Monash Macromolecular Crystallisation Facility

For full technical
information visit
Monash Macromolecular Crystallisation Facility

Contact us

+61 3 9902 9244
matthew.wilce@monash.edu
Building 16, Level 1
Monash University Clayton

Key contacts

Professor Mathew Wilce
Director
Monash Macromolecular Crystallisation Facility
+61 3 9902 9244
matthew.wilce@monash.edu

Dr Danuta Maksel
Manager
Monash Macromolecular Crystallisation Facility
+61 (3) 9905 9788
danuta.maksel@monash.edu

The Monash Macromolecular Crystallisation Facility is the largest-fully automated crystal production facility in the world.

Crystallography provides unparalleled details of the 3D structure of biological macromolecules. This can provide a basis for understanding protein function and the rational design of therapeutics.

We use high-speed robots to perform hundreds of protein crystallisation trials in a very short time frame. Our high-throughput system can maximise the number of crystals suitable for X-ray analysis. This can ease the common bottleneck that occurs when creating high-quality crystals.

Our purpose-built facility also houses state-of-the-art facilities for X-ray diffraction data collection and structure determination.

Our researchers can access their results remotely via a web interface.

Our services

  • Automated screening of crystallisation conditions
  • Design of optimisation experiments
  • Custom screen making and optimisation of crystallisation experiments
  • Crystal screening
  • X-ray diffraction data collection
  • Crystal structure determination

Our key technology

  • Rigaku CrystalMation robots (including:integrated Pheonix, Minstrel, Alchemist robots and capacity for ~5000x96 crystallisation trials)
  • X-ray diffractometers (including: Rigaku Micromax007 HF microfocus X-ray generators with copper anodes, equipped with Osmic Varimax multilayer focusing optics, LN cryostreams and R-Axis 4++ area detectors)

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Access details

You can access this facility via:

  • Collaborative research
  • Fee for service