV influences the vasculature, neurons and glia, and (pro)renin receptor expression in the retina, Hypertension [P], vol 55, issue 6, Lippincott Williams & Wilkins, United States, pp. 1454-1460.

Fletcher, E., Phipps, J., Ward, M., Vessey, K., Wilkinson-Berka, J., 2010, The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature, Progress in Retinal and Eye Research [P], vol 29, issue 4, Pergamon, United Kingdom, pp. 284-311.

Fletcher, E.L., Downie, L.E., Hatzopoulos, K., Vessey, K., Ward, M.M., Chow, C.L., Pianta, M.J., Vingrys, A., Kalloniatis, M., Wilkinson-Berka, J., 2010, The significance of neuronal and glial cell changes in the rat retina during oxygen-induced retinopathy., Documenta Ophthalmologica [P], vol 120, Springer, The Netherlands, pp. 67-86.

Wilkinson-Berka, J., Campbell, D.J., 2009, (Pro)renin receptor: A treatment target for diabetic retinopathy?, Diabetes [P], vol 58, issue 7, American Diabetes Association, United States, pp. 1485-1487.

Wilkinson-Berka, J., Tan, G.M.L., Jaworski, K.A., Miller, A.G., 2009, Identification of a retinal aldosterone system and the protective effects of mineralocorticoid receptor antagonism on retinal vascular pathology, Circulation Research, vol 104, issue 1, Lippincott Williams & Wilkins, United States, pp. 124-133.

Downie, L.E., Vessey, K., Miller, A.G., Ward, M.M., Pianta, M.J., Vingrys, A., Wilkinson-Berka, J., Fletcher, E.L., 2009, Neuronal and glial cell expression of angiotensin II type 1 (AT1) and type 2 (AT2) receptors in the rat retina, Neuroscience [P], vol 161, issue 1, Pergamon, United Kingdom, pp. 195-213.

Wilkinson-Berka, J., Allen, T., Miller, A., 2009, Prorenin and the (pro)renin receptor in retinal pathology, Current Hypertension Reviews [P], vol 5, issue 3, Bentham Science Publishers Ltd, Netherlands, pp. 245-250.

Downie, L.E., Pianta, M.J., Vingrys, A., Wilkinson-Berka, J., Fletcher, E.L., 2008, AT1 receptor inhibition prevents astrocyte degeneration and restores vascular growth in oxygen-induced retinopathy, Glia, vol 56, issue 10, John Wiley & Sons, Inc, United States, pp. 1076-1090.

Jayasooriya, A.P., Begg, D.P., Chen, N., Mathai, M.L., Sinclair, A.J., Wilkinson-Berka, J., Wark, J.D., Weisinger, H.S., Weisinger, R.S., 2008, Omega-3 polyunsaturated fatty acid supplementation reduces hypertension in TGR(mRen-2)27 rats, Prostaglandins Leukotrienes & Essential Fatty Acids, vol 78, Chruchill Livingstone, UK, pp. 67-72.

Wilkinson-Berka, J., 2008, Prorenin and the (pro)renin receptor in ocular pathology, American Journal of Pathology, vol 173, issue 6, American Society for Investigative Pathology, United States, pp. 1591-1594.

Wilkinson-Berka, J., Miller, A.G., 2008, Update on the treatment of diabetic retinopathy, The Scientific World Journal, vol 6, issue 8, The Scientific world Ltd, United Kingdom, pp. 98-120.

Wilkinson-Berka, J.L., Lofthouse, S., Jaworski, K.A., Ninkovic, S., Tachas, G., Wraight, C., 2007, An antisense oligonucleotide targeting the growth hormone receptor inhibits neovascularization in a mouse model of retinopathy, Molecular Vision, vol 13, Molecular Vision, USA, pp. 1529-1538.

Fletcher, E.L., Phipps, J., Ward, M.M., Puthussery, T., Wilkinson-Berka, J., 2007, Neuronal and glial cell abnormality as predictors of progression of diabetic retinopathy, Current Pharmaceutical Design, vol 13, issue 26, Betham Science Publishers Ltd, The Netherlands, pp. 2699-2712.

Downie, L.E., Pianta, M.J., Vingrys, A., Wilkinson-Berka, J., Fletcher, E.L., 2007, Neuronal and glial cell changes are determined by retinal vascularization in retinopathy of prematurity, The Journal of Comparative Neurology, vol 504, issue 4, John Wiley and Sons Inc, USA, pp. 404-417.

Kelly, D.J., Wilkinson-Berka, J., Gilbert, R.E., 2007, Progressive diabetic nephropathy in the Ren-2 rat., American Journal of Physiology: Renal Physiology, vol 292, issue 5, American Society, USA, p. F1662.

Phipps, J., Wilkinson-Berka, J., Fletcher, E.L., 2007, Retinal dysfunction in diabetic Ren-2 rats is ameliorated by treatment with valsartan but not atenolol, Investigative Ophthalmology and Visual Science, vol 48, issue 2, Association for Research into Vision Sciences and Ophthalmology (IOVS), USA, pp. 927-934.

Wilkinson-Berka, J., Tan, G.M.L., Jaworski, K.A., Ninkovic, S., 2007, Valsartan but not atenolol improves vascular pathology in diabetic Ren-2 rat retina, American Journal of Hypertension, vol 20, issue 4, Nature Publishing Group, USA, pp. 423-430.

Wilkinson-Berka, J., 2006, Angiotensin and diabetic retinopathy, The International Journal of Biochemistry and Cell Biology, vol 38, issue 5-6, Elsevier, United Kingdom, pp. 752-765.

Wilkinson-Berka, J., Jones, D., Taylor, G., Jaworski, K.A., Kelly, D.J., Ludbrook, S.B., Willette, R.N., Kumar, S., Gilbert, R.E., 2006, SB-267268, a nonpeptidic antagonist of alphavbeta3 and alphavbeta5 integrins, reduces angiogenesis and VEGF expression in a mouse model of retinopathy of prematurity, Investigative Ophthalmology and Visual Science, vol 47, issue 4, Association for Research in Vision and Ophthalmology, United States, pp. 1600-1605.

Wilkinson-Berka, J., Wraight, C., Werther, G.A., 2006, The role of growth hormone, insulin-like growth factor and somatostatin in diabetic retinopathy, Current Medicinal Chemistry, vol 13, Bentham Science Publishers Ltd, The Netherlands, pp. 3307-3317.

Fletcher, E.L., Phipps, J., Wilkinson-Berka, J., 2005, Dysfunction of retinal neurons and glia during diabetes, Clinical and Experimental Optometry, vol 88, issue 3, Blackwell Publishing Ltd, United Kingdom, pp. 132-145.

Bergman, P.B., Moravski, C.J., Edmondson, S., Russo, V.C., Bach, L.A., Wilkinson-Berka, J., Werther, G.A., 2005, Expression of the IGF system in normal and diabetic transgenic (mRen-2)27 rat eye, Investigative Ophthalmology and visual science, vol 46, issue 8, Association for Research in Vision and Ophthalmology, United States, pp. 2708-2715.

Kelly, D.J., Wilkinson-Berka, J., Gilbert, R.E., 2005, Renin inhibition; new potential for an old therapeutic target, Hypertension, vol 46, Lippencott Williams and Wilkins, United States, pp. 471-472.

Sarlos, S., Wilkinson-Berka, J., 2005, The renin-angiotensin system and the developing retinal vasculature, Investigative Ophthalmology and Visual Science, vol 46, issue 3, Association for Research in Vision and Ophthalmology, United States, pp. 1069-1077.

Martin, J., Kelly, D.J., Mifsud, S., Zhang, Y., Cox, A.J., See, F., Krum, H., Wilkinson-Berka, J.L., Gilbert, R.E., 2005, Tranilast attenuates cardiac matrix deposition in experimental diabetes: Role of transforming growth factor-beta, Cardiovascular Research, vol 65, Elsevier BV, The Netherlands, pp. 694-701.

de Gooyer, T.E., Skinner, S.L., Wlodek, M.E., Kelly, D.J., Wilkinson-Berka, J., 2004, Angiotensin II influences ovarian follicle development in the transgenic (mREN-2)27 and Sprague-Dawley rat, Journal of Endocrinology, vol 180, Society for Endocrinology, United Kingdom, pp. 311-324.

Wilkinson-Berka, J., Fletcher, E.L., 2004, Angiotensin and Bradykinin: targets for the treatment of vascular and neuro-glial pathology in diabetic retinopathy, Current Pharmaceutical Design, vol 10, Bentham Science Publishers Ltd, The Netherlands, pp. 3313-3330.

Mifsud, S.A., Burrell, L.M., Kubota, E., Jaworski, K.A., Cooper, M.E., Wilkinson-Berka, J., 2004, Cardiorenal Protective Effects of Vasopeptidase Inhibition with Omapatrilat in Hypertensive Transgenic (mREN-2)27 Rats, Clinical and Experimental Hypertension, vol 26, issue 1, Informa Healthcare, United States, pp. 69-80.

Wilkinson-Berka, J., 2004, Diabetes and retinal vascular disorders: role of the renin-angiotensin system, Expert reviews in Molecular Medicine, vol 6, issue 15, Cambridge University Press, United Kingdom, pp. 1-18.

Kelly, D.J., Stein-Oakley, A.N., Zhang, Y., Wassef, L., Maguire, J.A., Koji, T., Thomson, N.M., Wilkinson-Berka, J., Gilbert, R.E., 2004, Fas-induced apoptosis is a feature of progressive diabetic nephropathy in transgenic (mRen-2)27 rats: Attenuation with renin-angiotensin blockade, Nephrology, vol 9, issue 1, Wiley-Blackwell Publishing Asia, Australia, pp. 7-13.

Wilkinson-Berka, J., Babic, S., de Gooyer, T.E., Stitt, A.W., Jaworski, K.A., Ong, L., Kelly, D.J., Gilbert, R.E., 2004, Inhibition of platelet-derived growth factor promotes pericyte loss and angiogenesis in ischemic retinopathy, American Journal of Pathology, vol 164, issue 4, American Society for Investigative Pathology, USA, pp. 1263-1273.

Wilkinson-Berka, J., 2004, Vasoactive factors and diabetic retinopathy: Vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide, Current Pharmaceutical Design, vol 10, Bentham Science Publishers Ltd., Netherlands, pp. 3331-3348.

Wilkinson-Berka, J., Alousis, N.S., Kelly, D.J., Gilbert, R.E., 2003, COX-2 inhibition and retinal angiogenesis in a mouse model of retinopathy of prematurity, Investigative Ophthalmology & Visual Science, vol 44, issue 3, Association for Research in Vision and Ophthalmology, USA, pp. 974-979.

Mifsud, S., Kelly, D.J., Qi, W., Zhang, Y., Pollock, C.A., Wilkinson-Berka, J., Gilbert, R.E., 2003, Intervention with tranilast attenuates tubulointerstitial pathology and albuminuria in advanced experimental diabetic nephropathy, Nephron. Physiology [P], vol 95, issue 4, S Karger AG, Basel Switzerland, pp. 83-91.

Kelly, D.J., Zhang, Y., Hepper, C., Gow, R.M., Jaworski, K.A., Kemp, B.E., Wilkinson-Berka, J., Gilbert, R.E., 2003, Protein Kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension, Diabetes, vol 52, issue 2, American Diabetes Association, USA, pp. 512-518.

Kelly, D.J., Zhang, Y., Hepper, C., Gow, R.M., Jaworski, K., Kemp, B.E., Wilkinson-Berka, J.L., Gilbert, R.E., 2003, Protein kinase C beta inhibition attenuates the progression of experimental diabetic nephropathy in the presence of continued hypertension, Diabetes, vol 52, issue 2, American Diabetes Association, Alexandria USA, pp. 512-518.

Fabiani, M.E., Hawkes, D.J., Frauman, A.G., Tikellis, C., Johnston, C.I., Wilkinson-Berka, J., 2003, Regulation of angiotensin II receptors in the prostate of the transgenic (mRen-2)27 rat: effect of angiotensin-converting enzyme inhibition, The international Journal of Biochemistry and Cell Biology, vol 35, Pergamon, UK, pp. 973-983.

Sarlos, S., Rizkalla, B., Moravski, C.J., Cao, Z.M., Cooper, M.E., Wilkinson-Berka, J., 2003, Retinal angiogenesis is mediated by an interaction between the angiotensin type 2 receptor, VEGF, and angiopoietin, American Journal of Pathology, vol 163, issue 3, American Society for Investigative Pathology, United States, pp. 879-887.

Gilbert, R.E., Krum, H., Wilkinson-Berka, J.L., Kelly, D.J., 2003, The renin-angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations, Diabetic Medicine, vol 20, issue 8, Blackwell Publishing Ltd, UK, pp. 607-621.

Moravski, C.J., Skinner, S.L., Stubbs, A.J., Sarlos, S., Kelly, D.J., Cooper, M.E., Gilbert, R.E., Wilkinson-Berka, J., 2003, The renin-angiotensin system influences ocular endothelial cell proliferation in diabetes: transgenic and interventional studies, American Journal of Pathology, vol 162, issue 1, American Society for Investigative Pathology, United States, pp. 151-160.

Wilkinson-Berka, J., Kelly, D.J., Koerner, S.M., Jaworski, K.A., Davis, B., Thallas, V., Cooper, M.E., 2002, ALT-946 and aminoguanidine, inhibitors of advanced glycation, improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat, Diabetes, vol 51, American Diabetes Association, United States, pp. 3283-3289.

Kelly, D.J., Cox, A.J., Tolcos, M., Cooper, M., Wilkinson-Berka, J., Gilbert, R.E., 2002, Attenuation of tubular apoptosis by blockade of the renin-angiotensin system in diabetic Ren-2 rats, Kidney International, vol 61, Nature Publishing Group, United Kingdom, pp. 31-39.

Wilkinson-Berka, J., Kelly, D.J., Rong, P., Campbell, D.J., Skinner, S.L., 2002, Characterisation of a thymic renin-angiotensin system in the transgenic m(Ren-2)27 rat, Molecular and Cellular Endocrinology, vol 194, Elsevier Ireland Ltd, Ireland, pp. 201-209.

Mifsud, S.A., Skinner, S.L., Cooper, M.E., Kelly, D.J., Wilkinson-Berka, J., 2002, Effects of low-dose and early versus late perindopril treatment on the progression of severe diabetic nephropathy in (mREN-2)27 rats, Journal of the American Society of Nephrology, vol 13, Lippincott Williams and Wilkins, United States, pp. 684-692.

Kelly, D.J., Wilkinson-Berka, J.L., Ricardo, S.D., Cox, A.J., Gilbert, R., 2002, Progression of tubulointerstitial injury by osteopontin-induced macrophage recruitment in advanced diabetic nephropathy of transgenic (mRen-2) 27 rats, Nephrology Dialysis Transplantation, vol 17, Oxford University Press, Oxford UK, pp. 985-991.

Gilbert, R.E., Wilkinson-Berka, J., Kelly, D.J., 2001, Angiotensin II and kidney disease, Contributions to Nephrology, vol 135, Karger, Switzerland, pp. 171-186.

Rong, P., Wilkinson-Berka, J., Skinner, S.L., 2001, Control of renin secretion from adrenal gland in transgenic Ren-2 and normal rats, Molecular and Cellular Endocrinology, vol 173, Elsevier, Ireland, pp. 203-212.

Mifsud, S., Allen, T., Bertram, J.F., Hulthen, U., Kelly, D.J., Cooper, M., Wilkinson-Berka, J.L., Gilbert, R., 2001, Podocyte foot process broadening in experimental diabetic nephropathy: amelioration with renin-angiotensin blockade, Diabetologia, vol 44, issue 7, Springer-Verlag, New York NY USA, pp. 878-882.

Wilkinson-Berka, J., Gibbs, N.J., Cooper, M.E., Skinner, S.L., Kelly, D.J., 2001, Renoprotective and anti-hypertensive effects of combined valsartan and perindopril in progressive diabetic nephropathy in the transgenic (mRen-2)27 rat, Nephrology Dialysis Transplantation, vol 16, Oxford University Press, England, pp. 1343-1349.

Wilkinson-Berka, J., Kelly, D.J., Gilbert, R.E., 2001, The interaction between the Renin-Angiotensin system and Vascular Endothelial Growth Factor in the Pathogenesis of Retinal Neovascularization in diabetes, Journal of Vascular Research, vol 126, S Karger AG, Switzerland, pp. 527-535.

Moravski, C.J., Kelly, D.J., Cooper, M.E., Gilbert, R., Bertram, J.F., Shahinfar, S., Skinner, S.L., Wilkinson-Berka, J.L., 2000, Retinal neovascularization is prevented by blockage of the renin-angiotensin system, Hypertension, vol 36 issue 6, Lippincott Williams & Wilkins, Baltimore USA, pp. 1099-1104.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Aldosterone and the mineralocorticoid receptor's mediation of inflammation and vascular pathology in retinal disease..

Supervisors:

Wilkinson-Berka, J (Main), Miller, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Prorenin and the prorenin receptor (P)RR: mechanisms of action in diabetic retinopathy.

Supervisors:

Wilkinson-Berka, J (Main), Agrotis, A (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of the adaptive immune system in the formation and progression of retinopathy.

Supervisors:

Wilkinson-Berka, J (Main), Mackay, F (Associate).