Professor Jonathan Baell - Researcher Profile

Jonathan Baell

Address

Medicinal Chemistry
Faculty of Pharmacy and Pharmaceutical Sciences

Biography

Position

Larkins Fellow
NHMRC Senior Research Fellow
Medicinal Chemistry, Monash Institute of Pharmaceutical Sciences

Related Links:

Research & Supervision Interests

    • Molecular design
    • Peptidomimetics
    • Small molecule screening libraries and chemoinformatics
    • Hit-to-lead and lead optimisation medicinal chemistry
    • Drug discovery in infectious disease (particularly neglected diseases including malaria) and epigenetic modulation associated with cancer
    • Pre-clinical development of new drug candidates

Qualifications

DOCTOR OF PHILOSOPHY
Institution: Univeristy of Melbourne
Year awarded: 1992
DOCTORATE OF ORGANIC CHEMISTRY
Institution: University of Melbourne
Year awarded: 1992
BSC W/ HONORS
Institution: University of Tasmania
Year awarded: 1986

Publications

Journal Articles

Rahmani, R.S., Ban, K., Jones, A.J., Ferrins, L., Ganame, D., Sykes, M.L., Avery, V.M., White, K.L., Ryan, E., Kaiser, M., Charman, S.A., Baell, J.B., 2015, 6-Arylpyrazine-2-carboxamides: a new core for Trypanosoma brucei inhibitors, Journal of Medicinal Chemistry [P], vol 58, issue 17, ACS Publications, Washington DC USA, pp. 6753-6765.

Amani, P., Sneyd, T., Preston, S., Young, N.D., Mason, L., Bailey, U., Baell, J.B., Camp, D.G., Gasser, R.B., Gorse, A., Taylor, P.R., Hofmann, A., 2015, A practical Java tool for small-molecule compound appraisal, Journal of Cheminformatics [E], vol 7, Chemistry Central, London UK, pp. 1-4.

Baker, M.A., Weinberg, A.S., Hetherington, L., Villaverde, A., Velkov, T., Baell, J.B., Gordon, C.P., 2015, Defining the mechanisms by which the reactive oxygen species by-product, 4-hydroxynonenal, affects human sperm cell function, Biology Of Reproduction [P], vol 92, issue 4, Society for the Study of Reproduction, Madison WI USA, pp. 1-10.

Preston, S., Jabbar, A., Nowell, C.J., Joachim, A., Ruttkowski, B., Baell, J.B., Cardno, T., Korhonen, P.K., Piedrafita, D.M., Ansell, B.R.E., Jex, A.R., Hofmann, A., Gasser, R.B., 2015, Low cost whole-organism screening of compounds for anthelmintic activity, International Journal for Parasitology [P], vol 45, issue 5, Elsevier, Camden London UK, pp. 333-343.

Devine, S., Mulcair, M., Debono, C., Leung, E.W.W., Nissink, J.W.M., Lim, S.S., Chandrashekaran, I.R., Vazirani, M., Mohanty, B., Simpson, J.S., Baell, J.B., Scammells, P.J., Norton, R.S., Scanlon, M., 2015, Promiscuous 2-aminothiazoles (PrATs): a frequent hitting scaffold, Journal of Medicinal Chemistry [P], vol 58, issue 3, ACS Publications, Washington DC USA, pp. 1205-1214.

Priebbenow, D., Gable, R.W., Baell, J.B., 2015, Regio- and stereoselective iodoacyloxylations of alkynes, Journal Of Organic Chemistry [P], vol 80, issue 9, ACS Publications, Washington DC USA, pp. 4412-4418.

Baell, J.B., 2015, Screening-based translation of public research encounters painful problems, A C S Medicinal Chemistry Letters [E], vol 6, issue 3, ACS Publications, Washington DC USA, pp. 229-234.

Manos-Turvey, A., Watson, E.E., Sykes, M.L., Jones, A.J., Baell, J.B., Kaiser, M., Avery, V.M., Payne, R.J., 2015, Synthesis and evaluation of phenoxymethylbenzamide analogues as anti-trypanosomal agents, MedChemComm [P], vol 6, issue 3, RSC Publishing, Cambridge UK, pp. 403-406.

Leung, E.W.W., Yagi, H., Harjani, J.R., Mulcair, M., Scanlon, M., Baell, J.B., Norton, R.S., 2014, 19F NMR as a probe of ligand interactions with the iNOS binding site of SPRY domain-containing SOCS box protein 2, Chemical Biology and Drug Design [P], vol 84, issue 5, Wiley-Blackwell Publishing Inc., Hoboken NJ USA, pp. 616-625.

Harjani, J.R., Tang, A.X., Norton, R.S., Baell, J.B., 2014, A new methodology for the synthesis of 3-amino-1H-indole-2-carboxylates, Tetrahedron [P], vol 70, issue 43, Pergamon Press, Oxford UK, pp. 8047-8055.

Lackovic, K.P., Lessene, G., Falk, H., Leuchowius, K., Baell, J.B., Street, I.P., 2014, A perspective on 10-years HTS experience at the Walter and Eliza Hall Institute of Medical Research-eighteen million assays and counting, Combinatorial Chemistry and High Throughput Screening [P], vol 17, issue 3, Bentham Science Publishers Ltd, Bussum Netherlands, pp. 241-252.

Baell, J.B., Walters, M.A., 2014, Chemical con artists foil drug discovery, Nature [P], vol 513, issue 7519, Nature Publishing Group, London UK, pp. 481-483.

Brady, R., Vom, A., Roy, M.J., Toovey, N., Smith, B.J., Moss, R.M., Hatzis, E., Huang, D.C., Parisot, J.P., Yang, H., Street, I.P., Colman, P.M., Czabotar, P.E., Baell, J.B., Lessene, G., 2014, De-novo designed library of benzoylureas as inhibitors of BCL-XL: Synthesis, structural and biochemical characterization, Journal of Medicinal Chemistry [P], vol 57, issue 4, American Chemical Society, Washington DC USA, pp. 1323-1343.

Rashad, A.A., Jones, A.J., Avery, V.M., Baell, J.B., Keller, P.A., 2014, Facile synthesis and preliminary structure-activity analysis of new sulfonamides against Trypanosoma brucei, A C S Medicinal Chemistry Letters [E], vol 5, issue 5, American Chemical Society, Washington DC USA, pp. 496-500.

Callaghan, B., Kosari, S., Pustovit, R.V., Sartor, D.M., Ferens, D.M., Ban, K., Baell, J.B., Nguyen, T.V., Rivera, L.R., Brock, J.A., Furness, J.B., 2014, Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor, British Journal of Pharmacology [P], vol 171, issue 5, John Wiley & Sons Ltd, Chichester UK, pp. 1275-1286.

Ferrins, L., Gazdik, M., Rahmani, R.S., Varghese, S., Sykes, M.L., Jones, A.J., Avery, V.M., White, K.L., Ryan, E., Charman, S.A., Kaiser, M., Bergstrom, C.A.S., Baell, J.B., 2014, Pyridyl benzamides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, Journal of Medicinal Chemistry [P], vol 57, issue 15, American Chemical Society, Washington DC USA, pp. 6393-6402.

Dennis, M., Chhabra, S., Wang, Z., Debono, A.J., Dolezal, O., Newman, J., Pitcher, N., Rahmani, R.S., Cleary, B., Barlow, N., Hattarki, M., Graham, B., Peat, T.S., Baell, J.B., Swarbrick, J.D., 2014, Structure-based design and development of functionalized mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus, Journal of Medicinal Chemistry [P], vol 57, issue 22, American Chemical Society, Washington DC USA, pp. 9612-9626.

Koehler, M.F.T., Bergeron, P., Choo, E.F., Lau, K., Ndubaku, C.O., Dudley, D.A., Gibbons, P., Sleebs, B., Rye, C.S., Nikolakopoulos, G., Bui, C.T., Kulasegaram, S., Kersten, W.J.A., Smith, B.J., Czabotar, P.E., Colman, P.M., Huang, D.C., Baell, J.B., Watson, K.G., Hasvold, L., Tao, Z., Wang, L., Souers, A.J., Elmore, S.W., Flygare, J.A., Fairbrother, W.J., Lessene, G., 2014, Structure-guided rescaffolding of selective antagonists of BCL-XL, A C S Medicinal Chemistry Letters [E], vol 5, issue 8, American Chemical Society, Washington DC USA, pp. 662-667.

Ferrins, L., Rahmani, R.S., Sykes, M.L., Jones, A.J., Avery, V.M., Teston, E., Almohaywi, B., Yin, J., Smith, J., Chris, H., White, K.L., Ryan, E., Campbell, M., Charman, S.A., Kaiser, M., Baell, J.B., 2013, 3-(Oxazolo[4,5-b]pyridin-2-yl)anilides as a novel class of potent inhibitors for the kinetoplastid Trypanosoma brucei, the causative agent for human African trypanosomiasis, European Journal of Medicinal Chemistry [P], vol 66, Elsevier, Issy les Moulineaux France, pp. 450-465.

Baell, J.B., Congreve, M., Leeson, P., Abad-Zapatero, C., 2013, Ask the experts: Past, present and future of the rule of five, Future Medicinal Chemistry [P], vol 5, issue 7, Future Science Ltd., London UK, pp. 745-752.

Baell, J.B., 2013, Broad coverage of commercially available lead-like screening space with fewer than 350,000 compounds, Journal Of Chemical Information And Modeling [P], vol 53, issue 1, ACS Publications, Washington DC USA, pp. 39-55.

Brady, R., Zhang, M., Gable, R.W., Norton, R.S., Baell, J.B., 2013, De novo design and synthesis of a mu-conotoxin KIIIA peptidomimetic, Bioorganic & Medicinal Chemistry Letters [P], vol 23, issue 17, Pergamon-Elsevier, Oxford UK, pp. 4892-4895.

Sleebs, B., Kersten, W.J.A., Kulasegaram, S., Nikolakopoulos, G., Hatzis, E., Moss, R.M., Parisot, J.P., Yang, H., Czabotar, P.E., Fairlie, W.D., Lee, E.F., Adams, J.M., Chen, L., van Delft, M.F., Lowes, K.N., Wei, A., Huang, D.C., Colman, P.M., Street, I.P., Baell, J.B., Watson, K.G., Lessene, G., 2013, Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL, Journal of Medicinal Chemistry [P], vol 56, issue 13, ACS Publications, United States, pp. 5514-5540.

Ferrins, L., Rahmani, R.S., Baell, J.B., 2013, Drug discovery and human African trypanosomiasis: A disease less neglected?, Future Medicinal Chemistry [P], vol 5, issue 15, Future Science, London UK, pp. 1801-1841.

Avery, V.M., Buckner, F.S., Baell, J.B., Fairlamb, A.H., Michels, P., Tarleton, R.L., 2013, Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease, Future Medicinal Chemistry [P], vol 5, issue 15, Future Science Ltd, London UK, pp. 1709-1718.

Li, R., Doherty, J., Antonipillai, J., Chen, S., Devlin, M.G., Visser, K., Baell, J.B., Street, I.P., Anderson, R., Bernard, O., 2013, LIM kinase inhibition reduces breast cancer growth and invasiveness but systemic inhibition does not reduce metastasis in mice, Clinical and Experimental Metastasis [P], vol 30, issue 4, Springer, Netherlands, pp. 483-495.

Teguh, S., Klonis, N., Duffy, S., Lucantoni, L., Avery, V.M., Hutton, C.A., Baell, J.B., Tilley, L., 2013, Novel conjugated quinoline-indoles compromise Plasmodium falciparum mitochondrial function and show promising antimalarial activity, Journal of Medicinal Chemistry [P], vol 56, issue 15, ACS Publications, Washington DC USA, pp. 6200-6215.

Baell, J.B., Ferrins, L., Falk, H., Nikolakopoulos, G., 2013, PAINS: Relevance to tool compound discovery and fragment-based screening, Australian Journal of Chemistry [E], vol 66, issue 12, CSIRO Publishing, Collingwood Vic Australia, pp. 1483-1494.

Brady, R., Baell, J.B., Norton, R.S., 2013, Strategies for the development of conotoxins as new therapeutic leads, Marine Drugs [P], vol 11, issue 7, MDPI AG, Basel Switzerland, pp. 2293-2313.

Dror, R., Green, H.F., Valant, C., Borhani, D.W., Valcourt, J.R., Pan, A.C., Arlow, D.H., Canals, M., Lane, J.R.D., Rahmani, R.S., Baell, J.B., Sexton, P., Christopoulos, A., Shaw, D.E., 2013, Structural basis for modulation of a G-protein-coupled receptor by allosteric drugs, Nature [P], vol 503, issue 7475, Nature Publishing Group (NPG), London UK, pp. 295-299.

Lessene, G., Czabotar, P.E., Sleebs, B., Zobel, K., Lowes, K., Adams, J.M., Baell, J.B., Colman, P.M., Deshayes, K., Fairbrother, W.J., Flygare, J.A., Gibbons, P., Kersten, W.J.A., Kulasegaram, S., Moss, R.M., Parisot, J.P., Smith, B.J., Street, I.P., Yang, H., Huang, D.C., Watson, K.G., 2013, Structure-guided design of a selective BCL-XL inhibitor, Nature Chemical Biology [P], vol 9, issue 6, Nature Publishing Group (NPG), New York NY USA, pp. 390-400.

Taboureau, O., Baell, J.B., Fernandez-Recio, J., Villoutreix, B.O., 2012, Established and emerging trends in computational drug discovery in the structural genomics era, Chemistry and Biology [P], vol 19, issue 1, Cell Press, Cambridge, Massachusetts USA, pp. 29-41.

Sykes, M.L., Baell, J.B., Kaiser, M., Chatelain, E., Moawad, S.R., Ganame, D., Ioset, J.R., Avery, V.M., 2012, Identification of compounds with anti-proliferative activity against Trypanosoma brucei brucei strain 427 by a whole cell viability based HTS campaign, Public Library of science: Neglected Tropical Diseases [P], vol 6, issue 11, Public Library of Science, San Francisco, California USA, pp. 1-14.

Tranberg, C., Yang, A., Vetter, I., McArthur, J.R., Baell, J.B., Lewis, R.J., Tuck, K.L., Duggan, P., 2012, Omega-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca v2.2 ion channels, Marine Drugs [P], vol 10, issue 10, MDPI AG, Basel, Switzerland, pp. 2349-2368.

Callaghan, B., Hunne, B., Hirayama, H., Sartor, D.M., Nguyen, T.V., Abogadie, F.C., Ferens, D.M., McIntyre, P.B., Ban, K., Baell, J.B., Furness, J.B., Brock, J.A., 2012, Sites of action of ghrelin receptor ligands in cardiovascular control, American Journal Of Physiology-Heart And Circulatory Physiology [P], vol 303, issue 8, American Physiological Society, Bethesda, Maryland USA, pp. 1011-1021.

Hatzis, E., Brady, R., Connor, T., Street, I.P., Baell, J.B., Lessene, G., 2012, Synthesis of conformationally constrained benzoylureas as BH3-mimetics, Organic & Biomolecular Chemistry [P], vol 10, RSC Publishing, UK, pp. 5230-5237.

Brady, R., Hatzis, E., Connor, T., Street, I.P., Baell, J.B., Lessene, G., 2012, Synthesis of conformationally constrained benzoylureas as BH3-mimetics, Organic & Biomolecular Chemistry [P], vol 10, issue 27, RSC Publishing, Cambridge, England, pp. 5230-5237.

Falk, H., Connor, T., Yang, H., Loft, K.J., Alcindor, J.L., Nikolakopoulos, G., Surjadi, R.N., Bentley, J.D., Hattarki, M., Dolezal, O., Murphy, J.M., Monahan, B., Peat, T., Thomas, T., Baell, J.B., Parisot, J.P., Street, I.P., 2011, An efficient high-throughput screening method for MYST family acetyltransferases, a new class of epigenetic drug targets, Journal of Biomolecular Screening [P], vol 16, issue 10, SAGE Publications Ltd, Thousand Oaks, California USA, pp. 1196-1205.

Brady, R., Khakham, Y., Lessene, G., Baell, J.B., 2011, Benzoylureas as removable cis amide inducers: Synthesis of cyclic amides via ring closing metathesis (RCM), Organic & Biomolecular Chemistry [P], vol 9, issue 3, RSC Publishing, Cambridge, England, pp. 656-658.

Sleebs, B., Ganame, D., Levit, A., Street, I., Gregg, A., Falk, H., Baell, J., 2011, Development of substituted 7-phenyl-4-aminobenzothieno[3,2-d] pyrimidines as potent LIMK1 inhibitors, MedChemComm [P], vol 2, RSC Publishing, England, pp. 982-986.

Sleebs, B., Levit, A., Street, I.P., Falk, H., Hammonds, T.R., Wong, A., Charles, M.D., Olson, M.F., Baell, J.B., 2011, Identification of 3-aminothieno[2,3-b]pyridine-2-carboxamides and 4-aminobenzothieno[3,2-d]pyrimidines as LIMK1 inhibitors, MedChemComm [P], vol 2, issue 10, RSC Publishing, Cambridge, England, pp. 977-981.

Sleebs, B., Nikolakopoulos, G., Street, I.P., Falk, H., Baell, J.B., 2011, Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors, Bioorganic & Medicinal Chemistry Letters [P], vol 21, issue 19, Pergamon-Elsevier, Oxford, England, pp. 5992-5994.

Saubern, S., Guha, R., Baell, J.B., 2011, KNIME workflow to assess PAINS filters in SMARTS format. Comparison of RDKit and indigo cheminformatics libraries, Molecular Informatics [P], vol 30, issue 10, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany, pp. 847-850.

Sleebs, B., Czabotar, P.E., Fairbrother, W.J., Fairlie, W.D., Flygare, J.A., Huang, D.C., Kersten, W.J.A., Koehler, M.F.T., Lessene, G., Lowes, K.N., Parisot, J.P., Smith, B.J., Smith, M.L., Souers, A.J., Street, I.P., Yang, H., Baell, J.B., 2011, Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity, Journal of Medicinal Chemistry [P], vol 54, issue 6, ACS Publications, Washington DC, USA, pp. 1914-1926.

Baell, J.B., 2011, Redox-active nuisance screening compounds and their classification, Drug Discovery Today [P], vol 16, issue 17, Elsevier, Oxford, England, pp. 840-841.

Lagorce, D., Maupetit, J., Baell, J.B., Sperandio, O., Tuffery, P., Miteva, M.A., Galons, H., Villoutreix, B.O., 2011, The FAF-Drugs2 server: A multistep engine to prepare electronic chemical compound collections, Bioinformatics [P], vol 27, issue 14, Oxford University Press, Oxford, England, pp. 2018-2020.

Ban, K., Duffy, S., Khakham, Y., Avery, V., Hughes, A., Montagnat, O., Katneni, K., Ryan, E., Baell, J., 2010, 3-Alkylthio-1,2,4-triazine dimers with potent antimalarial activity, Bioorganic & Medicinal Chemistry Letters [P], vol 20, issue 20, Pergamon, United Kingdom, pp. 6024-6029.

Nhu, D.Q., Duffy, S., Avery, V.M., Hughes, A.B., Baell, J.B., 2010, Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines, Bioorganic & Medicinal Chemistry Letters [P], vol 20, issue 15, Pergamon-Elsevier, Oxford, England, pp. 4496-4498.

Sleebs, B., Street, I.P., Bu, X., Baell, J.B., 2010, De novo synthesis of a potent LIMK1 inhibitor, Synthesis-Stuttgart [P], vol 7, Georg Thieme, Stuttgart, Germany, pp. 1091-1096.

Holloway, G.A., Parisot, J.P., Novello, P.M., Watson, K.G., Armstrong, T., Thompson, R.C.A., Street, I.P., Baell, J.B., 2010, Discovery of novel and potent benzhydryl-tropane trypanocides highly selective for Trypanosoma cruzi, Bioorganic & Medicinal Chemistry Letters [P], vol 20, issue 6, Pergamon-Elsevier, Oxford, England, pp. 1816-1818.

Lackovic, K.P., Parisot, J.P., Sleebs, N., Baell, J.B., Debien, L., Watson, K.G., Curtis, J., Handman, E., Street, I.P., Kedzierski, L., 2010, Inhibitors of Leishmania GDP-mannose pyrophosphorylase identified by high-throughput screening of small-molecule chemical library, Antimicrobial Agents And Chemotherapy [P], vol 54, issue 5, American Society for Microbiology, Washington DC, USA, pp. 1712-1719.

Baell, J.B., Holloway, G.A., 2010, New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays, Journal of Medicinal Chemistry [P], vol 53, issue 7, ACS Publications, Washington DC, USA, pp. 2719-2740.

Baell, J.B., 2010, Observations on screening-based research and some concerning trends in the literature, Future Medicinal Chemistry [P], vol 2, issue 10, Future Science, London, England, pp. 1529-1546.

Lessene, G., Smith, B.J., Gable, R.W., Baell, J.B., 2009, Characterization of the two fundamental conformations of benzoylureas and elucidation of the factors that facilitate their conformational interchange, Journal Of Organic Chemistry [P], vol 74, issue 17, ACS Publications, Washington DC, USA, pp. 6511-6525.

Pietersz, G.A., Mottram, P.L., van de Velde, N.C., Sardjono, C.T., Esparon, S.E., Ramsland, P.A., Moloney, G., Baell, J.B., McCarthy, T.D., Matthews, B.R., Powell, M., Hogarth, P.M., 2009, Inhibition of destructive autoimmune arthritis in FcgRIIa transgenic mice by small chemical entities, Immunology And Cell Biology [P], vol 87, issue 1, Nature Publishing Group (NPG), New York, USA, pp. 3-12.

Andersson, A., Baell, J.B., Duggan, P., Graham, J.E., Lewis, R.J., Lumsden, N.G., Tranberg, C., Tuck, K.L., Yang, A., 2009, Omega-Conotoxin GVIA mimetics based on an anthranilamide core: Effect of variation in ammonium side chain lengths and incorporation of fluorine, Bioorganic & Medicinal Chemistry [P], vol 17, Elsevier, UK, pp. 6659-6670.

Holloway, G.A., Charman, W.N., Fairlamb, A.H., Brun, R., Kaiser, M., Kostewicz, E.S., Novello, P.M., Parisot, J.P., Richardson, J., Street, I.P., Watson, K.G., Baell, J.B., 2009, Trypanothione reductase high-throughput screening campaign identifies novel classes of inhibitors with antiparasitic activity, Antimicrobial Agents And Chemotherapy [P], vol 53, issue 7, American Society for Microbiology, USA, pp. 2824-2833.

Cianci, J., Baell, J.B., Flynn, B.L., Gable, R.W., Mould, J., Paul, D., Harvey, A.J., 2008, Synthesis and Biological Evaluation of Chalcones as Inhibitors of the Voltage-Gated Potassium Channel Kv1.3, Bioorganic & Medicinal Chemistry Letters [P], vol 18, issue 6, Pergamon, UK, pp. 2055-2061.

Holloway, G.A., Baell, J.B., Fairlamb, A.H., Novello, P.M., Parisot, J.P., Richardson, J., Watson, K.G., Street, I.P., 2007, Discovery of 2-iminobenzimidazoles as a new class of trypanothione reductase inhibitor by high-throughput screening, Bioorganic & Medicinal Chemistry Letters [P], vol 17, issue 5, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 1422-1427.

Nguyen, T.V., Matsuyama, H., Baell, J.B., Hunne, B.L., Fowler, C.J., Smith, J.E., Nurgali, K., Furness, J.B., 2007, Effects of compounds that influence I K (KCNN4) channels on afterhyperpolarizing potentials, and determination of I K channel sequence, in guinea pig enteric neurons, Journal Of Neurophysiology [P], vol 97, issue 3, American Physiological Society, Bethesda, Maryland USA, pp. 2024-2031.

Ferens, D.M., Baell, J.B., Lessene, G., Smith, J.E., Furness, J.B., 2007, Effects of modulators of Ca 2+-activated, intermediate- conductance potassium channels on motility of the rat small intestine, in vivo, Neurogastroenterology and Motility [P], vol 19, issue 5, Wiley-Blackwell, Malden, Massachusetts USA, pp. 383-389.

Cianci, J., Baell, J.B., Harvey, A.J., 2007, Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-a,a-disubstituted amino acids, Tetrahedron Letters [P], vol 48, issue 34, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 5973-5975.

Hirokawa, Y., Levitzki, A., Lessene, G., Baell, J.B., Xiao, Y., Zhu, H., Maruta, H., 2007, Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors), Cancer Letters [P], vol 245, issue 1, Elsevier Ireland Ltd, Clare, Ireland, pp. 242-251.

Rye, C.S., Baell, J.B., Street, I.P., 2007, Synthesis, reactivity and applications of 1-fluoroalkyl carboxylates: novel synthetic substrates for esterases and lipases, Tetrahedron [P], vol 63, issue 16, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 3306-3311.

Harvey, A.J., Baell, J.B., Toovey, N., Homerick, D., Wulff, H., 2006, A new class of blockers of the voltage-gated potassium channel Kv1.3 via modification of the 4- or 7-position of khellinone, Journal of Medicinal Chemistry [P], vol 49, issue 4, American Chemical Society, Washington DC, USA, pp. 1433-1441.

Baell, J.B., Duggan, P.J., Forsyth, S.A., Lewis, R.J., Lok, Y.P., Schroeder, C.I., Shepherd, N.E., 2006, Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of -conotoxin GVIA, Tetrahedron, vol 62, issue 31, Elsevier Ltd, UK, pp. 7284-7292.

Harvey, A.J., Gable, R.W., Baell, J.B., 2005, A three-residue, continuous binding epitope peptidomimetic of ShK toxin as a Kv1.3 inhibitor, Bioorganic & Medicinal Chemistry Letters [P], vol 15, issue 13, Pergamon-Elsevier Science Ltd, Oxford, England, pp. 3193-3196.

Baell, J.B., Duggan, P.J., Forsyth, S.A., Lewis, R.J., Lok, Y.P., Schroeder, C.I., 2004, Synthesis and biological evaluation of nonpeptide mimetics of w-conotoxin GVIA, Bioorganic & Medicinal Chemistry, vol 12, Pergamon-Elsevier Science Ltd, Oxford England, pp. 4025-4037.

Baell, J.B., Duggan, P.J., Lok, Y.P., 2004, w-conotoxins and approaches to their non-peptide mimetics, Australian Journal of Chemistry, vol 57, CSIRO Publishing, Collingwood Vic Australia, pp. 179-185.

Patel, O., Satchell, J., Baell, J.B., Fernley, R., Coloe, P., Macreadie, I., 2003, Inhibition studies of sulfonamide-containing folate analogs in yeast, Microbial Drug Resistance, vol 9, issue 2, Mary Ann Liebert Inc., New Rochelle USA, pp. 139-145.

Baell, J.B., Duggan, P.J., Fallon, G.D., Lok, Y.P., 2003, Methyl (RS)-[1-hydroxy-1-(3-nitrophenyl)-3-oxo-1,3-dihydroisoindol-2-yl]acetate, Acta Crystallographica Section E, vol 59, Munksgaard International Publishers Ltd, Copenhagen Denmark, pp. 1958-1959.

Other

Flynn, B.L., Baell, J.B., Chaplin, J.H., Gurmit, G.S., Grobelny, D., Harvey, A.J., Mould, J., Paul, D., 2009, Novel Aryl Potassium Channel Blockers and Uses Thereof, Worldwide.

Harvey, A.J., Flynn, B.L., Mould, J., Paul, D., Gurmit, G.S., Ripper, J.A., Cooke, R.C., Crossman, J.S., Baell, J.B., Kuchel, N.W., Singh, R., 2009, Novel Potassium Channel Blockers and Uses Thereof, Worldwide.

Baell, J.B., Sleebs, B., Flynn, B.L., Street, I.P., Quazi, N., Bui, C.T., 2008, Novel Anxiolytic Compounds, Worldwide.

Flynn, B.L., Baell, J.B., Harvey, A.J., Chaplin, J.H., Paul, D., Mould, J., 2008, Novel Benzofuran Potassium Channel Blockers and Uses Thereof, Worldwide.

Flynn, B.L., Baell, J.B., Harvey, A.J., Chaplin, J.H., Paul, D., Mould, J., 2008, Novel Chromenone Potassium Channel Blockers and Uses Thereof, Worldwide.

Postgraduate Research Supervisions

Current Supervision

Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
3-aminopyridines for the treatment of Chagas Disease and as potential anti-fungal agents.
Supervisors:
Baell, J (Main), Harjani, J (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Characterization and synthesis of isolated anticancer and antioxidant agent from Honeybee propolis collected around Monash..
Supervisors:
Baell, J (Main), Rahmani, R (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Fluorinated ligands of the tyrosine kinase, MGRTK, as diagnostic radiotracers of multiple sclerosis pathogenicity.
Supervisors:
Baell, J (Main), Scanlon, M (Associate).
Program of Study:
(MASTER'S BY RESEARCH).
Thesis Title:
Investigation into a new compound class for the treatment of human African trypanosomiasis.
Supervisors:
Baell, J (Main), Priebbenow, D (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigation into new compound classes for the treatment of human African trypanosomiasis.
Supervisors:
Baell, J (Main), Johnson, S (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Investigation of oxadiazoles as a novel treatment against pathogenic Clostridium difficile.
Supervisors:
Baell, J (Main), Carter, G (Associate), Rahmani, R (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
Novel compounds for anti-cancer Clostridium Directed Enzyme Prodrug Therapy.
Supervisors:
Baell, J (Main), Carter, G (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
SAR optimisation of potent anti-wolbachia compounds.
Supervisors:
Baell, J (Main), Nguyen, H (Associate).
Program of Study:
(DOCTORATE BY RESEARCH).
Thesis Title:
The Development of New Treatments for Multi-Drug Resistant Tuberculosis.
Supervisors:
Baell, J (Main), Priebbenow, D (Associate).

Completed Supervision

Student:
Cleary, B.
Program of Study:
Design and synthesis of novel small molecule inhibitors of MYST proteins. (PHD) 2016.
Supervisors:
Baell, J (Main), Thompson, P (Associate).
Student:
Ferrins, L.
Program of Study:
Novel heterocyclic inhibitors for Human African Trypanosomiasis. (PHD) 2015.
Supervisors:
Baell, J (Main), Simpson, J (Associate).
Student:
Yap, B.
Program of Study:
Inhibitors of SPSB-iNOS interactions as a potential novel class of anti-infectives. (PHD) 2016.
Supervisors:
Norton, R (Main), Baell, J (Associate).