Molecular Pharmacology of G Protein-Coupled Receptors 2010 meeting

Wednesday 1 December - conjoint symposium

Attendees of the Molecular Pharmacology of G Protein-Coupled Receptors 2010 meeting are invited to attend a conjoint symposium on Molecular Modelling of GPCRs. More details can be found on the MMGPCR program.

Thursday 2 December - Day 1

Session and ChairSponsorTimeSpeakers/event
Registration 1-4 pm 
Technology Workshops 

2-2.45pm

 

 

 2.45-3.30pm

 

 

PerkinElmer

GPCR signalling - measuring complexity with label-free detection. [2.4 mb, .pdf]
Dr. Richard Eglen, President of Biodiscovery (PerkinElmer, Waltham, USA).

BMG Technology

"Resonance Energy Transfer technologies to study GPCRs."

Associate Professor Kevin Pfleger (Western Australian Institute for Medical Research): Bioluminescence resonance energy transfer.

Dr Mohammed Akli Ayoub (Western Australian Institute for Medical Research): Time-resolved FRET.

Welcome 4-4.10pm

Patrick Sexton, Arthur Christopoulos, Roger Summers.

Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences.

Session 1

Plenary lecture
Chair: Patrick Sexton

Sponsored by:

Pfizer

4.10-5pm

Rob Parton University of Queensland (Australia)

'New insights into the domains and dynamics of the plasma membrane.'

Session 2

Posters
Chair: Debbie Hay 

  5-5.30pmOne minute poster summaries 
5.30-7.30pm 

Poster Session 1 (drinks included)

Light dinner (finger food).

Friday 3 December - Day 2

Session and Chair TimeSpeakers/event
Formal Opening  8.45-8.50 amProfessor William N Charman
Director, Monash Institute of Pharmaceutical Sciences.
Dean, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University.

Session 1

Biased Signalling symposium
Chair: Roger Summers   

Sponsored by:

Monash University Faculty of Medicine, Nursing and Health Sciences.

8.50-9.20am 

Stephen Hill University of Nottingham (UK)

'New insights into GPCR pharmacology from the use of fluorescent ligands in single living cells.'

9.20-9.50am 

Paul Insel University of California (USA)

'GPCR expression profiling: Surprising results away from the streetlights.'

9.50-10.20am 

Rob Leurs VU University (Netherlands)

'Modulation of chemokine receptor function: from small molecules to receptor proteins.'

10.20-10.50amMorning tea

Session 2

Early career research symposium
Chair: Paul Insel    

Sponsored by

Monash Institute of Pharmaceutical Sciences

10.50-11.10am 

Rob Lane Leiden University (Netherlands)

'The crystal structure of the A2a adenosine receptor – implications for drug discovery and design.'

11.10-11.30am  

Meritxell Canals Leiden/Amsterdam Center for Drug Research (Netherlands)

'Chemokine receptors: activation and regulation.'

11.30-11.50am 

Denise Wootten  Monash University (Australia)

'Structure – function analysis of the glucagon-like peptide -1 (GLP-1) receptor.'

11.50-12.10pm 

Lauren May University of Nottingham (UK) and Monash University (Australia)

'Allosteric interactions across homodimeric adenosine A3 receptors.'

12.10-12.30pm 

Michelle Halls Cambridge University (UK) and Monash University (Australia)

'A pre-assembled, constitutively active RXFP1-signalosome mediates responses to sub-picomolar concentrations of relaxin.'

12.30-1.30pmLunch

Session 3

Allosteric modulation of GPCRs   
Chair: Arthur Christopoulos

Sponsored by

Drug Discovery Biology (MIPS)

1.30- 2pm 

Terry Kenakin GlaxoSmithKline (USA)

'Screening through an Allosteric Looking Glass for New Drugs.'

2-2.30pm

Ad IJzerman Leiden University (Netherlands)

'Allosteric modulation of adenosine receptors.'

2.30-3pm 

Gerda Breitwieser Weis Center for Research (USA)

'Multiple mechanisms of allosteric agonist regulation of calcium sensing receptors'

3-3.30pmAfternoon tea

Session 4

GPCR signalling: in vivo correlates
Chair: Steve Hill 

   3.30-4pm 

Stefan Offermanns Max-Planck-Institute for Heart and Lung Research (Germany)

'Physiology and pharmacology of hydroxy-carboxylic acid receptors.'

4-4.30pm 

Marc Parmentier Université Libre de Bruxelles (Belgium)

'The chemerin/ChemR23 system in inflammatory and viral diseases.'

4.30-5pm 

Charles MacKay Monash University (Australia)

'Chemoattractant receptors for the regulation of inflammatory disease.'

Session 5

Poster session 2
Chair: Michelle Glass

   5-5.30pmOne minute poster summaries 
5.30-7.30pmPosters (plus drinks) 
8 pm - lateSpeakers dinner TBA

Saturday 4 December - Day 3

Session and Chair TimeSpeakers/event

Session 1

Regulation of GPCRs
Chair: Wally Thomas

Sponsored by:

TGR Biosciences

9-9.30am

David Siderovski University of North Carolina (USA)

'Regulators of G-protein Signaling (RGS Proteins).'

9.30-10am Kevin Pfleger Western Australian Institute for Medical Research (Australia)

'Can heteromerization regulate GPCR function?'

10-10.30am 

Henrik Dohlman University of North Carolina (USA)

'Regulation of G protein signaling by ubiquitination.'

10.30-11amMorning tea

Session 2

ASCEPT Student oral presentation prize symposium

Chair:Terry Kenakin

Sponsored by the:

Australasian Society of Experimental Pharmacologists and Toxicologists

11-11.15am

Natalie Witteveen (Florey Neurosciences Institute)

'A novel protein engineering approach for the investigation of GPCR/ligand interactions: Investigating the role of the extracellular loops in RXFP1 and RXFP2 activation.'

11.15-11.30am
Brian DeVree (University of Michigan)

'Dynamic and structural analysis of the nucleotide-free complex between the β2-adrenergic receptor and the heterotrimeric stimulatory G protein.'

11.30-11.45pmAnna Davey (Monash University)

'Pathway-dependent allosteric modulation of the calcium sensing receptor.'

11.45-12pm
Brandon Zimmerman (McGill University)

'Ligand-directed signaling and trafficking of the Angiotensin type I receptor.'

12-12.15pm
Cassandra Koole (Monash University)

'The effects of naturally occurring single nucleotide polymorphisms (SNPs) at the glucagon-like peptide 1 receptor (GLP-1R).'

12.15-12.30pmJessica Esseltine (University of Western Ontario)

'RAB8 regulates group I metabotropic glutamate receptor intracellular trafficking and signalling.'

12.30-1.30pmLunch

Session 3

GPCR structure and function
Chair: Didier Rognan

   1.30-2pm

Marc Laburthe (France)

Functional tyrosine-based motifs ITIM and ITSM in the GPCR OX1R for orexins: What about the superfamily of GPCRs?

2-2.30pm 

Chris Tate MRC Laboratory of Molecular Biology (UK)

'Comparison of agonist- and antagonist-bound structures of thermostabilised GPCRs.'

2.30-3pm

Mark Wheatley University of Birmingham (UK)

'Activation of peptide-GPCRs.'

3-3.30pmAfternoon tea

Session 4

ISN symposium on Novel insights into CNS GPCR function.

Chair: Phil Beart

Sponsored by the:

International Society for Neurochemistry

3.30-4pm 

MacDonald Christie University of Sydney (Australia)

'Mechanisms of rapid opioid receptor desensitization and opioid tolerance in brain neurons'.

4-4.30pm

Brigitte Kieffer Institut de Génétique et de Biologie Moléculaire et Cellulaire (France)

'Delta opoid receptor imaging in vivo using a knock-in approach: implications for GPCR research.'

4.30-5pm

Steve Ferguson Robarts Research Institute (Canada)

'CRF receptor1 regulation of anxiety behaviour via sensitisation of 5-HT2 receptor signalling.'

5-5.15pmAward of Prizes and meeting close.