Dr Alex Theodossis - Researcher Profile

Biography

Alex works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD STRUCURAL BIOLOGY

Institution: University of St Andrews, United Knigdom

Year awarded: 2006

BACHELOR OF SCIENCE (HONORS) BIOLOGY

Institution: University of St Andrews, United Kingdom

Year awarded: 2002

Publications

Journal Articles

Theodossis, A., 2013, On the trail of empty MHC class-I, Molecular Immunology [P], vol E-pub, Pergamon, UK, pp. 1-4.

Broughton, S.E., Petersen, J., Theodossis, A., Scally, S.W., Loh, K.L., Thompson, A., van Bergen, J., Kooy-Winkelaar, Y., Henderson, K.N., Beddoe, T.C., Tye-Din, J.A., Mannering, S.I., Purcell, A.W., McCluskey, J., Anderson, R.P., Koning, F., Reid, H.H., Rossjohn, J., 2012, Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease, Immunity [P], vol 37, issue 4, Cell Press, USA, pp. 611-621.

Patel, O.G., Pellicci, D.G., Gras, S., Sandoval Romero, M.L., Uldrich, A.P., Mallevaey, T., Clarke, A.J., Le Nours, J., Theodossis, A., Cardell, S.L., Gapin, L., Godfrey, D.I., Rossjohn, J., 2012, Recognition of CD1d-sulfatide mediated by a type II natural killer T cell antigen receptor, Nature Immunology [P], vol 13, issue 9, Nature Publishing Group, USA, pp. 857-863.

Bharadwaj, M., Illing, P., Theodossis, A., Purcell, A.W., Rossjohn, J., McCluskey, J., 2011, Drug hypersensitivity and human leukocyte antigens of the major histocompatibility complex, Annual Review Of Pharmacology And Toxicology [P], vol E, Annual Reviews, USA, pp. 1-31.

Theodossis, A., Guillonneau, C., Welland, A.D., Ely, L.K., Clements, C.S., Williamson, N.A., Webb, A.I., Wilce, J.A., Mulder, R.J., Dunstone, M.A., Doherty, P.C., McCluskey, J., Purcell, A.W., Turner, S.J., Rossjohn, J., 2010, Constraints within major histocompatibility complex class I restricted peptides: presentation and consequences for T-cell recognition, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 12, National Academy of Sciences, USA, pp. 5534-5539.

Bade-Doeding, C., Theodossis, A., Gras, S., Kjer-Nielsen, L., Eiz-Vesper, B., Seltsam, A., Huyton, T., Rossjohn, J., McCluskey, J., Blasczyk, R., 2010, The impact of human leukocyte antigen (HLA) micropolymorphism on ligand specificity within the HLA-B*41 allotypic family, Haematologica-The Hematology Journal [P], vol 96, issue 1, Fondazione Ferrata Storti, Italy, pp. 110-118.

Butler, N.S., Theodossis, A., Webb, A.I., Nastovska, R., Ramarathinam, S.H., Dunstone, M.A., Rossjohn, J., Purcell, A.W., Perlman, S., 2008, Prevention of cytotoxic T cell escape using a heteroclitic subdominant viral T cell determinant, PL o S Pathogens (online), vol 4, issue 10, Public Library of Science, United States, pp. 1-13.

Butler, N.S., Theodossis, A., Webb, A.I., Dunstone, M.A., Nastovska, R., Ramarathinam, S.H., Rossjohn, J., Purcell, A.W., Perlman, S., 2008, Structural and biological basis of CTL escape in coronavirus-infected mice, Journal of Immunology, vol 180, issue 6, American Association of Immunologists, United States, pp. 3926-3937.

Milburn, C.C., Lamble, H.J., Theodossis, A., Bull, S.D., Hough, D.W., Danson, M.J., Taylor, G.L., 2006, The structural basis of substrate promiscuity in glucose dehydrogenase from the hyperthermophilic archaeon Sulfolobus solfataricus, Journal of Biological Chemistry, vol 281, issue 21, American Society of Biochemistry & Molecular Biology, Inc., Bethesda USA, pp. 14796-14804.

Theodossis, A., Milburn, C.C., Heyer, N.I., Lamble, H.J., Hough, D.W., Danson, M.J., Taylor, G.L., 2005, Preliminary crystallographic studies of glucose dehydrogenase from the promiscuous Entner-Doudoroff pathway in the hyperthermophilic archaeon Sulfolobus solfataricus, ACTA Crystallographica Section F-Structural Biology and Crystallization Communications, vol 61, issue Pt 1, Blackwell Publishing, Oxford England, pp. 112-115.

Lamble, H.J., Theodossis, A., Milburn, C.C., Taylor, G.L., Bull, S.D., Hough, D.W., Danson, M.J., 2005, Promiscuity in the part-phosphorylative Entner-Doudoroff pathway of the archaeon Sulfolobus solfataricus, FEBS Letters, vol 579, issue 30, Elsevier Science BV, Amsterdam The Netherlands, pp. 6865-6869.

Theodossis, A., Walden, H., Westwick, E.J., Connaris, H., Lamble, H.J., Hough, D.W., Danson, M.J., Taylor, G.L., 2004, The structural basis for substrate promiscuity in 2-keto-3-deoxygluconate aldolase from the Entner-Doudoroff pathway in Sulfolobus solfataricus, Journal of Biological Chemistry, vol 279, issue 42, American Society of Biochemistry & Molecular Biology Inc, Bethesda USA, pp. 43886-43892.

Conference Proceedings

Theodossis, A., Ruiz-Gomez, G., Gibb, A., Welland, A.D., Jones, P., Fairlie, D.P., Rossjohn, J., 2012, Shedding light on MHC class I antigen loading: a UV-labile peptide ligand approach, Shedding light on MHC class I antigen loading: a UV-labile peptide ligand approach, 25-27 April 2012, Pergamon, UK, p. 33.