Professor Raymond Norton - Researcher Profile

Raymond Norton

Address

Monash Institute of Pharmaceutical Sciences
381 Royal Parade

Contact Details

Tel: +61 3 990 39167

Fax: +613 990 39582

Email: Ray.Norton@monash.edu

Web: http://www.monash.edu.au/pharm/research/researchers/profile.html?sid=45829&pid=4794


Biography

Position

NHMRC Principal Research Fellow
Professor of Medicinal Chemistry

Medicinal Chemistry
Monash Institute of Pharmaceutical Sciences

Ray Norton holds a personal chair at the Monash Institute of Pharmaceutical Sciences, Parkville, where his research focuses on therapeutically useful toxins, malaria surface proteins as vaccine candidates and drug targets, and fragment-based drug discovery against a range of targets. He has a BSc (Hons) degree from the University of Melbourne and a PhD from the Australian National University. Following postdoctoral study in the US, he was awarded a QEII Fellowship to work at the Roche Research Institute of Marine Pharmacology in Sydney, and was subsequently appointed as a staff research scientist. In 1981 he moved to a faculty position in the School of Biochemistry at the University of New South Wales, then in 1992 he took up the positions of Head of the NMR Laboratory at the Biomolecular Research Institute in Melbourne and Assistant Director. In 2001, his group became part of the new Structural Biology Division of the Walter and Eliza Hall Institute of Medical Research, before moving to Monash in 2010.

His achievements have been recognised by several awards: the Amersham Pharmacia Biotech Medal of the Australian Society of Biochemistry and Molecular Biology in 1998, the ANZMAG Medal of the Australian and New Zealand Society for Magnetic Resonance in February 2006, and the Sir Rutherford Robertson Medal of the Australian Society for Biophysics (ASB) in 2008.

He has published nearly 300 articles and holds several patents.

Qualifications

DOCTOR OF PHILOSOPHY
Institution: Australian National University
Year awarded: 1974
BACHELOR OF SCIENCE (HONOURS)
Institution: The University of Melbourne
Year awarded: 1971

Publications

Book Chapters

Norton, R.S., 2013, Sea anemone peptides, in Handbook of Biologically Active Peptides, eds Abba J Kastin, Elsevier, San Diego CA USA, pp. 430-436.

Journal Articles

Jin, L., Boyd, B.J., White, P.J., Pennington, M.W., Norton, R.S., Nicolazzo, J., 2015, Buccal mucosal delivery of a potent peptide leads to therapeutically-relevant plasma concentrations for the treatment of autoimmune diseases, Journal of Controlled Release [P], vol 199, Elsevier, Amsterdam Netherlands, pp. 37-44.

MacRaild, C.A., Zachrdla, M., Andrew, D.W., Krishnarjuna, B., Novacek, J., Zidek, L., Sklenar, V., Richards, J.S., Beeson, J.G., Anders, R.F., Norton, R.S., 2015, Conformational dynamics and antigenicity in the disordered malaria antigen merozoite surface protein 2, PLoS ONE [E], vol 10, issue 3, Public Library of Science, San Francisco CA USA, pp. 1-18.

Pennington, M.W., Chang, S.J., Chauhan, S., Huq, R., Tajhya, R.B., Chhabra, S., Norton, R.S., Beeton, C., 2015, Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK, Marine Drugs [P], vol 13, issue 1, M D P I AG, Basel Switzerland, pp. 529-542.

Robinson, S., Safavi-Hemami, H., Raghuraman, S.C., Imperial, J.S., Papenfuss, A.T., Teichert, R.W., Purcell, A.W., Olivera, B.M., Norton, R.S., 2015, Discovery by proteogenomics and characterization of an RF-amide neuropeptide from cone snail venom, Journal of Proteomics [P], vol 114, Elsevier, Amsterdam Netherlands, pp. 38-47.

Caon, T., Jin, L., Simoes, M.C., Norton, R.S., Nicolazzo, J., 2015, Enhancing the buccal mucosal delivery of peptide and protein therapeutics, Pharmaceutical Research [P], vol 32, issue 1, Springer, New York NY USA, pp. 1-21.

Guy, A.J., Irani, V.R., MacRaild, C.A., Anders, R.F., Norton, R.S., Beeson, J.G., Richards, J.S., Ramsland, P.A., 2015, Insights into the immunological properties of intrinsically disordered malaria proteins using proteome scale predictions, PLoS ONE [E], vol 10, issue 10 (Art. No: e0141729), Public Library of Science, United States, pp. 1-22.

Chang, J.S.C., Huq, R., Chhabra, S., Beeton, C., Pennington, M.W., Smith, B.J., Norton, R.S., 2015, N-terminally extended analogues of the K+ channel toxin from Stichodactyla helianthus as potent and selective blockers of the voltage-gated potassium channel Kv1.3, Febs Journal [P], vol 282, issue 12, Wiley-Blackwell, Chichester West Sussex UK, pp. 2247-2259.

Devine, S., Mulcair, M., Debono, C., Leung, E.W.W., Nissink, J.W.M., Lim, S.S., Chandrashekaran, I.R., Vazirani, M., Mohanty, B., Simpson, J.S., Baell, J.B., Scammells, P.J., Norton, R.S., Scanlon, M., 2015, Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold, Journal of Medicinal Chemistry [P], vol 58, issue 3, ACS Publications, Washington DC USA, pp. 1205-1214.

Safavi-Hemami, H., Gajewiak, J., Karanth, S., Robinson, S., Ueberheide, B., Douglass, A.D., Schlegel, A., Imperial, J.S., Watkins, M., Bandyopadhyay, P.K., Yandell, M., Li, Q., Purcell, A.W., Norton, R.S., Ellgaard, L., Olivera, B.M., 2015, Specialized insulin is used for chemical warfare by fish-hunting cone snails, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 112, issue 6, National Academy of Sciences, Washington DC USA, pp. 1743-1748.

Yagi, H., Conroy, P., Leung, E.W.W., Law, R.H.P., Trapani, J.A., Voskoboinik, I., Whisstock, J., Norton, R.S., 2015, Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes, Journal Of Biological Chemistry [P], vol 290, issue 42, American Society for Biochemistry and Molecular Biology Inc, Bethesda MD USA, pp. 25213-25226.

De Almeida Vilela Morales, R., MacRaild, C.A., Seow, J.T., Krishnarjuna, B., Drinkwater, N., Rouet, R., Anders, R.F., Christ, D., McGowan, S., Norton, R.S., 2015, Structural basis for epitope masking and strain specificity of a conserved epitope in an intrinsically disordered malaria vaccine candidate, Scientific Reports [E], vol 5, Macmillan Publishers, London UK, pp. 1-10.

Meirovitch, E., Tchaicheeyan, O., Sher, I., Norton, R.S., Chill, J., 2015, Structural dynamics of the potassium channel blocker ShK: SRLS analysis of 15N relaxation, Journal of Physical Chemistry B [P], vol 119, issue 49, ACS Publications, Washington DC USA, pp. 15130-15137.

Chandrashekaran, I.R., Mohanty, B., Linossi, E.M., Dagley, L.F., Leung, E.W.W., Murphy, J.M., Babon, J.J., Nicholson, S.E., Norton, R.S., 2015, Structure and functional characterization of the conserved JAK interaction region in the intrinsically disordered N-terminus of SOCS5, Biochemistry [P], vol 54, issue 30, ACS Publications, Washington DC USA, pp. 4672-4682.

Leung, E.W.W., Yagi, H., Harjani, J.R., Mulcair, M., Scanlon, M., Baell, J.B., Norton, R.S., 2014, 19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2, Chemical Biology and Drug Design [P], vol 84, issue 5, Wiley-Blackwell Publishing Inc., Hoboken NJ USA, pp. 616-625.

Devine, S., Lim, S.S., Chandrashekaran, I.R., MacRaild, C.A., Drew, D.R., Debono, C., Lam, R., Anders, R.F., Beeson, J.G., Scanlon, M., Scammells, P.J., Norton, R.S., 2014, A critical evaluation of pyrrolo[2,3-d]pyrimidine-4-amines as Plasmodium falciparum apical membrane antigen 1 (AMA1) inhibitors, MedChemComm [P], vol 5, issue 10, R S C Publications, Cambridge UK, pp. 1500-1506.

Harjani, J.R., Tang, A.X., Norton, R.S., Baell, J.B., 2014, A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates, Tetrahedron [P], vol 70, issue 43, Pergamon Press, Oxford UK, pp. 8047-8055.

Rashid, H., Huq, R., Tanner, M.R., Chhabra, S., Khoo, K.K., Estrada, R., Dhawan, V., Chauhan, S., Pennington, M.W., Beeton, C., Kuyucak, S., Norton, R.S., 2014, A potent and Kv1.3-selective analogue of the scorpion toxin HsTX1 as a potential therapeutic for autoimmune diseases, Scientific Reports [E], vol 4, issue 4509, Nature Publishing Group, London UK, pp. 1-9.

Yap, B.K., Leung, E.W.W., Yagi, H., Galea, C., Chhabra, S., Chalmers, D.K., Nicholson, S.E., Thompson, P., Norton, R.S., 2014, A potent cyclic peptide targeting SPSB2 protein as a potential anti-infective agent, Journal of Medicinal Chemistry [P], vol 57, issue 16, American Chemical Society, Washington DC USA, pp. 7006-7015.

Kuyucak, S., Norton, R.S., 2014, Computational approaches for designing potent and selective analogs of peptide toxins as novel therapeutics, Future Medicinal Chemistry [P], vol 6, issue 15, Future Science Ltd, London UK, pp. 1645-1658.

Sher, I., Chang, S.J., Li, Y., Chhabra, S., Palmer III, A.G., Norton, R.S., Chill, J., 2014, Conformational flexibility in the binding surface of the potassium channel blocker ShK, Chembiochem [P], vol 15, issue 16, Wiley - V C H Verlag GmbH & Co. KGaA, Weinheim Germany, pp. 2402-2410.

Robinson, S., Norton, R.S., 2014, Conotoxin gene superfamilies, Marine Drugs [P], vol 12, issue 12, MDPI AG, Basel Switzerland, pp. 6058-6101.

Chhabra, S., Belgi, A., Bartels, P., Van Lierop, B.J., Robinson, S., Kompella, S.N., Hung, A., Callaghan, B., Adams, D.J., Robinson, A.J., Norton, R.S., 2014, Dicarba analogues of a-conotoxin RgIA. Structure, stability, and activity at potential pain targets, Journal of Medicinal Chemistry [P], vol 57, issue 23, American Chemical Society, Washington DC USA, pp. 9933-9944.

Robinson, S., Safavi-Hemami, H., McIntosh, L.D., Purcell, A.W., Norton, R.S., Papenfuss, A.T., 2014, Diversity of conotoxin gene superfamilies in the venomous snail, Conus victoriae, PLoS ONE [E], vol 9, issue e87648, Public Library of Science, San Francisco CA USA, pp. 1-13.

Galea, C., Nguyen, H.M., Chandy, G.K., Smith, B.J., Norton, R.S., 2014, Domain structure and function of matrix metalloprotease 23 (MMP23): Role in potassium channel trafficking, Cellular and Molecular Life Sciences [E], vol 71, issue 7, Springer Basel AG, Basel Switzerland, pp. 1191-1210.

Green, B.R., Zhang, M., Chhabra, S., Robinson, S., Wilson, M.J., Redding, A., Olivera, B.M., Yoshikami, D., Bulaj, G., Norton, R.S., 2014, Interactions of disulfide-deficient selenocysteine analogs of u-conotoxin BuIIIB with the a-subunit of the voltage-gated sodium channel subtype 1.3, Febs Journal [P], vol 281, issue 13, Wiley-Blackwell Publishing Ltd, Chichester UK, pp. 2885-2898.

Chhabra, S., Chang, S.J., Nguyen, H.M., Huq, R., Tanner, M.R., Londono, L.M., Estrada, R., Dhawan, V., Chauhan, S., Upadhyay, S.K., Gindin, M., Hotez, P.J., Valenzuela, J.G., Mohanty, B., Swarbrick, J.D., Wulff, H., Iadonato, S.P., Gutman, G.A., Beeton, C., Pennington, M.W., Norton, R.S., Chandy, G.K., 2014, Kv1.3 channel-blocking immunomodulatory peptides from parasitic worms: Implications for autoimmune diseases, Faseb Journal [P], vol 28, Federation of American Societies for Experimental Biology, Bethesda MD USA, pp. 3952-3964.

Ge, X., MacRaild, C.A., Devine, S., Debono, C., Wang, G., Scammells, P.J., Scanlon, M., Anders, R.F., Foley, M., Norton, R.S., 2014, Ligand-induced conformational change of Plasmodium falciparum AMA1 detected using 19F NMR, Journal of Medicinal Chemistry [P], vol 57, issue 15, American Chemical Society, Washington DC USA, pp. 6419-6427.

Wang, G., MacRaild, C.A., Mohanty, B., Mobli, M., Cowieson, N.P., Anders, R.F., Simpson, J.S., McGowan, S., Norton, R.S., Scanlon, M., 2014, Molecular insights into the interaction between Plasmodium falciparum apical membrane antigen 1 and an invasion-inhibitory peptide, PLoS ONE [E], vol 9, issue 10, PUBLIC LIBRARY SCIENCE, San Francisco CA USA, pp. 1-12.

MacRaild, C.A., Norton, R.S., 2014, RASP: Rapid and robust backbone chemical shift assignments from protein structure, Journal Of Biomolecular Nmr [P], vol 58, issue 3, Springer Netherlands, Dordrecht Netherlands, pp. 155-163.

Lim, S., Yang, W.W., Bankala, K., Kannan Sivaraman, K., Chandrashekaran, I.R., Kass, I., MacRaild, C.A., Devine, S., Debono, C., Anders, R.F., Scanlon, M., Scammells, P.J., Norton, R.S., McGowan, S., 2014, Structure and dynamics of apical membrane antigen 1 from Plasmodium falciparum FVO, Biochemistry [P], vol 53, issue 46, American Chemical Society, Washington DC USA, pp. 7310-7320.

Green, B.R., Bulaj, G., Norton, R.S., 2014, Structure and function of mu-conotoxins, peptide-based sodium channel blockers with analgesic activity, Future Medicinal Chemistry [P], vol 6, issue 15, Future Science Ltd, London UK, pp. 1677-1698.

Luo, S., Christensen, S., Zhangsun, D., Wu, Y., Hu, Y., Zhu, X., Chhabra, S., Norton, R.S., McIntosh, J.M., 2013, A novel inhibitor of a9a10 nicotinic acetylcholine receptors from Conus vexillum delineates a new conotoxin superfamily, PLoS ONE [E], vol 8, issue 1, Public Library of Science, San Francisco CA USA, pp. 1-10.

Rashid, M.H., Heinzelmann, G., Huq, R., Tajhya, R.B., Chang, S.J., Chhabra, S., Pennington, M.W., Beeton, C., Norton, R.S., Kuyucak, S., 2013, A potent and selective peptide blocker of the Kv1.3 channel: Prediction from free-energy simulations and experimental confirmation, PLoS ONE [E], vol 8, issue 11, Public Library of Science, San Francisco CA USA, pp. 1-10.

Brady, R., Zhang, M., Gable, R.W., Norton, R.S., Baell, J.B., 2013, De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic, Bioorganic & Medicinal Chemistry Letters [P], vol 23, issue 17, Pergamon-Elsevier, Oxford UK, pp. 4892-4895.

Traore, D.A.K., Brennan, A.J., Law, R.H.P., Dogovski, C., Perugini, M.A., Lukoyanova, N., Leung, E.W.W., Norton, R.S., Lopez, J., Browne, K.A., Yagita, H., Lloyd, G., Ciccone, A., Verschoor, S., Trapani, J.A., Whisstock, J., Voskoboinik, I., 2013, Defining the interaction of perforin with calcium and the phospholipid membrane, Biochemical Journal [P], vol 456, issue 3, Portland Press, United Kingdom, pp. 323-335.

Lim, S., Debono, C., MacRaild, C.A., Chandrashekaran, I.R., Dolezal, O., Anders, R.F., Simpson, J.S., Scanlon, M., Devine, S., Scammells, P.J., Norton, R.S., 2013, Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening, Australian Journal of Chemistry [E], vol 66, issue 12, CSIRO Publishing, Collingwood Vic Australia, pp. 1530-1536.

Van Lierop, B.J., Robinson, S., Kompella, S.N., Belgi, A., McArthur, J.R., Hung, A., MacRaild, C.A., Adams, D.J., Norton, R.S., Robinson, A.J., 2013, Dicarba alpha-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABA(B) receptors, Acs Chemical Biology [P], vol 8, issue 8, ACS Publications, Washington USA, pp. 1815-1821.

Nguyen, H.M., Galea, C., Schmunk, G., Smith, B.J., Edwards, R.A., Norton, R.S., Chandy, K.G., 2013, Intracellular trafficking of the KV1.3 potassium channel is regulated by the prodomain of a matrix metalloprotease, Journal Of Biological Chemistry [P], vol 288, issue 9, American Society for Biochemistry and Molecular Biology, Bethesda MD USA, pp. 6451-6464.

Kuang, Z., Zhang, M., Gupta, K., Gajewiak, J., Gulyas, J., Balaram, P., Rivier, J.E., Olivera, B.M., Yoshikami, D., Bulaj, G., Norton, R.S., 2013, Mammalian neuronal sodium channel blocker u-conotoxin BuIIIB has a structured N-terminus that influences potency, Acs Chemical Biology [P], vol 8, issue 6, ACS Publications, Washington DC USA, pp. 1344-1351.

Brady, R., Baell, J.B., Norton, R.S., 2013, Strategies for the development of conotoxins as new therapeutic leads, Marine Drugs [P], vol 11, issue 7, MDPI AG, Basel Switzerland, pp. 2293-2313.

D'Cruz, A., Babon, J., Norton, R.S., Nicola, N.A., Nicholson, S.E., 2013, Structure and function of the SPRY/B30.2 domain proteins involved in innate immunity, Protein Science [P], vol 22, issue 1, Wiley-Blackwell, New Jersey NJ USA, pp. 1-10.

Linossi, E.M., Chandrashekaran, I.R., Kolesnik, T.B., Murphy, J.M., Webb, A.I., Willson, T.A., Kedzierski, L., Bullock, A.N., Babon, J., Norton, R.S., Nicola, N.A., Nicholson, S.E., 2013, Suppressor of cytokine signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1, PLoS ONE [E], vol 8, issue 8, Public Library of Science, San Fransisco CA USA, pp. 1-12.

Pennington, M.W., Rashid, M.H., Tajhya, R.B., Beeton, C., Kuyucak, S., Norton, R.S., 2012, A C-terminally amidated analogue of ShK is a potent and selective blocker of the voltage-gated potassium channel Kv1.3, FEBS Letters [P], vol 586, issue 22, Elsevier, Netherlands, pp. 3996-4001.

Ye, M., Khoo, K.K., Xu, S., Zhou, M., Boonyalai, N., Chi, C., Galea, C., Wang, C., Norton, R.S., 2012, A helical conotoxin from Conus imperialis has a novel cysteine framework and defines a new superfamily, Journal Of Biological Chemistry [P], vol 287, issue 18, American Society for Biochemistry and Molecular Biology, USA, pp. 14973-14983.

Adda, C.G., MacRaild, C.A., Reiling, L., Wycherley, K., Boyle, M.J., Kienzle, V., Masendycz, P., Foley, M., Beeson, J.G., Norton, R.S., Anders, R., 2012, Antigenic characterization of an intrinsically unstructured protein, plasmodium falciparum merozoite surface protein 2, Infection And Immunity [P], vol 80, issue 12, American Society for Microbiology, USA, pp. 4177-4185.

Chi, V., Pennington, M.W., Norton, R.S., Tarcha, E.J., Londono, L.M., Sims-Fahey, B., Upadhyay, S.K., Lakey, J.T., Iadonato, S., Wulff, H., Beeton, C., Chandy, K.G., 2012, Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases, Toxicon : official journal of the International Society on Toxinology [P], vol 59, issue 4, Pergamon, UK, pp. 529-546.

Khoo, K.K., Gupta, K., Green, B.R., Zhang, M., Watkins, M., Olivera, B.M., Balaram, P., Yoshikami, D., Bulaj, G., Norton, R.S., 2012, Distinct disulfide isomers of u-conotoxins KIIIA and KIIIB block voltage-gated sodium channels, Biochemistry [P], vol 51, issue 49, ACS Publications, USA, pp. 9826-9835.

Chang, S.C., Galea, C., Leung, E.W.W., Tajhya, R.B., Beeton, C., Pennington, M.W., Norton, R.S., 2012, Expression and isotopic labelling of the potassium channel blocker ShK toxin as a thioredoxin fusion protein in bacteria, Toxicon : official journal of the International Society on Toxinology [P], vol 60, issue 5, Pergamon, England, pp. 840-850.

Galea, C., Mobli, M., McNeil, K.A., Mulhern, T.D., Wallace, J.C., King, G.F., Forbes, B., Norton, R.S., 2012, Insulin-like growth factor binding protein-2: NMR analysis and structural characterization of the N-terminal domain, Biochimie [P], vol 94, issue 3, Elsevier, France, pp. 608-616.

Forbes, B., McCarthy, P., Norton, R.S., 2012, Insulin-like growth factor binding proteins: a structural perspective, Frontiers in Endocrinology [E], vol 3, issue 38, Frontiers Research Foundation, Switzerland, pp. 1-13.

MacRaild, C.A., Pedersen, M.O., Anders, R.F., Norton, R.S., 2012, Lipid interactions of the malaria antigen merozoite surface protein 2, Biochimica et Biophysica Acta - Biomembranes [P], vol 1818, issue 11, Elsevier, Netherlands, pp. 2572-2578.

Zhang, X., Adda, C.G., Low, A., Zhang, J., Zhang, W., Sun, H., Tu, X., Anders, R.F., Norton, R.S., 2012, Role of the helical structure of the N-terminal region of plasmodium falciparum merozoite surface protein 2 in fibril formation and membrane interaction, Biochemistry [P], vol 51, issue 7, ACS Publications, USA, pp. 1380-1387.

Babon, J.J., Kershaw, N.J., Murphy, J.M., Varghese, L.N., Laktyushin, A., Young, S.N., Lucet, I.S., Norton, R.S., Nicola, N.A., 2012, Suppression of cytokine signaling by SOCS3: characterization of the mode of inhibition and the basis of its specificity, Immunity [P], vol 36, issue 2, Cell Press, USA, pp. 239-250.

Feng, Z., Chandrashekaran, I.R., Low, A., Speed, T.P., Nicholson, S.E., Norton, R.S., 2012, The N-terminal domains of SOCS proteins: A conserved region in the disordered N-termini of SOCS4 and 5, Proteins: Structure, Function, and Bioinformatics [P], vol 80, issue 3, John Wiley & Sons, USA, pp. 946-957.

Robinson, M., Donnelly, S., Hutchinson, A., To, J., Taylor, N., Norton, R., Perugini, M., Dalton, J., 2011, A family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides, Plos Pathogens [P], vol 7, issue 5, Public Library of Science, USA, pp. 1-14.

Beeton, C., Pennington, M., Norton, R., 2011, Analogs of the sea anemone potassium channel blocker ShK for the treatment of autoimmune diseases, Inflammation & Allergy - Drug Targets [E], vol 10, issue 5, Bentham Science Publishers Ltd, United Arab Emirates, pp. 313-321.

MacRaild, C., Anders, R., Foley, M., Norton, R., 2011, Apical membrane antigen 1 as an anti-malarial drug target, Current Topics in Medicinal Chemistry [P], vol 11, issue 16, Bentham Science Publishers Ltd, U ARAB EMIRATES, pp. 2039-2047.

Chandrashekaran, I., Adda, C., MacRaild, C., Anders, R., Norton, R., 2011, EGCG disaggregates amyloid-like fibrils formed by Plasmodium falciparum merozoite surface protein 2, Archives Of Biochemistry And Biophysics [P], vol 513, issue 2, Elsevier, USA, pp. 153-157.

Safavi-Hemami, H., Siero, W.A., Kuang, Z., Williamson, N.A., Karas, J.A., Page, L.R., MacMillan, D., Kompella, S.N., Adams, D.J., Norton, R.S., Purcell, A.W., 2011, Embryonic toxin expression in the cone snail conus victoriae - primed to kill or divergent function?, Journal Of Biological Chemistry [P], vol 286, issue 25, American Society for Biochemistry and Molecular Biology, USA, pp. 22546-22557.

Yao, S., Hinds, M., Murphy, J., Norton, R., 2011, Exchange enhanced sensitivity gain for solvent-exchangeable protons in 2D (1)H-(15)N heteronuclear correlation spectra acquired with band-selective pulses, Journal of Magnetic Resonance [P], vol 211, issue 2, Elsevier, USA, pp. 243-247.

Khoo, K., Wilson, M., Smith, B., Zhang, M., Gulyas, J., Yoshikami, D., Rivier, J., Bulaj, G., Norton, R., 2011, Lactam-stabilized helical analogues of the analgesic mu-conotoxin KIIIA, Journal of Medicinal Chemistry [P], vol 54, issue 21, ACS Publications, USA, pp. 7558-7566.

Yao, S., Young, I., Norton, R., Murphy, J., 2011, Murine interleukin-3: structure, dynamics, and conformational heterogeneity in solution, Biochemistry [P], vol 50, issue 13, ACS Publications, USA, pp. 2464-2477.

Lee, E., Yao, S., Sabo, J., Fairlie, W., Stevenson, R., Harris, K., Anders, R., Foley, M., Norton, R., 2011, Peptide Inhibitors of the Malaria Surface Protein, Apical Membrane Antigen 1: Identification of Key Binding Residues, Biopolymers [P], vol 95, issue 5 (SI), Wiley-Blackwell, USA, pp. 354-364.

Mai, K., Smith, N., Feng, Z., Katrib, M., Slapetova, I., Wallach, M., Luxford, C., Davies, M., Zhang, X., Norton, R., Belli, S., 2011, Peroxidase catalysed cross-Linking of an intrinsically unstructured protein via dityrosine bonds in the oocyst wall of the apicomplexan parasite, Eimeria maxima, International Journal for Parasitology [P], vol 41, issue 11, Elsevier, England, pp. 1157-1164.

Lewis, R., Kolesnik, T., Kuang, Z., D'Cruz, A., Blewitt, M., Masters, S., Low, A., Willson, T., Norton, R., Nicholson, S., 2011, TLR regulation of SPSB1 controls inducible nitric oxide synthase induction, Journal Of Immunology [P], vol 187, issue 7, American Association of Immunologists, USA, pp. 3798-3805.

Yao, S., Murphy, J., Low, A., Norton, R., 2010, 1H, 13C and 15N resonance assignments of a highly-soluble murine interleukin-3 analogue with wild-type bioactivity, Biomolecular NMR Assignments [P], vol 4, issue 1, Springer, Netherlands, pp. 73-77.

Yang, X., Adda, C.G., MacRaild, C.A., Low, A., Zhang, X., Zeng, W., Jackson, D.C., Anders, R.F., Norton, R.S., 2010, Identification of key residues involved in fibril formation by the conserved N-terminal region of plasmodium falciparum merozoite surface protein 2 (MSP2), Biochimie [P], vol 92, issue 10, Elsevier, France, pp. 1287-1295.

Chandrashekaran, I.R., Adda, C.G., MacRaild, C.A., Anders, R.F., Norton, R.S., 2010, Inhibition by flavonoids of amyloid-like fibril formation by plasmodium falciparum merozoite surface protein 2, Biochemistry [P], vol 49, issue 28, ACS Publications, United States, pp. 5899-5908.

Richard, D., MacRaild, C.A., Riglar, D.T., Chan, J., Foley, M., Baum, J., Ralph, S.A., Norton, R.S., Cowman, A.F., 2010, Interaction between Plasmodium falciparum apical membrane antigen 1 and the rhoptry neck protein complex defines a key step in the erythrocyte invasion process of malaria parasites, Journal Of Biological Chemistry [P], vol 285, issue 19, American Society for Biochemistry and Molecular Biology, United States, pp. 14815-14822.

Norton, R.S., Gulbis, J.M., 2010, Potassium channel gating: Not an open and shut case, Proceedings Of The National Academy Of Sciences Of The United States Of America [P], vol 107, issue 17, National Academies Press, United States, pp. 7623-7624.

Rangaraju, S., Khoo, K.K., Feng, Z., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Pham, C., Calabresi, P., Pennington, M.W., Norton, R.S., Chandy, K.G., 2010, Potassium channel modulation by a toxin domain in matrix metalloprotease 23, Journal Of Biological Chemistry [P], vol 285, issue 12, American Society for Biochemistry and Molecular Biology, United States, pp. 9124-9136.

Anders, R.F., Adda, C.G., Foley, M., Norton, R.S., 2010, Recombinant protein vaccines against the asexual blood-stages of Plasmodium falciparum, Human Vaccines [E], vol 6, issue 1, Landes Bioscience, USA, pp. 39-53.

Lam, Y., Hung, A., Norton, R.S., Separovic, F., Watts, A., 2010, Solid-state NMR and simulation studies of equinatoxin II N-terminus interaction with lipid bilayers, Proteins: Structure, Function, and Bioinformatics [P], vol 78, issue 4, John Wiley & Sons, United States, pp. 858-872.

Drechsler, A., Anderluh, G., Norton, R.S., Separovic, F., 2010, Solid-state NMR study of membrane interactions of the pore-forming cytolysin, equinatoxin II, Biochimica et Biophysica Acta - Biomembranes [P], vol 1798, issue 2, Elsevier, Netherlands, pp. 244-251.

Filippakopoulos, P., Low, A., Sharpe, T.D., Uppenberg, J., Yao, S., Kuang, Z., Savitsky, P., Lewis, R.S., Nicholson, S.E., Norton, R.S., Bullock, A.N., 2010, Structural basis for par-4 recognition by the SPRY domain- and SOCS box-containing proteins SPSB1, SPSB2, and SPSB4, Journal of Molecular Biology [P], vol 401, issue 3, Academic Press, United Kingdom, pp. 389-402.

Kuang, Z., Lewis, R.S., Curtis, J.M., Zhan, Y., Saunders, B.M., Babon, J.J., Kolesnik, T.B., Low, A., Masters, S.L., Willson, T.A., Kedzierski, L., Yao, S., Handman, E., Norton, R.S., Nicholson, S.E., 2010, The SPRY domain-containing SOCS box protein SPSB2 targets iNOS for proteasomal degradation, Journal of Cell Biology [P], vol 190, issue 1, Rockefeller University Press, United States, pp. 129-141.

Norton, R.S., 2010, mu-Conotoxins as leads in the development of new analgesics, Molecules [P], vol 15, issue 4, MDPI AG, Switzerland, pp. 2825-2844.

Pennington, M.W., Beeton, C., Galea, C., Smith, B.J., Chi, V., Monaghan, K.P., Garcia, A., Rangaraju, S., Giuffrida, A., Plank, D.K., Crossley, G., Nugent, D., Khaytin, I., LeFievre, Y., Peshenko, I., Dixon, C., Chauhan, S., Orzel, A., Inoue, T., Hu, X., Moore, R.V., Norton, R.S., Chandy, K.G., 2009, Engineering a stable and selective peptide blocker of the Kv1.3 channel in T lymphocytes, Molecular Pharmacology [P], vol 75, issue 4, American Society for Pharmacology and Experimental Therapeutics, Bethesda MD USA, pp. 762-773.

Kuang, Z., Yao, S., McNeil, K.A., Forbes, B.E., Wallace, J.C., Norton, R.S., 2009, Insulin-like growth factor-I (IGF-I): Solution properties and NMR chemical shift assignments near physiological pH, Growth Hormone and IGF Research [P], vol 19, issue 3, Churchill Livingstone, UK & Germany, pp. 226-231.

Harris, K.S., Casey, J.L., Coley, A.M., Karas, J., Sabo, J.K., Tan, Y., Dolezal, O., Norton, R.S., Hughes, A.B., Scanlon, D., Foley, M., 2009, Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanning, Journal Of Biological Chemistry [P], vol 284, issue 14, American Society for Biochemistry and Molecular Biology, Bethesda MD USA, pp. 9361-9371.

Kuang, Z., Yao, S., Xu, Y., Lewis, R.S., Low, A., Masters, S.L., Willson, T.A., Kolesnik, T.B., Nicholson, S.E., Garrett, T.P., Norton, R.S., 2009, SPRY domain-containing SOCS box protein 2: crystal structure and residues critical for protein binding, Journal of Molecular Biology [P], vol 386, issue 3, Academic Press, UK, pp. 662-674.

MacRaild, C.A., Illesinghe, J., Van Lierop, B.J., Townsend, A.L., Chebib, M., Livett, B.G., Robinson, A.J., Norton, R.S., 2009, Structure and activity of (2,8)-dicarba-(3,12)-cystino alpha-ImI, an a-conotoxin containing a nonreducible cystine analogue, Journal of Medicinal Chemistry [P], vol 52, issue 3, ACS Publications, United States, pp. 755-762.

Khoo, K.K., Feng, Z., Smith, B.J., Zhang, M., Yoshikami, D., Olivera, B.M., Bulaj, G., Norton, R.S., 2009, Structure of the analgesic u-conotoxin KIIIA and effects on the structure and function of disulfide deletion, Biochemistry [P], vol 48, issue 6, ACS Publications, Washington DC USA, pp. 1210-1219.

Norton, R.S., 2009, Structures of sea anemone toxins, Toxicon : official journal of the International Society on Toxinology [P], vol 54, issue 8, Pergamon, Oxford UK, pp. 1075-1088.

Babon, J.J., Sabo, J.K., Zhang, J., Nicola, N.A., Norton, R.S., 2009, The SOCS box encodes a hierarchy of affinities for cullin5: Implications for ubiquitin ligase formation and cytokine signalling suppression, Journal of Molecular Biology [P], vol 387, issue 1, Academic Press, London UK, pp. 162-174.

Norton, R.S., McDonough, S.I., 2008, Peptides targeting voltage-gated calcium channels, Current Pharmaceutical Design [P], vol 14, issue 24, Bentham Science Publishers, Bassum Netherlands, pp. 2480-2491.

Zhang, X., Perugini, M.A., Yao, S., Adda, C.G., Murphy, V.J., Low, A., Anders, R.F., Norton, R.S., 2008, Solution conformation, backbone dynamics and lipid interactions of the intrinsically unstructured malaria surface protein MSP2, Journal of Molecular Biology [P], vol 379, issue 1, Academic Press, London UK, pp. 105-121.

Yao, S., Zhang, M., Yoshikami, D., Azam, L., Olivera, B.M., Bulaj, G., Norton, R.S., 2008, Structure, dynamics, and selectivity of the sodium channel blocker u-conotoxin SIIIA, Biochemistry [P], vol 47, issue 41, ACS Publications, Washington DC USA, pp. 10940-10949.

Beeton, C., Smith, B.J., Sabo, J.K., Crossley, G., Nugent, D., Khaytin, I., Chi, V., Chandy, G.K., Pennington, M.W., Norton, R.S., 2008, The D-diastereomer of ShK toxin selectively blocks voltage-gated K+ channels and inhibits T lymphocyte proliferation, Journal Of Biological Chemistry [P], vol 283, issue 2, American Society for Biochemistry and Molecular Biology, Bethesda MD USA, pp. 988-997.

Babon, J.J., Sabo, J.K., Soetopo, A., Yao, S., Bailey, M.F., Zhang, J., Nicola, N.A., Norton, R.S., 2008, The SOCS box domain of SOCS3: Structure and interaction with the elonginBC-cullin5 ubiquitin ligase, Journal of Molecular Biology [P], vol 381, issue 4, Academic Press, London UK, pp. 928-940.

Ellison, M., Feng, Z., Park, A.J., Zhang, X., Olivera, B.M., McIntosh, J.M., Norton, R.S., 2008, a-RgIA, a novel conotoxin that blocks the a9a10 nAChR: Structure and identification of key receptor-binding residues, Journal of Molecular Biology [P], vol 377, issue 4, Academic Press, London UK, pp. 1216-1227.

Kuang, Z., Yao, S., McNeil, K.A., Thompson, J.A., Bach, L.A., Forbes, B.E., Wallace, J.C., Norton, R.S., 2007, Cooperativity of the N- and C-terminal domains of insulin-like growth factor (IGF) binding protein 2 in IGF binding, Biochemistry [P], vol 46, issue 48, American Chemical Society, United States, pp. 13720-13732.

Chandrashekaran, I.R., Yao, S., Wang, C.C., Bansal, P.S., Alewood, P.F., Forbes, B., Wallace, J.C., Bach, L.A., Norton, R.S., 2007, The N-terminal subdomain of insulin-like growth factor (IGF) binding protein 6. Structure and interaction with IGFs, Biochemistry, vol 46, issue 11, American Chemical Society, USA, pp. 3065-3074.

Drechsler, A., Potrich, C., Jennifer, J., Frisanco, M., Guella, G., Serra, M., Anderluh, G., Separovic, F., Norton, R., 2006, Structure and activity of the N-terminal region of the eukaryotic cytolysin equinatoxin II, Biochemistry [P], vol 45, issue 6, American Chemical Society, United States, pp. 1818-1828.

Kuang, Z., Yao, S., Keizer, D.W., Wang, C.C., Bach, L.A., Forbes, B., Wallace, J.C., Norton, R.S., 2006, Structure, dynamics and heparin binding of the C-terminal domain of insulin-like growth factor-binding protein-2 (IGFBP-2), Journal of Molecular Biology, vol 364, issue 4, pp. 690-704.

Masters, S., Yao, S., Willson, T., Zhang, J., Palmer, K., Smith, B., Babon, J., Nicola, N., Norton, R., Nicholson, S., 2006, The SPRY domain of SSB-2 adopts a novel fold that presents conserved Par-4-binding residues, Nature Structural and Molecular Biology [E], vol 13, issue 1, Nature Publishing Group, United States, pp. 77-84.

Babon, J., McManus, E., Yao, S., De Souza, D.P., Mielke, L., Sprigg, N., Willson, T., Hilton, D., Nicola, N., Baca, M., Nicholson, S., Norton, R., 2006, The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability, Molecular Cell [P], vol 22, Cell Press, United States, pp. 205-216.

Lauth, X., Babon, J., Stannard, J., Singh, S., Nizet, V., Carlberg, J., Ostland, V., Pennington, M., Norton, R., Westerman, M., 2005, Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections, Journal Of Biological Chemistry [P], vol 280, issue 10, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 9272-9282.

Harris, K., Casey, J., Coley, A., Masciantonio, R., Sabo, J.K., Keizer, D., Lee, E., McMahon, A., Norton, R., Anders, R., Foley, M., 2005, Binding hot spot for invasion inhibitory molecules on Plasmodium falciparum apical membrane antigen 1, Infection And Immunity [P], vol 73, issue 10, American Society for Microbiology, United States, pp. 6981-6989.

Bach, L.A., Headey, S., Norton, R.S., 2005, IGF-binding proteins - The pieces are falling into place, Trends in Endocrinology and Metabolism, vol 16, issue 5, Elsevier Ltd., Trends Journal, UK, pp. 228-234.

Carrick, F., Hinds, M., McNeil, K., Wallace, J., Forbes, B., Norton, R., 2005, Interaction of insulin-like growth factor (IGF)-I and -II with IGF binding protein-2: mapping the binding surfaces by nuclear magnetic resonance, Journal of Molecular Endocrinology [P], vol 34, BioScientifica Ltd., United Kingdom, pp. 685-698.

Anderluh, G., Razpotnik, A., Podlesek, Z., Macek, P., Separovic, F., Norton, R., 2005, Interaction of the eukaryotic pore-forming cytolysin equinatoxin II with model membranes: 19F NMR studies, Journal of Molecular Biology [P], vol 347, issue 1, Academic Press, United Kingdom, pp. 27-39.

Yao, S., Masters, S., Zhang, J., Palmer, K., Nicola, N., Babon, J., Nicholson, S., Norton, R., 2005, Letter to the Editor: Backbone 1H, 13C and 15N assignments of the 25 kDa SPRY domain-containing SOCS box protein 2 (SSB-2) [4], Journal Of Biomolecular Nmr [P], vol 31, Springer Netherlands, Netherlands, pp. 69-70.

Bulaj, G., West, P., Garrett, J., Watkins, M., Zhang, M., Norton, R., Smith, B., Yoshikami, D., Olivera, B., 2005, Novel conotoxins from Conus striatus and Conus kinoshitai selectively block TTX-resistant sodium channels, Biochemistry [P], vol 44, issue 19, American Chemical Society, United States, pp. 7259-7265.

Babon, J., Yao, S., De Souza, D.P., Harrison, C., Fabri, L., Liepinsh, E., Scrofani, S., Baca, M., Norton, R., 2005, Secondary structure assignment of mouse SOCS3 by NMR defines the domain boundaries and identifies an unstructured insertion in the SH2 domain, Febs Journal [P], vol 272, issue 23, Wiley-Blackwell Publishing Ltd., United Kingdom, pp. 6120-6130.

Denley, A., Wang, C., McNeil, K., Walenkamp, M., Duyvenvoorde, H., Wit, J., Wallace, J., Norton, R., Karperien, M., Forbes, B., 2005, Structural and functional characteristics of the Val44Met insulin-like growth factor I missense mutation: correlation with effects on growth and development, Journal of Clinical Endocrinology and Metabolism [P], vol 19, issue 3, The Endocrine Society, United States, pp. 711-721.

Feng, Z., Keizer, D., Stevenson, R., Yao, S., Babon, J., Murphy, V., Anders, R., Norton, R., 2005, Structure and inter-domain interactions of domain II from the blood-stage malarial protein, apical membrane antigen 1, Journal of Molecular Biology [P], vol 350, issue 4, Academic Press, United Kingdom, pp. 641-656.

Fairlie, W., Uboldi, A., McCoubrie, J., Wang, C., Lee, E., Yao, S., De Souza, D.P., Mifsud, S., Metcalf, D., Nicola, N., Norton, R., Baca, M., 2004, Affinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling, Journal Of Biological Chemistry [P], vol 279, issue 3, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 2125-2134.

Headey, S., Keizer, D.W., Yao, S., Wallace, J.C., Bach, L.A., Norton, R.S., 2004, Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions, FEBS Letters [P], vol 568, issue 1, Elsevier BV, Netherlands, Denmark, pp. 19-22.

Headey, S., Keizer, D., Yao, S., Wallace, J., Bach, L., Norton, R., 2004, Binding site for the C-domain of insulin-like growth factor (IGF) binding protein-6 on IGF-II; implications for inhibition of IGF actions, FEBS Letters [P], vol 568, issue 1-3, Elsevier BV, Netherlands, pp. 19-22.

He, H., Shehan, P., Barnham, K., Norton, R., Shulkes, A., Baldwin, G., 2004, Biological activity and ferric ion binding of fragments of glycine-extended gastrin, Biochemistry [P], vol 43, issue 37, American Chemical Society, United States, pp. 11853-11861.

Headey, S., Keizer, D.W., Yao, S., Brasier, G., Kantharidis, P., Bach, L.A., Norton, R.S., 2004, C-terminal domain of Insulin-like Growth Factor (IGF) binding protein-6: Structure and interaction with IGF-II, Molecular Endocrinology [P], vol 18, issue 11, The Endocrine Society, United States, pp. 2740-2750.

Yao, S., Headey, S., Keizer, D.W., Bach, L.A., Norton, R.S., 2004, C-terminal domain of insulin-like growth factor (IGF) binding protein 6: conformational exchange and its correlation with IGF-II binding, Biochemistry [P], vol 43, issue 35, American Chemical Society, United States, pp. 11187-11195.

Yao, S., Headey, S., Keizer, D., Bach, L., Norton, R., 2004, C-terminal domain of insulin-like growth factor (IGF) binding protein 6: conformational exchange and its correlation with IGF-II binding, Biochemistry [P], vol 43, issue 35, American Chemical Society, United States, pp. 11187-11195.

Headey, S., Keizer, D., Yao, S., Brasier, G., Kantharidis, P., Bach, L., Norton, R., 2004, C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II, Molecular Endocrinology [P], vol 18, issue 11, The Endocrine Society, United States, pp. 2740-2750.

Headey, S., Leeding, K.S., Norton, R., Bach, L.A., 2004, Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding, Journal of Molecular Endocrinology [P], vol 33, issue 2, Society for Endocrinology, United Kingdom, pp. 377-386.

Headey, S., Leeding, K., Norton, R., Bach, L., 2004, Contributions of the N- and C-terminal domains of IGF binding protein-6 to IGF binding, Journal of Molecular Endocrinology [P], vol 33, issue 2, BioScientifica Ltd., United Kingdom, pp. 377-386.

Headey, S., Yao, S., Parker, N.J., Kantharidis, P., Bach, L.A., Norton, R., 2003, 1H, 13C and 15N resonance assignments of the C-terminal domain of insulin-like growth factor binding protein-6 (IGFBP-6), Journal Of Biomolecular Nmr [P], vol 25, issue 3, Springer Netherlands, Netherlands, pp. 251-252.

Pannequin, J., Kovac, S., Tantiongco, J., Norton, R., Shulkes, A., Barnham, K., Baldwin, G., 2003, A novel effect of bismuth ions: selective inhibition of the biological activity of glycine-extended gastrin, Journal Of Biological Chemistry [P], vol 279, issue 4, American Society for Biochemistry and Molecular Biology, Inc., United States, pp. 2453-2460.

Barnham, K.J., McKinstry, W.J., Multhaup, G., Galatis, D., Morton, C.J., Curtain, C.C., Williamson, N.A., White, A.R., Hinds, M.G., Norton, R.S., Beyreuther, K., Masters, C.L., Parker, M.W., Cappai, R., 2003, Structure of the Alzheimer's disease amyloid precursor protein copper binding domain, The Journal of Biological Chemistry, vol 278, issue 19, The American Society for Biochemistry and Molecular Biology, USA, pp. 17401-17407.

Curtain, C.C., Ali, F., Volitakis, I., Cherny, R.A., Norton, R.S., Beyreuther, K., Barrow, C.J., Masters, C.L., Bush, A.I., Barnham, K.J., 2001, Alzheimer's disease amyloid- binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits, The Journal of Biological Chemistry, vol 276, issue 23, American Society for Biochemistry and Molecular Biology, Inc., USA, pp. 20466-20473.

Norton, R.S., 1985, 1H nuclear magnetic resonance study of metronidazole metabolism by perfused rat liver, European Journal of Drug Metabolism and Pharmacokinetics [P], vol 10, issue 3, Springer, Paris France, pp. 253-260.

Norton, R.S., 1977, Studies of individual carbon sites of hen egg white lysozyme by natural abundance carbon 13 nuclear magnetic resonance spectroscopy. Assignment of the nonprotonated aromatic carbon resonances to specific residues in the sequence, Journal of Biological Chemistry [P], vol 252, issue 5, American Society for Biochemistry and Molecular Biology, Inc, Bethesda MD USA, pp. 1786-1794.

Conference Proceedings

D'Cruz, A., Linossi, E., Babon, J., Norton, R., Nicola, N., Nicholson, S., 2011, Redefining the SPRY/B30.2 domain and investigating its binding specificities, PS_002. Redefining the SPRY/B30.2 domain and investigating its binding specificities, 09 October 2011 to 12 October 2011, ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD, ENGLAND, p. 64.

Other

Norton, R., Babon, J., Nicholson, S., Nicola, N., McManus, E., Baca, M., Yao, S., 2009, Structure of SOCS and uses thereof - USA, United States.

Teaching Commitment

Bachelor of Pharmaceutical Science teaching

  • PSC3181 - Spectroscopy
  • PSC3182 - Research project

Activities

Affiliations with institutes

Medicinal Chemistry and Drug Action
Monash Institute of Pharmaceutical Sciences

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Design, synthesis and biological evaluation of Conotoxins peptidomimetics.
Supervisors:
Norton, R (Main), Chalmers, D (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Enhancing the efficacy of the malaria vaccine candidate MSP2 through protein engineering and lipid interactions.
Supervisors:
Norton, R (Main), Macraild, C (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Identification, expression and characterization of novel conotoxins.
Supervisors:
Norton, R (Main), Bunnett, N (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
New Peptides from Australian Sea Anemones.
Supervisors:
Norton, R (Main), Thompson, P (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
New malaria vaccine candidates based on merozoite surface protein 2.
Supervisors:
Norton, R (Main), Macraild, C (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Peptide toxins: structure, stability and engineering.
Supervisors:
Norton, R (Main), Morales, R (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Small Molecule Inhibitors of AMA1/RON2 Interaction as New Antimalarial Agents.
Supervisors:
Norton, R (Main), Macraild, C (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
The malaria surface antigen AMA1: a novel drug target.
Supervisors:
Scammells, P (Main), Norton, R (Associate), Shane, D (Associate).

Completed Supervision

Student:
Bankala, K.
Program of Study:
High-resolution NMR studies of malaria proteins as a basis for designing better drugs and vaccines. (PHD) 2016.
Supervisors:
Norton, R (Main), Scammells, P (Associate).
Student:
Chang, J.
Program of Study:
Novel potassium channel blockers for the treatment of multiple sclerosis and other autoimmune diseases. (PHD) 2014.
Supervisors:
Norton, R (Main).
Student:
Green, B.
Program of Study:
Structural and functional characterisation of peptide inhibitors of voltage-gated sodium channels from piscivorous cone snails. (PHD) 2016.
Supervisors:
Norton, R (Main), Scanlon, M (Associate).
Student:
Lim, S.
Program of Study:
Ligands for the malaria apical membrane antigen 1 as inhibitors of parasite invasion of host erythrocytes: screening, structure and dynamics. (PHD) 2014.
Supervisors:
Norton, R (Main), Scammells, P (Associate).
Student:
Robinson, S.
Program of Study:
Peptides from the venomous marine snail Conus victoriae: identification, characterisation and potential applications. (PHD) 2014.
Supervisors:
Norton, R (Main).
Student:
Yap, B.
Program of Study:
Inhibitors of SPSB-iNOS interactions as a potential novel class of anti-infectives. (PHD) 2016.
Supervisors:
Norton, R (Main), Baell, J (Associate).