Dr Heather Verkade - Researcher Profile

Biography

Heather works in the School of Biological Sciences at Monash University as a Lecturer

 

 

Heather’s research areas of interest are:

 

• Morphogenetic movements during zebrafish intestinal development
• Endodermal cell migration
• Cell polarity during cell movements.

 

Honours projects for prospective students: www.biolsci.monash.edu.au/honours/verkade.html

 

To see a movie of the first 18 hours of zebrafish development: http://zfin.org/zf_info/movies/movies.html

 

Keywords

Zebrafish development, Cell migration

Qualifications

PHD IN GENETICS

Institution: Peter MacCallum Cancer Institute / University of Melbourne

Year awarded: 2000

BACHELOR OF SCIENCE (HONS)

Institution: University of Melbourne

Year awarded: 1995

Publications

Book Chapters

Hogan, B.M., Verkade, H., Lieschke, G.J., Heath, J.K., 2009, Manipulation of gene expression during zebrafish embryonic development using transient approaches, in Wnt Signalling, Volume II: Pathway Models, eds Elizabeth Vincan, Humana Press, New York USA, pp. 273-300.

Verkade, H., Heath, J.K., 2009, Wnt signalling mediates diverse deveopmental processes in zebrafish, in Wnt Signalling, Volume II: Pathway Models, eds Elizabeth Vincan, Humana Press, New York USA, pp. 225-251.

Journal Articles

Schaub, M., Nussbaum, J., Verkade, H., Ober, E., Stainier, D., Sakaguchi, T., 2012, Mutation of zebrafish Snapc4 is associated with loss of the intrahepatic, Developmental Biology [E], vol 363, issue 1, Academic Press, United States, pp. 128-137.

Curado, S., Ober, E., Walsh, S., Cortes-Hernandez, P., Verkade, H., Koehler, C., Stainer, D., 2010, The mitochondrial import gene tomm22 is specifically required for hepatocyte survival and provides a liver regeneration model, Disease Models and Mechanisms [P], vol 3, issue 7-8, The Company of Biologists Ltd, Cambridge England, pp. 486-495.

de Jong-Curtain, T.A., Parslow, A.C., Trotter, A.J., Hall, N.E., Verkade, H., Tabone, T., Christie, E.L., Crowhurst, M.O., Layton, J.E., Shepherd, I.T., Nixon, S.J., Parton, R.G., Zon, L.I., Stainer, D.Y.R., Lieschke, G.J., Heath, J.K., 2009, Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish, Gastroenterology [P], vol 136, issue 3, Elsevier, USA, pp. 902-911.e7.

Wilkins, S.J., Yoong, S.H.S., Verkade, H., Mizoguchi, T., Plowman, S.J., Hancock, J.F., Kikuchi, Y., Heath, J.K., Perkins, A.C., 2008, Mtx2 directs zebrafish morphogenetic movements during epiboly by regulating microfilament formation, Developmental Biology [P], vol 314, issue 1, Academic Press, USA, pp. 12-22.

Shin, C., Chung, W., Hong, S., Ober, E.A., Verkade, H., Field, H.A., Huisken, J., Stainier, D.Y.R., 2008, Multiple roles for Med12 in vertebrate endoderm development, Developmental Biology, vol 317, Elsevier, USA, pp. 467-479.

Noel, E., Casal-Sueiro, A., Busch-Nentwich, E., Verkade, H., Dong, P.D.S., Stemple, D., Ober, E.A., 2008, Organ-specific requirements for Hdac1 in liver and pancreas formation, Developmental Biology, vol 322, Elsevier, USA, pp. 237-250.

Munson, C., Huisken, J., Bit-Avragim, N., Kuo, T., Dong, P.D.S., Ober, E.A., Verkade, H., Abdelilah-Seyfried, S., Stainier, D.Y.R., 2008, Regulation of neurocoel morphogenesis by Pard6gammab, Developmental Biology, vol 324, issue 1, Elsevier, USA, pp. 41-54.

Mizoguchi, T., Verkade, H., Heath, J.K., Kuroiwa, A., Kikuchi, Y., 2008, Sdf1/Cxcr4 signaling controls the dorsal migration of endodermal cells during zebrafish gastrulation, Development, vol 135, Company of Biologists, UK, pp. 2521-2529.

Osborne, N., Brand-Arzamendi, K., Ober, E.A., Jin, S., Verkade, H., Glickman Holtzman, N., Yelon, D., Stainier, D.Y.R., 2008, The Spinster Homolog, Two of Hearts, Is Required for Sphingosine 1-Phosphate Signaling in Zebrafish, Current Biology, vol 18, Elsevier, USA, pp. 1882-1888.

Jin, S., Herzog, W., Santoro, M.M., Mitchell, T.S., Frantsve, J., Jungblut, B., Beis, D., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H., Field, H.A., Chi, N.C., Wehman, A., Baier, H., Stainier, D.Y.R., 2007, A transgene-assisted genetic screen identifies essential regulators of vascular development in vertebrate embryos, Developmental Biology, vol 307, Academic Press, USA, pp. 29-42.

Ober, E.A., Verkade, H.M., Field, H.A., Stainier, D.Y.R., 2006, Mesodermal Wnt2b signalling positively regulates liver specification, Nature, vol 442, issue 7103, Nature Publishing Group, UK, pp. 688-691.

Beis, D., Bartman, T., Jin, S., Scott, I.C., D'Amico, L.A., Ober, E.A., Verkade, H.M., Frantsve, J., Field, H.A., Wehman, A., Baier, H., Tallafuss, A., Bally-Cuif, L., Chen, J., Stainier, D.Y.R., Jungblut, B., 2005, Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development, Development, vol 132, The Company of Biologists, Cambridge England, pp. 4193-4204.

Kikuchi, Y., Verkade, H.M., Reiter, J.F., Kim, C., Chitnis, A.B., Kuroiwa, A., Stainier, D.Y.R., 2004, Notch signaling can regulate endoderm formation in zebrafish, Developmental Dynamics, vol 229, John Wiley & Sons Inc, USA, pp. 756-762.

Loosli, F., Staub, W., Finger-Baier, K.C., Ober, E.A., Verkade, H.M., Wittbrodt, J., Baier, H., 2003, Loss of eyes in zebrafish caused by mutation of chokh/rx3, EMBO Reports, vol 4, issue 9, Nature Publishing Group, UK, pp. 894-899.

Verkade, H.M., Teli, T., Laursen, L.V., Murray, J.M., O'Connell, M.J., 2001, A homologue of the Rad18 postreplication repair gene is required for DNA damage responses throughout the fission yeast cell cycle, Molecular Genetics and Genomics, vol 265, Springer -Verlag, Germany, pp. 993-1003.

Reiter, J.F., Verkade, H.M., Stainier, D.Y.R., 2001, Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5, Developmental Biology, vol 234, Academic Press, USA, pp. 330-338.

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Investigation of MYH7 and Related Myopathies in the Zebrafish.

Supervisors:

Bryson-Richardson, R (Main), Verkade, H (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Producing a Danio rerio (zebrafish) model of Z antitrypsin.

Supervisors:

Bottomley, S (Main), Bird, P (Associate), Verkade, H (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The genetic and morphological characterisation of a novel zebrabish mutant, HL-7.2.

Supervisors:

Verkade, H (Main), Warr, C (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

The role of MACPF proteins in zebrafish development..

Supervisors:

Bird, P (Main), Verkade, H (Associate), Whisstock, J (Associate).

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Zebrafish skeletal muscle growth and repair: role of the muscle progenitor cell.

Supervisors:

Currie, P (Joint), Verkade, H (Joint-co).