Dr Celine Valant - Researcher Profile

Biography

Position

Post-doctoral Fellow
Faculty of Pharmacy and Pharmaceutical Sciences

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

PHD

Institution: Universite Louis Pasteur, Strasbourg, France

Year awarded: 2005

Publications

Journal Articles

Wootten, D.L., Savage, E.E., Valant, C., May, L.T., Sloop, K.W., Ficorilli, J., Showalter, A.D., Willard, F.S., Christopoulos, A., Sexton, P.M., 2012, Allosteric modulation of endogenous metabolites as an avenue for drug discovery, Molecular Pharmacology [P], vol 82, issue 2, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 281-290.

Davey, A.E., Leach, K., Valant, C., Conigrave, A.D., Sexton, P.M., Christopoulos, A., 2012, Positive and negative allosteric modulators promote biased signaling at the calcium-sensing receptor, Endocrinology [P], vol 153, issue 3, The Endocrine Society, USA, pp. 1232-1241.

Valant, C., Felder, C.C., Sexton, P.M., Christopoulos, A., 2012, Probe dependence in the allosteric modulation of a G protein-coupled receptor: implications for detection and validation of allosteric ligand effects, Molecular Pharmacology [P], vol 81, issue 1, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 41-52.

Conway, R., Valant, C., Christopoulos, A., Robertson, A.D., Capuano, B., Crosby, I.T., 2012, Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists, Bioorganic & Medicinal Chemistry Letters [P], vol 22, issue 7, Pergamon, UK, pp. 2560-2564.

Valant, C., Aurelio, L., Devine, S.M., Ashton, T.D., White, J.M., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2012, Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A1 receptor, Journal of Medicinal Chemistry [P], vol 55, issue 5, American Chemical Society, USA, pp. 2367-2375.

Koole, C., Wootten, D., Simms, J., Valant, C., Miller, L., Christopoulos, A., Sexton, P., 2011, Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: allosteric rescue of loss of function mutation, Molecular Pharmacology [P], vol 80, issue 3, American Society of Pharmacology & Experimental Therapeutics, USA, pp. 486-497.

Valant, C., Lane, J., Sexton, P., Christopoulos, A., 2011, The best of both worlds? Bitopic orthosteric/allosteric ligands of G protein - coupled receptors, Annual Review Of Pharmacology And Toxicology [P], vol 53, Annual Reviews, United States, pp. 153-178.

Aurelio, L., Christopoulos, A., Flynn, B., Scammells, P., Sexton, P., Valant, C., 2011, The synthesis and biological evaluation of 2-amino-4,5,6,7,8,9-hexahydrocycloocta[b]thiophenes as allosteric modulators of the A(1) adenosine receptor, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 12, Pergamon-Elsevier Science Ltd, UK, pp. 3704-3707.

Koole, C., Wootten, D., Simms, J., Valant, C., Sridhar, R., Woodman, O., Miller, L., Summers, R., Christopoulos, A., Sexton, P.M., 2010, Allosteric ligands of the glucagon-like peptide 1 receptor (GLP-1R) differentially modulate endogenous and exogenous peptide responses in a pathway-selective manner: Implications for drug screening, Molecular Pharmacology [P], vol 78, issue 3, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 456-465.

Valant, C., Aurelio, L., Urmaliya, V., White, P., Scammells, P., Sexton, P., Christopoulos, A., 2010, Delineating the mode of action of adenosine A1 receptor allosteric modulators, Molecular Pharmacology [P], vol 78, issue 3, American Society for Pharmacology and Experimental Therapeutics, United States, pp. 444-455.

Aurelio, L., Valant, C., Flynn, B., Sexton, P., White, J., Christopoulos, A., Scammells, P., 2010, Effects of conformational restriction of 2-amino-3-benzoylthiophenes on A1 adenosine receptor modulation, Journal of Medicinal Chemistry [P], vol 53, American Chemical Society, United States, pp. 6550-6559.

Aurelio, L., Valant, C., Figler, H., Flynn, B.L., Linden, J., Sexton, P., Christopoulos, A., Scammells, P.J., 2009, 3- and 6-substituted 2-amino-4,5,6,7-tetrahydrothieno[2,3-c]pyridines as A1 adenosine receptor allosteric modulators and antagonists, Bioorganic & Medicinal Chemistry [P], vol 17, issue 20, Pergamon, UK, pp. 7353-7361.

Aurelio, L., Valant, C., Flynn, B.L., Sexton, P.M., Christopoulos, A., Scammells, P.J., 2009, Allosteric modulators of the adenosine A1 receptor: Synthesis and pharmacological evaluation of 4-substituted 2-amino-3-benzoylthiophenes, Journal of Medicinal Chemistry [P], vol 52, issue 14, American Chemical Society, USA, pp. 4543-4547.

Stewart, G.D., Valant, C., Dowell, S.J., Mijaljica, D., Devenish, R.J., Scammells, P.J., Sexton, P., Christopoulos, A., 2009, Determination of adenosine A1 receptor agonist and antagonist pharmacology using Saccharomyces cerevisiae: Implications for ligand screening and functional selectivity, Journal Of Pharmacology And Experimental Therapeu..., vol 331, issue 1, American Society for Pharmacology and Experimental Therapeutics, USA, pp. 277-286.

Ferguson, G.N., Valant, C., Horne, H.J., Figler, H., Flynn, B.L., Linden, J., Chalmers, D.K., Sexton, P., Christopoulos, A., Scammells, P.J., 2008, 2-Aminothienopyridazines as novel adenosine A1 receptor allosteric modulators and antagonists, Journal of Medicinal Chemistry, vol 51, issue 19, American Chemical Society, USA, pp. 6165-6172.

Valant, C., Gregory, K.J., Hall, N.E., Scammells, P.J., Lew, M., Sexton, P., Christopoulos, A., 2008, A novel mechanism of G protein-coupled receptor functional selectivity: Muscarinic partial agonist McN-A-343 as a bitopic orthosteric/allosteric ligand, Journal of Biological Chemistry, vol 283, issue 43, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 29312-29321.

Other

Scammells, P.J., Aurelio, L., Christopoulos, A., Sexton, P., Valant, C., Flynn, B.L., Linden, J., 2009, A1 adenosine receptor allosteric enhancers, USA, AU.

Activities

Affiliations with institutes

Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:

(DOCTORATE BY RESEARCH).

Thesis Title:

Structure-function studies of the allosteric modulation of the M1 Muscarinic Acetylcholine Receptor.

Supervisors:

Christopoulos, A (Main), Lane, J (Associate), Valant, C (Associate).