Molecular Pharmacology of G Protein-Coupled Receptors, 2007

July 18th & 19th, 2007: Victorian College of Pharmacy,
Monash University, Parkville, Victoria

 Day 1

  7:30 – 8:30

Registration

  8:15 – 8:25

Opening of the Meeting by Professor David de Kretser, AC,
Governor of Victoria

  8:25 – 8:30

Welcome from organisers

 Session 1

Receptor oligomerisation/signaling

  8:30 – 9:05

Quaternary structure of the alpha 1b-adrenoceptor: interaction interfaces and the consequences for receptor maturation and function

Graeme Milligan
Glasgow University, Glasgow, Scotland, UK

  9:05 –  9:40

Disruption of Cell Surface Dopamine Receptor Oligomerization as Visualized in Living Cells

Brian O’Dowd
University of Toronto, Toronto, Canada

  9:40 – 10:15

IGF-1 receptors hijack GPCR-PACAP type-1 receptors and apoptosis

Joel Bockaert
CNRS UMR5203, INSERM, U661, Montpellier, France

 10:15 – 10:40

Asymetric interactions between a GPCR dimer and the G protein

Jean-Louis Baneres
UMR CNRS 5074, Montpellier, France

  10:40 – 11:10

Morning Tea

  Session 2

Regulation/arrestins

  11:10 – 11:45

Finding dessert in the GPCR conformational cafeteria

Annette Gilchrist
Caden Biosciences, Madison, WI, USA

  11:45 – 12:20

Epigenetic Regulation by G Protein-Coupled Receptors

Gang Pei
Shanghai Institute of Biomedical Sciences, Shanghai, China
Sponsored by the Monash University School of Biomedical Sciences

  12:20 – 14:00

Lunch and posters

  Session 3

STUDENT ORAL PRIZE (selected from abstracts) Sponsored by ASCEPT

  14:00 – 14:15

Student

  14:15 – 14:30

Student

  14:30 – 14:45

Student

  14:45 – 15:00

Student

  15:00 – 15:15

Student

  15:15 – 15:30

Student

  15:30 – 16:00

Afternoon Tea

  Session 4

Family B receptors

  16:00 – 16:35

Understanding amylin receptors

Patrick Sexton
Monash University, Clayton, Vic., Australia

  16:35 – 17:10

Molecular basis of ligand binding and activation of the secretin receptor

Maoqing Dong
Mayo Clinic, Scottsdale, AZ, USA

  17:10 – 17:25

Invited short talk

Identification of ligand binding epitopes on the Receptor Activity Modifying Protein 1 (RAMP1)

John Simms
Monash University, Clayton, Vic., Australia

 Session 5

POSTERS

  17:30 – 19:00

Poster manning and Drinks

  19:00

Bus for conference dinner

  19:30– 23.30

 Day 2

  Session 6

Structure/function 1

  9:00 – 9:35

Predicting molecular interactions and induced fit

Ruben Abagyan
The Scripps Research Institute, La Jolla, CA, USA

  9:35 – 10:10

Engineering of Adenosine Receptors and their Ligands

Ken Jacobson
NIH, Bethesda, MD, USA

  10:00 – 10:20

Invited short talk

Modulation of glucose uptake into cells by GPCRs acting via AMP-activated protein kinase

Dana Hutchinson
Monash University, Clayton, Vic., Australia

  10:20 – 10:40

Morning Tea

 Session 7

Structure/function 2

  10:40 – 11:15

GPCR structures: Lessons from the CCK receptor

Larry Miller
Mayo Clinic, Scottsdale, AZ, USA

  11:15 – 11:50

Molecular Basis of G Protein-Coupled Receptor Function: Studies with the M3 Muscarinic Receptor as a Model System

Jurgen Wess
NIH, Bethesda, MD, USA

  11:50 – 14:00

Lunch and posters

  Session 8

Allosteric drug interactions

  14:00 – 14:35

Allosteric modulators of GPCRs as a novel approach to treatment of CNS disorders

Jeff Conn
Vanderbilt University , USA

  14:35 – 15:10

Preclinical and clinical validation of mGluR5 allosteric modulators

Emmanuel Le Poul
Addex Pharmaceuticals, Geneva, Switzerland

  15:10 – 15:30

Pharmacological characterisation of novel, selective M1 mAChR allocsteric agonists

Chris Langmead
GlaxoSmithKline, Harlow, England, UK

  15:30 – 15:45

Invited short talk

Regulation of the M4 muscarinic acetylcholine receptor by an allosteric agonist

Katie Leach
Monash University, Clayton, Vic., Australia

  15:45 – 16:15

Afternoon Tea

 Session 9

Family C receptors

  16:15 – 16:50

Structural rearrangements and regulation mechanisms of the metabotropic glutamate receptor

Yoshihiro Kubo
National Institute for Physiological Sciences, Okazaki, Japan

  16:50 – 17:25

Activation of class C GPCRs: different or similar to class A GPCR activation?

Laurent Prezeau
CNRS UMR5203, INSERM, U661, Montpellier, France

  17:25 – 17:30

Prizes awarded, farewell from organizers

  17:30 – 18:30

Farewell drinks