Dr Rajendra Gurung - Researcher Profile

Biography

Rajendra works in the Faculty of Medicine, Nursing & Health Sciences at Monash University as a Research Fellow.

Qualifications

PHD (MOLECULAR BIOLOGY) - PHILOSOPHY

Institution: Monash University

Year awarded: 2001

BSC. BACHELOR OF SCIENCE (HONS)

Institution: Monash University

Year awarded: 1995

Publications

Journal Articles

Balamatsias, D., Kong, A., Waters, J.E., Sriratana, A., Gurung, R., Bailey, C.G., Rasko, J.E. ., Tiganis, T., Macaulay, S.L., Mitchell, C.A., 2011, Identification of P-Rex1 as a novel Rac1-guanine nucleotide exchange factor (GEF) that promotes actin remodeling and GLUT4 protein trafficking in adipocytes, Journal Of Biological Chemistry [P], vol 286, issue 50, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 43229-43240.

Rahman, P., Huysmans, R., Wiradjaja, F., Gurung, R., Ooms, L., Sheffield, D., Dyson, J., Layton, M., Sriratana, A., Takada, H., Tiganis, T., Mitchell, C., 2011, Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton, Journal Of Biological Chemistry [P], vol 286, issue 34, American Society of Biochemistry and Molecular Biology Inc., USA, pp. 29758-29770.

Fedele, C.G., Ooms, L.M., Ho, M., Vieusseux, J.L., O'Toole, S.A., Millar, E.K., Lopez-Knowles, E., Sriratana, A., Gurung, R., Baglietto, L., Giles, G., Bailey, C.G., Rasko, J.E., Shields, B.J., Price, J.T., Majerus, P.W., Sutherland, R.L., Tiganis, T., McLean, C., Mitchell, C.A., 2010, Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers, Proceedings Of The National Academy Of Sciences O..., vol 107, issue 51, National Academy of Sciences, USA, pp. 22231-22236.

Naughtin, M.J., Sheffield, D.A., Rahman, P., Hughes, W.E., Gurung, R., Stow, J., Nandurkar, H., Dyson, J.M., Mitchell, C.A., 2010, The myotubularin phosphatase MTMR4 regulates sorting from early endosomes, Journal Of Cell Science [P], vol 123, issue Pt 18, The Company of Biologists Ltd, UK, pp. 3071-3083.

Ivetac, I., Gurung, R., Hakim, S., Horan, K.A., Sheffield, D.A., Binge, L.C., Majerus, P.W., Tiganis, T., Mitchell, C.A., 2009, Regulation of PI(3)K/Akt signalling and cellular transformation by inositol polyphosphate 4-phosphatase-1, EMBO Reports, vol 10, issue 5, Nature Publishing Group, United Kingdom, Germany, pp. 487-493.

Ooms, L.M., Horan, K.A., Rahman, P., Seaton, G., Gurung, R., Kethesparan, D.S., Mitchell, C.A., 2009, The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease, Biochemical Journal, vol 419, issue 1, Portland Press Ltd, UK, pp. 29-49.

Waters, J.E., Astle, M.V., Ooms, L.M., Balamatsias, D., Gurung, R., Mitchell, C.A., 2008, P-Rex1 - a multidomain protein that regulates neurite differentiation, Journal of Cell Science, vol 121, issue 17, The Company of Biologists Ltd., United Kingdom, pp. 2892-2903.

Dyson, J.M., Kong, A.M., Wiradjaja, F., Astle, M.V., Gurung, R., Mitchell, C.A., 2005, The SH2 domain containing inositol polyphosphate 5-phosphatase-2: SHIP2, International Journal of Biochemistry & Cell Biology, vol 37, issue 11, Pergamon-Elsevier Science Ltd, Oxford UK, pp. 2260-2265.

Gurung, R., Tan, A., Ooms, L.M., Mcgrath, M.J., Huysmans, R.D., Munday, A.D., Prescott, M., Whisstock, J.C., Mitchell, C.A., 2003, Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization: the inositol 5-phosphatase SKIP localizes to the endoplasmic reticulum and translocates to membrane ruffles following, Journal of Biological Chemistry, vol 278, issue 13, American Society for Biochemistry and Molecular Biology Inc., Bethesda USA, pp. 11376-11385.

Mitchell, C.A., Gurung, R., Kong, A.M., Dyson, J.M., Tan, A., Ooms, L.M., 2002, Inositol polyphosphate 5-phospatases: Lipid phosphatases with flair, IUBMB Life, vol 25, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 25-36.

Robinson, P.A., Brown, S., Mcgrath, M.J., Coghill, I.D., Gurung, R., Mitchell, C.A., 2002, Skeletal muscle LIM protein 1 regulates intergrin-mediated myoblast adhesion, spreading and migration, American Journal of Physiology - Cell Physiology, vol 284, issue 3, American Physiological Society, Bethesda MD USA, pp. C681-C695.

Whisstock, J.C., Wiradjaja, F., Waters, J., Gurung, R., 2002, The structure and function of catalytic domains within inositol polyphosphate 5- phosphates, IUBMB Life, vol 53, issue 1, Taylor & Francis, Philadelphia PA USA, pp. 15-23.

Whisstock, J.C., Romero, S., Gurung, R., Nandurkar, H., Ooms, L.M., Bottomley, S.P., Mitchell, C.A., 2000, The inositol polyphosphate 5-phosphatases and the apurinic/apyrimidinic base excision repair endonucleases share a common mechanism for catalysis, Journal of Biological Chemistry, vol 275 issue 47, Amer Soc for Biochem & Molecular Biology, Bethesda USA, pp. 37055-37061.

Brown, S., Mcgrath, M.J., Ooms, L.M., Gurung, R., Maimone, M.M., Mitchell, C.A., 1999, Characterization of two isoforms of the skeletal muscle LIM protein 1, SLIM1, Journal of Biological Chemistry, vol 274, no 38, American Soc. for Biochem. and Mol. Biol. Inc., www.jbc.org, pp. 27083-27091.

Brown, S., Biben, C., Ooms, L.M., Maimone, M.M., Mcgrath, M.J., Gurung, R., Harvey, R.P., Mitchell, C.A., 1999, The cardiac expression of striated muscle LIM protein 1 (SLIM1) is restricted to the outflow tract of the developing heart, Journal of molecular and cellular cardiology, vol 31, Academic Press Ltd., London England, pp. 837-843.

Campbell, J.K., Gurung, R., Romero, S., Speed, C.J., Andrews, R.K., Berndt, M.C., Miitchell, C.A., 1997, Activation of the 43 kDa Inositol Polyphospate 5 - Phosphatase by 14 - 3 - 3z, Biochemistry, vol 36, ACS Publications, Duke University Medical Centre, pp. 15363-15370.

Postgraduate Research Supervisions

Completed Supervision

Student:

Balamatsias, D.

Program of Study:

The characterisation of the Rac guanine nucleotide exchange factor, P-Rex1, and the role of P-Rex1 and type I inositol 4-phosphatase in insulin-regulated GLUT4 trafficking and glucose transport. (PHD) 2011.

Supervisors:

Mitchell, C (Main), Gurung, R (Associate).

Student:

Huysmans, R.

Program of Study:

SODD ON, SKIP AND SHIP OFF; THE INHIBITION OF THE 5-PHOSPHATASES SKIP AND SHIP2 BY SODD.. (PHD) 2005.

Supervisors:

Mitchell, C (Main), Gurung, R (Associate), Nandurkar, H (Associate).