Prof David de Kretser - Researcher Profile

Professor David de Kretser

Address

Dept of Anatomy & Developmental Biology
Faculty of Medicine, Nursing & Health Sciences, Clayton

Biography

Professor David de Kretser AC, MBBS (Melb Univ), MD (Monash), FRACP, FAA, FTSE, LLD (Hon. Monash), LLD (Hon, Univ Melb) FRACOG (Hon), FRCOG (Hon), FRACGP (Hon)

David de Kretser is a reproductive endocrinologist, whose academic career at Monash University has included appointments as Professor of Anatomy, the founding Director of the Monash Institute of Medical Research and the Associate Dean for Biotechnology Development. In 2003, he was named a Sir John Monash Distinguished Professor.


Having served on the Human Reproduction Program at World Health Organisation and the Executive Council of the International Society of Andrology, including a term as its President, David has many international connections and has trained graduate students and post-doctoral fellows from over 20 countries. Some of these networks greatly facilitated some research programs.

He took time out from his scientific career to serve as the 28th Governor of Victoria from 2006 to 2011 during which he managed to find small amounts of time to keep up his research interests.


Since April 2011 David has resumed research at Monash University working at the Monash Institute of Medical Research, based at the Monash Medical Centre and also in the Department of Anatomy and Developmental Biology on the Clayton Campus of Monash.

Throughout his career David has practised as an endocrinologist with a major focus on male reproductive disorders. He believes that patients provide the triggers for research and, while some of his work is basic and molecular, there is always a translational aim.  Being an experienced microscopist using both light and electron microscopes, he always tries to link structure with function.

His research programs address the causes and management of male infertility and included the development, with his colleagues, of a collection of DNA samples from men with infertility to enable the identification of new genetic causes of male infertility. These studies include the use of random mutagenesis in mice to identify genes causing spermatogenic disorders.

His work on the hormonal regulation of reproduction identified inhibin and follistatin as novel proteins controlling FSH secretion. This work has led to a change in direction of some of his work since the activins, which raise FSH and are modulated by follistatin, turn out to be major regulators of the inflammatory and fibrotic responses. A significant part of his work today is involved in further characterising diagnostic and therapeutic applications of the activins and follistatin.

David is also a passionate advocate for the need to undertake preventive action to improve male health. For the past 10 years, with support form the Federal Government, he initiated, with colleagues from around Australia, a highly successful program of community and professional education in male reproductive health called Andrology Australia.

Throughout his career, David has built lasting collaborative programs in research with colleagues locally, nationally and internationally, recognizing that research today requires a multiplicity of technologies that are only available through research teams and not found in one person.

Keywords

reproductive biology, infertility, endocrinology,

Qualifications

MEDICINE
Institution: Monash University
Year awarded: 1969
MEDICINE, SURGERY
Institution: University of Melbourne
Year awarded: 1962

Publications

Book Chapters

de Kretser, D.M., O'Donnell, L., 2013, Phenotypic assessment of male fertility status in transgenic animal models, in Methods in Molecular Biology - Spermatogenesis, eds DT Carrell and KI Aston, Humana Press, USA, pp. 531-548.

Kerr, J.B., Loveland, K.A.L., O'Bryan, M.K., de Kretser, D.M., 2006, Cytology of the testis and intrinsic control mechanisms, in Knobil and Neill's Physiology of Reproduction, eds Jimmy D Neill, John R G Challis, David M de Kretser, Donald W Pfaff, JoAnne S Richards, Tony M Plant and Paul M Wassarman, Elsevier, London UK, pp. 827-947.

Kerr, J.B., de Kretser, D.M., 2005, Functional morphology of the testis, in Endocrinology, Volume 1, eds Leslie J DeGroot, J Larry jameson, David de Kretser, Shlomo Melmed, Ashley B Gorssman, John T Potts, Jr, Joch C Marshall, Gordon C Weir, Saunders, Philadelphia, pp. 3089-3120.

Phillips, D.J., de Kretser, D.M., 2003, Inhibins, in Encyclopedia of Hormones, Volume 2, eds Helen L Henry and Anthony W Norman, Academic Press, San Diego USA, pp. 303-307.

de Kretser, D.M., Phillips, D.J., Loveland, K.A.L., 2003, Inhibins, Activins, and Follistatins, in Encyclopedia of Hormones, Volume 2, eds Helen L Henry, Anthony W Norman, Academic Press, San Diego USA, pp. 307-310.

Cram, D.S., de Kretser, D.M., 2002, Genetic Diagnosis: The Future, in Assisted Reproductive Technology, eds Christopher J De Jonge and Christopher L R Barratt, Cambridge University Press, UK, pp. 186-205.

Phillips, D.J., de Kretser, D.M., Padmanabhan, V., 2001, Follistatin: From puberty to menopause, in Inhibin, Activin and Follistatin in Human Reproductive Physiology, eds Shanti Muttukrishna and William Ledger, Imperial College Press, London England, pp. 141-164.

de Kretser, D.M., Phillips, D.J., Meehan, T.A., Loveland, K.A.L., 2000, Inhibinm, activins and follistatins in the control of male reproduction, in Endocrine basis of reproductive function, Monduzzi Editore, Bologna Italy, pp. 169-182.

Hedger, M.P., de Kretser, D.M., 2000, Leydig cell function and its regulation, in The genetic basis of male infertility, Springer-Verlag, Berlin Germany, pp. 69-110.

de Kretser, D.M., Meehan, T., O'Bryan, M.K., Wreford, N.G., McLachlan, R.D., Loveland, K.L., 2000, Regulatory mechanisms in mammalian spermatogenesis, in Testis, epididymis and technologies in the year 2000, Springer-Verlag, Berlin Germany, pp. 87-106.

Loveland, K.L., de Kretser, D.M., 1999, Local control of spermatogenesis, in Male Fertility and Infertility, Cambridge Uni Press, Cambridge UK, pp. 56-84.

Baker, G.H., de Kretser, D.M., 1997, Treatment options for male subfertility, in The subfertility handbook : a clinician's guide, Cambridge University Press, Cambridge UK, pp. 50-68.

Journal Articles

O'Donnell, L., Rhodes, D., Smith, S.J., Merriner, D.J., Clark, B.J., Borg, C.L., Whittle, B., O'Connor, A.E., Smith, L.B., McNally, F.J., de Kretser, D.M., Goodnow, C.C., Ormandy, C.J., Jamsai, D., O'Bryan, M.K., 2012, An essential role for katanin p80 and microtubule severing in male gamete production, Plos Genetics [P], vol 8, issue 5 (Art. ID: e1002698), Public Library of Science, USA, pp. 1-12.

Craythorn, R., Winnall, W., Lederman, F., Gold, E., O'Connor, A., de Kretser, D., Hedger, M., Rogers, P., Girling, J., 2012, Progesterone stimulates expression of follistatin splice variants Fst288 and Fst315 in the mouse uterus, Reproductive Biomedicine Online [P], vol 24, issue 3, Elsevier Ltd, United Kingdom, pp. 364-374.

de Kretser, D., O'Hehir, R., Hardy, C., Hedger, M., 2012, The roles of activin A and its binding protein, follistatin, in inflammation and tissue repair, Molecular and Cellular Endocrinology [P], vol 359, issue 1-2, Elsevier Ireland Ltd, Ireland, pp. 101-106.

Youngson, N., Vickaryous, N., van der Horst, A., Epp, T., Harten, S., Fleming, J., Khanna, K., de Kretser, D., Whitelaw, E., 2011, A missense mutation in the transcription factor Foxo3a causes teratomas and oocyte abnormalities in mice, Mammalian Genome [P], vol 22, issue 3-4, Springer New York LLC, United States, pp. 235-248.

Zamudio, N., Scott, H., Wolski, K., Lo, J., Law, C., Leong, D., Kinkel, S., Chong, S., Jolley, D., Smyth, G., de Kretser, D., Whitelaw, E., O'Bryan, M., 2011, DNMT3L is a regulator of X chromosome compaction and post-meiotic gene transcription, PLoS ONE [P], vol 6, issue 3 (Art. No: e18276), Public Library of Science, USA, pp. 1-12.

McLachlan, R., Ishikawa, T., Osianlis, T., Robinson, P., Merriner, D.J., Healy, D.L., de Kretser, D.M., O'Bryan, M.K., 2011, Normal live birth after testicular sperm extraction and intracytoplasmic sperm injection in variant primary ciliary dyskinesia with completely immotile sperm and structurally abnormal sperm tails, Fertility and Sterility [P], vol E, Elsevier Inc., United States, pp. 1-6.

Hedger, M., Winnall, W., Phillips, D., de Kretser, D., 2011, The regulation and functions of activin and follistatin in inflammation and immunity, Vitamins And Hormones-Advances In Research And Applications [P], vol 85, Academic Press, United States, pp. 255-297.

de Kretser, D.M., 2010, Determinants of male health: The interaction of biological and social factors, Asian Journal of Andrology [P], vol 12, issue 3, Nature Publishing Group, United States, China, pp. 291-297.

Holden, C., McLachlan, R., Pitts, M., Cumming, R., Wittert, G., Ehsani, J., de Kretser, D., Handelsman, D., 2010, Determinants of male reproductive health disorders: The men in Australia telephone survey (MATeS), BMC Public Health [P], vol 10, issue Art. No: 96, BioMed Central Ltd, United Kingdom, pp. 1-9.

Fredericks, D., Clay, R., Warner, T., O'Connor, A., de Kretser, D., Hearn, M., 2010, Optimization of the expression of recombinant human activin A in the yeast Pichia pastoris, Biotechnology Progress [P], vol 26, issue 2, John Wiley & Sons LTD, Sussex England, pp. 372-383.

Ludlow, H., Phillips, D.J., Myers, M., McLachlan, R., de Kretser, D.M., Allan, C.A., Anderson, R.A., Groome, N.P., hyvonen, M., Duncan, W.C., Muttukrishna, S., 2009, A new 'total' activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples, Clinical Endocrinology [P], vol 71, issue 6, Wiley-Blackwell Publishing Inc, England, pp. 867-873.

Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2009, Activin and related proteins in inflammation: Not just interested bystanders, Cytokine and Growth Factor Reviews [P], vol 20, issue 2, Elsevier, UK, pp. 153-164.

Goldman, D.R., de Kretser, D.M., Morrison, J.R., 2008, Evidence that androgens regulate early developmental events, prior to sexual differentiation, Endocrinology, vol 149, issue 1, Endocrine Soc, United States, pp. 5-14.

Lin, S., Craythorn, R.G., O'Connor, A., Matzuk, M.M., Girling, J.E., Morrison, J.R., de Kretser, D.M., 2008, Female infertility and disrupted angiogenesis are actions of specific follistatin isoforms, Molecular Endocrinology, vol 22, issue epub ahead of print, Endocrine Society, USA, pp. 415-429.

Barakat, B.M., O'Connor, A., Gold, E.J., de Kretser, D.M., Loveland, K.A.L., 2008, Inhibin, activin, follistatin and FSH serum levels and testicular production are highly modulated during the first spermatogenic wave in mice, Reproduction, vol 136, issue 3, Bio Scientifica Ltd, England, pp. 345-359.

Foulds, L.M., Boysen, R.I., Crane, M., Yang, Y., Muir, J.A., Smith, A.I., de Kretser, D.M., Hearn, M.T.W., Hedger, M.P., 2008, Molecular Identification of lyso-glycerophosphocholines as endogenous immunosuppressives in bovine and rat gonadal fluids, Biology of Reproduction, vol 79, issue 3, Society for the Study of Reproduction, United States, pp. 525-536.

Jamsai, D., Reilly, A., Smith, S.J., Gibbs, G.M., Baker, H.W.G., McLachlan, R.I., de Kretser, D.M., O'Bryan, M.K., 2008, Polymorphisms in the human cysteine-rich secretory protein 2 (CRISP2) gene in Australian Men, Human Reproduction, vol 23, issue 9, Oxford University Press, UK, pp. 2151-2159.

O'Bryan, M.K., Takada, S., Borg, C.L., Scott, G., Harada, S., Ray, M.K., Dai, Q., Wilhelm, D., de Kretser, D.M., Eddy, E.M., Koopman, P.A., Mishina, Y., 2008, Sox8 is a critical regulator of adult sertoli cell function and male fertility, Developmental Biology, vol 316, issue 2, Academic Press Inc Elsevier Science, United States, pp. 359-370.

McLean, C.A., Cleland, H.J., Moncrieff, N.J., Barton, R.J., de Kretser, D.M., Phillips, D.J., 2008, Temporal expression of activin in acute burn wounds-From inflammatory cells to fibroblasts, BURNS, vol 34, Elsevier Sci Ltd, England, pp. 50-55.

Jones, K.L., Mansell, A.S., Patella, S., Scott, B.M., Hedger, M.P., de Kretser, D.M., Phillips, D.J., 2007, Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia, Proceedings of the National Academy of Sciences of the USA, vol 104, issue 41, Nationall Academy of Sciences, United States, pp. 16239-16244.

Gibbs, G.M., Bianco, D.M., Jamsai, D., Herlihy, A., Ristevski, S., Aitken, R.J., de Kretser, D.M., O'Bryan, M.K., 2007, Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm, Biology of Reproduction, vol 77, issue 1, Soc Study Reproduction, Madison USA, pp. 108-114.

McLachlan, R., Rajpert-De Meyts, E., Hoei-Hansen, C.E., de Kretser, D.M., Skakkebaek, N.E., 2007, Histological evaluation of the human testis - approaches to optimizing the clinical value of the assessment: mini review, Human Reproduction, vol 22, issue 1, Oxford University Press, UK, pp. 2-16.

Chong, S., Vickaryous, N., Ashe, A., Zamudio, N.M., Youngson, N., Hemley, S., Stopka, T., Skoultchi, A., Matthews, J.M., Scott, H.S., de Kretser, D.M., O'Bryan, M.K., Blewitt, M., Whitelaw, E., 2007, Modifiers of epigenetic reprogramming show paternal effects in the mouse, Nature Genetics, vol 39, issue 5, Nature Publishing Group, New York, pp. 614-622.

Kennedy, C.L., O'Connor, A.E., Sanchez-Partida, L.G., Holland, M.K., Goodnow, C.C., de Kretser, D.M., O'Bryan, M.K., 2006, A repository of ENU mutant mouse lines and their potential for male fertility research, Molecular Human Reproduction, vol 11, issue 12, Oxford University Press, UK, pp. 871-880.

Cotton, L.M., Gibbs, G.M., Sanchez-Partida, L.G., Morrison, J.R., de Kretser, D.M., O'Bryan, M.K., 2006, FGRF-1 signaling is involved in spermiogenesis and sperm capacitation, Journal of Cell Science, vol 119, issue 1, The Company of Biologists Ltd, Cambridge UK, pp. 75-84.

Arsov, T., Silva, D.G., O'Bryan, M.K., Sainsbury, A., Lee, N.J., Borg, C.L., Manji, S.S.M., Nelms, K., Liu, C., Vinuesa, C.G., de Kretser, D.M., Goodnow, C.C., Petrovsky, N., 2006, Fat Aussie - A new Alstrom syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis, Molecular Endocrinology, vol 20, issue 7, Endocrine Society, USA, pp. 1610-1622.

Patella, S., Phillips, D.J., Tchongue, J., de Kretser, D.M., Sievert, W., 2006, Follistatin attenuates early liver fibrosis: Effects on hepatic stellate cell activation and hepatocyte apoptosis, American Journal of Physiology - Gastrointestinal and Liver Physiology, vol 290, issue 1, Amer Physiological Soc, USA, pp. G137-G144.

Hardy, C.L., O'Connor, A.E., Yao, J.(., Sebire, K., de Kretser, D.M., Rolland, J.M., Anderson, G., Phillips, D.J., O'Hehir, R.E., 2006, Follistatin is a candidate endogenous negative regulator of Activin A in experimental allergic asthma, Clinical and Experimental Allergy, vol 36, issue 7, Blackwell Scientific Publications, UK, pp. 941-950.

McLachlan, R.L., de Kretser, D.M., 2006, Hypogonadotropism with elevated serum testosterone: reversible causes of secondary infertility, Nature Clinical Practice Urology [P], vol 3, issue 10, Nature Publishing Group, UK, pp. 560-565.

Holden, C.A., Jolley, D.J., McLachlan, R., Pitts, M., Cumming, R., Wittert, G.G., Handelsman, D.J., de Kretser, D.M., 2006, Men in Australia Telephone Survey (MATeS): predictors of men's help-seeking behaviour for reproductive health disorders, Medical Journal of Australia, vol 185, issue 8, Australasian Medical Publishing Company Pty Ltd, Sydney, NSW, Australia, pp. 418-422.

O'Bryan, M.K., de Kretser, D.M., 2006, Mouse models for genes involved in impaired spermatogenesis, International Journal of Andrology, vol 29, issue 1, American Society of Andrology, United States, pp. 76-89.

Okuma, Y., O'Connor, A., Hayashi, T., Loveland, K.A.L., de Kretser, D.M., Hedger, M.P., 2006, Regulated production of activin A and inhibin B throughout the cycle of the seminiferous epithelium in the rat, Journal of Endocrinology, vol 190, issue 2, Society for Endocrinology, Bristol England, pp. 331-340.

Lin, S., Morrison, J.R., Matzuk, M., de Kretser, D.M., 2006, Spermatogenesis does not require the local production of follistatin, Reproduction, vol 132, issue 4, BioScientifica Ltd, Bristol England, pp. 601-605.

de Kretser, D.M., Cock, M.L., Holden, C.A., 2006, The Men in Australia Telephone Survey (MATeS) - lessons for all, Medical Journal of Australia, vol 185, issue 8, Australasian Med Publ Co Ltd, Pyrmont NSW Australia, pp. 412-413.

Holden, C.A., Poljski, C., Andrews, C.N., Cock, M.L., Wolfe, R.S.J., de Kretser, D.M., 2006, The dynamics of community education in male reproductive health: findings from an Australian study, Australian Journal of Primary Health, vol 12, issue 2, Australian Institute for Primary Care, La Trobe University, Australia, pp. 146-155.

Ochsenkuhn, R., O'Connor, A.E., Hirst, J.J., Baker, H.W.G., de Kretser, D.M., Hedger, M.P., 2006, The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: influence of sperm autoimmunity and seminal leukocytes, Journal of Reproductive Immunology, vol 71, issue 1, Elsevier Ireland Ltd, Ireland, pp. 57-74.

Phillips, D.J., Jones, K.L., Clarke, I.J., Scheerlinck, J.Y., de Kretser, D.M., 2005, Activin A: From sometime reproductive factor to genuine cytokine, Veterinary Immunology and Immunopathology [P], vol 108, issue 1-2, Elsevier BV, The Netherlands, pp. 23-27.

O'Bryan, M.K., Gerdprasert, O., Nikolic-Paterson, D.J., Meinhardt, A., Muir, J.A., Foulds, L.M., Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2005, Cytokine profiles in the testes of rats treated with lipopolysaccharide reveal localized suppression of inflammatory responses, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, vol 288, issue 6, Amercan Physiological Society, USA, pp. R1744-R1755.

Webster, K.E., O'Bryan, M.K., Fletcher, S., Crewther, P.E., Aapola, U., Craig, J., Harrison, D.K., Aung, H., Phutikanit, N., Lyle, R., Meachem, S.J., Antonarakis, S.E., de Kretser, D.M., Hedger, M.P., Peterson, P., Carroll, B.J., Scott, H.S., 2005, Meiotic and epigenetic defects in Dnmt3L-knockout mouse spermatogenesis, Proceedings of the National Academy of Sciences, vol 102, issue 11, National Academy Sciences, USA, pp. 4068-4073.

Holden, C.A., McLachlan, R., Pitts, M., Cumming, R., Wittert, G.G., Agius, P.A., Handelsman, D.J., de Kretser, D.M., 2005, Men in Australia Telephone Survey (MATeS): A national survey of the reproductive health and concerns of middle-aged and older Australian men, Lancet, vol 366, Lancet Publishing Group, UK, pp. 218-224.

Okuma, Y., Saito, K., O'Connor, A., Phillips, D.J., de Kretser, D.M., Hedger, M.P., 2005, Reciprocal regulation of activin A and inhibin B by interleukin-1 (IL-1) and follicle-stimulating hormone (FSH) in rat Sertoli cells in vitro, Journal of Endocrinology, vol 185, issue 12, Society for Endocrinology, Bristol UK, pp. 99-110.

Okuma, Y., O'Connor, A.E., Muir, J.A., Stanton, P.G., de Kretser, D.M., Hedger, M.P., 2005, Regulation of activin A and inhibin B secretion by inflammatory mediators in adult rat Sertoli cell cultures, Journal of Endocrinology, vol 187, issue 1, Society for Endocrinology, UK, pp. 125-134.

Sikaris, K., McLachlan, R., Kazlauskas, R., de Kretser, D.M., Holden, C.A., Handelsman, D.J., 2005, Reproductive hormone reference intervals for healthy fertile young men: Evaluation of automated platform assays, Journal of Clinical Endocrinology & Metabolism, vol 90, issue 11, Endocrine Society, USA, pp. 5928-5936.

Holden, C.A., McLachlan, R., Cumming, R., Wittert, G.G., Handelsman, D.J., de Kretser, D.M., Pitts, M., 2005, Sexual activity, fertility and contraceptive use in middle-aged and older men: Men in Australia, Telephone Survey (MATeS), Human Reproduction, vol 20, issue 12, Oxford University Press, UK, pp. 3429-3434.

Shehu-Xhilaga, M., de Kretser, D.M., Dejucq-Rainsford, N., Hedger, M.P., 2005, Standing in the way of eradication: HIV-1 infection and treatment in the male genital tract, Current HIV Research, vol 3, issue 4, Bentham Science Publishers Ltd., The Netherlands, pp. 345-359.

Lynch, M., Cram, D.S., Reilly, A., O'Bryan, M.K., Baker, H.W.G., de Kretser, D.M., McLachlan, R., 2005, The Y chromosome gr/gr subdeletion is associated with male infertility, Molecular Human Reproduction, vol 11, issue 7, Oxford University Press, Oxford England, pp. 507-512.

Jones, K.L., de Kretser, D.M., Patella, S., Phillips, D.J., 2004, Activin A and follistatin in systemic inflammation, Mollecular Cell Endocrinology, vol 225, Elsevier Sci Ireland Ltd, Ireland, pp. 119-125.

Buzzard, J.J., Loveland, K.A.L., O'Bryan, M.K., O'Connor, A., Bakker, M.R., Hayashi, T., Wreford, N.G., Morrison, J.R., de Kretser, D.M., 2004, Changes in Circulating and Testicular Levels of Inhibin A and B and Activin A During Postnatal Development in the Rat, Endocrinology, vol 145, issue 7, The Endocrine Society, USA, pp. 3532-3541.

Jones, K.L., de Kretser, D.M., Clarke, I.J., Scheerlinck, J., Phillips, D.J., 2004, Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe, Journal of Endocrinology, vol 182, issue 1, Society for Endocrinology, UK, pp. 69-80.

de Kretser, D.M., 2004, Differences in the prevalence of cryptorchidism, Lancet, vol 363, issue 9417, Lancet Ltd, UK, pp. 1250-1251.

de Kretser, D.M., 2004, Editorial: Is Spermatogenic Damage Associated with Leydig Cell Dysfunction?, Journal of Clinical Endocrinology and Metabolism, vol 89, issue 7, The Endocrine Society, USA, pp. 3158-3160.

Jones, K.L., de Kretser, D.M., Phillips, D.J., 2004, Effect of heparin administration to sheep on the release profiles of circulating activin A and follistatin, Journal of Endocrinology, vol 181, issue 2, Society for Endocrinology, UK, pp. 307-314.

Zhang, Z., Short, R.V., Meehan, T.A., de Kretser, D.M., Renfree, M.B., Loveland, K.A.L., 2004, Functional Analysis of the Cooled Rat Testis, Journal of Andrology, vol 25, issue 1, American Society of Andrology, Inc, USA, pp. 57-68.

Cram, D.S., Lynch, M., O'Bryan, M.K., Salvado, C.L., McLachlan, R., de Kretser, D.M., 2004, Genetic screening of infertile men, Reproduction, Fertility and Development, vol 16, CSIRO Publishing, Vic Australia, pp. 573-580.

Kennedy, C.L., Sebire, K.L., de Kretser, D.M., O'Bryan, M.K., 2004, Human sperm associated antigen 4 (SPAG4) is a potential cancer marker, Cell and Tissue Research, vol 315, issue 2, Springer-Verlag, Germany, pp. 279-282.

Kennedy, C.L., Sebire, K.L., de Kretser, D.M., O'Bryan, M.K., 2004, Human sperm associated antigen 4 (SPAG4) is a potential cancer marker, Cell and Tissue Research, vol 315, issue 2, Springer-Verlag, Germany, pp. 279-283.

Loose, J.M., Miller, S.L., Supramaniam, V.G., Ward, J.W.A., O'Connor, A.E., de Kretser, D.M., Wallace, E.M., Jenkin, G., 2004, Hypoxia induced activin secretion by the fetoplacental unit: differential responses related to gestation. IF 2.171, British Journal of Obstetrics and Gynaecology, vol 111, Blackwell Publishing, Oxford England, pp. 1346-1352.

O'Bryan, M.K., Foulds, L.M., Cannon, J.F., Winnall, W.R., Muir, J.A., Sebire, K.L., Smith, A.I., Keah, H.H., Hearn, M.T.W., de Kretser, D.M., Hedger, M.P., 2004, Identification of a Novel Apolipoprotein, ApoN, in Ovarian Follicular Fluid, Endocrinology, vol 145, issue 11, The Endocrine Society, USA, pp. 5231-5242.

O'Connor, A., de Kretser, D.M., 2004, Inhibins in Normal Male Physiology, Seminars in Reproductive Medicine, vol 22, issue 3, Thieme Medical Publishers Inc, USA, pp. 177-185.

Supramaniam, V.G., Jenkin, G., Wallace, E.M., O'Connor, A.E., de Kretser, D.M., Miller, S.L., 2004, The effect of graded hypoxia on activin A, PGE2 and cortisol levels in the late pregnant sheep, Reproduction Fertility and Development:15, 625 - 632, vol 16, CSIRO Publishing, Collingwood Vic Australia, pp. 625-632.

de Kretser, D.M., Buzzard, J.J., Okuma, Y., O'Connor, A.E., Hayashi, T., Lin, S., Morrison, J.R., Loveland, K.A.L., Hedger, M.P., 2004, The role of activin, follistatin and inhibin in testicular physiology, Mollecular Cell Endocrinology, vol 225, Elsevier Sci Ireland Ltd, Netherland, pp. 57-64.

Loveland, K.A.L., Bakker, M.R., Meehan, T.A., Christy, E., von Schonfeldt, V., Drummond, A.E., de Kretser, D.M., 2003, Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells, Endocrinology, vol 144, issue 9, The Endocrine Society, Bethesda USA, pp. 4180-4186.

Poljski, C., Tasker, C., Andrews, C.N., Wijesinha, S., Piterman, L., de Kretser, D.M., 2003, GP attitudes to male reproductive and sexual health education and promotion, Australian Family Physician, vol 32, issue 6, Royal Australian College of General Practitioners, Australia, pp. 462-465.

Buzzard, J.J., Farnworth, P.G., de Kretser, D.M., O'Connor, A.E., Wreford, N.G., Morrison, J.R., 2003, Proliferative phase sertoli cells display a developmentally regulated response to activin in vitro, Endocrinology, vol 144, issue 2, The Endocrine Society, Bethesda USA, pp. 474-483.

Lin, S., Morrison, J.R., Phillips, D.J., de Kretser, D.M., 2003, Regulation of ovarian function by the TGF-superfamily and follistatin, Reproduction, vol 126, issue 2, Society for Reproduction and Fertility, Cambridge UK, pp. 133-148.

McLachlan, R.I., Baker, H.W.G., Clarke, G.N., Harrison, K.L., Matson, P.L., Holden, C.A., de Kretser, D.M., 2003, Semen analysis: its place in modern reproductive medical practice, Pathology, vol 35, Carfax Publishing, Basingstoke UK, pp. 25-33.

Ochsenkuhn, R., de Kretser, D.M., 2003, The contributions of deficient androgen action in spermatogenic disorders, International Journal of Andrology, vol 26, issue 4, Blackwell Publishing Ltd, Oxford UK, pp. 195-201.

McManamny, P., Chy, H.S., Finkelstein, D., Craythorn, R.G., Crack, P.J., Kola, I., Cheema, S., Horne, M.K., Wreford, N.G., O'Bryan, M.K., de Kretser, D.M., Morrison, J.R., 2002, A mouse model of spinal and bulbar muscular atrophy, Human Molecular Genetics, vol 11, issue 18, Oxford University Press, Oxford UK, pp. 2103-2111.

McLachlan, R., Stanton, P.G., Balourdos, G., Frydenberg, M., de Kretser, D.M., Robertson, D.M., O'Donnell, L., 2002, Effects of testosterone plus medroxyprogesterone acetate on semen quality, reproductive hormones and germ cell populations in normal young men, Journal of Clinical Endocrinology and Metabolism, vol 87, issue 2, Endocrine Society, Bethesda MD USA, pp. 546-556.

Gerdprasert, O., O'Bryan, M.K., Nikolic-Paterson, D.J., Sebire, K.L., de Kretser, D.M., Hedger, M.P., 2002, Expression of monocyte chemoattractant protein-1 and macrophage colony-stimulating factor in normal and inflamed rat testis, Molecular Human Reproduction, vol 8, issue 6, Oxford University Press, Oxford UK, pp. 518-524.

McFarlane, J.R., Xia, Y., O'Shea, T., Hayward, S., O'Connor, A.E., de Kretser, D.M., 2002, Follistatin concentrations in maternal and fetal fluids during the oestrus cycle, gestation and parturition in Merino sheep, Reproduction, vol 124, issue 2, Society of Reproduction and Fertility, Cambridge UK, pp. 259-265.

Katz, M.G., Chu, B., McLachlan, R., Alexopoulos, N.I., de Kretser, D.M., Cram, D.S., 2002, Genetic follow-up of male offspring born by ICSU, using a multiplex fluorescent PCR-based test for Yq deletions, Molecular Human Reproduction, vol 8, issue 6, Oxford University Press, UK, pp. 589-595.

McLachlan, R., O'Donnell, L., Meachem, S.J., Stanton, P.G., de Kretser, D.M., Pratis, K., Robertson, D.M., 2002, Hormonal regulation of spermatogenesis in primates and man: Insights for development of the male hormonal contraceptive, Journal of Andrology, vol 23, issue 2, American Society of Andrology Inc., Lawrence KS USA, pp. 149-162.

McLachlan, R., O'Donnell, L., Meachem, S.J., de Kretser, D.M., Pratis, K., Robertson, D.M., 2002, Identification of Specific Sites of Hormonal Regulation in Spermatogenesis in Rats, Monkeys and Man, Recent Progress in Hormone Research, vol 57, Endocrine Society, Bethesda MD USA, pp. 149-179.

Hickox, D., Gibbs, G., Morrison, J.R., Sebire, K.L., Edgar, K., Keah, H., Alter, K., Loveland, K.L., Hearn, M.T.W., de Kretser, D.M., O'Bryan, M.K., 2002, Identification of a novel testis-specific member of the phosphatidykethanolamine binding protein family, pebp-2, Biology of Reproduction, vol 67, Society for the study of Reproduction, Madison WI USA, pp. 917-927.

de Kretser, D.M., Hedger, M.P., Loveland, K.L., Phillips, D.J., 2002, Inhibins, activins and follistatin in reproduction, Human Reproduction Update, vol 8, issue 6, Oxford University Press, Oxford UK, pp. 529-541.

Gerdprasert, O., O'Bryan, M.K., Muir, J.A., Caldwell, A.M., Schlatt, S., de Kretser, D.M., Hedger, M.P., 2002, The response of testicular leukocytes to lipopolysaccharide-induced inflammation: further evidence for heterogeneity of the testicular macrophage population, Cell and Tissue Research, vol 308, issue 2, Springer-Verlag, New York NY USA, pp. 277-285.

Dickins, R.A., Frew, I.J., House, C.M., O'Bryan, M.K., Holloway, A.J., Haviv, I., Traficante, N., de Kretser, D.M., Bowtell, D.D.L., 2002, The ubiquitin ligase component sia 1a is required for completion of meiosis 1 in the male mouse, Molecular and Cellular Biology, vol 22, American Society for Microbiology, Washington DC USA, pp. 2294-2303.

Chopin, J.B., Chopin, L.K., Knott, L.M., de Kretser, D.M., Dowsett, K.F., 2002, Unusual ovarian activity in a mare preceding the development of an ovarian granulose call tumour, Australian Veterinary Journal, vol 80, issue 1 & 2, Australian Veterinary Association, Brunswick Vic Australia, pp. 32-36.

Wreford, N.G., Kumar, R., Matzuk, M., de Kretser, D.M., 2001, Analysis of the testicular phenotype of the follicle-stimulating hormone b-subunit knockout and the activin type II receptor knockout mice by stereological analysis, Endocrinology, vol 142, issue 7, Endocrine Society, Bethesda MD USA, pp. 2916-2920.

Patella, S., Phillips, D.J., de Kretser, D.M., Evans, L.W., Groome, N.P., Sievert, W., 2001, Characterization of serum activin-A and follistatin and their relation to virological and histological determinants in chronic viral hepatitis, Journal of Hepatology, vol 34, Elsevier Science BV, Amsterdam Netherlands, pp. 576-583.

Meehan, T.A., Loveland, K.L., de Kretser, D.M., Cory, S., Print, C.G., 2001, Developmental regulation of the bcl-2 family during spermatogenesis: Insights into the sterility of bcl-w-I- male mice, Cell Death and Differentiation, vol 8, Nature Publishing Group, Basingstoke England, pp. 225-233.

Phillips, D.J., Jones, K.L., Scheerlinck, J., Hedger, M., de Kretser, D.M., 2001, Evidence for activin A and follistatin involvement in the systemic inflammatory response, Molecular and Cellular Endocrinology, vol 180, Elsevier Science Ireland Ltd, Coclare Ireland, pp. 155-162.

Jenkin, G., Ward, J.N.A., Hooper, S.B., O'Connor, A., de Kretser, D.M., Wallace, E.M., 2001, Feto-placental hypoxemia regulates the release of fetal activin A and prostaglandin E2, Endocrinology, vol 142, issue 2, Endocrine Society, Bethesda USA, pp. 963-966.

Lahoud, M.H., Ristevski, S., Venter, D., Jermiin, L.S., Bertoncello, I., Zavarsek, S., Hasthorpe, S., Drago, J., de Kretser, D.M., Hertzog, P., Kola, I., 2001, Gene targeting of Desrt, a novel ARID class DNA-binding protein, causes growth retardation and abnormal development of reproductive organs, Genome Research, vol 11, Cold Spring Harbor Lab Press, New York NY USA, pp. 1327-1334.

Tilbrook, A., de Kretser, D.M., Clarke, I.J., 2001, Influence of the degree of stimulation of the pituitary by gonadotrophin-releasing hormone on the action of inhibin and testosterone to suppress the secretion of the gonadotrophins in rams, Biology of Reproduction, vol 64, Society for the Study of Reproduction, Madison Wisconsin USA, pp. 473-481.

de Kretser, D.M., Loveland, K.A.L., Meehan, T.A., O'Bryan, M.K., Phillips, D.J., Wreford, N.G., 2001, Inhibins, activins and follistatin: actions on the testis, Molecular and Cellular Endocrinology, vol 180, Elsevier Ireland Ltd, Ireland, pp. 87-92.

Cram, D.S., O'Bryan, M., de Kretser, D.M., 2001, Male infertility genetics - The future, Journal of Andrology, vol 22, issue 5, American Society of Andrology, Lawrence Kansas USA, pp. 738-746.

Kumar, R., Varani, S., Wreford, N.G., Telfer, N., de Kretser, D.M., Matzuk, M., 2001, Male reproductive phenotypes in double mutant mice lacking both FSHb and activin receptor IIA, Endocrinology, vol 142, issue 8, Endocrine Society, Bethesda MD USA, pp. 3512-3518.

Jenkin, G., Ward, J.W.A., Loose, J.M., Schneider-Kolsky, M.E., Young, I., Canny, B., O'Connor, A., de Kretser, D.M., Wallace, E.M., 2001, Physiological and regulatory roles of activin A in late pregnancy, Molecular and Cellular Endocrinology, vol 180, Elsevier Science Ireland Ltd, Ireland, pp. 131-138.

Murphy, H., George, C., de Kretser, D.M., Judd, S., 2001, Successful treatment with ICSI of infertility caused by azoospermia associated with adrenal rests in the testes, Human Reproduction, vol 16, issue 2, Oxford University Press, Oxford England, pp. 263-267.

Keah, H., O'Bryan, M., de Kretser, D.M., Hearn, M.T., 2001, Synthesis and application of peptide immunogens related to the sperm tail protein tpx-1, a member of the CRISP superfamily of proteins, Journal of Peptide Science, vol 57, John Wiley & Sons Ltd, West Sussex England, pp. 1-10.

O'Bryan, M., Sebire, K.L., Meinhardt, A., Edgar, K., Keah, H., Hearn, M.T., de Kretser, D.M., 2001, Tpx-1 is a component of the outer dense fibers and acrosome of rat spermatozoa, Molecular Reproduction and Development, vol 58, Wiley-Liss, New York NY USA, pp. 116-125.

Jones, K.L., Brauman, J., Groome, N.P., de Kretser, D.M., Phillips, D.J., 2000, Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin, Endocrinology, vol 141 issue 5, Endocrinology Society, Bethesda USA, pp. 1905-1908.

Meinhardt, A., McFarlane, J.R., Seitz, J., de Kretser, D.M., 2000, Activin maintains the condensed type of mitochondria in germ cells, Molecular and Cellular Endocrinology, vol 168, Elsevier Science Ireland Ltd, Co Clare Ireland, pp. 111-117.

O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 2000, Bacterial lipopolysaccharide-induced inflammation compromises testicular function at multiple levels in vivo, Endocrinology, vol 141 issue 1, Endocrine Society, Bethesda USA, pp. 238-246.

O'Bryan, M.K., Sebire, K.L., Gerdprasert, O., Hedger, M., Hearn, M.T.W., de Kretser, D.M., 2000, Cloning and regulation of the rat activin betaE subunit, Journal of Molecular Endocrinology, vol 24, Society for Endocrinology, Bristol UK, pp. 409-418.

Hedger, M., Phillips, D.J., de Kretser, D.M., 2000, Divergent cell-specific effects of activin-A on thymocyte proliferation stimulated by phytohemagglutinin, and interleukin 1beta or interleukin 6 in vitro, Cytokine, vol 12 issue 6, WB Saunders Co, Philadelphia USA, pp. 595-602.

de Kretser, D.M., O'Bryan, M.K., Cram, D.S., McLachlan, R.I., 2000, Expanding our understanding of spermatogenesis: the future genetic tests for infertility, International Journal of Andrology, vol 23 supp 2, Blackwell Science Ltd, Oxford UK, pp. 30-33.

D'Antona, D., Reis, F.M., Benedetto, C., Evans, L.W., Groome, N.P., de Kretser, D.M., Wallace, E.M., Petraglia, F., 2000, Increased maternal serum activin A but not follistatin levels in pregnant women with hypertensive disorders, Journal of Endocrinology, vol 165 issue 1, Society for Endocrinology, Bristol UK, pp. 157-162.

O'Bryan, M.K., Schlatt, S., Gerdprasert, O., Phillips, D.J., de Kretser, D.M., Hedger, M., 2000, Inducible nitric oxide synthase in the rat testis: Evidence for potential roles in both normal function and inflammation-mediated infertility, Biology of Reproduction, vol 63, Soc Study Reproduction, Madison USA, pp. 1285-1293.

Mellor, S., Cranfield, M., Ries, R., Pedersen, J.S., Cancilla, B., de Kretser, D.M., Groome, N.P., Mason, A.J., Risbridger, G.P., 2000, Localization of activin betaA-, betaB-, and betaC-subunits in human prostate and evidence for fomation of new activin heterodimers of betaC-subunit, Journal of Clinical Endocrinology and Metabolism, vol 85 issue 12, Endocrine Society, Bethesda USA, pp. 4851-4858.

Treetampinich, C., O'Conner, A., Maclachlan, V., Groome, N.P., de Kretser, D.M., 2000, Maternal serum inhibin A concentrations in early pregnancy after IVF and embryo transfer reflect the corpus luteum contribution and pregnancy outcome, Human Reproduction, vol 15 issue 9, Oxford University Press, Oxford UK, pp. 2028-2032.

Schneider-Kolsky, M., D'Antona, D., Evans, L.W., Taylor, N., O'Connor, A.E., Groome, N.P., de Kretser, D.M., Wallace, E.M., 2000, Maternal serum total activin A and follistatin in pregnancy and parturition, British Journal of Obstetrics and Gynaecology, vol 107, Blackwell Science Ltd, Oxford UK, pp. 995-1000.

Adashi, E.Y., Cohen, J., Jones, H.W., de Kretser, D.M., Lunefield, B., Rosenwaks, Z., Van Steirteghem, A., 2000, Public perception on infertility and its treatment: an international survey, Human Reproduction, vol 15 issue 2, Oxford University Press, Oxford UK, pp. 330-334.

Meehan, T., Schlatt, S., O'Bryan, M.K., de Kretser, D.M., Loveland, K.L., 2000, Regulation of germ cell and sertoli cell development by activin, follistatin, and FSH, Developmental Biology, vol 220, Academic Press Inc, San Diego USA, pp. 225-237.

Phillips, D.J., Jones, K.L., McGraw, D.J., Groome, N.P., Smolich, J.J., Parsson, H., de Kretser, D.M., 2000, Release of activin and follistatin during cardiovascular procedures is largely due to heparin administration, Journal of Clinical Endocrinology and Metabolism, vol 85 issue 7, Endocrinology Society, Bethesda USA, pp. 1-5.

de Kretser, D.M., 2000, Testicular cancer and infertility, British Medical Journal, vol 321, B M J Publishing Group, UK, pp. 781-782.

de Kretser, D.M., Meinhardt, A., Meehan, T., Phillips, D.J., O'Bryan, M.K., Loveland, K.L., 2000, The roles of inhibin and related peptides in gonadal function, Molecular and Cellular Endocrinology, vol 161, Elsevier Science Ireland Ltd, Co Clare Ireland, pp. 43-46.

Cram, D.S., Ma, K., Bhasin, S., Arias, J., Pandjaitan, M., Chu, B., Audrins, P., Saunders, D., Quinn, F., de Kretser, D.M., McLachlan, R.I., 2000, Y chromosome analysis of infertile men and their sons conceived through intracytoplamic sperm injection: vertical transmission of deletions and rarity of de novo deletions, Fertility and Sterility, vol 74 issue 5, Elsevier Science Inc, New York NY USA, pp. 909-914.

Phillips, D.J., Brauman, J., Mason, T., de Kretser, D.M., Hedger, M., 1999, A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, MPC-11, Journal of Endocrinology, vol 162, Society for Endocrinology, Bradley Stoke UK, pp. 111-116.

Meinhardt, A., Bacher, M., O'Bryan, M.K., McFarlane, J.R., Mallidis, C., Lehmann, C., Metz, C.N., de Kretser, D.M., Bucala, R., Hedger, M., 1999, A switch in the cellular localization of macrophage migration inhibitory factor in the rat testis after ethane dimethane sulfonate treatment, Journal of Cell Science, vol 112, Company of Biologists Ltd, Cambridge UK, pp. 1337-1344.

de Kretser, D.M., Hedger, M., Phillips, D.J., 1999, Activin A and follistatin: their role in the acute phase reaction and inflammation, Journal of Endocrinology, vol 161, Soc for Endocrinology, Bradley Stoke UK, pp. 195-198.

Russell, C., Hedger, M., Brauman, J., de Kretser, D.M., Phillips, D.J., 1999, Activin A regulates growth and acute phase proteins in the human liver cell line HepG2, Molecular and Cellular Endocrinology, vol 148, Elsevier Science Ireland Ltd, Coclare Ireland, pp. 129-136.

Schlatt, S., Zhengwei, Y., Meehan, T., de Kretser, D.M., Loveland, K.L., 1999, Application of morphometric techniques to postnatal rat testes in organ culture: insights into testis growth, Cell Tissue Research, vol 298, Springer-Verlag, New York NY USA, pp. 335-343.

Tilbrook, A.J., de Kretser, D.M., Clarke, I.J., 1999, Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin, Journal of Endocrinology, vol 161, Society for Endocrinology, Bradley Stoke UK, pp. 219-229.

Tilbrook, A.J., de Kretser, D.M., Clarke, I.J., 1999, Changes in the suppressive effects of recombinant inhibin A on FSH secretion in ram lambs during sexual maturation: evidence for alterations in the clearance rate of inhibin, Journal of Endocrinology, vol 161, Society for Endocrinology, Bristol UK, pp. 219-229.

Kim, Y.H., McFarlane, J.R., O'Bryan, M.K., Almahbobi, G., Temple-Smith, P.D., de Kretser, D.M., 1999, Isolation and characterization of rat sperm tail outer dense fibres and comparison with rabbit and human spermatozoa using a polyclonal antiserum, Journal of Reproduction and Fertility, vol 116, Journals of Reproduction & Fertility Ltd, Cambridge UK, pp. 345-353.

Dowsing, A., Yong, E.L., Clark, M.R., McLachlan, R.D., de Kretser, D.M., Trounson, A.O., 1999, Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene, Lancet, vol 354, Lancet Ltd, London UK, pp. 640-643.

Dowsing, A., Yong, E.L., Clark, R.M., McLachlan, R.I., de Kretser, D.M., Trounson, A.O., 1999, Linkage between male infertility and trinucleotide repeat expansion in the androgen-receptor gene, Lancet, vol 354 issue 9179, J Onwhyn, London UK, pp. 640-643.

Schlatt, S., de Kretser, D.M., Hedger, M., 1999, Mitosis of resident macrophages in the adult rat testis, Journal of Reproduction and Fertility, vol 116, Journals of Reproduction & Fertility Inc, Cambridge UK, pp. 223-228.

Loveland, K.L., Herszfeld, D., Chu, B., Rames, E., Christy, E., Briggs, L.J., Shakri, R., de Kretser, D.M., Jans, D.A., 1999, Novel low molecular weight microtubule-associated protein-2 isoforms contain a functional nuclear localization sequence, Journal of Biological Chemistry, vol 274, Amer Soc Biochem Molecul Biology Inc, Bethesda USA, pp. 19261-19268.

Tilbrook, A.J., de Kretser, D.M., Clarke, I.J., 1999, Seasonal changes in the negative feedback regulation of the secretion of the gonadotrophins by testosterone and inhibin in rams, Journal of Endocrinology, vol 160, Society for Endocrinology, Bristol UK, pp. 155-167.

O'Conner, A., McFarlane, J.R., Hayward, S., Yohkaichiya, T., Groome, N.P., de Kretser, D.M., 1999, Serum activin A and follistatin concentrations during human pregnancy: a cross-sectional and longitudinal study, Human Reproduction, vol 14, Oxford Uni Press, Oxford UK, pp. 827-832.

McFarlane, J.R., Foulds, L.M., O'Connor, A.E., Phillips, D.J., Jenkin, G., Hearn, M.T., de Kretser, D.M., 1999, Uterine milk production, a novel activin-binding protein, is present in ovine allantoic fluid, Endocrinology, vol 140 issue 10, The Endocrine Society, Bethesda MD USA, pp. 4745-4752.

McFarlane, J.R., Foulds, L.M., O'Conner, A., Phillips, D.J., Jenkin, G., Hearn, M.T., de Kretser, D.M., 1999, Uterine milk protein, a novel Activin Binding Protein, is present in ovine allantoic fluid, Endocrinology, vol 140, The Endocrine Society, Bethesda USA, pp. 4745-4752.

McFarlane, J.R., Foulds, L.M., O'Connor, A.E., Phillips, D.J., Jenkin, G., Hearn, M.T., de Kretser, D.M., 1999, Uterine milk protein, a novel activin-binding protein, is present in ovine allantoic fluid, Endocrinology, vol 140, issue 10, Endocrine Society, Bethesda USA, pp. 4745-4752.

Print, C.G., Loveland, K.L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N.G., de Kretser, D.M., Metcalf, D., Kontgen, F., Adams, J.M., Cory, S., 1998, APOPTOSIS REGULATOR Bcl-w IS ESSENTIAL FOR SPERMATOGENESIS BUT APPEARS OTHERWISE REDUNDANT, Proc National Academy Of Sciences USA (PNAS), vol 95, The National Academy of Sciences, USA, pp. 12424-12431.

Print, C.G., Loveland, K.L., Gibson, L., Meehan, T., Stylianou, A., Wreford, N.G., de Kretser, D.M., Metcalf, D., Kontgen, F., Adams, J.M., Corey, S., 1998, Apopotosis regulator BCL-W is essential for spermatogenesis but appears otherwise redundant, Proceedings of the National Academy of Sciences of the United States of America, vol 95, National Academy of Sciences, Washington USA, pp. 12424-12431.

Wang, Q., Ghadessy, F.J., Trounson, A.O., de Kretser, D.M., McLachlan, R.D., Ng, S., Yong, E.L., 1998, Azoospermia associated with a mutation in the ligand-binding domain of an androgen receptor displaying normal ligand binding, but defective trans-activation, Journal Of Clinical Endocrinology And Metabolism, vol 83, 12, THE ENDOCRINE SOCIETY, USA, pp. 4303-4309.

Hudson, D.F., Fowler, K.J., Earle, E., Saffery, R., Kalitis, P., Trowell, H., Hill, J., Wreford, N.G., de Kretser, D.M., Cancilla, M.R., Howman, E., Hii, L., Cutts, S.M., Irvine, D.V., Choo, K., 1998, Centromere protein B null mice are mitotically and meiotically normal but have lower body and testis weights, Journal of Cell Biology, vol 141 issue 2, Rockefeller University Press, New York NY USA, pp. 309-319.

Hudson, D.F., Fowler, K.J., Earle, E., Saffery, R., Kalitsis, P., Trowell, H., Hill, J., Wreford, N.G., de Kretser, D.M., Cancilla, M.R., Howman, E., Hii, L., Cutts, S.M., Irvine, D.V., Choo, K.H., 1998, Centromere protein b null mice are mitotically and meiotically normal but have lower body and testis weights, The Journal Of Cell Biology, vol 141 (2), THE ROCKEFELLER UNIVERSITY PRESS, USA HTTP://WWW.JCB.ORG/CGI/CONTENT/FULL/141/2/309, pp. 309-319.

Tompkins, A.B., Hutchinson, P., de Kretser, D.M., Hedger, M., 1998, Characterization of lymphocytes in the adult rat testis by flow cytometry: effects of activin and transforming growth factor beta on lymphocyte subsets in vitro, BIOLOGY OF REPRODUCTION, vol 58, Society for the Study of Reproduction Inc, MADISON WI USA, pp. 943-951.

Phillips, D.J., de Kretser, D.M., Pfeffer, A., Chie, W.N., Moore, L.G., 1998, Follistatin has a biphasic response but follicle-stimulating hormone is unchanged during an inflammatory episode in growing lambs, JOURNAL OF ENDOCRINOLOGY, vol 156, JOURNAL OF ENDOCRINOLOGY LTD, BRISTOL UK, pp. 77-82.

Phillips, D.J., de Kretser, D.M., 1998, Follistatin: a multifunctional regulatory protein, FRONTIERS IN NEUROENDOCRINOLOGY, vol 19, article no fn980169, ACADEMIC PRESS, New York NY USA, pp. 287-322.

O'Bryan, M.K., Loveland, K.L., Herszfeld, D., McFarlane, J.R., Hearn, M.T., de Kretser, D.M., 1998, Identification of a rat testis-specific gene encoding a potential rat outer dense fibre protein, MOLECULAR REPRODUCTION AND DEVELOPMENT, vol 50, WILEY-LISS, INC, New York NY USA, pp. 313-322.

O'Bryan, M.K., Loveland, K.L., Herszfeld, D., McFarlane, J.R., Hearn, M.T., de Kretser, D.M., 1998, Identification of a rat testis-specific gene encoding a potential rat outer dense fibre protein, Molecular Reproduction and Development, vol 50, Wiley-Liss Inc, West Sussex UK, pp. 313-322.

Hedger, M., Nikolic-Paterson, D.J., Hutchinson, P., Atkins, R.C., de Kretser, D.M., 1998, Immunoregulatory activity in adult rat testicular interstitial fluid: roles of interleukin-1 and transforming growth factor beta1, BIOLOGY OF REPRODUCTION, vol 58, Society for the Study of Reproduction, MADISON WI USA, pp. 927-934.

Toppari, J., Kaipia, A., Kaleva, M., Laato, M., de Kretser, D.M., Krummen, L.A., Mather, J.P., Salmi, T.T., 1998, Inhibin gene expression in a large cell calcifying sertoli cell tumour and serum inhibin and activin levels, APMIS, vol 106, APMIS 1998, DENMARK, pp. 101-113.

Meinhardt, A., O'Bryan, M.K., McFarlane, J.R., Loveland, K.L., Mallidis, C., Foulds, L.M., Phillips, D.J., de Kretser, D.M., 1998, Localization of follistatin in the rat testis, Journal Of Reproduction And Fertility, vol 112, Journals of Reproduction and Fertility Ltd, CAMBRIDGE UK, pp. 233-241.

de Kretser, D.M., Phillips, D.J., 1998, Mechanisms of protein feedback on gonadotropin secretion, JOURNAL OF REPRODUCTIVE IMMUNOLOGY, vol 39, ELSEVIER SCIENCE IRELAND LTD, IRELAND, pp. 1-12.

Reame, N.E., Wyman, T.L., Phillips, D.J., de Kretser, D.M., Padmanabhan, V., 1998, Net increase in stimulatory input resulting from a decrease in inhibin B and an increase in activin A may contribute in part to the rise in follicular phase follicle-stimulating hormone of aging cycling women, Journal Of Clinical Endocrinology And Metabolism, vol 83 (9), THE ENDOCRINE SOCIETY, BETHESDA MARYLAND USA, pp. 3302-3307.

Foulds, L.M., de Kretser, D.M., Farnworth, P.G., Buttress, D., Jenkin, G., Groome, N.P., McFarlane, J.R., 1998, Ovine allantoic fluid contains high concentrations of activin a: partial dissociation of immunoactivity and bioactivity, BIOLOGY OF REPRODUCTION, vol 59, Society for the Study of Reproduction, MADISON WI USA, pp. 233-240.

Foulds, L.M., de Kretser, D.M., Farnworth, P.G., Buttress, D., Jenkin, G., Groome, N.P., McFarlane, J.R., 1998, Ovine allantoic fluid contains high concentrations of activinA: Partial dissociation of immunoactivity and bioactivity1, Biology of Reproduction, vol 59 (2), Society for the Study of Reproduction Inc, Madison Wisconsin USA, pp. 233-240.

Zhengwei, Y., Wreford, N.G., Royce, P., de Kretser, D.M., McLachlan, R.D., 1998, Stereological evaluation of human spermatogenesis after suppression by testosterone treatment: heterogeneous pattern of spermatogenic impairment, Journal Of Clinical Endocrinology And Metabolism, vol 83 issue 4, THE ENDOCRINE SOCIETY, USA, pp. 1284-1291.

Zhengwei, Y., Wreford, N.G., Royce, P., de Kretser, D.M., McLachlan, R.I., 1998, Stereological evaluation of human spermatogenesis after suppression by testosterone treatment: heterogeneous pattern of spermatogenic impairment, Journal of Clinical Endocrinology and Metabolism Journal of Clinical Endocrinology and Metabolism, vol 83 issue 4, J B LIPPINCOTT, PHILADEPHIA USA, pp. 1284-1291.

Munsie, M., Schlatt, S., de Kretser, D.M., Loveland, K.L., 1997, Expression of Stem Cell factor in the Postnatal Rat Testis, Molecular Reproduction and Development, vol 47, A John Wiley & Sons, Inc, New York NY USA, pp. 19-25.

Imade, G., Baker, G.H., de Kretser, D.M., Hedger, M., 1997, Immunosuppressive activities in the seminal plasma of infertile men: relationship to sperm antibodies and autoimmunity, Human Reproduction, vol 12, Oxford University Press, Oxford UK, pp. 256-262.

Simorangkir, D.R., de Kretser, D.M., Wreford, N.G., 1997, Impaired Germ Cell Development in the Testes of Immature Rats with Neonatal Hypothyroidism, Journal of Andrology, vol 18, American Society of Andrology, San Francisco USA, pp. 186-193.

Simorangkir, D.R., Wreford, N.G., de Kretser, D.M., 1997, Impaired Germ Cell Development in the Testes of Immature Rats with Neonatal Hypothyroidism, Journal of Andrology, vol 18, American Society of Andrology, USA, pp. 186-193.

Phillips, D.J., McFarlane, J.R., Hearn, M.T., de Kretser, D.M., 1997, Inhibin, activin and follistatin bind preferentially to the transformed species of a2 - macroglobulin, Journal of Endocrinology, vol 155, Journal of Endocrinology Ltd., Bristol UK, pp. 65-71.

Phillips, D.J., McFarlane, J.R., Hearn, M.T., de Kretser, D.M., 1997, Inhibin, activin and follistatin bind preferentially to the transformed sprecies of alpha two - macroglobulin, Journal of Endocrinology, vol 155, Society for Endocrinology, Colchester UK, pp. 65-71.

Kim, Y.H., de Kretser, D.M., Temple-Smith, P.D., Hearn, M.T., McFarlane, J.R., 1997, Isolation and characterization of human and rabbit sperm tail fibrous sheath, Molecular Human Reproduction, vol 3, Oxford University Press, Oxford UK, pp. 307-313.

Kim, Y.H., de Kretser, D.M., Temple-Smith, P.D., Hearn, M.T., McFarlane, J.R., 1997, Isolation and characterization of human and rabbit sperm tail fibrous sheath, Molecular Human Reproduction, vol 3, European Society for Human Reprod & Embryology, Oxford UK, pp. 307-313.

de Kretser, D.M., 1997, Male Infertility, The Lancet, vol 349, The Lancet Ltd, London UK, pp. 787-790.

Miller, S., Wongprasartsuk, S., Young, I.R., Wlodek, M.E., McFarlane, J.R., de Kretser, D.M., Jenkin, G., 1997, Source of Inhibin in Ovine Fetal Plasma and Amniotic Fluid, Biology of Reproduction, vol 57, Society for the Study of Reproduction, Wisconsis USA, pp. 347-353.

Miller, S., Wongprasartsuk, S., Young, I.R., Wlodek, M.E., McFarlane, J.R., de Kretser, D.M., Jenkin, G., 1997, Source of inhibin in ovine fetal plasma and amniotic fluid during late gestation: Half-life of fetal inhibin, Biology of Reproduction, vol 57, Society for the Study of Reproduction, Madison Wisconsin USA, pp. 347-353.

de Kretser, D.M., Loveland, K.L., Meinhardt, A., Simorangkir, D.R., Wreford, N.G., 1997, Spermatogenesis, Human Reproduction, vol 12, Oxford University Press, Oxford UK, pp. 101-108.

Conference Proceedings

McFarlane, J.R., Xia, Y., O'Shea, T., O'Connor, A.E., Foulds, L.M., Jenkin, G., de Kretser, D.M., 1999, Follistatin levels during the estrus cycle and across gestation in merino sheep, The Endocrine Society 81st Annual Meeting Program and Abstracts, San Diego California USA 12-15 June 1999, The Endocrine Society Press, Bethesda MD USA, p. 546.

Jenkin, G., Young, I.R., Wallace, E.M., de Kretser, D.M., Coghill, I.C., Canny, B., 1999, Hypoxia is a specific stimulus to fetal activin A and follistatin release in late gestation, The Endocrine Society of Australia Proceedings, Melbourne VIC 26-29 September 1999, Endocrine Society of Australia, Adelaide SA Australia, p. 134.

McFarlane, J.R., O'Shea, T., O'Connor, A.E., Jenkin, G., de Kretser, D.M., 1998, A longitudinal study of serum activin A and follistatin levels across gestation and parturition in sheep, Proceedings of the Australian Physiological and Pharmacological Society, Brisbane Queensland 27 September - 1 October 1998, Aust Physiological and Pharmacological Society, Vic Australia, p. 74P.

Loveland, K.L., Rames, E., Herszfeld, D., Chu, B., de Kretser, D.M., Briggs, L.J., Jans, D., 1998, A novel microtubule-associated protein-2 (map-2) isoform in brain and testis with nuclear localisation, Proceedings of the 29th Annual Conference of Australian Society for Reproductive Biology, PERTH, W.A. 23.8.98, Australian Society for Reproductive Biology, WA University Perth WA Australia, p. 5.

Phillips, D.J., Brauman, J., Mason, T., de Kretser, D.M., Hedger, M., 1998, A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, mpc-11, Proceedings Of The Endocrine Society Of Australia, PERTH, WA 23.8.98, The Endocrine Society of Australia, Perth WA Australia, p. 111.

D'Antona, D., O'Connor, A., Taylor, N., de Kretser, D.M., Wallace, E.M., 1998, Activin A levels in late pregnancy and labour, Society for Gynecologic Investigation 45th Annual Meeting, Atlanta, 11-14 March 1998, Elsevier, USA, p. 194.

Hedger, M., Phillips, D.J., de Kretser, D.M., 1998, Activin is not a universal inhibitor of interleukin-6 action, The Endocrine Society Of Australia Proceedings, PERTH, W.A. 23.8.98, THE ENDOCRINE sOCIETY OF AUSTRALIA, Melbourne Vic Australia, p. 95.

Cram, D.S., Mallidis, C., Chu, B., McLachlan, R.D., Audrins, P., Holden, C.A., de Kretser, D.M., 1998, Analysis of Y chromosome microdeletions in men with spermatogenic disorders presenting for art, FSA'98 Program, Abstracts And Mini-Posters, HOBART, AUSTRALIA, The Fertility Society of Australia, Canberra ACT Australia, p. 23.

de Kretser, D.M., 1998, Are sperm counts really falling?, Genes And Environment In Human Reproductive Disorders, ADELAID, AUST. 30.11.97, CSIRO AUSTRALIA, Collingwood Vic Australia, pp. 93-95.

Meinhardt, A., Bacher, M., McFarlane, J.R., Metz, C.N., O'Bryan, M.K., de Kretser, D.M., Bucala, R., Hedger, M., 1998, Compensatory production of MIF in rat testis after EDS treatment, 10th European Workshop On Molecular And Cellular Endocrinology Of The Testis, CAPRI, ITALY 28.3.98, THE ARES-SERONO FOUNDATION, ROME ITALY, p. 23.

Loveland, K.L., Herszfeld, D., Chu, B., Rames, E., de Kretser, D.M., Briggs, L.J., Jans, D.A., 1998, DISTRIBUTION AND POTENTIAL FUNCTION OF A NOVEL MICROTUBULE-ASSOCIATED PROTEIN-2 (MAP-2) mRNA ISOFORM, 10th European Workshop On Molecular And Cellular Endocrinology Of The Testis, CAPRI, ITALY 28.3.98, ARES-SERONO FOUNDATION, ITALY, p. 1.

Duckett, R., de Kretser, D.M., Lewis, I., Song, Q., Wreford, N.G., 1998, Development of sertoli and leydig cell populations in holstein-friesian bulls, Proceedings Of The 28th Annual Conference Of Australian Society For Reproductive Biology, PERTH 23.8.99, Australian Society for Reproductive Biology Inc., UNIVERSITY OF WA Perth WA Australia, p. 38.

O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 1998, Endotoxin-induced inflammation causes a biphasic inhibition of testicular function: possible roles for nitric oxide?, 10th European Workshop On Molecular And Cellular Endocrinology Of The Testis, CAPRI, ITALY 28.3.98, THE ARES-SERONO FOUNDATION, ROME ITALY, p. 10.

de Kretser, D.M., Hedger, M., Jones, K.L., Groome, N.P., Phillips, D.J., 1998, Follistatin and activin: changes in inflammation and the acute phase reaction, Journal Of Endocrinology Volume 159 Supplement, LONDON, UK, SOCIETY FOR ENDOCRINOLOGY, BRISTOL UK, p. 6.

McLachlan, R.D., Mallidis, C., Ma, K., Bhasin, S., de Kretser, D.M., 1998, Genetic disorders and spermatogenesis, Genes And Environment In Human Reproductive Disorders, ADELAIDE AUST. 30.11.97, CSIRO PUBLISHING, Collingwood Vic Australia, pp. 97-104.

O'Bryan, M.K., Phillips, D.J., Schlatt, S., de Kretser, D.M., Hedger, M., 1998, Nitric oxide modulates steroidogenesis in the normal rat testis but is not the primary cause of reduced testosterone production during systemic inflammation, The Endocrine Society Of Australia Proceedings 1998 Volume 41, PERTH, 23.8.98, The Endocrine Society of Australia, Melbourne Vic Australia, p. 95.

Jones, K.L., Klein, R., Groome, N.P., de Kretser, D.M., Phillips, D.J., 1998, Release of activin into the circulation precedes that of follistatin during systemic inflammation: evidence of a novel regulatory loop?, JOURNAL OF ENDOCRINOLOGY (SUPPLEMENT), LONDON, UK, SOCIETY FOR ENDOCRINOLOGY, BRISTOL UK, p. 24.

O'Bryan, M.K., Hearn, M.T., de Kretser, D.M., 1998, Sperm tail genes and infertility, The Australian Society For Medical Research, HOBART, 22.11.98, LILLY AUSTRALIA, HTTP://WWW.LILLY.COM.AU, p. 39.

de Kretser, D.M., 1998, Testicular biopsy, Clinical Application Of Advances In Andrology, HOBART AUST. 28.10.98, SERONO COLLOQUIA AUSTRALASIA, FRENCHS FOREST NSW AUSTRALIA.

de Kretser, D.M., Damjanov, I., 1998, The 4th Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis : Concluding Remarks, Neoplastic Transformation of Testicular Germ Cells, Copenhagen, May 1997, Munksgaard, Copenhagen, pp. 259-263.

Loveland, K.L., Print, C.G., de Kretser, D.M., Meehan, T., Stylianou, A., Wreford, N.G., Gibson, L., Metcalf, D., Kontgen, F., Barnett, L., Adams, J.M., Cory, S., 1998, The cell survival Bcl-w protein is required for spermatogenesis, The Endocrine Society Of Australia Proceedings, PERTH, W.A. 23.8.98, The Endocrine Society of Australia, Melbourne Vic Australia, p. 94.

McLachlan, R.D., Cram, D.S., Dowsing, A., Bhasin, S., de Kretser, D.M., 1998, The genetics of male infertility, The Australian Society For Medical Research, HOBART, AUSTRALIA 22.11.98, LILLY AUSTRALIA, HTTP://WWW.LILLY.COM.AU, p. 39.

de Kretser, D.M., Huidobro, C., Southwick, G., Temple-Smith, P.D., 1998, The role of the epididymis in human infertility, The Epididymis: Cellular And Molecular Aspects, Robertson NSW, 24-28 February 1998, Journal of Reproduction and Fertility, CAMBRIDGE UK, pp. 271-275.

Keah, H., O'Bryan, M.K., de Kretser, D.M., Hearn, M.T., 1998, The use of synthetic peptides in the study of sperm tail development function, 3rd Australian Peptide Conference "From Discovery to Therapeutics", Laguna Quays The Whitsundays QLD Oct 4-9, 1998, Pink Panther Printing, Melbourne Vic Australia, p. 43.

O'Bryan, M.K., Keah, H., Hearn, M.T., de Kretser, D.M., 1998, Tpx-1 an outer dense fibre encoding gene in humans and rats, FSA'98 Program, Abstracts And Mini-Posters, HOBART, AUSTRALIA 28.10.98, The Fertility Society of Australia, Canberra ACT Australia, p. 25.

de Kretser, D.M., Mallidis, C., McLachlan, R.D., Baker, G.H., Loveland, K.L., Bhasin, S., 1998, Y chromosomal deletions and male infertility : implications for ICSI, Treatment Of Infertility: The New Frontiers, BOCA RATON, FLORIDA USA 22.1.98, North America Communications Media for Education, NEW JERSEY - USA, p. 31.

Mallidis, C., McLachlan, R.D., Baker, G.H., Loveland, K.L., Bhasin, S., de Kretser, D.M., 1998, Y-chromosome deletions and male infertility: the current status and unanswered questions, Treatment Of Infertility : The New Frontiers, BOCA RATON, FLORIDA 22-44/1/98, COMMUNICATIONS MEDIA FOR EDUCATION, PRINCETON JUNCTION NEW JERSEY USA, pp. 205-213.

Foulds, L.M., McFarlane, J.R., Jenkin, G., de Kretser, D.M., 1997, A novel activin binding protein in ovine allantoic fluid, Endocrine Society of Australia, Canberra, 28Sept-20 Oct, Endocrine Society of Australia, Australia, p. 53.

Foulds, L.M., McFarlane, J.R., Jenkin, G., de Kretser, D.M., 1997, A novel activin binding protein is present in ovine allantoic fluid, The Endocrine Society of Australia - Proceedings, 28/9-2/10/1997 Canberra, Endocrine Society of Australia, Prahran, p. 53.

Meinhardt, A., Bacher, M., McFarlane, J.R., Mallidis, C., Lehmann, C., Metz, C.N., de Kretser, D.M., Bucala, R., Hedger, M., 1997, A switch in the cellular localization of macrophage migration inhibitory factor (MIF) in rat testis after ethane dimethane sulfonate treatment, Journal of Reproductive Immunology, 30/9-3/10/97 Virginia USA, Elsevier, New York NY USA, pp. 35-36.

Russell, C., Hedger, M., de Kretser, D.M., Phillips, D.J., 1997, Activin regulates growth and haptoglobin production in the human liver cell line, HepG2, The Endocrine Society of Australia - Proceedings, 28/9-2/10/97 Canberra, Endocrine Society of Australia - Proceedings, Prahran, p. 54.

Phillips, D.J., de Kretser, D.M., Moore, L.G., 1997, Biphasic response of plasma follistatin after the generation of an acute-phase response in growing lambs, The Endocrine Society Program and Abstracts, June 11-14, 1997, Minneapolis, Minnesota, The Endocrine Society Press, Bethesda USA, p. 368.

Schlatt, S., Zhengwei, Y., Meehan, T., de Kretser, D.M., Loveland, K.L., 1997, Cell density is a critical parameter for cessation of Sertoli cell mitosis in organ culture, Aust Society for Reproductive Biology Program, 29/9-1/10/97 Canberra, Vertebrate Biocontrol Cooperative Research Centre, Canberra ACT Australia, p. 65.

de Kretser, D.M., 1997, Ethical issues in the use of assisted reproduction technologies in the treatment of male infertility, Genetics of Human male fertility, 4-6Sept 1997 France, Editions E.D.K., Paris, pp. 235-243.

de Kretser, D.M., McFarlane, J.R., Foulds, L.M., O'Connor, A.E., Yohkaichiya, T., Loveland, K.L., Jenkin, G., 1997, Inhibin, Activin and Follistatin: Observations on their role in the physiology of pregnancy, Inhibin, Activin and Follistatin: Regulatory Functions in System and Cell Biology, Serono Symp S.A. Pub/Springer-Verlag New York, Norwell Massachusetts USA, pp. 85-95.

de Kretser, D.M., McFarlane, J.R., Foulds, L.M., O'Conner, A., Yohkaichiya, T., Loveland, K.L., Jenkin, G., 1997, Inhibin, Activin, and Follistatin : Observations on their role in the physiology of pregnancy, Inhibin, Activin, and Follistatin - Regulatory functions in system and cell biology, 9-10 November 1996, Tokushima Japan, Springer-Verlag, New York NY USA, pp. 85-95.

O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 1997, Inhibition of testicular function during lipopolysaccharide-induced inflammation, The Endocrine Society of Australia - Proceedings, 28/9-2/10/97 Canberra, Endocrine Society of Australia, Prahran, p. 64.

Taylor, N., D'Antona, D., O'Connor, A.E., de Kretser, D.M., Wallace, E.M., 1997, Maternal serum activin A during late pregnancy and at the onset of labour, Endocrine Nurses Society of Australia Inc, ACT, 29 September 1997, Endocrine Nurses Society of Australia, ACT Australia, p. 24.

Kabourakis, A.A., O'Conner, A., de Kretser, D.M., McFarlane, J.R., 1997, Maternal serum activin A profiles across gestation in the rat, The Endocrine Society of Australia - Proceedings, 28/9-2/10/97 Canberra, Endocrine Society of Australia, Prahran, p. 75.

Tilbrook, A.J., de Kretser, D.M., Clarke, I.J., 1997, Negative feedback regulation of FSH secretion by inhibin in pre-pubertal rams, Biology of Reproduction, Portland, Oregon USA, 02/08/97 - 05/08/97, Biology of Reproduction, Portland Oregon USA, p. 170.

de Kretser, D.M., Loveland, K.L., McFarlane, J.R., Meinhardt, A., O'Bryan, M.K., Simorangkir, D.R., Wreford, N.G., 1997, Paracrine interactions influencing germ cell development in the testis, The Endocrine Society Program and Abstracts, June 11-14 1997 Minnesota USA, The Endocrine Society Press, Bethesda USA, p. 54.

Gerdprasert, O., O'Bryan, M.K., Schlatt, S., Phillips, D.J., de Kretser, D.M., Hedger, M., 1997, Regulation of macrophages in the testis during endotoxin-induced imflammation, Australian Society for Medical Research Program and Abstracts, 23-26 November, Adelaide, Australian Society for Medical Research, Adelaide SA Australia, p. P23.B.

O'Conner, A., McFarlane, J.R., Yohkaichiya, T., Groome, N.P., de Kretser, D.M., 1997, Serum activin A and follistatin levels in Human Pregnancy, The Endocrine Society of Australia - Proceedings, 28/9-2/10/97 Canberra, Endocrine Society of Australia, Prahran, p. 76.

Zhengwei, Y., Wreford, N.G., de Kretser, D.M., Royce, P., McLachlan, R.D., 1997, Stereological evaluation of the human testis during testosterone-based contraception, The Endocrine Society of Australia - Proceedings, Canberra 28.9.97-2.10.97, Endocrine Society of Australia, Prahran Vic Australia, p. 66.

O'Donnell, L., Zhengwei, Y., Stanton, P., Perryman, K., Meachem, S.J., Robertson, D.M., Wreford, N.G., de Kretser, D.M., McLachlan, R.D., 1997, Studies on the hormonal control of spermatogenesis using in vivo models of spermatogenic suppression and restoration, Polish Journal of Endocrinology, 21-22 May 1997, Cracow, Poland, Polish Society of Endocrinology, Drukarnia Wydawnictw Naukowych SA Lodz Poland, pp. 67-74.

Hedger, M., Baker, G.H., de Kretser, D.M., 1997, Testicular Immunology and Sperm antibodies, Hormones & Men's Health Programme and Abstract Book, 19-21 March 1997 Clayton, IRD & PHIMR, Clayton Vic Australia, p. 39.

McLachlan, R.D., O'Donnell, L., Zhengwei, Y., Stanton, P., Perryman, K., Meachem, S.J., Robertson, D.M., Wreford, N.G., de Kretser, D.M., 1997, The Effects of Gonadotropin withdrawal on spermatogenesis, Current Advances in Andrology, May 25-29, 1997, Monduzzi Editore S.p.A., Bologna - Italy, pp. 363-369.

Hedger, M., O'Bryan, M.K., Phillips, D.J., Schlatt, S., de Kretser, D.M., 1997, The effects of lipopolysaccharide on testicular androgen secretion are preceded by changes in the testicular vasculature, Journal of Reproductive Immunology, 30/9-3/10/97 Virginia, USA, Elsevier, New York NY USA, p. 35.

de Kretser, D.M., 1997, The endocrine control of male reproduction : An overview, Hormones & Men's Health Programme and Abstract Book, 19-21 March 1997 Clayton, IRD and PHIMR, Clayton Vic Australia, p. 33.

O'Bryan, M.K., Loveland, K.L., Herszfeld, D., McFarlane, J.R., Hearn, M.T., de Kretser, D.M., 1997, Tpx-1: A Rat Outer Dense Fibre Protein Gene, Aust Society for Reproductive Biology program and miniposters of abstracts, 29/9-1/10/97 Canberra, Vertebrate Biocontrol Cooperative Research Centre, Canberra ACT Australia, p. 27.

Mallidis, C., Loveland, K.L., McLachlan, R.D., Baker, G.H., Bhasin, S., de Kretser, D.M., 1997, Y Chromosome deletions and male infertility, Hormones & Men's Health Programme and Abstract Book, 19-21 March 1997 Clayton, IRD & PHIMR, Clayton Vic Australia, p. 24.

Other

Loveland, K.A.L., de Kretser, D.M., 2005, Male reproductive system: testis development and spermatogenesis, Encyclopedia of Molecular Cell Biology and Molecular Medicine, vol minorencyc, Wiley-VCH, Weinheim Germany, pp. 499-533.

de Kretser, D.M., Phillips, D.J., Jones, K.J., O'Hehir, R.E., Patella, S., Wilson, K.M., Sebire, K.L., 2004, Therapeutic method.

Phillips, D.J., de Kretser, D.M., Sievert, W., Patella, S., Smolich, J.J., McGaw, D.J., Fennessy, P., 2002, Composition and Method for the Treatment of Disease.

de Kretser, D.M., Mallidis, C., Ma, K., Bhasin, S., 1997, Y Chromosome deletions and Male infertility, Reproductive Medicine Review, vol 6, Cambridge University Press, Cambridge, pp. 37-53.

Grants

Title:
A Fluorescence Activated Cell Sorter to Support Research Into Human Reproduction Development and Immunology.
Investigators:
Trounson, A, de Kretser, D, Kola, I, Holdsworth, S, Pera, M
Funding:
(1997 - 1999). Wellcome Trust (UK).
Title:
A Randomised Double-blind, Placebo-controlled Study to Investigate the Use of R-.
Investigators:
de Kretser, D
Funding:
( - ). Serono Australia Ltd.
Title:
A single-blind randomised study on the effects of the isoflavone preparation P-04 on prostatic, hepatic, lipid and haematological markers in normal men.
Investigators:
de Kretser, D
Funding:
(1998 - 2002). Novogen Limited.
Title:
Activin A and follistatin are potential key regulators of organ transplant dysfunction and graft survival. .
Investigators:
de Kretser, D, Dwyer, K, Kotsimbos, A, Snell, G, Hedger, M
Funding:
(2013 - 2017). National Health & Medical Research Council (NHMRC).
Title:
Application of follistatin to the resolution of liver fibrosis.
Investigators:
Phillips, D, de Kretser, D, Sievert, W
Funding:
(2003 - 2007). National Health & Medical Research Council (NHMRC).
Title:
Biomedical and Public Health Research - Operational Infrastructure grant.
Investigators:
de Kretser, D
Funding:
(2003 - 2007). Victorian Department of Innovation, Industry & Regional Development (DIIRD).
Title:
Biosensor equipment for On-line Measurement of Binding Constants and Kinetics.
Investigators:
Hearn, M, de Kretser, D, Holdsworth, S, Thompson, P
Funding:
Title:
Clinical Study with Buccal Adhesive Testosterone Tablet.
Investigators:
de Kretser, D
Funding:
(1999 - 2003). Abbott Australasia Pty Ltd.
Title:
Confocal Laser Scanning Microscope.
Investigators:
Trounson, A, Gardner, D, de Kretser, D, Kola, I
Funding:
(1996 - 2000). National Health & Medical Research Council (NHMRC).
Title:
Control of FSH by inhibin, activin, follistatin and testosterone.
Investigators:
Tilbrook, A, de Kretser, D, Clarke, I
Funding:
Title:
CopyRat P/L - Prof D De Kretser.
Investigators:
Unknown, ., de Kretser, D
Funding:
(2001 - ). CopyRat Pty Ltd.
Title:
CopyRat P/L- Injenko Research Contract- Injenko Research Contract.
Investigators:
de Kretser, D
Funding:
(2005 - ). CopyRat Pty Ltd.
Title:
Denaturing high pressure liquid chromatography (DHPLC) system.
Investigators:
de Kretser, D, O'Bryan, M, Cram, D, McLachlan, R, Clyne, C, Stanley, E, Fuller, P, Elefanty, A, Harley, V, Simpson, E, Perkins, A
Funding:
(2003 - 2007). National Health & Medical Research Council (NHMRC).
Title:
Donation to support research programs carried out within the IRD.
Investigators:
de Kretser, D
Funding:
(2000 - 2009). Various Donations.
(2001 - 2001). Various Donations.
Title:
Effects of Steroid-based Contraceptive Regimes on Germ Cell Populations and Fsh Levels.
Investigators:
de Kretser, D, McLachlan, R, Loveland, K, Robertson, D
Funding:
(1998 - 2001). Wellcome Trust (UK).
Title:
Effects of growth promoters and inhibitors on fibroblast activity in normal and fibrotic tissues: developing improved treatment options.
Investigators:
Temple-Smith, P, Southwick, G, de Kretser, D
Funding:
(2008 - 2013). Advanced Plastic Surgery Education Foundation Grant.
(2009 - 2013). Advanced Plastic Surgery Education Foundation Grant.
Title:
Equipment Grant: Purchase of Micro-manipulation Apparatus for Investigating Gene Function and Role in Disease.
Investigators:
Kola, I, de Kretser, D
Funding:
(1999 - 1999). Clive & Vera Ramaciotti Foundation.
Title:
Equipment grant - acessories pump.
Investigators:
Hedger, M, Risbridger, G, de Kretser, D
Funding:
Title:
Evaluation of Testicular Stem Cells As a Target for the Development of a Male Contraceptive.
Investigators:
de Kretser, D, Schlatt, S
Funding:
(1997 - 1998). Wellcome Trust.
Title:
Expansion of Facilities to Develop Genetic Models of Disease.
Investigators:
de Kretser, D
Funding:
(1999 - 2003). H and L Hecht Trust.
Title:
Genetic Causes of Male Infertility.
Investigators:
Morrison, J, de Kretser, D
Funding:
(1998 - 1998). Monash Ivf.
Title:
HIH Es Cells Support (Donation).
Investigators:
de Kretser, D
Funding:
(2001 - 2001). Hih Insurance Ltd.
Title:
HIH Prostate Support (Donation).
Investigators:
de Kretser, D
Funding:
(2001 - 2001). Hih Insurance Ltd.
Title:
HIH Rat Cloning Support (Donation).
Investigators:
de Kretser, D
Funding:
(2001 - 2001). Hih Insurance Ltd.
Title:
High Performance Liquid Chromatography (hplc) System - Equipment Grant 2000.
Investigators:
de Kretser, D, Phillips, D, Hedger, M, Loveland, K, O'Bryan, M, Morrison, J, Risbridger, G, Pera, M, Hertzog, P
Funding:
(2000 - 2000). National Health & Medical Research Council (NHMRC).
Title:
Infrastructure Funding Deed - Department of Human Services.
Investigators:
de Kretser, D, Hart, W, Carnie, J
Funding:
(1998 - 2002). Department of Human Services VIC.
Title:
Katanin p80 is a key regulator of microtubule dynamics and male fertility.
Investigators:
O'Bryan, M, O'Donnell, L, de Kretser, D
Funding:
(2012 - 2016). National Health & Medical Research Council (NHMRC).
Title:
Laser Capture Microdissection Equipment.
Investigators:
Risbridger, G, de Kretser, D, Trounson, A, Simpson, E
Funding:
(2000 - 2000). National Health & Medical Research Council (NHMRC).
Title:
Leucine-rich guanylate kinase is a regulator of sperm tail development and motile cilia function.
Investigators:
O'Bryan, M, McLachlan, R, de Kretser, D
Funding:
(2013 - 2017). National Health & Medical Research Council (NHMRC).
Title:
Lightcycler Instument.
Investigators:
Kola, I, de Kretser, D, Holdsworth, S, Hertzog, P
Funding:
(1999 - 1999). National Health & Medical Research Council (NHMRC).
Title:
Male fertility control: A multi-pronged approach to target identification.
Investigators:
de Kretser, D
Funding:
(2004 - 2008). Schering Aktiengesellschaft.
Title:
Microtubule associated proteins and testicular function.
Investigators:
de Kretser, D, Loveland, K
Funding:
(1997 - 2001). National Health & Medical Research Council (NHMRC).
Title:
Monitoring of Androgen Use.
Investigators:
de Kretser, D
Funding:
(2001 - 2005). ANZAC Research Institute.
Title:
Novogen Ltd - Prof D De Kretser.
Investigators:
de Kretser, D
Funding:
(1999 - ). Novogen Limited.
Title:
Phospor Imager - phospho image analyser.
Investigators:
Kola, I, Tipping, P, Hearn, M, de Kretser, D
Funding:
(2011 - 2015). National Health & Medical Research Council (NHMRC).
Title:
Provision of Equipment to Expand the Facility to Make Genetic Models of Disease (Donation).
Investigators:
de Kretser, D
Funding:
(1998 - 2002). Pratt Foundation.
Title:
Ray Williams HIH Post-doctoral Fellowships (Donations).
Investigators:
de Kretser, D
Funding:
( - ). Hih Insurance Ltd.
Title:
Tattersall's Research Programme on Infant and Child Health (Donation).
Investigators:
de Kretser, D
Funding:
(1997 - 1997). Tattersalls.
Title:
Testicular physiology of inhibin and related proteins.
Investigators:
de Kretser, D, Hedger, M, Wreford, N
Funding:
Title:
Testosterone effect on rat spermatogenesis: Role of the androgen receptor.
Investigators:
McLachlan, R, Robertson, D, de Kretser, D
Funding:
Title:
The Genetics of Male Infertility - Gene Discovery and Mutation Detection.
Investigators:
O'Bryan, M, de Kretser, D, Loveland, K
Funding:
(2001 - 2001). Rebecca L. Cooper Medical Research Foundation Ltd.
Title:
The actions of stem cell factor and platelet-derived growth factor on testicular function.
Investigators:
Loveland, K, de Kretser, D
Funding:
(1995 - 1999). National Health & Medical Research Council (NHMRC).
Title:
The control of Sertoli cell division and the initiation of postnatal germ cell division in the testis.
Investigators:
Wreford, N, de Kretser, D
Funding:
(1996 - 2000). Australian Research Council (ARC).
Title:
The genetics of male infertility.
Investigators:
de Kretser, D
Funding:
(1994 - 2016). Prince Henry's Institute of Medical Research.
Title:
The physiology of activin in pregnancy.
Investigators:
de Kretser, D, Jenkin, G, McFarlane, J
Funding:
(1996 - 2000). National Health & Medical Research Council (NHMRC).
Title:
The prediction and treatment of radiation induced fibrosis following cancer radiotherapy.
Investigators:
Sprung, C, de Kretser, D, Rogers, P
Funding:
(2011 - 2015). Cancer Australia.
Title:
The role of inhibin and related proteins in fetal gonadal physiology.
Investigators:
de Kretser, D, Jenkin, G
Funding:
Title:
The use of follistatin to treat the reperfusion injury in organ transplants.
Investigators:
de Kretser, D, O'Hehir, R
Funding:
(2012 - 2016). CASS Foundation Limited.
Title:
ARC SRC 2003-S/Ship (N/Castle)-DeKretser M36009 2003 ARC Centre for Excellence Grant CE0348239 Administered by the University of Newcastle.
Investigators:
de Kretser, D
Funding:
(2006 - 2010). Australian Research Council (ARC).
Title:
NHMRC Australian Phenome Bank.
Investigators:
Goodnow, C, de Kretser, D, O'Bryan, M
Funding:
(2004 - 2008). National Health & Medical Research Council (NHMRC).
(2006 - 2010). National Health & Medical Research Council (NHMRC).
Title:
The role of importins in the control of spermatogenesis: (ARC Centre of Excellence in Biotechnology and Development).
Investigators:
Aitken, R, Jans, D, Loveland, K, Koopman, P, Sinclair, A, de Kretser, D, O'Bryan, M, Hime, G, Roman, S, McLaughlin, E, Goodnow, C, Holland, M
Funding:
(2003 - 2007). Australian Research Council (ARC).
(2009 - 2013). Australian Research Council (ARC).
Title:
The actions of stem cell factor and patelet-derived growth factor on testicular function.
Investigators:
Loveland, K, de Kretser, D
Funding:
(1995 - 1999). National Health & Medical Research Council (NHMRC).
Title:
Control mechanisms of reproductive processes. ID: 334011.
Investigators:
de Kretser, D, Wallace, E, Risbridger, G, Hearn, M, Jenkin, G, Hedger, M, Loveland, K, Phillips, D, O'Bryan, M
Funding:
(2004 - 2008). National Health & Medical Research Council (NHMRC).
(2006 - 2010). National Health & Medical Research Council (NHMRC).
(2008 - 2012). National Health & Medical Research Council (NHMRC).
(2010 - 2014). National Health & Medical Research Council (NHMRC).
Title:
Novel Roles for Follistatin in Reproduction and Angiogenesis.
Investigators:
Girling, J, Hedger, M, de Kretser, D, Rogers, P
Funding:
(2010 - 2013). National Health & Medical Research Council (NHMRC).
(2011 - 2014). National Health & Medical Research Council (NHMRC).

Postgraduate Research Supervisions

Completed Supervision

Student:
Barakat, B.
Program of Study:
Investigating the role of activin, inhibin and bone morphogenetic proteins during the first wave of mouse spermatogenesis. (PHD) 2011.
Supervisors:
De Kretser, D (Joint), Loveland, K (Joint-Co).
Student:
Cotton, L.
Program of Study:
FIBROBLAST GROWTH FACTOR RECEPTOR-1 (FGFR-1) IS ESSENTAL FOR SPERMIOGENESIS AND MALE FERTILITY. (PHD) 2005.
Supervisors:
De Kretser, D (Joint-Co), O''Bryan, M (Joint).
Student:
Crane, M.
Program of Study:
Characterisation of immunosuppressive molecules of gonadal origin. (PHD) 2006.
Supervisors:
Hedger, M (Main), De Kretser, D (Associate).
Student:
Duckett, R.
Program of Study:
ENHANCEMENT OF TESTICULAR DEVELOPMENT IN THE BULL AND RAM VIA POSTNATAL HORMONAL MANIPULATION. (PHD) 2002.
Supervisors:
De Kretser, D (Main), Wreford, N (Joint).
Student:
Gerdprasert, O.
Program of Study:
CELLULAR AND CYTOKINE RESPONSES TO INFLAMMATION IN THE RAT TESTIS. (PHD) 2002.
Supervisors:
De Kretser, D (Main), O''Bryan, M (Joint).
Student:
Goldman, D.
Program of Study:
A potential role for androgens in mouse embryogenesis. (PHD) 2006.
Supervisors:
De Kretser, D (Main), Morrison, J (Associate).
Student:
Hickox, D.
Program of Study:
CHARACTERISATION OF THE MOUSE TESTIS-SPECIFIC CYSTEINE-RICH SECRETORY PROTEIN TPX-1. (PHD) 2003.
Supervisors:
De Kretser, D (Main), O''Bryan, M (Associate).
Student:
Jones, K.
Program of Study:
THE ROLE OF ACTIVIN A AND FOLLISTATIN IN THE INFLAMMATORY RESPONSE. (PHD) 2004.
Supervisors:
De Kretser, D (Main), Phillips, D (Associate).
Student:
Kennedy, C.
Program of Study:
STUDIES TO IDENTIFY KEY MALE FERTILITY RELATED GENES USING ENU MUTAGENESIS. (PHD) 2005.
Supervisors:
De Kretser, D (Joint-Co), O''Bryan, M (Joint).
Student:
Lin, S.
Program of Study:
GENETICALLY ENGINEERED MOUSE MODELS FOR THE STUDY OF FOLLISTATIN BIOLOGY. (PHD) 2003.
Supervisors:
De Kretser, D (Main).
Student:
Mcmanamny, P.
Program of Study:
DEVELOPMENT OF A MOUSE MODEL OF SBMA. (PHD) 2002.
Supervisors:
De Kretser, D (Main), Morrison, J (Temp).
Student:
Meehan, T.
Program of Study:
REGULATION OF CELL FATE DECISIONS IN THE POSTNATAL RODENT TESTIS. (PHD) 2004.
Supervisors:
Loveland, K (Main), De Kretser, D (Joint).
Student:
Okuma, Y.
Program of Study:
STUDIES ON THE REGULATION OF ACTIVIN AND INHIBIN SECRETION BY THE RAT SERTOLI CELL. (PHD) 2003.
Supervisors:
Hedger, M (Main), De Kretser, D (Associate).
Student:
Wongprasartsuk, S.
Program of Study:
HHT - OSLER-WEBER-RENDU SYNDROME IN VICTORIA: A SURVEY OF CURRENT MANAGEMENT AND HISTOPATHOLOGIC STUDIES ON THE RHINOLOGIC MANIFESTATIONS OF THE DISEASE AND RESPONSE TO VARIOUS TREATMENT REGIMENS. (Masters) 2005.
Supervisors:
Smith, J (Main), De Kretser, D (Associate), Vallance, N (Associate).