Prof Nigel Bunnett - Researcher Profile

Biography

Position
Professor of Pharmacology and Medicine
NHMRC Australia Fellow

Theme leader - Drug Discovery Biology
Monash Institute of Pharmaceutical Sciences

Qualifications

DOCTOR OF PHILOSOPHY (PHD)

Institution: Darwin College University of Cambidge UK

Year awarded: 1981

BACHELOR OF SCIENCE(HONS)ANIMAL PHYSIOLOGY&NUTRITI

Institution: University of Leeds England UK

Year awarded: 1978

Publications

Book Chapters

Grant, A., Amadesi, S., Bunnett, N., 2007, Protease-activated receptors: mechanisms by which proteases sensitize TRPV channels to induce neurogenic inflammation and pain, in TRP ion channel function in sensory transduction and cellular signaling cascades, eds Wolfgang B. Liedtke and Stefan Heller, Taylor & Francis, United States, pp. 1-12.

Journal Articles

Lyo, V., Cattaruzza, F., Kim, T.N., Walker, A.W., Paulick, M., Cox, D.N., Cloyd, J., Buxbaum, J.L., Ostroff, J., Bogyo, M., Grady, E.F., Bunnett, N.W., Kirkwood, K.S., 2012, Active cathepsins B, L, and S in murine and human pancreatitis, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 303, issue 8, American Physiological Society, Bethesda USA, pp. G894-G903.

Hasdemir, B., Mahajan, S., Bunnett, N.W., Liao, M., Bhargava, A., 2012, Endothelin-converting enzyme-1 actions determine differential trafficking and signaling of corticotropin-releasing factor receptor 1 at high agonist concentrations, Molecular Endocrinology [P], vol 26, issue 4, Endocrine Soc, Chevy Chase, Maryland USA, pp. 681-695.

Veldhuis, N.A., Lew, M., Abogadie, F.C., Poole, D.P., Jennings, E.A., Ivanusic, J.J., Eilers, H., Bunnett, N.W., Mcintyre, P., 2012, N-glycosylation determines ionic permeability and desensitization of the TRPV1 capsaicin receptor, Journal Of Biological Chemistry [P], vol 287, issue 28, Amer Soc Biochemistry Molecular Biology Inc, Bethesda Maryland USA, pp. 21765-21772.

Law, I.K.M., Murphy, J.E., Bakirtzi, K., Bunnett, N.W., Pothoulakis, C., 2012, Neurotensin-induced proinflammatory signaling in human colonocytes is regulated by beta-arrestins and endothelin-converting enzyme-1-dependent endocytosis and resensitization of neurotensin receptor 1, Journal Of Biological Chemistry [P], vol 287, issue 18, Amer Soc Biochemistry Molecular Biology Inc, Bethesda Maryland USA, pp. 15066-15075.

Haerteis, S., Krappitz, M., Bertog, M., Krappitz, A., Baraznenok, V.A., Henderson, I., Lindstrom, E., Murphy, J.E., Bunnett, N.W., Korbmacher, C., 2012, Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S, Pflugers Archiv-European Journal Of Physiology [P], vol 464, issue 4, Springer, New York USA, pp. 353-365.

Haerteis, S., Krappitz, M., Bertog, M., Krappitz, A., Barazenok, V., Henderson, I., Murphy, J., Bunnett, N.W., Korbmacher, C., 2012, Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S, Pflugers Archiv European Journal of Physiology [E], vol 464, issue 4, Scopus, USA, pp. 353-365.

Ibeakanma, C., Ochoacortes, F., Miranda-Morales, M., McDonald, T.G., Spreadbury, I., Cenac, N., Cattaruzza, F., Hurlbut, D.J., Vanner, S.J., Bunnett, N.W., Vergnolle, N., Vanner, S., 2011, Brain-Gut interactions increase peripheral nociceptive signaling in mice with postinfectious irritable bowel syndrome, Gastroenterology [P], vol 141, issue 6, W B Saunders Co-Elservier Inc, Philadelphia, Pennsylvania USA, pp. 2098-2108.e5.

Xie, W., Fisher, J., Lynch, T., Luo, M., Evans, T., Neff, T., Zhou, W., Zhang, Y., Ou, Y., Bunnett, N., Russo, A., Goodheart, M., Parekh, K., Liu, X., Engelhardt, J., 2011, CGRP induction in cystic fibrosis airways alters the submucosal gland progenitor cell niche in mice, Journal of Clinical Investigation [P], vol 121, issue 8, American Society for Clinical Investigation, United States, pp. 3144-3158.

Cattaruzza, F., Lyo, V., Jones, E., Pham, D., Hawkins, J., Kirkwood, K., Valdez-Morales, E., Ibeakanma, C., Vanner, S., Bogyo, M., Bunnett, N., 2011, Cathepsin s is activated during colitis and causes visceral hyperalgesia by a PAR(2)-dependent mechanism in mice, Gastroenterology [P], vol 141, issue 5, W B SAUNDERS CO-ELSEVIER INC, USA, pp. 1864-1874.

Pelayo, J., Poole, D.P., Steinhoff, M., Cottrell, G.S., Bunnett, N.W., 2011, Endothelin-converting enzyme-1 regulates trafficking and signalling of the neurokinin 1 receptor in endosomes of myenteric neurones, Journal Of Physiology-London [P], vol 589, issue 21, Wiley-Blackwell, Malden, Massachusetts USA, pp. 5213-5230.

Poole, D., Pelayo, J., Scherrer, G., Evans, C., Kieffer, B., Bunnett, N., 2011, Localization and regulation of fluorescently labeled delta opioid receptor, expressed in enteric neurons of mice, Gastroenterology [P], vol 141, issue 3, W.B. Saunders Co., United States, pp. 982-991.

Murphy, J., Roosterman, D., Cottrell, G., Padilla, B., Feld, M., Brand, E., Cedron, W., Bunnett, N., Steinhoff, M., 2011, Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor, American Journal Of Physiology-Cell Physiology [P], vol 301, issue 4, American Physiological Society, United States, pp. 780-791.

Ceppa, E., Lyo, V., Grady, E., Knecht, W., Grahn, S., Peterson, A., Bunnett, N., Kirkwood, K., Cattaruzza, F., 2011, Serine proteases mediate inflammatory pain in acute pancreatitis, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 300, American Physiological Society, United States, pp. 1033-1042.

Poole, D., Pelayo, J., Cattaruzza, F., Kuo, Y., Gai, G., Chiu, J., Bron, R., Furness, J., Grady, E., Bunnett, N., 2011, Transient receptor potential ankyrin 1 is expressed by inhibitory motoneurons of the mouse intestine, Gastroenterology [P], vol 141, W.B. Saunders Co., United States, pp. 565-575.

Vergnolle, N., Cenac, N., Altier, C., Cellars, L., Chapman, K., Zamponi, G., Materazzi, S., Nassini, R., Liedtke, W., Cattaruzza, F., Grady, E., Geppetti, P., Bunnett, N., 2010, A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation, British Journal of Pharmacology [P], vol 159, issue 5, John Wiley & Sons Ltd., United Kingdom, pp. 1161-1173.

Poole, D.P., Godfrey, C.B., Cattaruzza, F., Cottrell, G.S., Kirkland, J.G., Pelayo, J., Bunnett, N.W., Corvera, C.U., 2010, Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system, Neurogastroenterology and Motility [P], vol 22, issue 7, Wiley-Blackwell, Malden, Massachusetts USA, pp. 814-e228.

Eilers, H., Cattaruzza, F., Nassini, R., Materazzi, S., Andre, E., Chu, C., Cottrell, G., Schumacher, M., Geppetti, P., Bunnett, N., 2010, Pungent general anesthetics activate transient receptor potential-A1 to produce hyperalgesia and neurogenic bronchoconstriction, Anesthesiology [P], vol 112, issue 6, Lippincott Williams & Wilkins, United States, pp. 1452-1463.

Bunnett, N., Cottrell, G., 2010, Trafficking and signaling of G protein-coupled receptors in the nervous system: implications for disease and therapy, CNS and Neurological Disorders - Drug Targets [P], vol 9, issue 5, Bentham Science Publishers Ltd., Netherlands, pp. 539-556.

Cattaruzza, F., Spreadbury, I., Miranda-Morales, M., Grady, E., Vanner, S., Bunnett, N., 2010, Transient receptor potential ankyrin-1 has a major role in mediating visceral pain in mice, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 298, American Physiological Society, United States, pp. 81-91.

Ceppa, E., Cattaruzza, F., Lyo, V., Amadesi, S., Pelayo, J., Poole, D., Vaksman, N., Liedtke, W., Cohen, D., Grady, E., Bunnett, N., Kirkwood, K., 2010, Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 299, American Physiological Society, United States, pp. 556-571.

Hasdemir, B., Murphy, J., Cottrell, G., Bunnett, N., 2009, Endosomal deubiquitinating enzymes control ubiquitination and down-regulation of protease-activated receptor 2, Journal Of Biological Chemistry [P], vol 284, issue 41, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 28453-28466.

Cottrell, G., Padilla, B., Amadesi, S., Poole, D., Murphy, J., Hardt, M., Roosterman, D., Steinhoff, M., Bunnett, N., 2009, Endosomal endothelin-converting enzyme-1: A regulator of beta-arrestin-dependent ERK signaling, Journal Of Biological Chemistry [P], vol 284, issue 33, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 22411-22425.

Murphy, J., Padilla, B., Hasdemir, B., Cottrell, G., Bunnett, N., 2009, Endosomes: A legitimate platform for the signaling train, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 106, issue 42, National Academy of Sciences, United States, pp. 17615-17622.

Cattaruzza, F., Cottrell, G., Vaksman, N., Bunnett, N., 2009, Endothelin-converting enzyme 1 promotes re-sensitization of neurokinin 1 receptor-dependent neurogenic inflammation, British Journal of Pharmacology [P], vol 156, issue 5, John Wiley & Sons Ltd., United Kingdom, pp. 730-739.

Amadesi, S., Grant, A., Cottrell, G., Vaksman, N., Poole, D., Rozengurt, E., Bunnett, N., 2009, Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2, The Journal of Comparative Neurology [P], vol 516, issue 2, John Wiley & Sons, Inc., United States, pp. 141-156.

Lennerz, J., Ruhle, V., Ceppa, E., Neuhuber, W., Bunnett, N., Grady, E., Messlinger, K., 2008, Calcitonin receptor-like receptor (CLR), receptor activity-modifying protein 1 (RAMP1), and calcitonin gene-related peptide (CGRP) immunoreactivity in the rat trigeminovascular system:Differences between peripheral and central CGRP receptor distribut, The Journal of Comparative Neurology [P], vol 507, issue 3, John Wiley & Sons, Inc., United States, pp. 1277-1299.

Andr??, E., Campi, B., Materazzi, S., Trevisani, M., Amadesi, S., Massi, D., Creminon, C., Vaksman, N., Nassini, R., Civelli, M., Baraldi, P., Poole, D., Bunnett, N., Geppetti, P., Patacchini, R., 2008, Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents, Journal of Clinical Investigation [P], vol 118, issue 7, American Society for Clinical Investigation, United States, pp. 2574-2582.

Materazzi, S., Nassini, R., Andr??, E., Campi, B., Amadesi, S., Trevisani, M., Bunnett, N., Patacchini, R., Geppetti, P., 2008, Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 105, issue 33, National Academy of Sciences, United States, pp. 12045-12050.

Roosterman, D., Kempkes, C., Cottrell, G., Padilla, B., Bunnett, N., Turck, C., Steinhoff, M., 2008, Endothelin-converting enzyme-1 degrades internalized somatostatin-14, Endocrinology [P], vol 149, issue 5, The Endocrine Society, United States, pp. 2200-2207.

Wang, H., Wen, S., Bunnett, N., Leduc, R., Hollenberg, M., MacNaughton, W., 2008, Proteinase activated-receptor-2 induces cyclooxygenase-2 expression through beta-catenin and cyclic AMP response element binding protein, Journal Of Biological Chemistry [P], vol 283, issue 2, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 809-815.

Poole, D., Amadesi, S., Rozengurt, E., Thacker, M., Bunnett, N., Furness, J., 2008, Stimulation of the neurokinin 3 receptor activates protein kinase Cepsilon and protein kinase D in enteric neurons, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 294, American Physiological Society, United States, pp. 1245-1256.

Sipe, W., Brierley, S., Martin, C., Phillis, B., Bautista-Cruz, F., Grady, E., Liedtke, W., Cohen, D., Vanner, S., Blackshaw, L., Bunnett, N., 2008, Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 294, issue 5, American Physiological Society, United States, pp. 1288-1298.

Trevisani, M., Siemens, J., Materazzi, S., Bautista, D., Nassini, R., Campi, B., Imamachi, N., Andre, E., Patacchini, R., Cottrell, G., Gatti, R., Basbaum, A., Bunnett, N., Julius, D., Geppetti, P., 2007, 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 104, issue 33, National Academy of Sciences, United States, pp. 13519-13524.

Roosterman, D., Kreuzer, O., Brune, N., Cottrell, G., Bunnett, N., Meyerhof, W., Steinhoff, M., 2007, Agonist-induced endocytosis of rat somatostatin receptor 1, Endocrinology [P], vol 148, issue 3, The Endocrine Society, United States, pp. 1050-1058.

Kirkland, J., Cottrell, G., Bunnett, N., Corvera, C., 2007, Agonists of protease-activated receptors 1 and 2 stimulate electrolyte secretion from mouse gallbladder, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 293, American Physiological Society, United States, pp. 335-346.

Marvizon, J.C., Perez, O.A., Song, B., Chen, W., Bunnett, N., Grady, E., Todd, A., 2007, Calcitonin receptor-like receptor and receptor activity modifying protein 1 in the rat dorsal horn: Localization in glutamatergic presynaptic terminals containing opioids and adrenergic alpha2C receptors, Neuroscience [P], vol 148, issue 1, Pergamon, United Kingdom, pp. 250-265.

Roosterman, D., Cottrell, G., Padilla, B., Muller, L., Eckman, C., Bunnett, N., Steinhoff, M., 2007, Endothelin-converting enzyme 1 degrades neuropeptides in endosomes to control receptor recycling, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 104, issue 28, National Academy of Sciences, United States, pp. 11838-11843.

Padilla, B., Cottrell, G., Roosterman, D., Pikios, S., Muller, L., Steinhoff, M., Bunnett, N., 2007, Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins, Journal of Cell Biology [P], vol 179, issue 5, Rockefeller University Press, United States, pp. 981-997.

Hasdemir, B., Bunnett, N., Cottrell, G., 2007, Hepatocyte growth factor-regulated tyrosine kinase substrate (Hrs) mediates post-endocytic trafficking of protease-activated receptor 2 and calcitonin receptor-like receptor, Journal Of Biological Chemistry [P], vol 282, issue 40, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 29646-29657.

Barbara, G., Wang, B., Stanghellini, V., De Giorgio, R., Cremon, C., Di Nardo, G., Trevisani, M., Campi, B., Geppetti, P., Tonini, M., Bunnett, N., Grundy, D., Corinaldesi, R., 2007, Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome, Gastroenterology [P], vol 132, issue 1, W.B. Saunders Co., United States, pp. 26-37.

Kayssi, A., Amadesi, S., Bautista, F., Bunnett, N., Vanner, S., 2007, Mechanisms of protease-activated receptor 2-evoked hyperexcitability of nociceptive neurons innervating the mouse colon, Journal Of Physiology-London [P], vol 580, issue 3, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 977-991.

Cottrell, G., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Grady, E., Bunnett, N., 2007, Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1, Journal Of Biological Chemistry [P], vol 282, issue 16, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 12260-12271.

Lessard, A., Grady, E., Bunnett, N., Pickel, V., 2007, Predominant surface distribution of neurokinin-3 receptors in non-dopaminergic dendrites in the rat substantia nigra and ventral tegmental area, Neuroscience [P], vol 144, issue 4, Pergamon, United Kingdom, pp. 1393-1408.

Grant, A., Cottrell, G., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G., Bautista-Cruz, F., Barajas-Lopez, C., Joseph, E., Levine, J., Liedtke, W., Vanner, S., Vergnolle, N., Geppetti, P., Bunnett, N., 2007, Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice, Journal of Physiology [E], vol 578, issue 3, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 715-733.

Shpacovitch, V., Feld, M., Bunnett, N., Steinhoff, M., 2007, Protease-activated receptors: novel PARtners in innate immunity, Trends In Immunology [P], vol 28, issue 12, Elsevier Ltd., United Kingdom, pp. 535-544.

Cenac, N., Andrews, C., Holzhausen, M., Chapman, K., Cottrell, G., Andrade-Gordon, P., Steinhoff, M., Barbara, G., Beck, P., Bunnett, N., Sharkey, K., Ferraz, J., Shaffer, E., Vergnolle, N., 2007, Role for protease activity in visceral pain in irritable bowel syndrome, Journal of Clinical Investigation [P], vol 117, issue 3, American Society for Clinical Investigation, United States, pp. 636-647.

Gazzieri, D., Trevisani, M., Springer, J., Harrison, S., Cottrell, G., Andre, E., Nicoletti, P., Massi, D., Zecchi, S., Nosi, D., Santucci, M., Gerard, N., Lucattelli, M., Lungarella, G., Fischer, A., Grady, E., Bunnett, N., Geppetti, P., 2007, Substance P released by TRPV1-expressing neurons produces reactive oxygen species that mediate ethanol-induced gastric injury, Free Radical Biology and Medicine [P], vol 43, issue 4, Elsevier Inc., United States, pp. 581-589.

Knecht, W., Cottrell, G., Amadesi, S., Mohlin, J., Skaregarde, A., Geddal, K., Peterson, A., Chapman, K., Hollenberg, M., Vergnolle, N., Bunnett, N., 2007, Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia, Journal Of Biological Chemistry [P], vol 282, issue 36, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 26089-26100.

Cottrell, G., Amadesi, S., Pikios, S., Camerer, E., Willardsen, J., Murphy, B., Caughey, G., Wolters, P., Coughlin, S., Peterson, A., Knecht, W., Pothoulakis, C., Bunnett, N., Grady, E., 2007, {A figure is presented}Protease-Activated Receptor 2, Dipeptidyl Peptidase I, and Proteases Mediate Clostridium difficile Toxin A Enteritis, Gastroenterology [P], vol 132, issue 7, W.B. Saunders Co., United States, pp. 2422-2437.

Boutaghou-Cherid, H., Porcher, C., Liberge, M., Jule, Y., Bunnett, N., Christen, M., 2006, Expression of the neurokinin type 1 receptor in the human colon, Autonomic Neuroscience: Basic and Clinical [P], vol 124, issue 1, Elsevier BV, Netherlands, pp. 9-17.

Hu, W., Zhang, C., Li, J., Luo, Z., Amadesi, S., Bunnett, N., Zhou, Q., 2006, Impaired pain sensation in mice lacking prokineticin 2, Molecular Pain [P], vol 2, issue 35, BioMed Central Ltd., United Kingdom, pp. 1-9.

Roosterman, D., Goerge, T., Schneider, S., Bunnett, N., Steinhoff, M., 2006, Neuronal control of skin function: The skin as a neuroimmunoendocrine organ, Physiological Reviews [E], vol 86, issue 4, American Physiological Society, United States, pp. 1309-1379.

Amadesi, S., Cottrell, G., Divino, L., Chapman, K., Grady, E., Bautista, F., Karanjia, R., Barajas-Lopez, C., Vanner, S., Vergnolle, N., Bunnett, N., 2006, Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice, Journal of Physiology [E], vol 575, issue 2, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 555-571.

Gatti, R., Andre, E., Amadesi, S., Dinh, T., Fischer, A., Bunnett, N., Harrison, S., Geppetti, P., Trevisani, M., 2006, Protease-activated receptor-2 activation exaggerates TRPV1-mediated cough in guinea pigs, Journal Of Applied Physiology [P], vol 101, American Physiological Society, United States, pp. 506-511.

Oikonomopoulou, K., Hansen, K., Saifeddine, M., Tea, I., Blaber, M., Blaber, S., Scarisbrick, I., Andrade-Gordon, P., Cottrell, G., Bunnett, N., Diamandis, E., Hollenberg, M., 2006, Proteinase-activated receptors, targets for kallikrein signaling, Journal Of Biological Chemistry [P], vol 281, issue 43, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 32095-32112.

Wick, E., Hoge, S., Grahn, S., Kim, E., Divino, L., Grady, E., Bunnett, N., Kirkwood, K., 2006, Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis, American Journal Of Physiology-Gastrointestinal And Liver Physiology [P], vol 290, American Physiological Society, United States, pp. 959-969.

Cottrell, G., Padilla, B., Pikios, S., Roosterman, D., Steinhoff, M., Gehringer, D., Grady, E., Bunnett, N., 2006, Ubiquitin-dependent down-regulation of the neurokinin-1 receptor, Journal Of Biological Chemistry [P], vol 281, issue 38, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 27773-27783.

Cottrell, G., Roosterman, D., Marvizon, J., Song, B., Wick, E., Pikios, S., Wong, H., Berthelier, C., Tang, Y., Sternini, C., Bunnett, N., Grady, E., 2005, Localization of calcitonin receptor-like receptor and receptor activity modifying protein 1 in enteric neurons, dorsal root ganglia, and the spinal cord of the rat, The Journal of Comparative Neurology [P], vol 490, issue 3, John Wiley & Sons, Inc., United States, pp. 239-255.

Jacob, C., Yang, P., Darmoul, D., Amadesi, S., Saito, T., Cottrell, G., Coelho, A., Singh, P., Grady, E., Perdue, M., Bunnett, N., 2005, Mast cell tryptase controls paracellular permeability of the intestine: Role of protease-activated receptor 2 and beta-arrestins, Journal Of Biological Chemistry [P], vol 280, issue 36, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 31936-31948.

Day, A., Wick, E., Jordan, T., Jaffray, C., Bunnett, N., Grady, E., Kirkwood, K., 2005, Neutral endopeptidase determines the severity of pancreatitis-associated lung injury, Journal Of Surgical Research [P], vol 128, issue 1, Academic Press, United States, pp. 21-27.

Dulon, S., Leduc, D., Cottrell, G., D'Alayer, J., Hansen, K., Bunnett, N., Hollenberg, M., Pidard, D., Chignard, M., 2005, Pseudomonas aeruginosa elastase disables proteinase-activated receptor 2 in respiratory epithelial cells, American Journal Of Respiratory Cell And Molecular Biology [P], vol 32, American Thoracic Society, United States, pp. 411-419.

Bunnett, N., 2005, The stressed gut: Contributions of intestinal stress peptides to inflammation and motility, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 102, issue 21, National Academy of Sciences, United States, pp. 7409-7410.

Jacob, C., Cottrell, G., Gehringer, D., Schmidlin, F., Grady, E., Bunnett, N., 2005, c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2, Journal Of Biological Chemistry [P], vol 280, issue 16, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 16076-16087.

Vergnolle, N., Cellars, L., Mencarelli, A., Rizzo, G., Swaminathan, S., Beck, P., Steinhoff, M., Andrade-Gordon, P., Bunnett, N., Hollenberg, M., Wallace, J., Cirino, G., Fiorucci, S., 2004, A role for proteinase-activated receptor-1 in inflammatory bowel diseases, Journal of Clinical Investigation [P], vol 114, issue 10, American Society for Clinical Investigation, United States, pp. 1444-1456.

Barbara, G., Stanghellini, V., De Giorgio, R., Cremon, C., Cottrell, G., Santini, D., Pasquinelli, G., Morselli-Labate, A., Grady, E., Bunnett, N., Collins, S., Corinaldesi, R., 2004, Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome, Gastroenterology [P], vol 126, issue 3, W.B. Saunders Co., United States, pp. 693-702.

SCHOLZEN, T., Steinhoff, M., SINDRILARU, A., SCHWARZ, A., Bunnett, N., LUGER, T., ARMSTRONG, C., ANSEL, J., 2004, Cutaneous allergic contact dermatitis responses are diminished in mice deficient in neurokinin 1 receptors and augmented by neurokinin 2 receptor blockage, Faseb Journal [P], vol 18, issue 9, Federation of American Societies for Experimental Biology, United States, pp. 1-22.

Amadesi, S., Nie, J., Vergnolle, N., Cottrell, G., Grady, E., Trevisani, M., Manni, C., Geppetti, P., McRoberts, J., Ennes, H., Davis, J., Mayer, E., Bunnett, N., 2004, Protease-activated receptor 2 sensitizes the capsaicin receptor transient receptor potential vanilloid receptor 1 to induce hyperalgesia, Journal Of Neuroscience [P], vol 24, issue 18, Society for Neuroscience, United States, pp. 4300-4312.

OSSOVSKAYA, V., Bunnett, N., 2004, Protease-activated receptors: contribution to physiology and disease, Physiological Reviews [P], vol 84, American Physiological Society, United States, pp. 579-621.

Amadesi, S., Bunnett, N., 2004, Protease-activated receptors: protease signaling in the gastrointestinal tract, Current Opinion in Pharmacology [P], vol 4, issue 6, Elsevier Ltd., Current Opinion Journals, United Kingdom, pp. 551-556.

Roosterman, D., Cottrell, G., Schmidlin, F., Steinhoff, M., Bunnett, N., 2004, Recycling and resensitization of the neurokinin 1 receptor, Journal Of Biological Chemistry [P], vol 279, issue 29, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 30670-30679.

Cottrell, G., Amadesi, S., Grady, E., Bunnett, N., 2004, Trypsin IV, a novel agonist of protease-activated receptors 2 and 4, Journal Of Biological Chemistry [P], vol 279, issue 14, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 13532-13539.