CHE3171 - Bioprocess technology
6 points, SCA Band 2, 0.125 EFTSL
Undergraduate Faculty of Engineering
Leader(s): M Danquah
Clayton Second semester 2009 (Day)
This unit explores how scalable, commercially viable process-unit operations are harnessed by the biotechnology industry for the production of valuable biomolecules (eg recombinant proteins, peptides, vaccines, enzymes, and nucleic acids). The design, operation and economic issues surrounding large-scale biomolecular process equipment including bioreactors, filtration systems, chromatographic columns, sterilisation and aseptic operation, auxiliary equipment and the associated control systems will be considered. The wider biotechnology environment will be considered especially with regards to GxP, national and international regulatory bodies, biosafety and commercialisation.
At the completion of the unit students will: have an understanding of biological systems and molecules and how these are harnessed in biotechnology; have an understanding of how scalable, commercially viable process-unit operations are employed in bioprocessing for the production of biotechnology products; understand the design, operation and economic issues surrounding large-scale biomolecular process equipment including fermenters/bioreactors, filtration systems, chromatography, aseptic operation, auxiliary equipment and the control systems; be able to read, understand, critically evaluate and develop process flow diagrams; have an understanding of the wider influences on the biotechnology industry: regulatory compliance, ethics and societal expectations; have had direct exposure to the industry through talks from industry representatives and site visits.
Industry assignment: 10%
Plant visit reports: 10%
Research assignment: 30%
Examination (3 hours): 50%
Students are required to achieve at least 45% in the total continuous assessment component (assignments, tests, mid-semester exams, laboratory reports) and at least 45% in the final examination component. Students faiing to achieve this requirement will be given a maximum of 44% in the unit.
2 hours lectures, 3 hours tutorials/practice sessions and 7 hours of private study per week