units

PSC2132

Faculty of Pharmacy and Pharmaceutical Sciences

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This unit entry is for students who completed this unit in 2016 only. For students planning to study the unit, please refer to the unit indexes in the the current edition of the Handbook. If you have any queries contact the managing faculty for your course or area of study.

6 points, SCA Band 2, 0.125 EFTSL

Undergraduate - Unit

Refer to the specific census and withdrawal dates for the semester(s) in which this unit is offered.

Faculty

Pharmacy and Pharmaceutical Sciences

Coordinator(s)

Associate Professor Martin Scanlon

Offered

Parkville

  • Second semester 2016 (Day)

Notes

Previously coded PSC2182

Synopsis

An introduction to the major techniques which underpin the practical aspects of compound identification for medicinal chemistry: UV spectroscopy, IR spectroscopy, Mass spectroscopy and NMR spectroscopy.

Outcomes

After completing this unit students will be expected to be able to:

  1. Describe how spectroscopic techniques can be used in the process of identification of small drug like molecules;
  2. Describe briefly the phenomena behind the spectroscopic techniques;
  3. Use the molecular formula of a compound to determine the index of hydrogen deficiency
  4. Interpret infra-red (IR) spectra to enable the identification of functional groups in small molecules
  5. Interpret mass spectra (MS) for small molecules to determine patterns of fragmentation and rearrangement that generate the observed ions
  6. Analyze nuclear magnetic resonance (NMR) spectra and measure the relevant spectroscopic parameters (chemical shift, intensity, coupling)
  7. Calculate coupling constants from NMR spectra
  8. Draw coupling trees to account for the patterns of coupling observed in NMR spectra
  9. Identify elements of symmetry in the chemical structure of small molecules
  10. Analyse IR, 1D NMR and Mass spectra of an unknown molecules and to use these to determine their structure;
  11. Analyse 2D NMR spectra as a means to assign the NMR spectra of more complex molecules;
  12. Demonstrate the correct reporting of spectroscopic data as used in medicinal chemistry.

Assessment

Final exam (3 hour): 60%; Mid-semester exam: 20%; Practical assessments: 20%.

Workload requirements

Contact hours for on-campus students:

  • Thirty-six hours of lectures and tutorials
  • Thirty-six hours of computational and laboratory based practical classes

See also Unit timetable information

Chief examiner(s)

Prerequisites

Additional information on this unit is available from the faculty at: