Molecular Pharmacology of G Protein-Coupled Receptors 2010 meeting

Wednesday 1 December - conjoint symposium

Attendees of the Molecular Pharmacology of G Protein-Coupled Receptors 2010 meeting are invited to attend a conjoint symposium on Molecular Modelling of GPCRs. More details can be found on the MMGPCR program.

Thursday 2 December - Day 1

Session and ChairSponsorTimeSpeakers/event
Registration 1-4 pm 
Technology Workshops 








GPCR signalling - measuring complexity with label-free detection. [2.4 mb, .pdf]
Dr. Richard Eglen, President of Biodiscovery (PerkinElmer, Waltham, USA).

BMG Technology

"Resonance Energy Transfer technologies to study GPCRs."

Associate Professor Kevin Pfleger (Western Australian Institute for Medical Research): Bioluminescence resonance energy transfer.

Dr Mohammed Akli Ayoub (Western Australian Institute for Medical Research): Time-resolved FRET.

Welcome 4-4.10pm

Patrick Sexton, Arthur Christopoulos, Roger Summers.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences.

Session 1

Plenary lecture
Chair: Patrick Sexton

Sponsored by:



Rob Parton University of Queensland (Australia)

'New insights into the domains and dynamics of the plasma membrane.'

Session 2

Chair: Debbie Hay 

  5-5.30pmOne minute poster summaries 

Poster Session 1 (drinks included)

Light dinner (finger food).

Friday 3 December - Day 2

Session and Chair TimeSpeakers/event
Formal Opening  8.45-8.50 amProfessor William N Charman
Director, Monash Institute of Pharmaceutical Sciences.
Dean, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University.

Session 1

Biased Signalling symposium
Chair: Roger Summers   

Sponsored by:

Monash University Faculty of Medicine, Nursing and Health Sciences.


Stephen Hill University of Nottingham (UK)

'New insights into GPCR pharmacology from the use of fluorescent ligands in single living cells.'


Paul Insel University of California (USA)

'GPCR expression profiling: Surprising results away from the streetlights.'


Rob Leurs VU University (Netherlands)

'Modulation of chemokine receptor function: from small molecules to receptor proteins.'

10.20-10.50amMorning tea

Session 2

Early career research symposium
Chair: Paul Insel    

Sponsored by

Monash Institute of Pharmaceutical Sciences


Rob Lane Leiden University (Netherlands)

'The crystal structure of the A2a adenosine receptor – implications for drug discovery and design.'


Meritxell Canals Leiden/Amsterdam Center for Drug Research (Netherlands)

'Chemokine receptors: activation and regulation.'


Denise Wootten  Monash University (Australia)

'Structure – function analysis of the glucagon-like peptide -1 (GLP-1) receptor.'


Lauren May University of Nottingham (UK) and Monash University (Australia)

'Allosteric interactions across homodimeric adenosine A3 receptors.'


Michelle Halls Cambridge University (UK) and Monash University (Australia)

'A pre-assembled, constitutively active RXFP1-signalosome mediates responses to sub-picomolar concentrations of relaxin.'


Session 3

Allosteric modulation of GPCRs   
Chair: Arthur Christopoulos

Sponsored by

Drug Discovery Biology (MIPS)

1.30- 2pm 

Terry Kenakin GlaxoSmithKline (USA)

'Screening through an Allosteric Looking Glass for New Drugs.'


Ad IJzerman Leiden University (Netherlands)

'Allosteric modulation of adenosine receptors.'


Gerda Breitwieser Weis Center for Research (USA)

'Multiple mechanisms of allosteric agonist regulation of calcium sensing receptors'

3-3.30pmAfternoon tea

Session 4

GPCR signalling: in vivo correlates
Chair: Steve Hill 


Stefan Offermanns Max-Planck-Institute for Heart and Lung Research (Germany)

'Physiology and pharmacology of hydroxy-carboxylic acid receptors.'


Marc Parmentier Université Libre de Bruxelles (Belgium)

'The chemerin/ChemR23 system in inflammatory and viral diseases.'


Charles MacKay Monash University (Australia)

'Chemoattractant receptors for the regulation of inflammatory disease.'

Session 5

Poster session 2
Chair: Michelle Glass

   5-5.30pmOne minute poster summaries 
5.30-7.30pmPosters (plus drinks) 
8 pm - lateSpeakers dinner TBA

Saturday 4 December - Day 3

Session and Chair TimeSpeakers/event

Session 1

Regulation of GPCRs
Chair: Wally Thomas

Sponsored by:

TGR Biosciences


David Siderovski University of North Carolina (USA)

'Regulators of G-protein Signaling (RGS Proteins).'

9.30-10am Kevin Pfleger Western Australian Institute for Medical Research (Australia)

'Can heteromerization regulate GPCR function?'


Henrik Dohlman University of North Carolina (USA)

'Regulation of G protein signaling by ubiquitination.'

10.30-11amMorning tea

Session 2

ASCEPT Student oral presentation prize symposium

Chair:Terry Kenakin

Sponsored by the:

Australasian Society of Experimental Pharmacologists and Toxicologists


Natalie Witteveen (Florey Neurosciences Institute)

'A novel protein engineering approach for the investigation of GPCR/ligand interactions: Investigating the role of the extracellular loops in RXFP1 and RXFP2 activation.'

Brian DeVree (University of Michigan)

'Dynamic and structural analysis of the nucleotide-free complex between the β2-adrenergic receptor and the heterotrimeric stimulatory G protein.'

11.30-11.45pmAnna Davey (Monash University)

'Pathway-dependent allosteric modulation of the calcium sensing receptor.'

Brandon Zimmerman (McGill University)

'Ligand-directed signaling and trafficking of the Angiotensin type I receptor.'

Cassandra Koole (Monash University)

'The effects of naturally occurring single nucleotide polymorphisms (SNPs) at the glucagon-like peptide 1 receptor (GLP-1R).'

12.15-12.30pmJessica Esseltine (University of Western Ontario)

'RAB8 regulates group I metabotropic glutamate receptor intracellular trafficking and signalling.'


Session 3

GPCR structure and function
Chair: Didier Rognan


Marc Laburthe (France)

Functional tyrosine-based motifs ITIM and ITSM in the GPCR OX1R for orexins: What about the superfamily of GPCRs?


Chris Tate MRC Laboratory of Molecular Biology (UK)

'Comparison of agonist- and antagonist-bound structures of thermostabilised GPCRs.'


Mark Wheatley University of Birmingham (UK)

'Activation of peptide-GPCRs.'

3-3.30pmAfternoon tea

Session 4

ISN symposium on Novel insights into CNS GPCR function.

Chair: Phil Beart

Sponsored by the:

International Society for Neurochemistry


MacDonald Christie University of Sydney (Australia)

'Mechanisms of rapid opioid receptor desensitization and opioid tolerance in brain neurons'.


Brigitte Kieffer Institut de Génétique et de Biologie Moléculaire et Cellulaire (France)

'Delta opoid receptor imaging in vivo using a knock-in approach: implications for GPCR research.'


Steve Ferguson Robarts Research Institute (Canada)

'CRF receptor1 regulation of anxiety behaviour via sensitisation of 5-HT2 receptor signalling.'

5-5.15pmAward of Prizes and meeting close.